TANABE Chiaki 田邉千晶

Researcher Number	00552902
Affiliation (based on the past Project Information) *help	2011 – 2013: 岩手医科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Nerve anatomy/Neuropathology Except Principal Investigator Biological pharmacy
Keywords	Principal Investigator アミロイドβ / Rer1 / synoviolin / ERAD / γセクレターゼ / アルツハイマー病 / 老化性痴呆疾患 Except Principal Investigator ユビキチン化 / amyloid beta / アルツハイマー病 … More / OS-9 / 小胞体関連分解 / 小胞体 / アミロイドベータ / アルツハイマー / Rer1 / シノビオリン / ニカストリン / プレセニリン複合体 Less

The development of new diagnostic and therapeutic tools for AD based on regulation of the gamma-secretase complex assembly.
- Principal Investigator
  
  MAEDA Tomoji
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Iwate Medical University
A・generation regulated by the degradation of Rer1 through ERADPrincipal Investigator
- Principal Investigator
  
  TANABE Chiaki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Iwate Medical University

All 2013 2012 2011

All Journal Article Presentation

[Journal Article] アルツハイマー病にかかわるプロテアーゼ活性調節機構の解明を目指して2013
- Author(s)
  田邉千晶、前田智司、駒野宏人
- Journal Title
  
  臨床検査
  
  Volume: vol.57 Pages: 110-110
- Data Source
  KAKENHI-PROJECT-23700425
[Journal Article] Localization of mature neprilysin in lipid rafts.2012
- Author(s)
  Sato K, Tanabe C, Yonemura Y, Watahiki H, Zhao Y, Yagishita S, Ebina M, Suo S, Futai E, Murata M, Ishiura S.
- Journal Title
  
  J. Neurosci. Res.
  
  Volume: 90 Issue: 4 Pages: 870-877
- DOI
  10.1002/jnr.22796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657082, KAKENHI-PROJECT-23700425, KAKENHI-PROJECT-23700429
[Journal Article] The ubiquitin ligase synoviolin up-regulates amyloid β production by targeting a negative regulator of γ-secretase, Rer1, for degradation.2012
- Author(s)
  Tanabe C, Maeda T, Zou K, Liu J, Liu S, Nakajima T, Komano H.
- Journal Title
  
  J Biol Chem.
  
  Volume: 287 Issue: 53 Pages: 44203-44211
- DOI
  10.1074/jbc.m112.365296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590110, KAKENHI-PROJECT-23659176, KAKENHI-PROJECT-23700425, KAKENHI-PROJECT-24700383
[Journal Article] ER-stress-inducible Herp, facilitates the degradation of immature nicastrin. Biochim2011
- Author(s)
  Marutani, T., Maeda, T., Tanabe, C ., Zou, K., Araki, W., Kokame, K., Michikawa, M. and Komano, H
- Journal Title
  
  Biophys. Acta
  
  Volume: 1810 Pages: 790-798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700425
[Presentation] The stability of endoplasmic stress-inducible Herp is regulated by synoviolin-mediated and ubiquitin-independent proteasomal degradation2013
- Author(s)
  前田智司、田邉千晶、鄒鶤、鈴木ひとみ、稲垣学人、劉俊俊、劉しゅ余、駒野宏人
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590110
[Presentation] Synoviolin is involved in the ubiquitination of Rer1 and regulates the generation of amyloid beta2012
- Author(s)
  ○Chiaki Tanabe, Tomoji Maeda, Kun Zou, Junjun Liu, Syuyu Liu, Toshihiro Nakajima, Hiroto Komano
- Organizer
  XIIIth International Symposium on Proteinase inhibitors and Biological Control
- Place of Presentation
  Slovenia
- Data Source
  KAKENHI-PROJECT-23700425
[Presentation] SynoviolinによるRer1分解を介したAβ産生制御2012
- Author(s)
  ○田邉千晶、前田智司、鄒鶤、劉俊俊、Shuyu Liu、中島利博、駒野宏人
- Organizer
  第17回日本病態プロテアーゼ学会
- Place of Presentation
  オークラアクトシティホテル浜松
- Data Source
  KAKENHI-PROJECT-23700425
[Presentation] Synoviolin is involved in the ubiquitination of Rer1 and regulates the generation of amyloid bet2012
- Author(s)
  Chiaki Tanabe, Tomoji Maeda, Kun Zou, Junjun Liu, Syuyu Liu, Toshihiro Nakajima, Hiroto Komano
- Organizer
  XIIIth International Symposium on Proteinase inhibitors and Biological
- Place of Presentation
  Control. Slovenia
- Data Source
  KAKENHI-PROJECT-23700425
[Presentation] 小胞体ストレス誘導タンパク質Herpの分解機構の解析2012
- Author(s)
  鈴木ひとみ、稲垣学人、田邉千晶、鄒鶤、Junjun Liu、Shuyu Liu、小亀浩一、前田智司、駒野宏人
- Organizer
  日本生化学会東北支部第78回例会・シンポジウム
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-23590110
[Presentation] SynoviolinによるRer1分解を介したAβ産生制御2012
- Author(s)
  田邉千晶、前田智司、鄒鶤、劉俊俊、劉〓余、中島利博、駒野宏人
- Organizer
  第17回日本病態プロテアーゼ学会
- Place of Presentation
  オークラアクトシティホテル浜松、静岡
- Data Source
  KAKENHI-PROJECT-23700425
[Presentation] 小胞体ストレス誘導タンパク質Herp の分解機構の解析2012
- Author(s)
  鈴木ひとみ, 稲垣学人, 田邉千晶, 鄒鶤, 劉俊俊, 劉姝余, 小亀浩市, 前田智司, 駒野宏人
- Organizer
  日本生化学会東北支部　第78回　例会・シンポジウム
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-23590110
[Presentation] Synoviolin facilitates the degradation of an ER-stress-inducible protein, Herp2011
- Author(s)
  前田智司、田邉千晶、鄒鶤、劉俊俊、劉しゅ余、小亀浩市、駒野宏人
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590110
[Presentation] Synoviolin is involved in the degradation of Rer1, thereby modulating Amyloid beta2011
- Author(s)
  田邉千晶、前田智司、鄒鶤、劉俊俊、劉しゅ余、駒野宏人
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590110
[Presentation] Synoviolin is involved in the degradation of Rer1, thereby modulating A β generation2011
- Author(s)
  田邉千晶、前田智司、鄒鶤、Liu Junjun 、Liu Shuyu、駒野宏人
- Organizer
  第84回日本生化学会
- Place of Presentation
  国立京都国際会館、京都
- Data Source
  KAKENHI-PROJECT-23700425
[Presentation] αとγセクレターゼの解析2011
- Author(s)
  田邉千晶
- Organizer
  日本認知症学会主催-認知症研究を知る若手研究者の集まり
- Place of Presentation
  あいち健康プラザ、愛知県大府市
- Data Source
  KAKENHI-PROJECT-23700425
[Presentation] Synoviolin facilitates the degradation of an ER-stress-inducible protein, Herp.2011
- Author(s)
  前田智司、田邉千晶、鄒鶤、小亀浩市、駒野宏人
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590110
[Presentation] Synoviolin is involved in the degradation of Rer1, thereby modulating Aβ generation.2011
- Author(s)
  田邉千晶
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23700425

1. MAEDA Tomoji (60303294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. KOMANO Chiaki (40170378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. FUTAI Eugene

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TANABE Chiaki 田邉 千晶

Research Projects

Research Products

Co-Researchers

The development of new diagnostic and therapeutic tools for AD based on regulation of the gamma-secretase complex assembly.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A・generation regulated by the degradation of Rer1 through ERADPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] アルツハイマー病にかかわるプロテアーゼ活性調節機構の解明を目指して2013

Author(s)

Journal Title

Data Source

[Journal Article] Localization of mature neprilysin in lipid rafts.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The ubiquitin ligase synoviolin up-regulates amyloid β production by targeting a negative regulator of γ-secretase, Rer1, for degradation.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ER-stress-inducible Herp, facilitates the degradation of immature nicastrin. Biochim2011

Author(s)

Journal Title

Data Source

[Presentation] The stability of endoplasmic stress-inducible Herp is regulated by synoviolin-mediated and ubiquitin-independent proteasomal degradation2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Synoviolin is involved in the ubiquitination of Rer1 and regulates the generation of amyloid beta2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] SynoviolinによるRer1分解を介したAβ産生制御2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Synoviolin is involved in the ubiquitination of Rer1 and regulates the generation of amyloid bet2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 小胞体ストレス誘導タンパク質Herpの分解機構の解析2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] SynoviolinによるRer1分解を介したAβ産生制御2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 小胞体ストレス誘導タンパク質Herp の分解機構の解析2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Synoviolin facilitates the degradation of an ER-stress-inducible protein, Herp2011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Synoviolin is involved in the degradation of Rer1, thereby modulating Amyloid beta2011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Synoviolin is involved in the degradation of Rer1, thereby modulating A β generation2011

TANABE Chiaki 田邉千晶