Tosha Takehiko 當舎武彦

… Alternative Names

TOSHA Takehiko 當舎武彦

TOSHA Takehiro 當舎武彦

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Researcher Number	00548993
Other IDs	https://orcid.org/0000-0002-8971-0759
Affiliation (Current)	2025: 兵庫県立大学, 理学研究科, 教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 兵庫県立大学, 理学研究科, 教授 2018 – 2023: 国立研究開発法人理化学研究所, 放射光科学研究センター, 専任研究員 2015 – 2017: 国立研究開発法人理化学研究所, 放射光科学総合研究センター, 専任研究員 2012: 独立行政法人理化学研究所, 城生体金属科学研究室, 専任研究員 2010 – 2011: 独立行政法人理化学研究所, 城生体金属科学研究室, 研究員
Review Section/Research Field	Principal Investigator Complex systems / Medium-sized Section 37:Biomolecular chemistry and related fields / Basic Section 37010:Bio-related chemistry / Medium-sized Section 34:Inorganic/coordination chemistry, analytical chemistry, and related fields / Bio-related chemistry / Science and Engineering / Functional biochemistry Except Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Transformative Research Areas, Section (II) / Basic Section 32010:Fundamental physical chemistry-related / Bio-related chemistry / Chemistry related to living body
Keywords	Principal Investigator 金属酵素 / ヘム / 一酸化窒素 / 反応中間体 / ケージド化合物 / 時間分解計測 / 時間分解構造解析 / X線自由電子レーザー / 酵素反応 / 金属タンパク質 … More / 酵素反応機構 / X線結晶構造解析 / 一酸化窒素還元酵素 / 生体分子分光 / 非ヘム鉄 / 時間分解X線結晶構造解析 / クライオフォトリシス / 核共鳴散乱分光 / 二核鉄中心 / 電子スピン共鳴 / 振動分光 / 低温光解離 / 核共鳴非弾性散乱 / 時間分解構造奇跡 / X線構造解析 / 嫌気条件 / 酸素分子発生 / 不均化 / 酸素発生 / 嫌気的メタン酸化 / タンパク質複合体 / CryoEM / 電子顕微鏡 / 相互作用 / 超分子複合体 / 反応機構 / 脱窒 / 蛋白質複合体 / 複核鉄活性中心 / 時間分解分光計測 / X線 / 蛋白質 / 生体分子 / 膜蛋白質 / 共鳴ラマン分光 / 呼吸鎖末端酸化酵素 / 呼吸酵素 / プロトンポンプ / 膜タンパク質 / 結晶構造解析 … More Except Principal Investigator 一酸化窒素還元酵素 / 一酸化窒素 / シクロデキストリン / 硫化水素 / ヘム / 生体内ガス / 機械学習 / 菌体内反応 / 高難度物質変換 / 擬似基質 / 機会学習 / 構造活性相関 / 結晶構造解析 / デコイ分子 / シトクロムP450 / 中性子結晶構造解析 / シリアルフェムト秒X線結晶構造解析 / 中性子線結晶構造解析 / 翻訳後修飾 / 時間分解構造解析 / システインスルフェン酸 / ニトリルヒドラターゼ / 触媒反応機構 / 中性子構造解析 / 時分割結晶構造解析 / XFEL / 反応中間体 / 遷移状態 / 生物物理 / 高性能レーザー / 蛋白質 / ポンププローブ法 / ケージド化合物 / フェムト秒レーザー / 超精密計測 / 膜タンパク質 / 酵素反応 / マイクロ流路フローセル / 時間分解赤外分光 / X線結晶構造解析 / チトクロム酸化酵素 / 分子進化 / オゾン層破壊 / 温室効果ガス / 亜酸化窒素 / 脱窒 / 呼吸酵素 Less

Study on Biologically Active Gas Molecules Using Synthetic Heme-model Compounds
- Principal Investigator
  
  北岸宏亮
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Doshisha University
Molecular movie of metalloenzyme-catalyzed reactions obtained by serial X-ray crystallography with fixed target chipPrincipal Investigator
- Principal Investigator
  
  當舎武彦
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  University of Hyogo
Design of transition state of the enzyme catalyzing oxidation reactions by molecules that make the enzyme malfunction
- Principal Investigator
  
  荘司長三
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Nagoya University
Molecular movie for nitric oxide reduction at the active site of metalloenzymePrincipal Investigator
- Principal Investigator
  
  當舎武彦
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  University of Hyogo
  Institute of Physical and Chemical Research
Elucidation of the chemistry of gaseous molecule at iron binuclear center using nuclear resonance spectroscopiesPrincipal Investigator
- Principal Investigator
  
  Tosha Takehiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  University of Hyogo
  Institute of Physical and Chemical Research
Observation of NO reduction reaction in the active site of metalloenzyme by molecular moviePrincipal Investigator
- Principal Investigator
  
  當舎武彦
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Institute of Physical and Chemical Research
Characterization of a metalloenzyme producing oxygen molecule from nitric oxidePrincipal Investigator
- Principal Investigator
  
  Tosha Takehiko
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 34:Inorganic/coordination chemistry, analytical chemistry, and related fields
- Research Institution
  Institute of Physical and Chemical Research
Structural determination of the reaction intermediate of nitrile hydratase by XFEL and neutron beam
- Principal Investigator
  
  Odaka Masafumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 32010:Fundamental physical chemistry-related
- Research Institution
  Akita University
Elucidation of effective consecutive chemical reaction in cell with formation of supramolecular enzyme complexPrincipal Investigator
- Principal Investigator
  
  Tosha Takehiko
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Institute of Physical and Chemical Research
構造・電子状態の同時計測に基づく生体系感応性化学種の反応機構解析Principal Investigator
- Principal Investigator
  
  當舎武彦
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Institute of Physical and Chemical Research
Development of a micro-flow time-resolved IR spectrometer for analyzing short-lived reaction intermediates of enzymes
- Principal Investigator
  
  Kubo Minoru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Institute of Physical and Chemical Research
Mechanism of catalytic nitric oxide reduction by membrane-bound nitric oxide reductase : comparison with oxygen reduction reactionPrincipal Investigator
- Principal Investigator
  
  TOSHA Takehiko
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  The Institute of Physical and Chemical Research
Molecular Evolution of Respiratory Enzymes; Functional Conversion from NO Reduction to O2 Reduction
- Principal Investigator
  
  SHIRO Yoshitsugu
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemistry related to living body
- Research Institution
  The Institute of Physical and Chemical Research

[Book] 第4章、第2節生体鉄の分子科学と細胞生物学、“生命金属ダイナミクス生体内における金属の挙動と制御”2021
- Author(s)
  城宜嗣、澤井仁美、當舎武彦
- Total Pages
  13
- Publisher
  NTS出版
- Data Source
  KAKENHI-PUBLICLY-20H05451
[Book] 第4章、第2節生体鉄の分子科学と細胞生物学、“生命金属ダイナミクス生体内における金属の挙動と制御”2021
- Author(s)
  城宜嗣、澤井仁美、當舎武彦
- Total Pages
  13
- Publisher
  NTS出版
- Data Source
  KAKENHI-PROJECT-21H02064
[Book] Metalloenzymes in Denitrification: Applications and Environmental Impacts2016
- Author(s)
  Takehiko Tosha and Yoshitsugu Shiro
- Total Pages
  27
- Publisher
  Royal Society of Chemistry
- Data Source
  KAKENHI-PUBLICLY-15H00965
[Journal Article] A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron-binding protein FutA from <i>Prochlorococcus</i>2024
- Author(s)
  Bolton,Machelett.Stubbs,Axford,Caramello,Catapano,Mal,Rodrigues,Cordery,Tizzard,MacMillan,Engilberge,von Stetten,Tosha,Sugimoto,Worrall,Webb,Zubkov,Coles,Mathieu,Steiner,Murshudov,Schrader,Orville,Royant,Evans,Hough,Owen,Tews
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 121 Issue: 12 Pages: 1-6
- DOI
  10.1073/pnas.2308478121
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04760, KAKENHI-PROJECT-21H02421
[Journal Article] Catalytic Oxidation of Methane by Wild-Type Cytochrome P450BM3 with Chemically Evolved Decoy Molecules2023
- Author(s)
  Ariyasu Shinya、Yonemura Kai、Kasai Chie、Aiba Yuichiro、Onoda Hiroki、Shisaka Yuma、Sugimoto Hiroshi、Tosha Takehiko、Kubo Minoru、Kamachi Takashi、Yoshizawa Kazunari、Shoji Osami
- Journal Title
  
  ACS Catalysis
  
  Volume: 13 Issue: 13 Pages: 8613-8623
- DOI
  10.1021/acscatal.3c01158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05271, KAKENHI-PUBLICLY-22H04760, KAKENHI-PROJECT-21H02064
[Journal Article] Serial Femtosecond Crystallography Reveals that Photoactivation in a Fluorescent Protein Proceeds via the Hula Twist Mechanism2023
- Author(s)
  Fadini Alisia et al.
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 145 Issue: 29 Pages: 15796-15808
- DOI
  10.1021/jacs.3c02313
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05777, KAKENHI-PLANNED-19H05781, KAKENHI-PUBLICLY-22H04760, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21H02064
[Journal Article] Time-resolved serial crystallography to track the dynamics of carbon monoxide in the active site of cytochrome c oxidase2023
- Author(s)
  Safari Cecilia et. al.
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 49 Pages: 1-12
- DOI
  10.1126/sciadv.adh4179
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06238, KAKENHI-PLANNED-19H05777, KAKENHI-PLANNED-19H05781, KAKENHI-PUBLICLY-22H04760, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21H02064
[Journal Article] Trapping of a Mononitrosyl Nonheme Intermediate of Nitric Oxide Reductase by Cryo-Photolysis of Caged Nitric Oxide2023
- Author(s)
  Takeda Hanae、Shimba Kanji、Horitani Masaki、Kimura Tetsunari、Nomura Takashi、Kubo Minoru、Shiro Yoshitsugu、Tosha Takehiko
- Journal Title
  
  The Journal of Physical Chemistry B
  
  Volume: 127 Issue: 4 Pages: 846-854
- DOI
  10.1021/acs.jpcb.2c05852
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18937, KAKENHI-PROJECT-19H00926, KAKENHI-PROJECT-21H02064, KAKENHI-PLANNED-19H05761, KAKENHI-PLANNED-19H05784, KAKENHI-PUBLICLY-22H04760, KAKENHI-PUBLICLY-22H04816, KAKENHI-PROJECT-23K23465
[Journal Article] Serial Femtosecond Crystallography Reveals the Role of Water in the One- or Two-Electron Redox Chemistry of Compound I in the Catalytic Cycle of the B-Type Dye-Decolorizing Peroxidase DtpB2022
- Author(s)
  Lucic Marina、Wilson Michael T.、Tosha Takehiko、Sugimoto Hiroshi、Shilova Anastasya、Axford Danny、Owen Robin L.、Hough Michael A.、Worrall Jonathan A. R.
- Journal Title
  
  ACS Catalysis
  
  Volume: 12 Issue: 21 Pages: 13349-13359
- DOI
  10.1021/acscatal.2c03754
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02064, KAKENHI-PUBLICLY-22H04760
[Journal Article] Structural basis for heme detoxification by an ATP-binding cassette?type efflux pump in gram-positive pathogenic bacteria2022
- Author(s)
  Nakamura Hiro、Hisano Tamao、Rahman Md. Mahfuzur、Tosha Takehiko、Shirouzu Mikako、Shiro Yoshitsugu
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 27
- DOI
  10.1073/pnas.2123385119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H00926, KAKENHI-PROJECT-21H02064, KAKENHI-PLANNED-19H05761, KAKENHI-PUBLICLY-22H04760
[Journal Article] Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.2022
- Author(s)
  Nishida Y, Yanagisawa S, Morita R, Shigematsu H, Shinzawa-Itoh K, Yuki H, Ogasawara S,　et al
- Journal Title
  
  Nat Commun.
  
  Volume: 13 Issue: 1 Pages: 7591-7591
- DOI
  10.1038/s41467-022-34771-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06130, KAKENHI-PROJECT-22K09391, KAKENHI-PROJECT-21H02064, KAKENHI-PROJECT-20K03794, KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-21K15443, KAKENHI-PROJECT-21K15776, KAKENHI-PLANNED-18H05425, KAKENHI-PLANNED-19H05761, KAKENHI-PLANNED-19H05784, KAKENHI-PUBLICLY-22H04760, KAKENHI-PUBLICLY-22H04800, KAKENHI-PROJECT-21H02914
[Journal Article] Single crystal spectroscopy and multiple structures from one crystal (MSOX) define catalysis in copper nitrite reductases2022
- Author(s)
  Rose Samuel L.、Baba Seiki、Okumura Hideo、Antonyuk Svetlana V.、Sasaki Daisuke、Hedison Tobias M.、Shanmugam Muralidharan、Heyes Derren J.、Scrutton Nigel S.、Kumasaka Takashi、Tosha Takehiko、Eady Robert R.、Yamamoto Masaki、Hasnain S. Samar
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 30
- DOI
  10.1073/pnas.2205664119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02064, KAKENHI-PLANNED-19H05783, KAKENHI-PUBLICLY-22H04760
[Journal Article] Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature2022
- Author(s)
  Moreno-Chicano, Carey, Axford, Beale, Doak, Duyvesteyn, Ebrahim, Henning, Monteiro, Myles, Owada, Sherrell, Straw, Srajer, Sugimoto, Tono, Tosha T., Tews, Trebbin, Strange, Weiss, Worrall, Meilleur, Owen, Ghiladi, Hough
- Journal Title
  
  IUCrJ
  
  Volume: 9 Issue: 5 Pages: 610-624
- DOI
  10.1107/s2052252522006418
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02064, KAKENHI-PUBLICLY-22H04760
[Journal Article] Mechanism of substrate inhibition in cytochrome-c dependent NO reductases from denitrifying bacteria (cNORs)2022
- Author(s)
  Matsumura Hirotoshi、Faponle Abayomi S.、Hagedoorn Peter-Leon、Tosha Takehiko、de Visser Sam P.、Moenne-Loccoz Pierre
- Journal Title
  
  Journal of Inorganic Biochemistry
  
  Volume: 231 Pages: 111781-111781
- DOI
  10.1016/j.jinorgbio.2022.111781
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05451, KAKENHI-PROJECT-21H02064
[Journal Article] Short-lived intermediate in N2O generation by P450 NO reductase captured by time-resolved IR spectroscopy and XFEL crystallography2021
- Author(s)
  Nomura, T., Kimura, T., Kanematsu, Y., Yamada, D., Yamashita, K., Hirata, K., Ueno, G., Murakami, H., Hisano, T., Yamagiwa, R., Takeda, H., Gopalasingam, C., Kousaka, R., Yanagisawa, S., Shoji, O., Kumasaka, T., Yamamoto, M., Takano, Y., Sugimoto, H., Tosha, T., Kubo, M., Shiro, Y
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 21
- DOI
  10.1073/pnas.2101481118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05698, KAKENHI-PLANNED-19H05761, KAKENHI-PLANNED-19H05784, KAKENHI-PUBLICLY-20H05451, KAKENHI-PLANNED-20H05883, KAKENHI-PROJECT-19H00926, KAKENHI-PROJECT-19H03171, KAKENHI-PROJECT-21H02064
[Journal Article] An unprecedented insight into the catalytic mechanism of copper nitrite reductase from atomic-resolution and damage-free structures2021
- Author(s)
  Rose Samuel L.、Antonyuk Svetlana V.、Sasaki Daisuke、Yamashita Keitaro、Hirata Kunio、Ueno Go、Ago Hideo、Eady Robert R.、Tosha Takehiko、Yamamoto Masaki、Hasnain S. Samar
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 1
- DOI
  10.1126/sciadv.abd8523
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05451, KAKENHI-PROJECT-17H03092
[Journal Article] Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival2021
- Author(s)
  Nishinaga Megumi、Sugimoto Hiroshi、Nishitani Yudai、Nagai Seina、Nagatoishi Satoru、Muraki Norifumi、Tosha Takehiko、Tsumoto Kouhei、Aono Shigetoshi、Shiro Yoshitsugu、Sawai Hitomi
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 467-467
- DOI
  10.1038/s42003-021-01987-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05761, KAKENHI-PLANNED-19H05762, KAKENHI-PROJECT-19H00926, KAKENHI-PROJECT-17H03093, KAKENHI-PROJECT-18K05321, KAKENHI-PUBLICLY-20H05451, KAKENHI-PROJECT-21H02064, KAKENHI-PROJECT-21H02421, KAKENHI-PROJECT-20K06517, KAKENHI-PROJECT-21K05281, KAKENHI-PROJECT-20H02531, KAKENHI-PLANNED-19H05766
[Journal Article] Impact of membrane protein-lipid interactions on formation of bilayer lipid membranes on SAM-modified gold electrode2021
- Author(s)
  Kato Masaru、Masuda Yuya、Yoshida Narumi、Tosha Takehiko、Shiro Yoshitsugu、Yagi Ichizo
- Journal Title
  
  Electrochimica Acta
  
  Volume: 373 Pages: 137888-137888
- DOI
  10.1016/j.electacta.2021.137888
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05761, KAKENHI-PUBLICLY-20H05451, KAKENHI-PROJECT-19H00926, KAKENHI-PROJECT-17H03092, KAKENHI-PROJECT-19H02664
[Journal Article] XFEL Crystal Structures of Peroxidase Compound II2021
- Author(s)
  Kwon, H., Basran, J., Pathak, C., Hussain, M., Freeman, S. L., Fielding, A. J., Bailey, A. J., Stefanou, N., Sparkes, H. A., Tosha, T., Yamashita, K., Hirata, K., Murakami, H., Ueno, G., Ago, H., Tono, K., Yamamoto, M., Sawai, H., Shiro, Y., Sugimoto, H., Raven, E., Moody, P. C. E.
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: - Issue: 26 Pages: 14578-14585
- DOI
  10.1002/anie.202103010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05452, KAKENHI-PLANNED-19H05761, KAKENHI-PUBLICLY-20H05451, KAKENHI-PROJECT-19H00926, KAKENHI-PROJECT-21H02064, KAKENHI-PROJECT-21K05281
[Journal Article] NO Dynamics in Microbial Denitrification System2021
- Author(s)
  Tosha Takehiko、Yamagiwa Raika、Sawai Hitomi、Shiro Yoshitsugu
- Journal Title
  
  Chemistry Letters
  
  Volume: 50 Issue: 2 Pages: 280-288
- DOI
  10.1246/cl.200629
- NAID
  130007986360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05761, KAKENHI-PUBLICLY-20H05451, KAKENHI-PROJECT-19H00926, KAKENHI-PROJECT-17H03092, KAKENHI-PROJECT-18K05321, KAKENHI-PROJECT-19K22208
[Journal Article] Time-resolved studies of metalloproteins using X-ray free electron laser radiation at SACLA2020
- Author(s)
  Suga Michihiro、Shimada Atsuhiro、Akita Fusamichi、Shen Jian-Ren、Tosha Takehiko、Sugimoto Hiroshi
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1864 Issue: 2 Pages: 129466-129466
- DOI
  10.1016/j.bbagen.2019.129466
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22208, KAKENHI-PROJECT-19K22403, KAKENHI-PROJECT-17H03092, KAKENHI-ORGANIZER-17H06433, KAKENHI-PLANNED-17H06434
[Journal Article] Timing of NO Binding and Protonation in the Catalytic Reaction of Bacterial Nitric Oxide Reductase as Established by Time-Resolved Spectroscopy.2020
- Author(s)
  Hanae Takeda, Tatsunari Kimura, Takashi Nomura, Masaki Horitani, Azusa Yokota, Akiko Matsubayashi, Shoko Ishii, Yoshitsugu Shiro, Minoru Kubo and Takehiko Tosha
- Journal Title
  
  Bulletin of the Chemical Society of Japan
  
  Volume: - Issue: 7 Pages: 825-833
- DOI
  10.1246/bcsj.20200038
- NAID
  130007879554
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19J15471, KAKENHI-PLANNED-19H05761, KAKENHI-PLANNED-19H05784, KAKENHI-PUBLICLY-20H05451, KAKENHI-PROJECT-19H00926, KAKENHI-PROJECT-17H03092, KAKENHI-PROJECT-19H03171, KAKENHI-PROJECT-19K22208, KAKENHI-PROJECT-18H02412
[Journal Article] Serial Femtosecond Zero Dose Crystallography Captures a Water‐Free Distal Heme Site in a Dye‐Decolorising Peroxidase to Reveal a Catalytic Role for an Arginine in Fe IV =O Formation2020
- Author(s)
  Lucic Marina、Svistunenko Dimitri A.、Wilson Michael T.、Chaplin Amanda K.、Davy Bradley、Ebrahim Ali、Axford Danny、Tosha Takehiko、Sugimoto Hiroshi、Owada Shigeki、Dworkowski Florian S. N.、Tews Ivo、Owen Robin L.、Hough Michael A.、Worrall Jonathan A. R.
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 59 Issue: 48 Pages: 21656-21662
- DOI
  10.1002/anie.202008622
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05451, KAKENHI-PROJECT-17H03092, KAKENHI-PROJECT-19K22403
[Journal Article] Hijacking the Heme Acquisition System of Pseudomonas aeruginosa for the Delivery of Phthalocyanine as an Antimicrobial2019
- Author(s)
  Shisaka Yuma、Iwai Yusuke、Yamada Shiho、Uehara Hiromu、Tosha Takehiko、Sugimoto Hiroshi、Shiro Yoshitsugu、Stanfield Joshua K.、Ogawa Kazuya、Watanabe Yoshihito、Shoji Osami
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 14 Issue: 7 Pages: 1637-1642
- DOI
  10.1021/acschembio.9b00373
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05258, KAKENHI-PROJECT-19K22208, KAKENHI-PLANNED-15H05806, KAKENHI-PROJECT-17H03092, KAKENHI-PROJECT-18J15250, KAKENHI-PROJECT-18H02084
[Journal Article] Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo-electron microscopy2019
- Author(s)
  Gopalasingam Chai C.、Johnson Rachel M.、Chiduza George N.、Tosha Takehiko、Yamamoto Masaki、Shiro Yoshitsugu、Antonyuk Svetlana V.、Muench Stephen P.、Hasnain S. Samar
- Journal Title
  
  Science Advances
  
  Volume: 5 Issue: 8
- DOI
  10.1126/sciadv.aax1803
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22208, KAKENHI-PLANNED-19H05761, KAKENHI-PROJECT-19H00926, KAKENHI-PROJECT-17H03092
[Journal Article] Visualization of Enzymatic Reactions Using SACLA2019
- Author(s)
  TOSHA Takehiko、KUBO Minoru
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 59 Issue: 4 Pages: 205-207
- DOI
  10.2142/biophys.59.205
- NAID
  130007683542
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22208, KAKENHI-PROJECT-17H03092
[Journal Article] Identification of a novel zinc-binding protein, C1orf123, as an interactor with a heavy metal-associated domain2018
- Author(s)
  Furukawa Yoshiaki、Lim Carolyn、Tosha Takehiko、Yoshida Koki、Hagai Tomoaki、Akiyama Shuji、Watanabe Shoji、Nakagome Kenta、Shiro Yoshitsugu
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 9 Pages: e0204355-e0204355
- DOI
  10.1371/journal.pone.0204355
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05705, KAKENHI-PUBLICLY-18H04564, KAKENHI-PROJECT-17H06165, KAKENHI-PROJECT-26220807, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-17H03092
[Journal Article] An unprecedented dioxygen species revealed by serial femtosecond rotation crystallography in copper nitrite reductase2018
- Author(s)
  Halsted Thomas P.、Yamashita Keitaro、Hirata Kunio、Ago Hideo、Ueno Go、Tosha Takehiko、Eady Robert R.、Antonyuk Svetlana V.、Yamamoto Masaki、Hasnain S. Samar
- Journal Title
  
  IUCrJ
  
  Volume: 5 Issue: 1 Pages: 22-31
- DOI
  10.1107/s2052252517016128
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03092
[Journal Article] Characterization of the Quinol-dependent Nitric Oxide Reductase from the Pathogen Neisseria meningitidis, an Electrogenic Enzyme2018
- Author(s)
  N. Gonska, D. R. Young, R. Yuki, T. Okamoto, T. Hisano, S. V. Antonyuk, S. S. Hasnain, K. Muramoto, Y. Shiro, T. Tosha, P. Adelroth
- Journal Title
  
  Sci. Rep.
  
  Volume: 8: 3637 Issue: 1 Pages: 3637-3637
- DOI
  10.1038/s41598-018-21804-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26220807, KAKENHI-PROJECT-17H03092, KAKENHI-PROJECT-15K07029
[Journal Article] Surface-Enhanced Infrared Absorption Spectroscopy of Bacterial Nitric Oxide Reductase under Electrochemical Control Using Vibrational Probe of Carbon Monoxide2018
- Author(s)
  M. Kato, S. Nakagawa, T. Tosha, Y. Shiro, Y. Masuda, K. Nakata, I. Yagi
- Journal Title
  
  J. Phys. Chem. Lett.
  
  Volume: 9 Issue: 17 Pages: 5196-5200
- DOI
  10.1021/acs.jpclett.8b02581
- NAID
  120006887743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26220807, KAKENHI-PROJECT-17H03092, KAKENHI-PROJECT-16K20882
[Journal Article] Structural basis for promotion of duodenal iron absorption by enteric ferric reductase with ascorbate.2018
- Author(s)
  Ganasen M, Togashi H, Takeda H, Asakura H, Tosha T, Yamashita K, Hirata K, Nariai Y, Urano T, Yuan X, Hamza I, Mauk AG, Shiro Y, Sugimoto H, Sawai H.
- Journal Title
  
  Communications Biology
  
  Volume: 1 Issue: 1 Pages: 120-120
- DOI
  10.1038/s42003-018-0121-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08983, KAKENHI-PROJECT-18K05321, KAKENHI-PROJECT-26220807, KAKENHI-PROJECT-17H03092, KAKENHI-PROJECT-18H02396
[Journal Article] Pseudomonas aeruginosa overexpression system of nitric oxide reductase for in vivo and in vitro mutational analyses2018
- Author(s)
  Yamagiwa Raika、Kurahashi Takuya、Takeda Mariko、Adachi Mayuho、Nakamura Hiro、Arai Hiroyuki、Shiro Yoshitsugu、Sawai Hitomi、Tosha Takehiko
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Bioenergetics
  
  Volume: 1859 Issue: 5 Pages: 333-341
- DOI
  10.1016/j.bbabio.2018.02.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03092, KAKENHI-PROJECT-15K07351, KAKENHI-PROJECT-18K05321, KAKENHI-PROJECT-26220807
[Journal Article] Capturing an initial intermediate during the P450nor enzymatic reaction using time-resolved XFEL crystallography and caged-substrate2017
- Author(s)
  Tosha Takehiko、Kubo Minoru, et. al
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 1-9
- DOI
  10.1038/s41467-017-01702-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05806, KAKENHI-PUBLICLY-17H05896, KAKENHI-PLANNED-26105012, KAKENHI-PROJECT-26220807, KAKENHI-PROJECT-15H03841, KAKENHI-PROJECT-17H03092, KAKENHI-PROJECT-15H05476, KAKENHI-PROJECT-15K18487
[Journal Article] Structural basis for binding and transfer of heme in bacterial heme-acquisition systems2017
- Author(s)
  Naoe Youichi、Nakamura Nozomi、Rahman Md. Mahfuzur、Tosha Takehiko、Nagatoishi Satoru、Tsumoto Kouhei、Shiro Yoshitsugu、Sugimoto Hiroshi
- Journal Title
  
  Proteins: Structure, Function, and Bioinformatics
  
  Volume: 85 Issue: 12 Pages: 2217-2230
- DOI
  10.1002/prot.25386
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05896, KAKENHI-PROJECT-26220807, KAKENHI-PROJECT-16H02420, KAKENHI-PROJECT-16H04710, KAKENHI-PROJECT-17H03092
[Journal Article] Dynamics of Nitric Oxide Controlled by Protein Complex in Bacterial System2017
- Author(s)
  Erina Terasaka, Kenta Yamada, Po-Hung Wang, Kanta Hosokawa, Raika Yamagiwa, Kimi Matsumoto, Shoko Ishii, Takaharu Mori, Kiyoshi Yagi, Hitomi Sawai, Hiroyuki Arai, Hiroshi Sugimoto, Yuji Sugita, Yoshitsugu Shiro and Takehiko Tosha
- Journal Title
  
  PNAS
  
  Volume: 114 Issue: 37 Pages: 9888-9893
- DOI
  10.1073/pnas.1621301114
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26119006, KAKENHI-PROJECT-26220807, KAKENHI-PROJECT-17H03092, KAKENHI-PROJECT-15K07351
[Journal Article] A Nearly On-axis Spectroscopic System for Simultaneously Measuring UV-visible Absorption and X-ray Diffraction in the SPring-8 Structural Genomics Beamline2016
- Author(s)
  M. Sakaguchi, T. Kimura, T. Nishida, T. Tosha, Y. Yamaguchi, S. Yanagisawa, G. Ueno, H. Murakami, H. Ago, M. Yamamoto, T. Ogura, Y. Shiro, M. Kubo
- Journal Title
  
  J. Synchro. Rad.
  
  Volume: 23 Issue: 1 Pages: 334-338
- DOI
  10.1107/s1600577515018275
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26620140, KAKENHI-PUBLICLY-15H00960, KAKENHI-PUBLICLY-15H00965, KAKENHI-PUBLICLY-15H01055, KAKENHI-PUBLICLY-15H01655, KAKENHI-PUBLICLY-26104532, KAKENHI-PROJECT-26220807, KAKENHI-PROJECT-15H05476, KAKENHI-PUBLICLY-16H00848
[Journal Article] Molecular mechanism of the catalytic reaction of NO reductase revealed by novel time-resolved visible/IR absorption spectrometers with microfluidic device2016
- Author(s)
  Kimura, T., Takeda, H., Ishii, S., Tosha, T., Shiro, Y., Kubo, M.
- Journal Title
  
  Biophysical Journal
  
  Volume: 110 Supp1 Issue: 3 Pages: 548a-548a
- DOI
  10.1016/j.bpj.2015.11.2933
- Data Source
  KAKENHI-PROJECT-15H03841
[Journal Article] Crystal Structures of Nitric Oxide Reductases Provide Key Insights into Functional Conversion of Respiratory Enzymes2013
- Author(s)
  T. Tosha, Y. Shiro
- Journal Title
  
  IUBMB Life
  
  Volume: 65 Pages: 217-226
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Crystal Structures of Nitric Oxide Reductases Provide Key Insights into Functional Conversion of Respiratory Enzymes2013
- Author(s)
  T. Tosha, Y. Shiro
- Journal Title
  
  IUBMB (International Union of Biochemistry and Molecular Biology)
  
  Volume: Life 65 Pages: 217-226
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Crystal Structure of Quinol-Dependent Nitric Oxide Reductase from Geobacillus Stearothermophilus2012
- Author(s)
  Y. Matsumoto, T. Tosha, A. V. Pisliakov, T. Hino, H. Sugimoto, S. Nagano, Y. Sugita and Y. Shiro
- Journal Title
  
  Nat. Struct. Mol. Biol
  
  Volume: 19 Pages: 238-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770136
[Journal Article] Ferritin Protein Nanocage Ion Channels : Gating by N-terminal Extensions2012
- Author(s)
  T.Tosha, R.K.Behera, H.-L.Ng, O.Bhattasali, T.Alber, E.C.Theil
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: (印刷中) Issue: 16 Pages: 13016-13025
- DOI
  10.1074/jbc.m111.332734
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770136
[Journal Article] Structural Basis for Nitrous Oxide Generation by Bacterial Nitric Oxide Reductases2012
- Author(s)
  Y. Shiro, H. Sugimoto, T. Tosha, S. Nagano and T. Hino
- Journal Title
  
  Phil. Trans. Royal Soc. B
  
  Volume: 367 Pages: 1195-1203
- Data Source
  KAKENHI-PROJECT-22770136
[Journal Article] Molecular Structure and Function of Bacterial Nitric Oxide Reductase2012
- Author(s)
  T. Hino, S. Nagano, H. Sugimoto, T. Tosha and Y. Shiro
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1817 Pages: 680-687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770136
[Journal Article] Proton Transfer in the Quinol-dependent Nitric Oxide Reductase from Geobacillus stearothermophilus during Reduction of Oxygen2012
- Author(s)
  L. Salomonsson, J. Reimann, T. Tosha, N. Krause, N. Gonska, Y. Shiro, P. Adelroth
- Journal Title
  
  Biochim. Biophys. Acta - Bioenergetics
  
  Volume: 1817 Pages: 1914-1920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Molecular Structures and Mechanism of Bacterial Nitric Oxide Reductase2012
- Author(s)
  T. Hino, S. Nagano, H. Sugimoto, T. Tosha, Y. Shiro
- Journal Title
  
  Special Issue on Respiratory Oxidases in Biochim
  
  Volume: Biophys. Acta - Bioenergetics 1817 Pages: 680-687
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Molecular Structure and Function of Bacterial Nitric Oxide Reductase2012
- Author(s)
  T.Hino, S.Nagano, H.Sugimoto, T.Tosha, Y.Shiro
- Journal Title
  
  Biochimica et Biophysica Acta-Bioenergetics
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770136
[Journal Article] Molecular Structures and Mechanism of Bacterial Nitric Oxide Reductase2012
- Author(s)
  T. Hino, S. Nagano, H. Sugimoto, T. Tosha, Y. Shiro
- Journal Title
  
  Biochim. Biophys. Acta - Bioenergetics
  
  Volume: 1817 Pages: 680-687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Structural Basis for Nitrous Oxide Generation by Bacterial Nitric Oxide Reductases2012
- Author(s)
  Y. Shiro, H. Sugimoto, T. Tosha, S. Nagano, T. Hino
- Journal Title
  
  Philosophical Transactions B, The Royal Society
  
  Volume: 367 Pages: 1195-1203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Proton Transfer in the Quinol-dependent Nitric Oxide Reductase from Geobacillus Stearothermophilus during Reduction of Oxygen2012
- Author(s)
  L. Salomonsson, J. Reimann, T. Tosha, N. Krause, N. Gonska, Y. Shiro and P. Adelroth
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770136
[Journal Article] Crystal Structure of Quinol-Dependent Nitric Oxide Reductase from Geobacillus Stearothermophilus2012
- Author(s)
  Y. Matsumoto, T. Tosha, A. V. Pisliakov, T. Hino, H. Sugimoto, S. Nagano, Y. Sugita, Y. Shiro
- Journal Title
  
  Nat. Strl. Mol. Biol
  
  Volume: 19 Pages: 238-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] 一酸化窒素還元酵素の結晶構造から見えてきた呼吸酵素の機能変換2012
- Author(s)
  日野智也,當舎武彦,城宜嗣
- Journal Title
  
  生物物理
  
  Volume: (印刷中)
- NAID
  10030494649
- Data Source
  KAKENHI-PROJECT-22770136
[Journal Article] Crystal Structure of Quinol-Dependent Nitric Oxide Reductase from Geobacillus stearithermophilus2012
- Author(s)
  Y.Matsumoto, T.Tosha, A.V.Pisliakov, T.Hino, H.Sugimoto, S.Nagano, Y.Sugita, Y.Shiro
- Journal Title
  
  Nat.Strl.Mol.Biol.
  
  Volume: 19 Issue: 2 Pages: 238-245
- DOI
  10.1038/nsmb.2213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041, KAKENHI-PLANNED-22105012, KAKENHI-PROJECT-22310137, KAKENHI-PROJECT-22770136, KAKENHI-PROJECT-22770163, KAKENHI-PUBLICLY-23121531
[Journal Article] Proton Transfer in the Quinol-dependent Nitric Oxide Reductase from Geobacillus stearothermophilus during Reduction of Oxygen2012
- Author(s)
  L. Salomonsson, J. Reimann, T. Tosha, N. Krause, N. Gonska, Y. Shiro, P. Adelroth
- Journal Title
  
  Special Issue on Respiratory Oxidases in Biochim
  
  Volume: Biophys. Acta - Bioenergetics 1817 Pages: 1914-1920
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] 一酸化窒素還元酵素の結晶構造から見えてきた呼吸酵素の機能変換2012
- Author(s)
  日野智也、當舎武彦、城宜嗣
- Journal Title
  
  生物物理
  
  Volume: (印刷中)
- NAID
  10030494649
- Data Source
  KAKENHI-PROJECT-22770136
[Journal Article] "Structural Basis for Nitrous Oxide Generation by Bacterial Nitric Oxide Reductases" the Proceedings of the Royal Society Meeting2012
- Author(s)
  Y. Shiro, H. Sugimoto, T. Tosha, S. Nagano, T. Hino
- Journal Title
  
  'Nitrous oxide, the forgotten greenhouse gas', Philosophical Transactions B, The Royal Society
  
  Volume: 367 Pages: 1195-1203
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Moving Iron Through Ferritin Protein Nanocages Depends on Residues Throughout Each Four α-Helix Bundle Subunit2011
- Author(s)
  S.Haldar, L.E.Bevers, T.Tosha, E.C.Theil
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 286 Issue: 29 Pages: 25620-25627
- DOI
  10.1074/jbc.m110.205278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770136
[Journal Article] Structural Basis for Nitrous Oxide Generation by Bacterial Nitric Oxide Reductases2011
- Author(s)
  Y.Shiro, H.Sugimoto, T.Tosha, S.Nagano, T.Hino
- Journal Title
  
  Philosophical Transactions of the Royal Society B
  
  Volume: 00 Issue: 1593 Pages: 1-9
- DOI
  10.1098/rstb.2011.0310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770136, KAKENHI-PROJECT-24687015
[Journal Article] Moving Metal Ions Through Ferritin Protein Nanocages from Three-fold Pores to Catalytic Sites2010
- Author(s)
  T.Tosha, et al.
- Journal Title
  
  J.Am.Chem.Soc.
  
  Volume: 132 Pages: 14562-14569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770136
[Presentation] Characterization of reaction intermediates of nitric oxide reductases involved in denitrification2023
- Author(s)
  Takehiko Tosha
- Organizer
  ThermusQ高度好熱菌研究を切り拓くネオテクノロジー
- Data Source
  KAKENHI-PROJECT-21H02064
[Presentation] Characterization of the short-lived reaction intermediate of NO reductase with caged substrate2023
- Author(s)
  Takehiko Tosha
- Organizer
  Dynamic Crystallography-XFELs and Synchrotrons to study enzyme reactions
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04760
[Presentation] Characterization of reaction intermediates of nitric oxide reductases involved in denitrification2023
- Author(s)
  Takehiko Tosha
- Organizer
  ThermusQ高度好熱菌研究を切り拓くネオテクノロジー
- Data Source
  KAKENHI-PUBLICLY-22H04760
[Presentation] Characterization of the short-lived reaction intermediate of NO reductase with caged substrate2023
- Author(s)
  Takehiko Tosha
- Organizer
  Dynamic Crystallography-XFELs and Synchrotrons to study enzyme reactions
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02064
[Presentation] Mechanism of nitric oxide reduction by P450 in fungal denitrification2023
- Author(s)
  Takehiko Tosha
- Organizer
  日本薬物動態学会第38回年会/第23回シトクロムP450国際会議国際合同大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02064
[Presentation] Mechanism of nitric oxide reduction by P450 in fungal denitrification2023
- Author(s)
  Takehiko Tosha
- Organizer
  日本薬物動態学会第38回年会/第23回シトクロムP450国際会議国際合同大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04760
[Presentation] 嫌気呼吸酵素を標的とした緑膿菌の抗菌薬開発に向けて2023
- Author(s)
  當舎武彦、川上凌平、Chai Gopalasingam、重松秀樹、西田優也、新谷泰範
- Organizer
  第2回生命金属科学シンポジウム
- Data Source
  KAKENHI-PUBLICLY-22H04760
[Presentation] 嫌気呼吸酵素を標的とした緑膿菌の抗菌薬開発に向けて2023
- Author(s)
  當舎武彦、川上凌平、Chai Gopalasingam、重松秀樹、西田優也、新谷泰範
- Organizer
  第2回生命金属科学シンポジウム
- Data Source
  KAKENHI-PROJECT-21H02064
[Presentation] ケージド基質の低温光解離を利用した金属酵素反応中間体の捕捉2023
- Author(s)
  當舎武彦、武田英恵、榛葉幹治、堀谷正樹、城宜嗣
- Organizer
  第49回生体分子科学討論会
- Data Source
  KAKENHI-PUBLICLY-22H04760
[Presentation] ケージド基質の低温光解離を利用した金属酵素反応中間体の捕捉2023
- Author(s)
  當舎武彦、武田英恵、榛葉幹治、堀谷正樹、城宜嗣
- Organizer
  第49回生体分子科学討論会
- Data Source
  KAKENHI-PROJECT-21H02064
[Presentation] Elucidation of Mechanisms for Catalytic Reaction of Nitric Oxide Reductases by Time-resolved Techniques2022
- Author(s)
  T. Tosha, H. Takeda, Y. Shiro, M. Kubo
- Organizer
  International Conference on Porphyrins and Phthalocyanines (ICPP)-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04760
[Presentation] 金属酵素活性中心における一酸化窒素還元反応の分子機構2022
- Author(s)
  當舎武彦
- Organizer
  物性研短期研究会「理論タンパク質物性科学の最前線：理論と実験との密な協働」
- Invited
- Data Source
  KAKENHI-PROJECT-21H02064
[Presentation] 酸素バリア性フィルムを利用した嫌気下での構造解析の試み2022
- Author(s)
  當舎武彦、榛葉幹治、松浦滉明、平田邦生、山本雅貴、城宜嗣
- Organizer
  第60回日本生物物理学会年会
- Data Source
  KAKENHI-PUBLICLY-22H04760
[Presentation] NO reduction chemistry at heme/non-heme binuclear active center proved by methods using photo-sensitive caged NO2022
- Author(s)
  Takehiko Tosha
- Organizer
  10th Asian Biological Inorganic Chemistry Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04760
[Presentation] 金属酵素活性中心における一酸化窒素還元反応の分子機構2022
- Author(s)
  當舎武彦
- Organizer
  物性研短期研究会「理論タンパク質物性科学の最前線：理論と実験との密な協働」
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04760
[Presentation] 酸素バリア性フィルムを利用した嫌気下での構造解析の試み2022
- Author(s)
  當舎武彦、榛葉幹治、松浦滉明、平田邦生、山本雅貴、城宜嗣
- Organizer
  第60回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21H02064
[Presentation] Mechanism of biological nitric oxide reduction proved by time-resolved structural analysis2022
- Author(s)
  Takehiko Tosha
- Organizer
  REDOX WEEK IN SENDAI 2022, 4th International conference on persulfide and sulfur metabolism in biology and medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04760
[Presentation] 光解離性基質の低温光解離を利用した金属酵素短寿命反応中間体の同定2022
- Author(s)
  當舎武彦
- Organizer
  第61回電子スピンサイエンス学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04760
[Presentation] Mechanism of biological nitric oxide reduction proved by time-resolved structural analysis2022
- Author(s)
  Takehiko Tosha
- Organizer
  REDOX WEEK IN SENDAI 2022, 4th International conference on persulfide and sulfur metabolism in biology and medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02064
[Presentation] Elucidation of Mechanisms for Catalytic Reaction of Nitric Oxide Reductases by Time-resolved Techniques2022
- Author(s)
  T. Tosha, H. Takeda, Y. Shiro, M. Kubo
- Organizer
  International Conference on Porphyrins and Phthalocyanines (ICPP)-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02064
[Presentation] 光解離性ケージド基質を用いた金属酵素反応機構の解明2022
- Author(s)
  當舎武彦
- Organizer
  メタルバイオサイエンス研究会2022
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04760
[Presentation] NO reduction chemistry at heme/non-heme binuclear active center proved by methods using photo-sensitive caged NO2022
- Author(s)
  Takehiko Tosha
- Organizer
  10th Asian Biological Inorganic Chemistry Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02064
[Presentation] 光解離性基質の低温光解離を利用した金属酵素短寿命反応中間体の同定2022
- Author(s)
  當舎武彦
- Organizer
  第61回電子スピンサイエンス学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02064
[Presentation] 光解離性ケージド基質を用いた金属酵素反応機構の解明2022
- Author(s)
  當舎武彦
- Organizer
  メタルバイオサイエンス研究会2022
- Invited
- Data Source
  KAKENHI-PROJECT-21H02064
[Presentation] 各種分光計測を駆使した鉄活性中心における一酸化窒素還元酵素の反応機構の解明2022
- Author(s)
  當舎武彦
- Organizer
  第22回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04760
[Presentation] 各種分光計測を駆使した鉄活性中心における一酸化窒素還元酵素の反応機構の解明2022
- Author(s)
  當舎武彦
- Organizer
  第22回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02064
[Presentation] 光解離性ケージド基質を利用した一酸化窒素還元酵素の反応機構の解明2021
- Author(s)
  當舎武彦
- Organizer
  第94回日本生化学大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05451
[Presentation] 光解離性ケージド基質を利用した一酸化窒素還元酵素の反応機構の解明2021
- Author(s)
  當舎武彦
- Organizer
  第94回日本生化学大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02064
[Presentation] 光解離性ケージド基質を利用した時間分解構造解析による酵素反応の可視化2021
- Author(s)
  當舎武彦
- Organizer
  日本薬学会第141回年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] 構造生物学におけるXFELと放射光の相補的利用～金属酵素の反応機構解明を目指して～2021
- Author(s)
  當舎武彦
- Organizer
  放射光ユーザーのためのSACLAの利活用に関するワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] Time-resolved techniques provide mechanism for nitric oxide reduction by nitric oxide reductase2021
- Author(s)
  Tosha T., Takeda H., Shiro Y., Kubo M.
- Organizer
  Pacifichem 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02064
[Presentation] Time-resolved techniques provide mechanism for nitric oxide reduction by nitric oxide reductase2021
- Author(s)
  Tosha T., Takeda H., Shiro Y., Kubo M.
- Organizer
  Pacifichem 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05451
[Presentation] Unveiling the catalytic mechanism of nitrile hydratase by time-resolved crystallography and neutron crystallography2020
- Author(s)
  尾高雅文, 山中保明, 辻井広夢，岩藤秀直，林　英輝，松村洋寿，野村高志, 當舎武彦, 玉田太郎，日下勝弘，野口恵一，養王田正文
- Organizer
  令和2年度化学系学協会東北大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H02667
[Presentation] 光解離性ケージド基質を利用した時間分解構造解析による酵素反応の可視化2020
- Author(s)
  當舎武彦
- Organizer
  日本薬学会第141回年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22208
[Presentation] Crystallization of nitrile hydratase for XFEL crystallography2020
- Author(s)
  Iwatoh, H., Tsujii, H., Matsumura, H., Tosha, T., Shiro, Y., Yamada, D., Kubo, M., Odaka, M.
- Organizer
  令和2年度化学系学協会東北大会
- Data Source
  KAKENHI-PROJECT-19H02667
[Presentation] 時間分解結晶構造解析および分光解析が明らかにする金属酵素による一酸化窒素分解機構2020
- Author(s)
  當舎武彦
- Organizer
  第2回量子線科学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] マイクロ秒時間領域で形成される一酸化窒素還元酵素反応中間体の分光解析2020
- Author(s)
  當舎武彦
- Organizer
  第58回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-19K22208
[Presentation] XFELを用いたNHase触媒反応解析に向けた微結晶の作製と構造解析2020
- Author(s)
  岩藤秀直、林英樹、松村洋寿、小川信明、野村高志、當舎武彦、城　宜嗣、野口恵一、養王田正文、尾高雅文
- Organizer
  酵素工学研究会第82回講演会 2020年08月 - 2020年08月
- Data Source
  KAKENHI-PROJECT-19H02667
[Presentation] マイクロ秒時間領域で形成される一酸化窒素還元酵素反応中間体の分光解析2020
- Author(s)
  當舎武彦
- Organizer
  第58回日本生物物理学会年会
- Data Source
  KAKENHI-PUBLICLY-20H05451
[Presentation] XFELを用いたNHase触媒反応解析に向けた微結晶の作製と構造解析2020
- Author(s)
  岩藤秀直、林　英樹、松村洋寿、小川信明、野村高志、當舎武彦、城　宜嗣、野口恵一、養王田正文、尾高雅文
- Organizer
  生物工学若手研究者の集い第二回オンラインセミナー
- Data Source
  KAKENHI-PROJECT-19H02667
[Presentation] 構造生物学におけるXFELと放射光の相補的利用～金属酵素の反応機構解明を目指して～2020
- Author(s)
  當舎武彦
- Organizer
  放射光ユーザーのためのSACLAの利活用に関するワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-19K22208
[Presentation] 構造生物学におけるXFELと放射光の相補的利用～金属酵素の反応機構解明を目指して～2020
- Author(s)
  當舎武彦
- Organizer
  放射光ユーザーのためのSACLAの利活用に関するワークショップ
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05451
[Presentation] 時間分解結晶構造解析および分光解析が明らかにする金属酵素による一酸化窒素分解機構2020
- Author(s)
  當舎武彦
- Organizer
  第2回量子線科学セミナー
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05451
[Presentation] マイクロ秒時間領域で形成される一酸化窒素還元酵素反応中間体の分光解析2020
- Author(s)
  當舎武彦
- Organizer
  第58回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] 時間分解結晶構造解析および分光解析が明らかにする金属酵素による一酸化窒素分解機構2020
- Author(s)
  當舎武彦
- Organizer
  第2回量子線科学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K22208
[Presentation] 光解離性ケージド基質を利用した時間分解構造解析による酵素反応の可視化2020
- Author(s)
  當舎武彦
- Organizer
  日本薬学会第141回年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05451
[Presentation] Elucidation of NO reduction mechanism in soluble NO reductase by time-resolved crystallography with photosensitive caged compound2019
- Author(s)
  Takehiko Tosha
- Organizer
  32nd European Crystallographic Meeting (ECM32)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] Functional roles of conserved residues near the active site of nitric oxide reductase based on the structural analysis2019
- Author(s)
  當舎武彦、山際来佳、倉橋拓也、新井博之、杉本宏、城宜嗣
- Organizer
  第57回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] ニトリルヒドラターゼの中性子構造解析に向けた取り組み2019
- Author(s)
  辻井啓夢，林英輝，松村洋寿，野村高志，當舎武彦，玉田太郎，日下勝弘，久保稔，城宜嗣，尾高雅文
- Organizer
  第71回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-19H02667
[Presentation] NO-binding and Protonation Process in the Catalytic Reaction of Heme/non-heme Iron Nitric Oxide Reductase Proved by Time-Resolved Spectroscopic System2019
- Author(s)
  H. Takeda, T. Kimura, T. Nomura, T. Tosha, Y. Shiro, M. Kubo
- Organizer
  15th International Symposium on Applied Bioinorganic Chemistry(ISABIC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] NO-binding and Protonation Process in the Catalytic Reaction of Heme/non-heme Iron Nitric Oxide Reductase Proved by Time-Resolved Spectroscopic System2019
- Author(s)
  H. Takeda, T. Kimura, T. Nomura, T. Tosha, Y. Shiro, M. Kubo
- Organizer
  15th International Symposium on Applied Bioinorganic Chemistry(ISABIC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22208
[Presentation] NO-binding and protonation process in the catalytic reaction of the bacterial Nitric oxide reductase as established by time-resolved spectroscopy2019
- Author(s)
  武田英恵、木村哲就、野村高志、當舎武彦、城宜嗣、久保稔
- Organizer
  第57回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-19K22208
[Presentation] NO-binding and protonation process in the catalytic reaction of the bacterial Nitric oxide reductase as established by time-resolved spectroscopy2019
- Author(s)
  武田英恵、木村哲就、野村高志、當舎武彦、城宜嗣、久保稔
- Organizer
  第57回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] XFELを用いたNHase触媒反応解析に向けた微結晶の作製と構造解析2019
- Author(s)
  岩藤秀直，林英輝，松村洋寿，小川信明，野村高志，當舎武彦，城宜嗣，野口恵一，養王田正文，尾高雅文
- Organizer
  酵素工学研究会第82回講演会
- Data Source
  KAKENHI-PROJECT-19H02667
[Presentation] ニトリルヒドラターゼの時間分解SFX解析と中性子構造解析に向けた取り組み2019
- Author(s)
  林英輝，辻井啓夢，岩藤秀直，松村洋寿，當舎武彦，野村高志，玉田太郎，日下勝弘，尾高雅文
- Organizer
  第13回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-19H02667
[Presentation] Mechanism of P450nor-Catalyzed NO Reduction Proved by Time-Resolved Spectroscopic and Crystallographic Analyses2019
- Author(s)
  T. Tosha, T. Nomura, H. Takeda, T. Kimura, H. Sugimoto, M. Kubo and Y. Shiro
- Organizer
  19th International Conference on Biological Inorganic Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22208
[Presentation] Elucidation of NO reduction mechanism in soluble NO reductase by time-resolved crystallography with photosensitive caged compound2019
- Author(s)
  Takehiko Tosha
- Organizer
  32nd European Crystallographic Meeting (ECM32)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22208
[Presentation] Mechanism of P450nor-Catalyzed NO Reduction Proved by Time-Resolved Spectroscopic and Crystallographic Analyses2019
- Author(s)
  T. Tosha, T. Nomura, H. Takeda, T. Kimura, H. Sugimoto, M. Kubo and Y. Shiro
- Organizer
  19th International Conference on Biological Inorganic Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] ニトリルヒドラターの中性子構造解析に向けた取り組み2019
- Author(s)
  辻井啓夢，林英輝，松村洋寿，野村高志，當舎武彦，玉田太郎，日下勝弘，久保稔，城宜嗣，尾高雅文
- Organizer
  第46回生体分子科学討論会
- Data Source
  KAKENHI-PROJECT-19H02667
[Presentation] Functional roles of conserved residues near the active site of nitric oxide reductase based on the structural analysis2019
- Author(s)
  當舎武彦、山際来佳、倉橋拓也、新井博之、杉本宏、城宜嗣
- Organizer
  第57回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-19K22208
[Presentation] Regulation of nitric oxide dynamics in microbial denitrification2018
- Author(s)
  Takehiko Tosha
- Organizer
  The International Symposium on Bioinorganic Chemistry 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] Time-resolved XFEL crystallography and in crystallo spectroscopy for probing reaction dynamics of respiratory metalloenzymes2018
- Author(s)
  當舎武彦
- Organizer
  5th BioXFEL International Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] 亜硝酸還元酵素と一酸化窒素還元酵素の複合体形成による迅速なNO分解機構2018
- Author(s)
  當舎武彦
- Organizer
  平成30年度内外環境応答・代謝酵素研究会
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] Mechanism of Biological Nitric Oxide Reduction2018
- Author(s)
  當舎武彦
- Organizer
  平成30年度化学系学協会東北大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] NITRIC OXIDE DYNAMICS CONTROLLED BY FORMATION OF PROTEIN COMPLEX IN DENTRIFICATION2018
- Author(s)
  Takehiko Tosha, Erina Terasaka, Kenta Yamada, Po-Hung Wang, Hiroyuki Arai, Hiroshi Sugimoto, Yuji Sugita, Yoshistugu Shiro
- Organizer
  9th Asian Biological Inorganic Chemistry Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] Mechanism of Biological Nitric Oxide Reduction Proved by Time-resolved Spectroscopic Analyses2018
- Author(s)
  Tosha Tosha, Tetsunari Kimura, Hanae Takeda, Shoko Ishii, Takashi Nomura, Minoru Kubo, Yoshitsugu Shiro
- Organizer
  International Conference on Porphyrins and Phthalocyanines
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] X線自由電子レーザーを用いた時間分解結晶構造解析による酵素反応の追跡2018
- Author(s)
  當舎武彦
- Organizer
  日本化学会第98春季年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] 脱窒にみられる金属タンパク質複合体による効率的な連続化学反応2018
- Author(s)
  當舎武彦
- Organizer
  第56回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] 光解離性基質を利用した時間分解X線結晶構造解析による酵素反応の追跡2018
- Author(s)
  當舎武彦
- Organizer
  第18回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] Elucidation of Mechanism of Biological Nitric Oxide Reduction2018
- Author(s)
  Takehiko Tosha, Hanae Takeda, Takashi Nomura, Tetsunari Kimura, Minoru Kubo, Yoshitsugu Shiro
- Organizer
  43rd International Conference on Coordination Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] Elucidation of the NO reduction mechanism of nitric oxide reductase using time-resolved vis/IR spectroscopy．2017
- Author(s)
  武田英恵，木村哲就，野村高志，松林亜希子，石井頌子，當舎武彦，城宜嗣，久保稔
- Organizer
  日本生物物理学会，第55回年会
- Data Source
  KAKENHI-PROJECT-15H03841
[Presentation] Time-resolved X-ray crystallography at SACLA: Application to enzymatic reaction2017
- Author(s)
  當舎武彦、西田拓真、野村高志、佐伯直哉、杉本宏、山下恵太郎、平田邦生、吾郷日出夫、山本雅貴、中根崇智、菅原道泰、南後恵理子、岩田想、城宜嗣、久保稔
- Organizer
  錯体化学会第67回討論会
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] X線自由電子レーザーを利用した時間分解X線結晶構造解析による酵素反応の観測2017
- Author(s)
  當舎武彦、西田拓真、野村高志、佐伯直哉、杉本宏、山下恵太郎、平田邦生、吾郷日出夫、山本雅貴、中根崇智、菅原道泰、南後恵理子、岩田想、城宜嗣、久保稔
- Organizer
  第44回生体分子科学討論会
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] 時間分解赤外分光法および凍結トラップXFEL結晶構造解析を用いたP450norの反応中間体の解析．2017
- Author(s)
  野村高志, 當舎武彦, 杉本宏, 久野玉雄, 山際来佳, Chai Gopalasingam, 山下恵太郎, 平田邦生, 山本雅貴, 城宣嗣, 久保稔
- Organizer
  第44回生体分子科学討論会
- Data Source
  KAKENHI-PROJECT-15H03841
[Presentation] 凍結トラップX線結晶構造解析および時間分解赤外分光法を用いた P450nor の反応中間体の構造解析．2017
- Author(s)
  野村高志, 當舎武彦, 杉本宏, 久野玉雄, 山際来佳, Chai Gopalasingam, 山下恵太郎, 平田邦生, 山本雅貴, 城宣嗣, 久保稔
- Organizer
  平成29年度日本結晶学会年会
- Data Source
  KAKENHI-PROJECT-15H03841
[Presentation] 酵素反応機構解明のためのX線自由電子レーザーを利用した時間分解X線結晶構造解析2017
- Author(s)
  當舎武彦、西田拓真、野村高志、佐伯直哉、杉本宏、山下恵太郎、平田邦生、吾郷日出夫、山本雅貴、中根崇智、菅原道泰、南後恵理子、岩田想、城宜嗣、久保稔
- Organizer
  第50回酸化反応討論会
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] X線自由電子レーザーを利用した時間分解X線結晶構造解析による酵素反応の観測．2017
- Author(s)
  當舎武彦, 西田拓真, 野村高志, 佐伯直哉, 杉本宏, 山下恵太郎, 平田邦生, 吾郷日出夫, 山本雅貴, 中根崇智, 菅原道泰, 南後恵理子, 岩田想, 城宜嗣, 久保稔
- Organizer
  第44回生体分子科学討論会
- Data Source
  KAKENHI-PROJECT-15H03841
[Presentation] X線自由電子レーザーを用いた時間分解結晶構造解析：酵素反応への応用2017
- Author(s)
  當舎武彦
- Organizer
  第55回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03092
[Presentation] マイクロ流路フロー・フラッシュ時間分解赤外分光法による一酸化窒素還元酵素の反応機構解析．2016
- Author(s)
  木村哲就, 武田英恵, 石井頌子, 當舎武彦, 城宜嗣, 久保稔
- Organizer
  第43回生体分子科学討論会
- Place of Presentation
  名古屋大学野依記念学術交流館（名古屋市千種区）
- Data Source
  KAKENHI-PROJECT-15H03841
[Presentation] フェムト秒赤外レーザーを用いた生体分子ダイナミクスの観測2016
- Author(s)
  久保稔，木村哲就，武田英恵，石井頌子，當舎武彦，城宜嗣
- Organizer
  分子研研究会“高輝度・高強度赤外光源の現状と展望”
- Place of Presentation
  岡崎コンファレンスセンター（愛知県岡崎市）
- Year and Date
  2016-02-11
- Data Source
  KAKENHI-PROJECT-15H03841
[Presentation] Kinetic analysis of the NO reduction reaction of nitric oxide reductase using nanoliter-flow time-resolved visible/IR spectroscopy.2016
- Author(s)
  Takeda, H., Kimura, T., Ishii, S., Tosha, T., Shiro, Y., Kubo, M.
- Organizer
  The 4th International Symposium for Young Chemists on Stimuli-Responsive Chemical Species for the Creation of Functional Molecules.
- Place of Presentation
  大阪大学吹田キャンパスサントリーメモリアルホール（吹田市山田丘）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03841
[Presentation] Time-resolved spectroscopic analysis of the key intermediate in the enzymatic NO reduction2016
- Author(s)
  T. Tosha, T. Kimura, H. Takeda, S. Ishii, Y. Shiro and M. Kubo
- Organizer
  感応性化学種が拓く新物質科学The 4th International Symposium for Young Chemists
- Place of Presentation
  大阪大学
- Year and Date
  2016-12-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H00965
[Presentation] X線結晶構造解析とラマン分光の統合的利用による酵素活性中心の構造解析2016
- Author(s)
  當舎武彦
- Organizer
  SPring-8シンポジウム・放射光赤外研究会サテライトミーティング
- Place of Presentation
  関西学院大学三田キャンパス
- Year and Date
  2016-08-30
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H00965
[Presentation] Structural basis for effective nitric oxide decomposition in microbial denitrification2016
- Author(s)
  T. Tosha, E. Terasaka, K. Matsumoto, H. Sugimoto and Y. Shiro
- Organizer
  The 30th anniversary symposium of the protein society
- Place of Presentation
  Baltimore, USA
- Year and Date
  2016-07-16
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H00965
[Presentation] 脱窒酵素複合体形成による効率的な一酸化窒素分解の分子機構2016
- Author(s)
  當舎武彦,寺坂瑛里奈,松本喜慎,杉本宏,城宜嗣
- Organizer
  26回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  北海道大学
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PUBLICLY-15H00965
[Presentation] Molecular mechanism of the catalytic reaction of NO reductase revealed by novel time-resolved visible/IR absorption spectrometers with microfluidic device2016
- Author(s)
  Kimura, T., Takeda, H., Ishii, S., Tosha, T., Shiro, Y., Kubo, M.
- Organizer
  The 60th Biophysical Society Annual Meeting
- Place of Presentation
  Los Angeles Convention Center (Los Angeles, USA)
- Year and Date
  2016-03-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03841
[Presentation] Mechanism of effective nitric oxide decomposition in microbial denitrification2015
- Author(s)
  T. Tosha, E. Terasaka, K. Matsumoto, H. Sugimoto and Y. Shiro
- Organizer
  Pacifichem 2015
- Place of Presentation
  ホノルル・米国
- Year and Date
  2015-12-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H00965
[Presentation] マイクロ流体フローを用いた一酸化窒素還元酵素の触媒反応の動的分光観察2015
- Author(s)
  木村哲就, 石井頌子, 當舎武彦, 城宜嗣, 久保稔
- Organizer
  第15回日本蛋白質科学会年会若手奨励賞シンポジウム
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2015-06-25
- Invited
- Data Source
  KAKENHI-PROJECT-15H03841
[Presentation] ）「Structural evidence for complex formation between nitric oxide reductase and nitrite reductase2015
- Author(s)
  T. Tosha, E. Terasaka, K. Matsumoto, H. Sugimoto and Y. Shiro
- Organizer
  “Metals in Biology” in Wako
- Place of Presentation
  理研和光本所・（埼玉県・和光市）
- Year and Date
  2015-06-17
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H00965
[Presentation] 亜硝酸還元酵素と一酸化窒素還元酵素の複合体形成による効率的な一酸化窒素分解機構2015
- Author(s)
  當舎武彦,寺坂瑛里奈,松本喜慎,杉本宏,城宜嗣
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  金沢大学角間キャンパス・（石川県・金沢市）
- Year and Date
  2015-09-14
- Data Source
  KAKENHI-PUBLICLY-15H00965
[Presentation] Molecular mechanism of effective nitric oxide decomposition by denitrification enzymes2015
- Author(s)
  T. Tosha, E. Terasaka, K. Matsumoto, H. Sugimoto and Y. Shiro
- Organizer
  17th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  北京・中国
- Year and Date
  2015-07-23
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H00965
[Presentation] Development of a time-resolved visible/IR absorption spectrometer with a novel microfluidic device and its application to catalytic reaction of NO reductase2015
- Author(s)
  Kimura, T., Ishii, S., Tosha, T., Shiro, Y., Kubo, M.
- Organizer
  Pacifichem 2015
- Place of Presentation
  Hawaii Convention Center (Hawaii, USA)
- Year and Date
  2015-12-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03841
[Presentation] マイクロ流体フロー・フラッシュ赤外分光測定系による一酸化窒素還元酵素の触媒反応の実時間観察2015
- Author(s)
  木村哲就, 石井頌子, 當舎武彦, 城宜嗣, 久保稔
- Organizer
  第9回分子科学討論会
- Place of Presentation
  東京工業大学大岡山キャンパス（東京都目黒区）
- Year and Date
  2015-09-19
- Data Source
  KAKENHI-PROJECT-15H03841
[Presentation] 脱窒にみられる効率的な一酸化窒素分解システムの構造基盤2015
- Author(s)
  當舎武彦,寺坂瑛里奈,松本喜慎,杉本宏,城宜嗣
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール・（徳島市・徳島県）
- Year and Date
  2015-06-25
- Data Source
  KAKENHI-PUBLICLY-15H00965
[Presentation] Development of micro-channel flow-flash infrared absorption spectroscopy and its application to early intermediate of nitric oxide reductase2015
- Author(s)
  木村哲就，石井頌子，當舎武彦，城宜嗣，久保稔
- Organizer
  日本生物物理学会，第53回年会
- Place of Presentation
  金沢大学角間キャンパス（石川県金沢市）
- Year and Date
  2015-09-14
- Data Source
  KAKENHI-PROJECT-15H03841
[Presentation] Structural basis for molecular evolution in respiratory enzymes : from NO reductase to O_2 reductase2011
- Author(s)
  T.Tosha
- Organizer
  Mini Symposium on Energy Conversion in Bacteria
- Place of Presentation
  Stockholm University, Stockholm, Sweden(口頭)
- Year and Date
  2011-06-16
- Data Source
  KAKENHI-PROJECT-22770136
[Presentation] 緑膿菌由来シアン化型一酸化窒素還元酵素のX線結晶構造解析2011
- Author(s)
  佐藤希美,當舎武彦,日野智也,杉本宏,左子芳彦,城宜嗣
- Organizer
  平成23年度日本結晶学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22770136
[Presentation] Spectroscopic characterization of the ferrous-NO form as a model of active species using Zn-substituted bacterial nitric oxide reductase2011
- Author(s)
  N. Okada, T. Tosha, and Y. Shiro
- Organizer
  第49回日本生物物理学会年会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-22770136
[Presentation] Functional Role of Ca Ion in Nitric Oxide Reductase from Geobacillus Stearothermophilus2011
- Author(s)
  T. Tosha, Y. Matsumoto, S. Nagano, and Y. Shiro
- Organizer
  15th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-22770136
[Presentation] Functional Role of Ca Ion in Nitric Oxide Reductase from Geobacillus Stearother mophilus2011
- Author(s)
  T.Tosha, Y.Matsumoto, S.Nagano, Y.Shiro
- Organizer
  15th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  University of British Columbia, Vancouver, BC, Canada(口頭)
- Year and Date
  2011-08-09
- Data Source
  KAKENHI-PROJECT-22770136
[Presentation] Structural basis for molecular evolution in respiratory enzymes : from NO reductase to O2 reductase2011
- Author(s)
  T. Tosha
- Organizer
  Mini Symposium on Energy Conversion in Bacteria
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2011-06-16
- Data Source
  KAKENHI-PROJECT-22770136
[Presentation] Quinol-dependent Nitric Oxide Reductase : A Key Enzyme in the Molecular Evolution of Respiratory Enzymes2011
- Author(s)
  T.Tosha
- Organizer
  Theil Fest
- Place of Presentation
  Children's Hospital Research Institute, California, USA(招待講演)
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-22770136
[Presentation] 金属蛋白質における構造機能相関:蛋白質ならではの機能制御機構2011
- Author(s)
  當舎武彦
- Organizer
  錯体化学若手の会夏の学校2011
- Place of Presentation
  石川県羽咋市(招待講演)
- Year and Date
  2011-08-01
- Data Source
  KAKENHI-PROJECT-22770136
[Presentation] 金属蛋白質における構造機能相関:蛋白質ならではの機能制御機構2011
- Author(s)
  當舎武彦
- Organizer
  錯体化学若手の会夏の学校2011
- Place of Presentation
  羽咋
- Data Source
  KAKENHI-PROJECT-22770136
[Presentation] Construction of E.coli overexpression system for membrane-bound bacterial nitric oxide reductase2010
- Author(s)
  T.Tosha
- Organizer
  第48回日本生物物理学会年会
- Place of Presentation
  仙台市
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22770136
[Presentation] 嫌気呼吸系の一酸化窒素還元酵素の構造と分子進化2010
- Author(s)
  永野真吾、松本悠史、當舎武彦、日野智也、杉本宏、城宜嗣
- Organizer
  第10回日本蛋白質化学会
- Place of Presentation
  札幌
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-21245041
[Presentation] Quinol and Ca Binding Sites in Bacterial Nitric Oxide Reductase2010
- Author(s)
  T.Tosha
- Organizer
  Pacifichem 2010
- Place of Presentation
  米国、ハワイ、ホノルル
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-22770136
[Presentation] 膜結合型一酸化窒素還元酵素におけるカルシウム結合部位の同定とその機能的役割2010
- Author(s)
  當舎武彦
- Organizer
  第10回日本蛋白質科学会
- Place of Presentation
  札幌市
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-22770136
[Presentation] Construction of E. coli overexpression system for membrane-bound bacterial nitric oxide reductase2010
- Author(s)
  T. Tosha, A. Kohara, Y. Shiro
- Organizer
  第48回日本生物物理学会年会
- Place of Presentation
  東北大学
- Data Source
  KAKENHI-PROJECT-22770136
[Presentation] ナノデスクを用いた病原菌の生体鉄感知システムの解析2010
- Author(s)
  伊藤陽子、當舎武彦、中村寛夫、城宜嗣
- Organizer
  第33回日本分子生物学年会・第83回日本生化学会大会合同大会(BMB2020)
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21245041
[Presentation] 膜結合型一酸化窒素還元酵素におけるカルシウム結合部位の同定とその機能的役割2010
- Author(s)
  當舎武彦,松本悠史,永野真吾,城宜嗣
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22770136
[Presentation] Nitric Oxide Reductases: Chemistry of N-O bond Cleavage and N-N Bond Formation2010
- Author(s)
  Shiro, Y., Hino, T., Matsumoto, Y., Nagano, S., Sugimoto, H., Tosha, T
- Organizer
  Sixth International Conference on Porphyrins and Phtalocyanines
- Place of Presentation
  New Mexico, USA
- Data Source
  KAKENHI-PROJECT-21245041
[Presentation] 呼吸酵素における分子進化の構造基盤2010
- Author(s)
  當舎武彦
- Organizer
  分子アンサンブル2010
- Place of Presentation
  埼玉県和光市
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-22770136
[Presentation] Nitric Oxide Reductase ; Chemistry of N-O Bond Cleavage and N-N Bond Formation2010
- Author(s)
  Yoshitsugu Shiro, Tomoya Hino, Yushi Matsumoto, Shingo Nagano, Hiroshi Sugimoto, Takehiko Tosha
- Organizer
  Sixth International Conference on Porphyrins and Phthalocyanines (ICPP-6)
- Place of Presentation
  Albuquerque, Mew Mexico, USA
- Year and Date
  2010-07-06
- Data Source
  KAKENHI-PROJECT-21245041
[Presentation] Quinol and Ca Binding Sites in Bacterial Nitric Oxide Reductase2010
- Author(s)
  T. Tosha, Y. Matsumoto, S. Nagano, and Y. Shiro
- Organizer
  Pacifichem2010
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-22770136
[Presentation] 電子供与体キノールから一酸化窒素還元酵素への電子伝達2009
- Author(s)
  當舎武彦、松本悠史、永野真吾、城宜嗣
- Organizer
  第82回日本生化学大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21245041

1. Odaka Masafumi (20224248)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. SHIRO Yoshitsugu (70183051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
3. SUGIMOTO Hiroshi (90344043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
4. KIKUCHI Akihiro (90321752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAGANO Shingo (60286440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
6. Kubo Minoru (90392878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
7. KIMURA Tetsunari (70506906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
8. PISLIAKOV Andrei (70565770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 新井博之 (70291052)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 松村洋寿 (60741824)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
11. 荘司長三 (90379587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 有安真也 (50586998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 堀谷正樹 (80532134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 北岸宏亮 (60448090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小寺政人 (00183806)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 東田怜 (10908122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ADELROTH Pia

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. YANAGISAWA Sachiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. SAWAI Hitomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. HISANO Tamao

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. YAGI Kiyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 古川良明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 新沢伊藤恭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 小川和也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 浦野健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 杉田有治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tosha Takehiko 當舎 武彦

TOSHA Takehiko 當舎 武彦

TOSHA Takehiro 當舎 武彦

Research Projects

Research Products

Co-Researchers

Study on Biologically Active Gas Molecules Using Synthetic Heme-model Compounds

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Molecular movie of metalloenzyme-catalyzed reactions obtained by serial X-ray crystallography with fixed target chipPrincipal Investigator

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Design of transition state of the enzyme catalyzing oxidation reactions by molecules that make the enzyme malfunction

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Molecular movie for nitric oxide reduction at the active site of metalloenzymePrincipal Investigator

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Elucidation of the chemistry of gaseous molecule at iron binuclear center using nuclear resonance spectroscopiesPrincipal Investigator

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Observation of NO reduction reaction in the active site of metalloenzyme by molecular moviePrincipal Investigator

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Characterization of a metalloenzyme producing oxygen molecule from nitric oxidePrincipal Investigator

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Structural determination of the reaction intermediate of nitrile hydratase by XFEL and neutron beam

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Elucidation of effective consecutive chemical reaction in cell with formation of supramolecular enzyme complexPrincipal Investigator

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構造・電子状態の同時計測に基づく生体系感応性化学種の反応機構解析Principal Investigator

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Development of a micro-flow time-resolved IR spectrometer for analyzing short-lived reaction intermediates of enzymes

Principal Investigator

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Mechanism of catalytic nitric oxide reduction by membrane-bound nitric oxide reductase : comparison with oxygen reduction reactionPrincipal Investigator

Principal Investigator

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Molecular Evolution of Respiratory Enzymes; Functional Conversion from NO Reduction to O2 Reduction

Principal Investigator

Tosha Takehiko 當舎武彦

TOSHA Takehiko 當舎武彦

TOSHA Takehiro 當舎武彦

[Book] 第4章、第2節生体鉄の分子科学と細胞生物学、“生命金属ダイナミクス生体内における金属の挙動と制御”2021

[Book] 第4章、第2節生体鉄の分子科学と細胞生物学、“生命金属ダイナミクス生体内における金属の挙動と制御”2021