KURAMITSU Madoka 倉光球

… Alternative Names

Kuramitsu Madoka 倉光球

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Researcher Number	00566383
Other IDs	https://orcid.org/0000-0002-3064-5219
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所次世代生物学的製剤研究センター, 室長
Affiliation (based on the past Project Information) *help	2024: 国立感染症研究所, 次世代生物学的製剤研究センター, 室長 2022: 国立感染症研究所, 次世代生物学的製剤研究センター, 室長 2021: 国立感染症研究所, 血液・安全性研究部, 室長 2020: 国立感染症研究所, 血液・安全性研究部, 主任研究官 2013 – 2014: 国立感染症研究所, その他部局等, 研究員 2010 – 2012: 国立感染症研究所, 血液・安全性研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Hematology
Keywords	Principal Investigator ゲノム不安定性 / 成人T細胞白血病 / HTLV-1 / リボソームタンパク質 / 遺伝子変異 / 相同組換え / 遺伝子修復 / デジタルPCR / 定量PCR / 遺伝子欠失 … More / Adult T-cell Leukemia / digital PCR / provirus / genomic deletion / タンパク質代謝 / 赤血球 / 代謝 / タンパク質分解 / 貧血 / 赤芽球分化 / 赤芽球 / リボソーム / Anemia / オートファジー / 血球分化 / anemia / 血液内科学 Less

HTLV-1感染による細胞ゲノム不安定性の亢進と遺伝子変異リスク評価法の開発Principal Investigator
- Principal Investigator
  
  倉光球
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Institute of Infectious Diseases
Genomic instability of HTLV-1 provirus and application to clinical testing for adult T-cell leukaemia.Principal Investigator
- Principal Investigator
  
  Kuramitsu Madoka
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Institute of Infectious Diseases
Analysis for erythroid defect in Diamond Blackfan anemia using patient-derived iPS cellsPrincipal Investigator
- Principal Investigator
  
  KURAMITSU Madoka
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  National Institute of Infectious Diseases
Analysis for the association of autophagy with diamond blackfan anemia associated genes.Principal Investigator
- Principal Investigator
  
  KURAMITSU Madoka
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  National Institute of Infectious Diseases

All 2023 2022 2021 2020 2015 2014 2013 2011 2010 Other

All Journal Article Presentation Book Patent

[Book] 血液フロンティア2014
- Author(s)
  倉光　球、浜口　功
- Total Pages
  9
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-25860798
[Book] Diamond-Blackfan 貧血の分子異常細胞 42(7)(通号 554)2010
- Author(s)
  浜口功、倉光球
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-22790922
[Book] 血液診療エキスパート貧血2010
- Author(s)
  倉光球
- Publisher
  中外医学者
- Data Source
  KAKENHI-PROJECT-22790922
[Journal Article] First case of molecularly identified and genetically characterized human T-cell leukemia virus type 2 infection in a pregnant woman in non-endemic Japan2021
- Author(s)
  Kuramitsu Madoka、Okuma Kazu、Horiya Madoka、Sekizuka Tsuyoshi、Kaneko Noriaki、Saito Ema、Sokunaga Jun、Kuroda Makoto、Hamaguchi Isao
- Journal Title
  
  Journal of Virological Methods
  
  Volume: 287 Pages: 114005-114005
- DOI
  10.1016/j.jviromet.2020.114005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08378, KAKENHI-PROJECT-20K07670
[Journal Article] No SARS-CoV-2 RNA detected in the convalescent plasma of COVID-19 patients with different disease severity2021
- Author(s)
  Hidetoshi Nomoto, Satoshi Kutsuna, Kazu Okuma, Madoka Kuramitsu, Kenta Tezuka, Emi Ikebe, Sho Saito, Noriko Kinoshita, Mari Terada, Mio Endo, Tetsuya Suzuki, Yusuke Miyazato, Takato Nakamoto, Makoto Inada, Isao Hamaguchi, Norio Ohmagari.
- Journal Title
  
  J Infect Chemother.
  
  Volume: 27(4) Issue: 4 Pages: 653-655
- DOI
  10.1016/j.jiac.2021.01.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16032, KAKENHI-PROJECT-20K07670
[Journal Article] HTLV-1 targets human placental trophoblasts in seropositive pregnant women2020
- Author(s)
  Tezuka Kenta、Fuchi Naoki、Okuma Kazu、Tsukiyama Takashi、Miura Shoko、Hasegawa Yuri、Nagata Ai、Komatsu Nahoko、Hasegawa Hiroo、Sasaki Daisuke、Sasaki Eita、Mizukami Takuo、Kuramitsu Madoka、Matsuoka Sahoko、Yanagihara Katsunori、Miura Kiyonori、Hamaguchi Isao
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 130 Issue: 11 Pages: 6171-6186
- DOI
  10.1172/jci135525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09265, KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-18K16805, KAKENHI-PROJECT-19K16032, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-18K08378
[Journal Article] Frequent horizontal and mother-to-child transmission may contribute to high prevalence of STLV-1 infection in Japanese macaques2020
- Author(s)
  Murata Megumi、Yasunaga Jun-ichirou、Washizaki Ayaka、Seki Yohei、Kuramitsu Madoka、Tan Wei Keat、Hu Anna、Okuma Kazu、Hamaguchi Isao、Mizukami Takuo、Matsuoka Masao、Akari Hirofumi
- Journal Title
  
  Retrovirology
  
  Volume: 17 Issue: 1 Pages: 1-10
- DOI
  10.1186/s12977-020-00525-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-19H03689, KAKENHI-PROJECT-18K08378, KAKENHI-PROJECT-20H03514
[Journal Article] Establishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting: a collaborative study for performance evaluation of diagnostic assays in Japan,2020
- Author(s)
  Okuma K, Kuramitsu M, Niwa T, et al.(40人中17番目)
- Journal Title
  
  Retrovirology
  
  Volume: 17 Issue: 1 Pages: 26-26
- DOI
  10.1186/s12977-020-00534-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07983, KAKENHI-PROJECT-19K07999, KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-19K16032, KAKENHI-PROJECT-19H03575, KAKENHI-PROJECT-18K08378, KAKENHI-PROJECT-19K16580, KAKENHI-PROJECT-16H06277
[Journal Article] A high-throughput detection method for the clonality of Human T-cell leukemia virus type-1-infected cells in vivo2020
- Author(s)
  Saito M, Hasegawa H, Yamauchi S, Nakagawa S, Sasaki D, Nao N, Tanio M, Wada Y, Matsudaira T, Momose H, Kuramitsu M, Yamagishi M, Nakashima M, Nakahata S, Iha H, Ogata M, Imaizumi Y, Uchimaru K, Morishita K, Watanabe T, Miyazaki Y, Yanagihara K.
- Journal Title
  
  Int J Hematol.
  
  Volume: 112 Issue: 3 Pages: 300-306
- DOI
  10.1007/s12185-020-02935-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08868, KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-17H03594, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-19H03575, KAKENHI-PROJECT-18K08317, KAKENHI-PROJECT-19K16580, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277
[Journal Article] Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1-infected cells2020
- Author(s)
  Ikebe E, Matsuoka S, Tezuka K, Kuramitsu M, Okuma K, Nakashima M,, Seiichiro Kobayashi S, Makiyama J, Yamagishi M, Oyadomari S, Uchimaru K, Hamaguchi I
- Journal Title
  
  Blood adv
  
  Volume: 4 Issue: 9 Pages: 1845-1858
- DOI
  10.1182/bloodadvances.2019001139
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08378, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-19K16032, KAKENHI-PROJECT-20K17390, KAKENHI-PROJECT-19H02853, KAKENHI-PROJECT-19H03575, KAKENHI-PROJECT-19K16580
[Journal Article] Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia.2015
- Author(s)
  Wang R, Yoshida K, Toki T, Sawada T, Uechi T, Okuno Y, Sato-Otsubo A, Kudo K, Kamimaki I, Kanezaki R, Shiraishi Y, Chiba K, Tanaka H, Terui K, Sato T, Iribe Y, Ohga S, Kuramitsu M, Hamaguchi I, Ohara A, Hara J, et al.
- Journal Title
  
  British Journal of Haematology
  
  Volume: 168 Issue: 6 Pages: 854-864
- DOI
  10.1111/bjh.13229
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591556, KAKENHI-PROJECT-25291003, KAKENHI-PROJECT-25461601, KAKENHI-PROJECT-25461609, KAKENHI-PROJECT-25860798, KAKENHI-PROJECT-26253061
[Journal Article] Identification of TL-Om1, an ATL Cell Line, as a Reference Material for Human T-Lymphotropic Virus 1 Quantitative PCR.2015
- Author(s)
  Kuramitsu M, Okuma K, Yamagishi M, Yamochi T, Firouzi S, Momose H, Mizukami T, Takizawa K, Araki K, Sugamura K, Yamaguchi K, Watanabe T, Hamaguchi I.
- Journal Title
  
  Journal of Clinical Microbiology
  
  Volume: 53 Issue: 2 Pages: 587-596
- DOI
  10.1128/jcm.02254-14
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J06916, KAKENHI-PROJECT-24570142, KAKENHI-PROJECT-24591383, KAKENHI-PROJECT-24591414, KAKENHI-PROJECT-25290047, KAKENHI-PROJECT-25860798, KAKENHI-PROJECT-26293226, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15K06848, KAKENHI-PROJECT-25461440
[Journal Article] 8. リボソーム異常症と関連疾患2014
- Author(s)
  倉光球、浜口功
- Journal Title
  
  血液フロンティア　特集　赤血球造血の基礎と臨床
  
  Volume: Vol. 24 No.4 Pages: 81-89
- Data Source
  KAKENHI-PROJECT-25860798
[Journal Article] HUMAN T-CELL LEUKEMIA VIRUS TYPE I (HTLV-1) -INDETERMINATE WESTERN BLOT PATTERNS IN VOLUNTARY DONATED BLOOD SAMPLES IN JAPAN2014
- Author(s)
  相良康子、後藤信代、井上由紀子、守田麻衣子、倉光球、大隈和、浜口功、入田和男、清川博之
- Journal Title
  
  Japanese Journal of Transfusion and Cell Therapy
  
  Volume: 60 Issue: 1 Pages: 18-24
- DOI
  10.3925/jjtc.60.18
- NAID
  130004542706
- ISSN
  1881-3011, 1883-0625
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860798
[Journal Article] System vaccinology for the evaluation of influenza vaccine safety by multiplex gene detection of novel biomarkers in a preclinical study and batch release test.2014
- Author(s)
  Mizukami T, Momose H, Kuramitsu M, Takizawa K, Araki K, Furuhata K, Ishii KJ, Hamaguchi I, Yamaguchi K.
- Journal Title
  
  PloS one
  
  Volume: 9 (7) Issue: 7 Pages: e101835-e101835
- DOI
  10.1371/journal.pone.0101835
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860798, KAKENHI-PROJECT-26893331
[Journal Article] Degenerate polymerase chain reaction strategy with DNA microarray for detection of multiple and various subtypes of virus during blood screening2013
- Author(s)
  Takizawa K, Nakashima T, Mizukami T, Kuramitsu M, Endoh D, Kawauchi S, Sasaki K, Momose H, Kiba Y, Mizutani T, Furuta RA, Yamaguchi K, Hamaguchi I
- Journal Title
  
  Transfusion.
  
  Volume: 17 Issue: 10pt2 Pages: 17-17
- DOI
  10.1111/trf.12193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590314, KAKENHI-PROJECT-23791093, KAKENHI-PROJECT-25304043, KAKENHI-PROJECT-25461440, KAKENHI-PROJECT-25860798
[Journal Article] Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia2011
- Author(s)
  Kuramitsu M, Matsubara A, Morio T, Takagi M, Toki T, Terui K, RuNan W, Kanno H, Ohga S, Ohara A, Kitoh T, Sugita K, Kudo K, Matsubayashi T, Mizue N, Ozeki M, Masumi A, Momose H, Takizawa K, Mizukami T, Yamaguchi K, Ogawa S, Ito E, Hamaguchi I
- Journal Title
  
  Blood
  
  Volume: (in press) Issue: 10 Pages: 2376-84
- DOI
  10.1182/blood-2011-07-368662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591388, KAKENHI-PROJECT-22591071, KAKENHI-PROJECT-22790922, KAKENHI-PROJECT-23390266, KAKENHI-PROJECT-23791093, KAKENHI-PROJECT-23791162, KAKENHI-PUBLICLY-23118501
[Patent] HTLV-1プロウイルス検出のためのプライマーセット、及びそれを用いた検出方法2013
- Inventor(s)
  倉光　球、浜口　功、大隈　和
- Industrial Property Rights Holder
  倉光　球、浜口　功、大隈　和
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-196247
- Filing Date
  2013-09-20
- Data Source
  KAKENHI-PROJECT-25860798
[Presentation] Elucidation of the mechanism of transplacental and horizontal HTLV-1 transmission using a novel cell-free infection system2023
- Author(s)
  Koh Nagata, Kenta Tezuka, Madoka Kuramitsu, Naoki Fuchi, Yuri Hasegawa, Kiyonori Miura, Isao Hamaguchi
- Organizer
  日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-20K07670
[Presentation] イムノクロマト法による新規HTLV-1抗体検査法の性能評価―多施設共同研究2022
- Author(s)
  倉光球、石塚賢治、久保田龍二、佐藤知雄、山野嘉久、橋倉悠輝、梅北邦彦、野坂生郷、長谷川寛雄、三浦清徳、宇都宮與、高起良、相良康子、蕎麦田理英子、佐竹正博、浜口功
- Organizer
  第８回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07670
[Presentation] Extensive gene deletions in Japanese patients with Diamond Blackfan anemia2011
- Author(s)
  Madoka Kuramitsu, Aiko Matsubara, Tomohiro Morio, Masatoshi Takagi, Tsutomu Toki, Kiminori Terui, RuNan Wang, Hitoshi Kanno, Shoichi Ohga, Akira Ohara, Atsuko Masumi, Haruka Momose, Takuo Mizukami, Kazuya Takizawa, Kazunari Yamaguchi, Seishi Ogawa, Etsuro Ito, Isao Hamaguchi
- Organizer
  第73回日本血液学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22790922
[Presentation] Extensive gene deletions in Japanese patients with Diamond Blackfan anemia2011
- Author(s)
  Madoka Kuramitsu
- Organizer
  日本血液学会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-22790922
[Presentation] A novel method to analyze genomic c opy number of Diamond Blackfan anemia responsible genes.2010
- Author(s)
  Madoka Kuramitsu, Tomohiro Morio, Masatoshi Takagi, Mic hio Ozeki, Atsuko Masumi, Takuo Miz ukami, Haruka Momose, Kazuya Takiz awa, Ito Etsuro, Kazunari Yamaguchi, Isao Hamaguchi
- Organizer
  第72回日本血液学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22790922
[Presentation] Deficiency of Ribosomal protein associated with Diamond Blackfan anemia induces autophagy2010
- Author(s)
  倉光球
- Organizer
  第72回日本血液学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22790922
[Presentation] New Determination Method for Extensive Gene Deletions in Diamond-Blackfan Anemia2010
- Author(s)
  倉光球
- Organizer
  第52回アメリカ血液学会
- Place of Presentation
  オーランド、フロリダ(米)
- Data Source
  KAKENHI-PROJECT-22790922
[Presentation] New Determination Method for Extens ive Gene Deletions in Diamond .Blackfan Anemia2010
- Author(s)
  Madoka Kuramitsu, Tomohiro Morio,, Masatoshi Takagi, Tsutomu Toki, Ki minori Terui, RuNan Wang, Atsuko Masumi, Takuo Mizukami, Haruka Momose, Kazuya Takizawa, Kazunari Yamaguchi, Etsuro Ito, and Isao Hamaguchi
- Organizer
  Poster III-1010、第52回アメリカ血液学会
- Place of Presentation
  オーランド、米国
- Data Source
  KAKENHI-PROJECT-22790922
[Presentation] A novel method to analyze genomic copy number of Diamond Blackfan anemia responsible genes2010
- Author(s)
  倉光球
- Organizer
  第72回日本血液学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22790922
[Presentation] Development of a HTLV-1 DNA standard.
- Author(s)
  Madoka Kuramitsu, Isao Hamaguchi
- Organizer
  SCIENTIFIC WORKING GROUP ON THE STANDARDISATION OF GENOME AMPLIFICATION TECHNIQUES
- Place of Presentation
  GRAZ (Austria)
- Year and Date
  2014-05-28 – 2014-05-29
- Data Source
  KAKENHI-PROJECT-25860798

1. MIURA Kiyonori

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# of Collaborated Products: 1 results
2. MIURA Shoko

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3. KAWAUCHI Shigeto

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4. 上地珠代

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5. 浜口功

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# of Collaborated Products: 2 results
6. FIROUZI Sanaz

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7. 大賀正一

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8. 手塚健太

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9. 今泉芳孝

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10. 佐々木功典

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KURAMITSU Madoka 倉光 球

Kuramitsu Madoka 倉光 球

Research Projects

Research Products

Co-Researchers

HTLV-1感染による細胞ゲノム不安定性の亢進と遺伝子変異リスク評価法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genomic instability of HTLV-1 provirus and application to clinical testing for adult T-cell leukaemia.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis for erythroid defect in Diamond Blackfan anemia using patient-derived iPS cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis for the association of autophagy with diamond blackfan anemia associated genes.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 血液フロンティア2014

Author(s)

Total Pages

Publisher

Data Source

[Book] Diamond-Blackfan 貧血の分子異常 細胞 42(7)(通号 554)2010

Author(s)

Publisher

Data Source

[Book] 血液診療エキスパート貧血2010

Author(s)

Publisher

Data Source

[Journal Article] First case of molecularly identified and genetically characterized human T-cell leukemia virus type 2 infection in a pregnant woman in non-endemic Japan2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] No SARS-CoV-2 RNA detected in the convalescent plasma of COVID-19 patients with different disease severity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HTLV-1 targets human placental trophoblasts in seropositive pregnant women2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Frequent horizontal and mother-to-child transmission may contribute to high prevalence of STLV-1 infection in Japanese macaques2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting: a collaborative study for performance evaluation of diagnostic assays in Japan,2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A high-throughput detection method for the clonality of Human T-cell leukemia virus type-1-infected cells in vivo2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1-infected cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia.2015

Author(s)

Journal Title

KURAMITSU Madoka 倉光球

Kuramitsu Madoka 倉光球

[Book] Diamond-Blackfan 貧血の分子異常細胞 42(7)(通号 554)2010