Shirakami Yoshifumi 白神宜史

Researcher Number	00560400
Other IDs
Affiliation (Current)	2025: 大阪大学, 放射線科学基盤機構, 特任准教授(常勤)
Affiliation (based on the past Project Information) *help	2019 – 2024: 大阪大学, 放射線科学基盤機構, 特任准教授(常勤) 2016 – 2018: 大阪大学, 医学系研究科, 特任准教授(常勤)
Review Section/Research Field	Principal Investigator Basic Section 52040:Radiological sciences-related / Radiation science Except Principal Investigator Basic Section 52040:Radiological sciences-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 211At / アスタチン / 核医学治療 / α線 / ペプチド / 放射性医薬品 / 核医学 / アミノ酸 / アルファ線 / 47Sc … More / tyrosine / astatine / TAT / amino acids / radiotheranostics / targeted alpha therapy / ギャップ結合チャネル / PET / コネキシン43 / SPECT / 123I / アルファ線内用療法 / SPECT診断 / 心不全 / ギャップ結合 / 内用療法 / 甲状腺がん / グリオーマ / すい臓がん / 内容療法 … More Except Principal Investigator アルファ線 / 核医学治療 / アスタチン / FAP / 線維芽細胞活性化タンパク質 / アミノ酸トランスポーター / がん / トランスポーター / アミノ酸 / LAT1 / アスタチン211 / 癌関連線維芽細胞 / 低侵襲 / がん治療 / At-211 / PET / がん間質 / FAPI / がん関連線維芽細胞 / 核医学 / アルファ線治療 / 難治性がん / 核医学治療薬 Less

Development of innovative alpha therapy targeting cancer-associated fibroblasts
- Principal Investigator
  
  渡部直史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Osaka University
Research on alpha-particle therapeutics for targeting SGLT2Principal Investigator
- Principal Investigator
  
  白神宜史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Osaka University
A challenge to low-invasive one-day cancer treatment using alpha emitting nuclide
- Principal Investigator
  
  Kaneda-Nakashima Kazuko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Osaka University
Targeted alpha therapy for patients with tumorPrincipal Investigator
- Principal Investigator
  
  Shirakami Yoshifumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Osaka University
Development of Nuclear Medicine Therapy targeting Cancer Stroma
- Principal Investigator
  
  Watabe Tadashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Osaka University
Development of cancer missile therapy targeting amino acid transporter LAT1 by alpha emitting nuclide
- Principal Investigator
  
  Kaneda Kazuko
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Osaka University
Drug discovery research for SPECT imaging of cell-cell comunication in in vivoPrincipal Investigator
- Principal Investigator
  
  Shirakami Yoshifumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Comparison of Nuclear Medicine Therapeutics Targeting PSMA among Alpha-Emitting Nuclides2024
- Author(s)
  Kaneda-Nakashima Kazuko、Shirakami Yoshifumi、Kadonaga Yuichiro、Watabe Tadashi、Ooe Kazuhiro、Yin Xiaojie、Haba Hiromitsu、Shirasaki Kenji、Kikunaga Hidetoshi、Tsukada Kazuaki、Toyoshima Atsushi、Cardinale Jens、Giesel Frederik L.、Fukase Koichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 2 Pages: 933-933
- DOI
  10.3390/ijms25020933
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07619, KAKENHI-PROJECT-23K21426
[Journal Article] Evaluation of Astatine-211-Labeled Fibroblast Activation Protein Inhibitor (FAPI): Comparison of Different Linkers with Polyethylene Glycol and Piperazine2023
- Author(s)
  Aso A、Nabetani H、Matsuura Y、Kadonaga Y、Shirakami Y、Watabe T、Yoshiya T、Mochizuki M、Ooe K、Kawakami A、Jinno N、Toyoshima A、Haba H、Wang Y、Cardinale J、Giesel FL、Shimoyama A、Kaneda-Nakashima K、Fukase K
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 10 Pages: 8701-8701
- DOI
  10.3390/ijms24108701
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07619, KAKENHI-PROJECT-20H05675
[Journal Article] Fibroblast Activation Protein Inhibitor Theranostics2023
- Author(s)
  Kaneda-Nakashima Kazuko、Shirakami Yoshifumi、Kadonaga Yuichiro、Watabe Tadashi
- Journal Title
  
  PET Clinics
  
  Volume: 18 Issue: 3 Pages: 397-408
- DOI
  10.1016/j.cpet.2023.02.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07619
[Journal Article] Mathematical Model for Evaluation of Tumor Response in Targeted Radionuclide Therapy with 211At Using Implanted Mouse Tumor2022
- Author(s)
  Yonekura Yoshiharu、Toki Hiroshi、Watabe Tadashi、Kaneda-Nakashima Kazuko、Shirakami Yoshifumi、Ooe Kazuhiro、Toyoshima Atsushi、Nakajima Hiroo、Tomiyama Noriyuki、Bando Masako
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 24 Pages: 15966-15966
- DOI
  10.3390/ijms232415966
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07619
[Journal Article] Targeted α-therapy using astatine (211At)-labeled PSMA1, 5, and 6: a preclinical evaluation as a novel compound2022
- Author(s)
  Watabe Tadashi、Kaneda-Nakashima Kazuko、Shirakami Yoshifumi、Kadonaga Yuichiro、Ooe Kazuhiro、Wang Yang、Haba Hiromitsu、Toyoshima Atsushi、Cardinale Jens、Giesel Frederik L.、Tomiyama Noriyuki、Fukase Koichi
- Journal Title
  
  European Journal of Nuclear Medicine and Molecular Imaging
  
  Volume: 50 Issue: 3 Pages: 849-858
- DOI
  10.1007/s00259-022-06016-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07619, KAKENHI-PROJECT-20K08105
[Journal Article] Effect to Therapy of Sodium-Iodine Symporter Expression by Alpha-Ray Therapeutic Agent via Sodium/Iodine Symporter2022
- Author(s)
  Kaneda-Nakashima Kazuko、Shirakami Yoshifumi、Watabe Tadashi、Ooe Kazuhiro、Yoshimura Takashi、Toyoshima Atsushi、Wang Yang、Haba Hiromitsu、Fukase Koichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 24 Pages: 15509-15509
- DOI
  10.3390/ijms232415509
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07619
[Journal Article] Substrate Study for Dihydroxyboryl Astatine Substitution Reaction with Fibroblast Activation Protein Inhibitor (FAPI)2022
- Author(s)
  Aso Ayaka、Kaneda-Nakashima Kazuko、Nabetani Hinako、Kadonaga Yuichiro、Shirakami Yoshifumi、Watabe Tadashi、Yoshiya Taku、Mochizuki Masayoshi、Koshino Yuki、Ooe Kazuhiro、Kawakami Atsuko、Jinno Naoya、Toyoshima Atsushi、Haba Hiromitsu、Wang Yang、Cardinale Jens、Giesel Frederik L.、Shimoyama Atsushi、Fukase Koichi
- Journal Title
  
  Chemistry Letters
  
  Volume: 51 Issue: 11 Pages: 1091-1094
- DOI
  10.1246/cl.220391
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07619, KAKENHI-PROJECT-20H05675, KAKENHI-PROJECT-20K05749
[Journal Article] Dioxetane Derivative Containing Carboxy Group as a Chemiluminophore‐Introducing Reagent2022
- Author(s)
  Nohara Yukie、Masuda Shun、Kaneda‐Nakashima Kazuko、Shirakami Yoshifumi、Matsumoto Masakatsu、Yoshiya Taku
- Journal Title
  
  ChemBioChem
  
  Volume: 23 Issue: 24 Pages: 1-5
- DOI
  10.1002/cbic.202200556
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07619
[Journal Article] Comparison of the Therapeutic Effects of [211At]NaAt and [131I]NaI in an NIS-Expressing Thyroid Cancer Mouse Model2022
- Author(s)
  Watabe Tadashi、Liu Yuwei、Kaneda-Nakashima Kazuko、Sato Tatsuhiko、Shirakami Yoshifumi、Ooe Kazuhiro、Toyoshima Atsushi、Shimosegawa Eku、Wang Yang、Haba Hiromitsu、Nakano Takashi、Shinohara Atsushi、Hatazawa Jun
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 16 Pages: 9434-9434
- DOI
  10.3390/ijms23169434
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07619, KAKENHI-PROJECT-23K21426
[Journal Article] α‐Emitting cancer therapy using 211 At‐AAMT targeting LAT12021
- Author(s)
  Kaneda‐Nakashima Kazuko、Zhang ZiJian、Manabe Yoshiyuki、Shimoyama Atsushi、Kabayama Kazuya、Watabe Tadashi、Kanai Yoshikatsu、Ooe Kazuhiro、Toyoshima Atsushi、Shirakami Yoshifumi、Yoshimura Takashi、Fukuda Mitsuhiro、Hatazawa Jun、Nakano Takashi、Fukase Koichi、Shinohara Atsushi
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 3 Pages: 1132-1140
- DOI
  10.1111/cas.14761
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05356, KAKENHI-PROJECT-20K08105, KAKENHI-PLANNED-15H05836, KAKENHI-PROJECT-16H05924, KAKENHI-PUBLICLY-20H04709, KAKENHI-PROJECT-19H03407, KAKENHI-PROJECT-18K07323, KAKENHI-PUBLICLY-20H04776, KAKENHI-PLANNED-21H05074, KAKENHI-PROJECT-20H05675, KAKENHI-PROJECT-20K05727, KAKENHI-PROJECT-20K05749
[Journal Article] Fibroblast activation protein targeted therapy using [177Lu]FAPI-46 compared with [225Ac]FAPI-46 in a pancreatic cancer model2021
- Author(s)
  Liu Yuwei、Watabe Tadashi、Kaneda-Nakashima Kazuko、Shirakami Yoshifumi、Naka Sadahiro、Ooe Kazuhiro、Toyoshima Atsushi、Nagata Kojiro、Haberkorn Uwe、Kratochwil Clemens、Shinohara Atsushi、Hatazawa Jun、Giesel Frederik
- Journal Title
  
  European Journal of Nuclear Medicine and Molecular Imaging
  
  Volume: 49 Issue: 3 Pages: 871-880
- DOI
  10.1007/s00259-021-05554-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07323, KAKENHI-PROJECT-21K07619, KAKENHI-PROJECT-19H03602, KAKENHI-PROJECT-23K21426
[Journal Article] Development of GGAG alpha camera system for targeted alpha radionuclide therapy research2021
- Author(s)
  Yamamoto S.、Watabe T.、Kaneda-Nakashima K.、Shirakami Y.、Ooe K.、Toyoshima A.、Teramoto T.、Shinohara A.、Hatazawa J.
- Journal Title
  
  Journal of Instrumentation
  
  Volume: 16 Issue: 06 Pages: P06009-P06009
- DOI
  10.1088/1748-0221/16/06/p06009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07619
[Journal Article] Synthesis of [211At]4-astato-L-phenylalanine by dihydroxyboryl-astatine substitution reaction in aqueous solution2021
- Author(s)
  Shirakami Yoshifumi、Watabe Tadashi、Obata Honoka、Kaneda Kazuko、Ooe Kazuhiro、Liu Yuwei、Teramoto Takahiro、Toyoshima Atsushi、Shinohara Atsushi、Shimosegawa Eku、Hatazawa Jun、Fukase Koichi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 12982-12982
- DOI
  10.1038/s41598-021-92476-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07323, KAKENHI-PROJECT-21K07619
[Journal Article] Extended single-dose toxicity study of [211At]NaAt in mice for the first-in-human clinical trial of targeted alpha therapy for differentiated thyroid cancer2021
- Author(s)
  Watabe Tadashi、Kaneda-Nakashima Kazuko、Ooe Kazuhiro、Liu Yuwei、Kurimoto Kenta、Murai Takashi、Shidahara Yuka、Okuma Kenji、Takeuchi Masanori、Nishide Masayuki、Toyoshima Atsushi、Shinohara Atsushi、Shirakami Yoshifumi
- Journal Title
  
  Annals of Nuclear Medicine
  
  Volume: 35 Issue: 6 Pages: 702-718
- DOI
  10.1007/s12149-021-01612-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07323, KAKENHI-PROJECT-21K07619, KAKENHI-PROJECT-23K21426
[Journal Article] Targeted alpha therapy using astatine (211At)-labeled phenylalanine: A preclinical study in glioma bearing mice2020
- Author(s)
  Watabe Tadashi、Kaneda-Nakashima Kazuko、Shirakami Yoshifumi、Liu Yuwei、Ooe Kazuhiro、Teramoto Takahiro、Toyoshima Atsushi、Shimosegawa Eku、Nakano Takashi、Kanai Yoshikatsu、Shinohara Atsushi、Hatazawa Jun
- Journal Title
  
  Oncotarget
  
  Volume: 11 Issue: 15 Pages: 1388-1398
- DOI
  10.18632/oncotarget.27552
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07323, KAKENHI-PROJECT-19H03407
[Journal Article] Preclinical Evaluation of Radiation-Induced Toxicity in Targeted Alpha Therapy Using [211At] NaAt in Mice: A Revisit2020
- Author(s)
  Liu Yuwei、Watabe Tadashi、Kaneda-Nakashima Kazuko、Ooe Kazuhiro、Shirakami Yoshifumi、Toyoshima Atsushi、Shimosegawa Eku、Nakano Takashi、Shinohara Atsushi、Hatazawa Jun
- Journal Title
  
  Translational Oncology
  
  Volume: 13 Issue: 4 Pages: 100757-100757
- DOI
  10.1016/j.tranon.2020.100757
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07323, KAKENHI-PROJECT-19H03602
[Journal Article] Development of high‐resolution YAP(Ce) x‐ray camera for the imaging of astatine‐211(At‐211) in small animals2020
- Author(s)
  Nakanishi Kouhei、Yamamoto Seiichi、Watabe Tadashi、Kaneda‐Nakashima Kazuko、Shirakami Yoshifumi、Ooe Kazuhiro、Toyoshima Atsushi、Shinohara Atsushi、Teramoto Takahiro、Hatazawa Jun、Kamada Kei、Yoshikawa Akira
- Journal Title
  
  Medical Physics
  
  Volume: 47 Issue: 11 Pages: 5739-5748
- DOI
  10.1002/mp.14455
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07323, KAKENHI-PROJECT-17H06159, KAKENHI-PROJECT-19H00672, KAKENHI-PROJECT-20K20488
[Journal Article] Enhancement of astatine-211 uptake via the sodium iodide symporter by the addition of ascorbic acid in targeted alpha therapy of thyroid cancer2019
- Author(s)
  Watabe Tadashi、Kaneda-Nakashima Kazuko、Liu Yuwei、Shirakami Yoshifumi、Ooe Kazuhiro、Toyoshima Atsushi、Shimosegawa Eku、Fukuda Mitsuhiro、Shinohara Atsushi、Hatazawa Jun
- Journal Title
  
  Journal of Nuclear Medicine
  
  Volume: - Issue: 9 Pages: 1-43
- DOI
  10.2967/jnumed.118.222638
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07323, KAKENHI-PROJECT-16K10277, KAKENHI-PROJECT-19H03602
[Journal Article] Theranostics Targeting Fibroblast Activation Protein in the Tumor Stroma: 64Cu- and 225Ac-Labeled FAPI-04 in Pancreatic Cancer Xenograft Mouse Models2019
- Author(s)
  Watabe Tadashi、Liu Yuwei、Kaneda-Nakashima Kazuko、Shirakami Yoshifumi、Lindner Thomas、Ooe Kazuhiro、Toyoshima Atsushi、Nagata Kojiro、Shimosegawa Eku、Haberkorn Uwe、Kratochwil Clemens、Shinohara Atsushi、Giesel Frederik、Hatazawa Jun
- Journal Title
  
  Journal of Nuclear Medicine
  
  Volume: 61 Issue: 4 Pages: 563-569
- DOI
  10.2967/jnumed.119.233122
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07323, KAKENHI-PROJECT-19H03602
[Journal Article] Enhancement of At-211 uptake in the thyroid gland- SPECT study in rats.2018
- Author(s)
  Liu Y, Watabe T, Kaneda-Nakashima K, Shirakami Y, Toyoshima A, Tatsumi M, Shimosegawa E, Fukuda M, Shinohara A, Hatazawa J.
- Journal Title
  
  J Nucl Med
  
  Volume: 59 Pages: 1129-1129
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07323
[Journal Article] Species difference of astatine-211 uptakes in the whole body distribution: preclinical study using treated At-solution.2018
- Author(s)
  Watabe T, Kaneda-Nakashima K, Liu Y, Shirakami Y, Toyoshima A, Tatsumi M, Shimosegawa E, Fukuda M, Shinohara A, Hatazawa J.
- Journal Title
  
  J Nucl Med
  
  Volume: 59 Pages: 1269-1269
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07323
[Patent] 放射標識されたチロシン誘導体およびその用途2023
- Inventor(s)
  兼田加珠子、白神宜史、角永悠一郎、豊嶋厚史、深瀬浩一、長田宏
- Industrial Property Rights Holder
  国立大学法人大阪大学
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-21K07619
[Patent] ハロゲン化フェノール含有化合物の新規アスタチン-211(211At)標識化法の開発2022
- Inventor(s)
  深瀬浩一,豊嶋厚史,篠原厚,白神宜史,兼田加珠子,他2名
- Industrial Property Rights Holder
  国立大学法人大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-035169
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-21K07619
[Patent] 放射標識されたチロシン誘導体およびその用途2022
- Inventor(s)
  兼田加珠子、白神宜史、角永悠一郎、豊嶋厚史、深瀬浩一、長田宏
- Industrial Property Rights Holder
  国立大学法人大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-150608
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-21K07619
[Patent] 放射標識されたFAPα親和性化合物およびその用途2022
- Inventor(s)
  白神宜史,角永悠一郎,兼田加珠子,渡部直史,深瀬浩一,他3名
- Industrial Property Rights Holder
  国立大学法人大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-026194
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-21K07619
[Patent] 放射標識されたＦＡＰα親和性化合物およびその用途2022
- Inventor(s)
  白神、渡部、他
- Industrial Property Rights Holder
  白神、渡部、他
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-19H03602
[Patent] 放射標識された化合物およびその用途2021
- Inventor(s)
  白神宜史、兼田加珠子、角永悠一郎、他
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-125774
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K08105
[Patent] ボロン酸化合物およびその製造方法2021
- Inventor(s)
  白神宜史、兼田加珠子、角永悠一郎、豊嶋厚史、他4名
- Industrial Property Rights Holder
  白神宜史、兼田加珠子、角永悠一郎、豊嶋厚史、他4名
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-052352
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-18K07323
[Patent] 放射標識されたFAPα親和性化合物およびその用途2021
- Inventor(s)
  白神宜史,角永悠一郎,兼田加珠子,渡部直史,深瀬浩一,他3名
- Industrial Property Rights Holder
  国立大学法人大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-026194
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-18K07323
[Patent] ボロン酸化合物およびその製造方法2021
- Inventor(s)
  白神宜史、兼田加珠子、渡部直史、角永悠一郞
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-052352
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K08105
[Patent] 放射標識された化合物およびその用途2021
- Inventor(s)
  白神宜史,兼田加珠子,角永悠一郎,渡部直史,他3名
- Industrial Property Rights Holder
  国立大学法人大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-125774
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-18K07323
[Patent] ハロゲン化フェノール含有化合物の新規アスタチン-211(211At)標識化法の開発2021
- Inventor(s)
  深瀬浩一,豊嶋厚史,篠原厚,白神宜史,兼田加珠子,他2名
- Industrial Property Rights Holder
  国立大学法人大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-035169
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-18K07323
[Patent] 放射標識された化合物およびその用途2021
- Inventor(s)
  白神宜史,兼田加珠子,角永悠一郎,渡部直史,他3名
- Industrial Property Rights Holder
  国立大学法人大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-125774
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21K07619
[Patent] 放射標識されたアリール化合物の製造方法2020
- Inventor(s)
  白神宜史
- Industrial Property Rights Holder
  白神宜史
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Acquisition Date
  2023
- Data Source
  KAKENHI-PROJECT-20K08105
[Patent] 211At標識アミノ酸誘導体を含む医薬組成物及びその製造方法2019
- Inventor(s)
  深瀬浩一, 篠原厚,金井好克, 白神宜史, 他
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-16K10277
[Patent] アスタチン溶液及びその製造方法2018
- Inventor(s)
  白神宜史、渡部直史、兼田加珠子、篠原厚、下瀬川恵久、畑澤順
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-16K10277
[Patent] 放射標識されたアリール化合物の製造方法2018
- Inventor(s)
  白神宜史、渡部直史、兼田加珠子、池田隼人、金井泰和、他
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-16K10277
[Patent] アスタチン溶液及びその製造方法2017
- Inventor(s)
  白神宜史、渡部直史、兼田加珠子、下瀬川恵久、篠原厚、畑澤順
- Industrial Property Rights Holder
  白神宜史、渡部直史、兼田加珠子、下瀬川恵久、篠原厚、畑澤順
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-255109
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K10277
[Patent] 放射標識されたアリール化合物の製造方法2017
- Inventor(s)
  白神宜史、池田隼人、金井泰和、下瀬川恵久、畑澤順
- Industrial Property Rights Holder
  白神宜史、池田隼人、金井泰和、下瀬川恵久、畑澤順
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-151632
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K10277
[Presentation] [211At]PSMA5の非臨床試験：First-in-human医師主導治験開始に向けて.2023
- Author(s)
  渡部直史、兼田加珠子、角永悠一郎、大江一弘、羽場宏光、豊嶋厚史、Jens Cardinale、Frederik L. Giesel、深瀬浩一、富山憲幸、白神宜史.
- Organizer
  第63回日本核医学会学術総会・第43回日本核医学技術学会総会学術総会
- Data Source
  KAKENHI-PROJECT-21K07619
[Presentation] 前立腺がんの標的α線治療を目的とする[211At]PSMA5の製法と品質確立.2023
- Author(s)
  白神宜史、渡部直史、兼田（中島）加珠子、仲定宏、角永悠一郎、大江一弘、羽場宏光、Xiaojie Yin、神野直哉、豊嶋厚史、深瀬浩一.
- Organizer
  第63回日本核医学会学術総会・第43回日本核医学技術学会総会学術総会
- Data Source
  KAKENHI-PROJECT-21K07619
[Presentation] [211At]PSMA5の薬物動態試験ならびにヒト吸収線量の推定.2023
- Author(s)
  渡部直史、佐藤達彦、兼田加珠子、角永悠一郎、大江一弘、羽場宏光、豊嶋厚史、Frederik L. Giesel、深瀬浩一、富山憲幸、白神宜史.
- Organizer
  第43回日本核医学技術学会総会学術総会
- Data Source
  KAKENHI-PROJECT-21K07619
[Presentation] アスタチン-211標識線維芽細胞活性化タンパク質阻害薬（FAPI）の合成およびα線核医学治療の検討.2023
- Author(s)
  白神宜史、渡部直史、兼田加珠子、角永悠一郎、大江一弘、下山敦史、川上厚子、神野直哉、羽場宏光、豊嶋厚史、深瀬浩一.
- Organizer
  第63回日本核医学会学術総会・第43回日本核医学技術学会総会学術総会
- Data Source
  KAKENHI-PROJECT-21K07619
[Presentation] Preparation of 211At-PSMA for TAT of prostate cancer2022
- Author(s)
  Yoshifumi Shirakami, Tadashi Watabe, Kazuko Kaneda-Nakashima, Yuichiro Kadonaga, Kazuhiro Ooe, Yang Wang, Hiromitsu Haba, Atsushi Toyoshima, Koichi Fukase
- Organizer
  日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08105
[Presentation] Preparation of 211At-PSMA for TAT of prostate cancer.2022
- Author(s)
  Shirakami Y, Watabe T, Kaneda-Nakashima K, Kadonaga Y, Ooe K, Wang Y, Haba H, Toyoshima A, FukaseK.
- Organizer
  第62回日本核医学会学術総会・第42回日本核医学技術学会総合学術大会・第13回世界核医学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07619
[Presentation] The comparison of therapeutic effect between [211At]NaAt and [131I]NaI: preclinical study using mice xenograft model of differentiated thyroid cancer2021
- Author(s)
  Yuwei Liu, Tadashi Watabe, Kazuko Kaneda-Nakashima, Kazuhiro Ooe, Yoshifumi Shirakami, Atsushi Toyoshima, Eku Shimosegawa, Takashi Nakano, Atsushi Shinohara, Jun Hatazawa
- Organizer
  SNMMI 2021 Virtual Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07619
[Presentation] The comparison of therapeutic effect between [211At]NaAt and [131I]NaI: preclinical study using mice xenograft model of differentiated thyroid cancer2021
- Author(s)
  Yuwei Liu, Tadashi Watabe, Kazuko Kaneda-Nakashima, Kazuhiro Ooe, Yoshifumi Shirakami, Atsushi Toyoshima, Eku Shimosegawa, Takashi Nakano, Atsushi Shinohara, Jun Hatazawa
- Organizer
  SNMMI 2021 Virtual Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07323
[Presentation] Extended single-dose toxicity study of [211At]NaAt in mice for the FIH clinical trial of targeted alpha therapy for differentiated thyroid cancer2021
- Author(s)
  Tadashi Watabe, Kazuko Kaneda-Nakashima, Kazuhiro Ooe, Yuwei Liu, Kenta Kurimoto, Atsushi Toyoshima, Atsushi Shinohara, Yoshifumi Shirakami
- Organizer
  SNMMI 2021 Virtual Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07323
[Presentation] アスタト－脱ボロン酸反応による211At標識αメチルチロシンの製造と生物活性に関する研究2021
- Author(s)
  白神宜史，兼田加珠子，渡部直史，大江一弘，角永悠一郎，仲定宏，川上厚子，中山敏夫，近藤裕，豊嶋厚史，深瀬浩一
- Organizer
  第61回日本核医学会学術総会・第41回日本核医学技術学会総会学術大会
- Data Source
  KAKENHI-PROJECT-18K07323
[Presentation] アスタチンを用いた難治性甲状腺がんに対するアルファ線核医学治療2021
- Author(s)
  渡部直史, 兼田加珠子, 白神宜史, 大江一弘, 豊嶋厚史, 篠原厚
- Organizer
  第58回アイソトープ・放射線研究発表会
- Data Source
  KAKENHI-PROJECT-18K07323
[Presentation] アスタト－脱ボロン酸反応による211At標識αメチルチロシンの製造と生物活性に関する研究2021
- Author(s)
  白神宜史，兼田加珠子，渡部直史，大江一弘，角永悠一郎，仲定宏，川上厚子，中山敏夫，近藤裕，豊嶋厚史，深瀬浩一
- Organizer
  第61回日本核医学会学術総会・第41回日本核医学技術学会総会学術大会
- Data Source
  KAKENHI-PROJECT-21K07619
[Presentation] Extended single-dose toxicity study of [211At]NaAt in mice for the FIH clinical trial of targeted alpha therapy for differentiated thyroid cancer2021
- Author(s)
  Tadashi Watabe, Kazuko Kaneda-Nakashima, Kazuhiro Ooe, Yuwei Liu, Kenta Kurimoto, Atsushi Toyoshima, Atsushi Shinohara, Yoshifumi Shirakami
- Organizer
  SNMMI 2021 Virtual Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07619
[Presentation] アスタチンを用いた難治性甲状腺がんに対するアルファ線核医学治療2021
- Author(s)
  渡部直史, 兼田加珠子, 白神宜史, 大江一弘, 豊嶋厚史, 篠原厚
- Organizer
  第58回アイソトープ・放射線研究発表会
- Data Source
  KAKENHI-PROJECT-21K07619
[Presentation] Enhanced therapeutic effect with repeated administration of [211At]NaAt for differentiated thyroid cancer in mice2021
- Author(s)
  Yuwei Liu, Tadashi Watabe, Kazuko Kaneda-Nakashima, Kazuhiro Ooe, Yoshifumi Shirakami, Atsushi Toyoshima, Eku Shimosegawa, Takashi Nakano, Atsushi Shinohara, Jun Hatazawa
- Organizer
  SNMMI 2021 Virtual Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07323
[Presentation] Enhanced therapeutic effect with repeated administration of [211At]NaAt for differentiated thyroid cancer in mice2021
- Author(s)
  Yuwei Liu, Tadashi Watabe, Kazuko Kaneda-Nakashima, Kazuhiro Ooe, Yoshifumi Shirakami, Atsushi Toyoshima, Eku Shimosegawa, Takashi Nakano, Atsushi Shinohara, Jun Hatazawa
- Organizer
  SNMMI 2021 Virtual Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07619
[Presentation] がん細胞型アミノ酸トランスポーターを標的としたAt-211標識核医学治療薬の検討.2020
- Author(s)
  兼田加珠子、白神宜史、大江一弘、寺本高啓、渡部直史、下山敦史、真鍋良幸、樺山一哉、豊嶋厚史、深瀬浩一、篠原厚
- Organizer
  日本放射化学会第64回討論会
- Data Source
  KAKENHI-PROJECT-18K07323
[Presentation] 核医学利用に向けたアスタチン化ナトリウム[211At]NaAtの高純度調製.2020
- Author(s)
  白神宜史、大江一弘、兼田加珠子、寺本高啓、渡部直史、豊嶋厚史、篠原厚、畑澤順
- Organizer
  日本放射化学会第64回討論会
- Data Source
  KAKENHI-PROJECT-18K07323
[Presentation] 還元剤による[211At]NaAtの調製とイオン対逆相HPLC分析2020
- Author(s)
  白神宜史, 兼田加珠子, 渡部直史, 大江一弘, 劉雨薇, 寺本高啓, 豊嶋厚史, 篠原厚, 中野貴志, 下瀬川恵久, 畑澤順
- Organizer
  第60回日本核医学会総会学術集会
- Data Source
  KAKENHI-PROJECT-18K07323
[Presentation] Targeted alpha therapy of thyroid cancer: evaluation of [At-211]NaAt treatment in the xenograft model.2019
- Author(s)
  Watabe T, Kaneda K, Liu Y, Shirakami Y, Ooe K, Toyoshima A, Shimosegawa E, Fukuda M, Shinohara A, Hatazawa
- Organizer
  第59回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03602
[Presentation] Enhancement of astatine-211 uptake via the sodium iodide symporter by the addition of ascorbic acid in targeted alpha therapy of thyroid cancer2019
- Author(s)
  Tadashi Watabe, Kazuko Kaneda-Nakashima, Yuwei Liu, Yoshifumi Shirakami, Kazuhiro Ooe, Atsushi Toyoshima, Eku Shimosegawa, Mitsuhiro Fukuda, Atsushi Shinohara, Jun Hatazawa.
- Organizer
  第14回日本分子イメージング学会総会
- Data Source
  KAKENHI-PROJECT-18K07323
[Presentation] 放射線の種類弁別可能なイメージング装置開発とα線分布計測への応用2019
- Author(s)
  山本誠一, 渡部直史, 兼田加珠子, 白神宣史, 大江一弘, 篠原厚, 豊嶋厚史, 畑澤順.
- Organizer
  第14回日本分子イメージング学会総会
- Data Source
  KAKENHI-PROJECT-18K07323
[Presentation] がん間質を標的とするα線治療薬255Ac-FAPI-04の研究2019
- Author(s)
  白神宜史, 渡部直史, Yuwei Liu, 兼田加珠子, 永田光知郎, 豊嶋厚史, 下瀬川恵久,篠原厚,畑澤順, Frederik Giesel
- Organizer
  第3回放射性薬品科学研究会／第19回放射性医薬品・画像診断薬研究会
- Data Source
  KAKENHI-PROJECT-18K07323
[Presentation] 水溶液中におけるボロノ基-アスタチン交換反応の特異性の解明2019
- Author(s)
  尾幡穂乃香, 白神宜史, 兼田加珠子, 大江一弘, 永田光知郎, 寺本高啓, 市村聡一朗, 中川創太, 吉村崇豊嶋厚史, 篠原厚.
- Organizer
  日本放射化学会第63回討論会
- Data Source
  KAKENHI-PROJECT-18K07323
[Presentation] Theranostics targeting fibroblast activation protein in the tumor stroma: [64Cu] and [225Ac] labelled FAPI-04 in pancreatic cancer xenograft mice.2019
- Author(s)
  Watabe T, Shirakami Y, Kaneda K, Liu Y, Lindner T, Ooe K, Toyoshima A, Naka S, Shimosegawa E, Haberkorn Uwe; Giesel F, Hatazawa J.
- Organizer
  ヨーロッパ核医学会（EANM2019）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03602
[Presentation] アミノ酸トランスポーターLAT1を標的とするα線がんミサイル療法の開発.2018
- Author(s)
  兼田　加珠子, 張子見, 真鍋良幸, 下山敦史, 樺山一哉, 白神　宜史, 金井好克, 畑澤　順, 深瀬浩一, 篠原厚.
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07323
[Presentation] Enhancement of At-211 uptake in the thyroid gland: SPECT study in rats.2018
- Author(s)
  Yuwei Liu, Tadashi Watabe, Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Atsushi Toyoshima, Mitsuaki Tatsumi, Eku Shimosegawa, Mitsuhiro Fukuda, Atsushi Shinohara, Jun Hatazawa.
- Organizer
  日本分子イメージング学会第13回学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K07323
[Presentation] Enhancement of At-211 uptake in the thyroid gland: SPECT study in rats2018
- Author(s)
  Liu Y, Watabe T, Kaneda-Nakashima K, Shirakami Y, Toyoshima A, Tatsumi M, Shimosegawa E, Fukuda M, Shinohara A, Hatazawa J
- Organizer
  Jpn Soc Mol Imag
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10277
[Presentation] Preparation of aqueous solution of 211At-sodium astatide (Na211At) in a high radiochemical purity and its biodistribution study in rats2018
- Author(s)
  Shirakami Y, Kaneda K, Watabe T, Liu Y, Shimosegawa E, Shinohara A, Hatazawa J.
- Organizer
  World J Nucl Med
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10277
[Presentation] Preparation of aqueous solution of 211At-sodium astatide (Na211At) in high radiochemical purity and its biological properties in rats2018
- Author(s)
  Yoshifumi Shirakami, Kazuko Kaneda-Nakashima, Tadashi Watabe, Yuwei LiuAtsushi Toyoshima, Eku Shimosegawa, Atsushi Shinohara, Jun Hatazawa
- Organizer
  WFNMB2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10277
[Presentation] アスタチン(211At)の酸化還元反応とα線治療薬の創薬研究2018
- Author(s)
  白神宜史, 兼田加珠子, 渡部直史, Victor Romanov, 張子見, 大江一弘, Yuwei Liu, 下瀬川恵久, 篠原厚, 畑澤順
- Organizer
  第2回日本核医学会分科会放射薬品科学研究会
- Data Source
  KAKENHI-PROJECT-16K10277
[Presentation] Radiolabeling of small molecules with astatine (211At) for theranostics2018
- Author(s)
  Y Shirakami
- Organizer
  BER2018
- Invited
- Data Source
  KAKENHI-PROJECT-16K10277
[Presentation] Chemical properties of 211At-NaAt and its biological behaviors in small animals.2018
- Author(s)
  Yoshifumi Shirakami, Victor Romanov, Tadashi Watabe, Kazuko Kaneda, Yuwai Liu, Atsushi Shinohara, Eku Shimosegawa, Jun Hatazawa.
- Organizer
  第58回　日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07323
[Presentation] A new method for the preparation of astatine-211(211At) and iodine-123(123I) labelled amino acid analogues of phenylalanine, 211At-Phe and 123I-Phe, for radionuclide therapy and SPECT imaging applications2017
- Author(s)
  Y Shirakami, H Ikeda, J Hatazawa
- Organizer
  EANM2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10277

1. Kaneda Kazuko (00533209)

# of Collaborated Projects: 6 results

# of Collaborated Products: 48 results
2. Watabe Tadashi (90648932)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 畑澤順 (70198745)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. 豊嶋厚史 (40414578)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 仲定宏 (60599843)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 深瀬浩一 (80192722)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 大江一弘 (90610303)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. 池田隼人 (30649083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 下瀬川恵久 (30370258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 篠原厚 (60183050)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 福田光宏 (60370467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 白崎謙次 (70447176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 吉村崇 (90323336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 樺山一哉 (00399974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Shirakami Yoshifumi 白神 宜史

Research Projects

Research Products

Co-Researchers

Development of innovative alpha therapy targeting cancer-associated fibroblasts

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Research on alpha-particle therapeutics for targeting SGLT2Principal Investigator

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A challenge to low-invasive one-day cancer treatment using alpha emitting nuclide

Principal Investigator

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Targeted alpha therapy for patients with tumorPrincipal Investigator

Principal Investigator

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Review Section

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Development of Nuclear Medicine Therapy targeting Cancer Stroma

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Research Institution

Development of cancer missile therapy targeting amino acid transporter LAT1 by alpha emitting nuclide

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Drug discovery research for SPECT imaging of cell-cell comunication in in vivoPrincipal Investigator

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Research Institution

[Journal Article] Comparison of Nuclear Medicine Therapeutics Targeting PSMA among Alpha-Emitting Nuclides2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of Astatine-211-Labeled Fibroblast Activation Protein Inhibitor (FAPI): Comparison of Different Linkers with Polyethylene Glycol and Piperazine2023

Author(s)

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DOI

Data Source

[Journal Article] Fibroblast Activation Protein Inhibitor Theranostics2023

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[Journal Article] Mathematical Model for Evaluation of Tumor Response in Targeted Radionuclide Therapy with 211At Using Implanted Mouse Tumor2022

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[Journal Article] Targeted α-therapy using astatine (211At)-labeled PSMA1, 5, and 6: a preclinical evaluation as a novel compound2022

Author(s)

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DOI

Data Source

[Journal Article] Effect to Therapy of Sodium-Iodine Symporter Expression by Alpha-Ray Therapeutic Agent via Sodium/Iodine Symporter2022

Author(s)

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DOI

Data Source

[Journal Article] Substrate Study for Dihydroxyboryl Astatine Substitution Reaction with Fibroblast Activation Protein Inhibitor (FAPI)2022

Author(s)

Journal Title

DOI

Shirakami Yoshifumi 白神宜史