Watanabe Nobuo 渡邉宣夫

Researcher Number	00568644
Other IDs
Affiliation (Current)	2025: 芝浦工業大学, システム理工学部, 教授
Affiliation (based on the past Project Information) *help	2024: 芝浦工業大学, システム理工学部, 教授 2021 – 2022: 芝浦工業大学, システム理工学部, 教授 2017 – 2020: 芝浦工業大学, システム理工学部, 准教授 2015: 芝浦工業大学, システム工学部, 准教授 2014 – 2015: 芝浦工業大学, システム理工学部, 准教授
Review Section/Research Field	Principal Investigator Biomedical engineering/Biomaterial science and engineering / Basic Section 90110:Biomedical engineering-related Except Principal Investigator Sections That Are Subject to Joint Review: Basic Section90130:Medical systems-related , Basic Section90140:Medical technology assessment-related / Basic Section 90140:Medical technology assessment-related / Basic Section 90130:Medical systems-related
Keywords	Principal Investigator 赤血球 / せん断応力 / 流れの可視化 / 血小板活性 / 血漿タンパク / 血液損傷 / 赤血球変形能 / 血小板凝集 / 画像解析 / 血小板 … More / 心血管デバイス / せん断負荷 / 血小板凝集能 / 流れの可視化実験 / 機械式血液循環装置 / 高せん断応力 / 流動変形 / 変動せん断流れ / 一様せん断流れ / せん断脆弱性 / 膜上タンパク応答 / 細胞損傷 / 細胞機能 / 人工臓器学 / 血液 / 人工臓器 / 血漿タンパク損傷 / 機械式循環補助 / せん断刺激 / 血液細胞 / 血液ポンプ / NO産生 / せん断流れ / 血液流動可視化 / 血栓止血 / バイオレオロジー / 初期血栓 / 繊維配向と粘着特性 / コラーゲン繊維 / 血小板粘着 / 粘着成功率 / コラーゲン繊維勾配 / 流れ依存性 / 血小板粘着挙動 / コラーゲン繊維の形態学的評価 / Image analysis / Morphology of Collagen … More Except Principal Investigator 補助人工心臓 / 臓器保存 / 臓器機能評価 / 心拍同期制御法 / 左心室補助人工心臓 / 体外心臓灌流 / 心臓移植 Less

Prolonged ex vivo heart perfusion incorporating ventricular assist device to preserve the myocardial function
- Principal Investigator
  
  迫田大輔
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90130:Medical systems-related
  Basic Section 90140:Medical technology assessment-related
  Sections That Are Subject to Joint Review: Basic Section90130:Medical systems-related , Basic Section90140:Medical technology assessment-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Elucidation of blood cell's response to constant and fluctuating shear stressesPrincipal Investigator
- Principal Investigator
  
  Watanabe Nobuo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Shibaura Institute of Technology
Multidisciplinary basic studies on the shear stress related functional deterioration and damage phenomenon of erythrocytes and plateletsPrincipal Investigator
- Principal Investigator
  
  Watanabe Nobuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Shibaura Institute of Technology
Elucidation of Platelet Adhesion Behavior using Manufacturing technique, Confocal Microscopy, and Image AnalysisPrincipal Investigator
- Principal Investigator
  
  Watanabe Nobuo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Shibaura Institute of Technology

All 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] In vitro comparative study of activated clotting time in fresh human whole blood with various levels of coagulability using two devices2022
- Author(s)
  N. Watanabe, M. Inoue, M. Honda, K. Masnok, T. Negishi,
- Journal Title
  
  Journal of Biorheology
  
  Volume: 2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12609
[Journal Article] In vitro comparative study of activated clotting time in fresh human whole blood with various levels of coagulability using two devices2022
- Author(s)
  Watanabe Nobuo、Inoue Masataka、Honda Masaki、Masnok Kriengsak、Negishi Teruhiko
- Journal Title
  
  Journal of Biorheology
  
  Volume: 36 Issue: 2 Pages: 39-44
- DOI
  10.17106/jbr.36.39
- ISSN
  1867-0466, 1867-0474
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12609
[Journal Article] Direct observation of deformation of individual red blood cells in oscillatory fluid flow produced using a generator of precise sinusoidal shear flow2022
- Author(s)
  Masnok Kriengsak、Inoue Masataka、Watanabe Nobuo
- Journal Title
  
  AIP Advances
  
  Volume: 12 Issue: 9 Pages: 095020-095020
- DOI
  10.1063/5.0113873
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12609
[Journal Article] Discrete responses of erythrocytes, platelets, and von Willebrand factor to shear2022
- Author(s)
  Chan Chris H.H.、Simmonds Michael J.、Fraser Katharine H.、Igarashi Kosuke、Ki Katrina K.、Murashige Tomotaka、Joseph Mary T.、Fraser John F.、Tansley Geoff D.、Watanabe Nobuo
- Journal Title
  
  Journal of Biomechanics
  
  Volume: 130 Pages: 110898-110898
- DOI
  10.1016/j.jbiomech.2021.110898
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K12609
[Journal Article] Erythrocyte morphological symmetry analysis to detect sublethal trauma in shear flow2021
- Author(s)
  McNamee Antony P.、Simmonds Michael J.、Inoue Masataka、Horobin Jarod T.、Hakozaki Masaya、Fraser John F.、Watanabe Nobuo
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 23566-23566
- DOI
  10.1038/s41598-021-02936-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K12609
[Journal Article] Preliminary study of the effect of hemolysis on platelet aggregation through microscopic observation under physiological shear flow2021
- Author(s)
  Watanabe Nobuo、Kawada Naoki
- Journal Title
  
  Journal of Biorheology
  
  Volume: 35 Issue: 2 Pages: 62-67
- DOI
  10.17106/jbr.35.62
- NAID
  130008133903
- ISSN
  1867-0466, 1867-0474
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12609
[Journal Article] Shear‐dependent platelet aggregation size2020
- Author(s)
  Chan Chris Hoi Houng、Inoue Masataka、Ki Katrina K.、Murashige Tomotaka、Fraser John F.、Simmonds Michael J.、Tansley Geoff D.、Watanabe Nobuo
- Journal Title
  
  Artificial Organs
  
  Volume: 44 Issue: 12 Pages: 1286-1295
- DOI
  10.1111/aor.13783
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K12609
[Journal Article] Shear-stress mediated nitric oxide production within red blood cells: A dose-response2019
- Author(s)
  Horobin Jarod T.、Watanabe Nobuo、Hakozaki Masaya、Sabapathy Surendran、Simmonds Michael J.
- Journal Title
  
  Clinical Hemorheology and Microcirculation
  
  Volume: 71 Issue: 2 Pages: 203-214
- DOI
  10.3233/ch-189412
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01370
[Journal Article] Intravital Observation of Microvascular Remodeling During Chronic Exposure to Hypoxia in Mice2018
- Author(s)
  H. Nakamura, M. Shibata, N. Watanabe
- Journal Title
  
  Adv Exp Med Biol 2018
  
  Volume: 1072 Pages: 245-249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01370
[Journal Article] Visualization of erythrocyte deformation induced by supraphysiological shear stress2018
- Author(s)
  Watanabe Nobuo、Shimada Takahiro、Hakozaki Masaya、Hara Ryohei
- Journal Title
  
  The International Journal of Artificial Organs
  
  Volume: 41 Issue: 12 Pages: 838-844
- DOI
  10.1177/0391398818793387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01370
[Journal Article] Blood-device interaction2018
- Author(s)
  Simmonds Michael J.、Watanabe Nobuo、Nandakumar Deepika、Horobin Jarod
- Journal Title
  
  Mechanical Circulatory and Respiratory Support
  
  Volume: 1 Pages: 597-626
- DOI
  10.1016/b978-0-12-810491-0.00019-9
- ISBN
  9780128104910
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] 赤血球の加齢と膜酸化現象の関連性検証2022
- Author(s)
  久保田玲，福井浩二，渡邉宣夫
- Organizer
  第75回日本酸化ストレス学会学術集会、
- Data Source
  KAKENHI-PROJECT-20K12609
[Presentation] Observation of red blood cell's rheological behavior under fluctuating shear conditions using a specially built sinusoidal shear chamber2022
- Author(s)
  Kriengsak Masnok, Nobuo Watanabe
- Organizer
  48th Annual European Society for Artificial Organs　(ESAO) Congress Austria
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K12609
[Presentation] 赤血球の加齢と膜酸化現象の関連性検証2022
- Author(s)
  久保田玲、福井浩二、渡邉宣夫
- Organizer
  第75回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-20K12609
[Presentation] 共焦点蛍光顕微鏡を用いた血小板活性状態の観察‐GPIIb/IIaに着目した血小板活性評価指標の検討‐2022
- Author(s)
  三浦千代子, 渡邉宣夫
- Organizer
  第31回ライフサポート学会フロンティア講演会,
- Data Source
  KAKENHI-PROJECT-20K12609
[Presentation] 共焦点蛍光顕微鏡を用いた血小板活性状態の観察‐GPIIb/IIaに着目した血小板活性評価指標の検討‐2022
- Author(s)
  三浦千代子, 渡邉宣夫
- Organizer
  第31回ライフサポート学会フロンティア講演会
- Data Source
  KAKENHI-PROJECT-20K12609
[Presentation] 機械式補助循環を模擬した変動せん断流れ環境下の赤血球観察実験システムの試作2022
- Author(s)
  松澤ふく大, 大和田将広,井上雅喬,渡邉宣夫
- Organizer
  第60 回日本人工臓器学会大会
- Data Source
  KAKENHI-PROJECT-20K12609
[Presentation] 一様単純せん断流れ発生装置を用いた血液細胞の観察結果から予想される機械式補助循環装置利用環境において生じうる血液損傷現象に対する考察2022
- Author(s)
  井上雅喬,渡邉宣夫
- Organizer
  第50回人工心臓と補助循環懇話会学術集会
- Data Source
  KAKENHI-PROJECT-20K12609
[Presentation] Examination of new method to express in detailed expression of plasma vWF for elucidation of their shear stress induced diminishment2021
- Author(s)
  Reina Kato, Yugo Kato, Koji Fukui, Nobuo Watanabe
- Organizer
  47th Annual European Society for Artificial Organs(ESAO) Congress, Brunel University, London, Uxbridge, during 7-11 September, 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K12609
[Presentation] 止血タンパク研究のための血漿アルブミン除去法の検討2021
- Author(s)
  加藤玲奈，加藤優吾，福井浩二，渡邉宣夫
- Organizer
  第44回日本バイオレオロジー学会年会
- Data Source
  KAKENHI-PROJECT-20K12609
[Presentation] Asymmetrical erythrocyte morphology to detect sublethal damage2021
- Author(s)
  Nobuo Watanabe, Antony P. McNamee, Jarod T. Horibin, John F Fraser, Masataka Inoue, Masaya Hakozaki, Fukuta Matsuzawa, Michael J. Simmonds,
- Organizer
  2nd Joint Meeting of ESCHM-ISCH-ISB Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K12609
[Presentation] せん断流れ下における血小板凝集の顕微鏡観察2021
- Author(s)
  川田尚輝, 柴田政廣, 渡邉宣夫
- Organizer
  第44回日本バイオレオロジー学会年会
- Data Source
  KAKENHI-PROJECT-20K12609
[Presentation] せん断流れに起因した血液損傷の解明　‐画像解析を用いた赤血球損傷および血小板凝集評価‐2020
- Author(s)
  井上雅喬, 渡邉宣夫
- Organizer
  ライフサポート学会　フロンティア講演会
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] Abrupt change of shear stress as additional hemolysis factor2019
- Author(s)
  Nobuo Watanabe and Reina Ioka
- Organizer
  ESAO Congress Sept 3-7 2019 Hannover, Germany
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] the effect of shear rate and exposure time on the formation size of human platelet aggregations2019
- Author(s)
  Masataka Inoue, Katrina K. Ki, Tomotaka Murashige, Michael J. Simmonds, Nobuo Watanabe, Geoff D. Tansley, John F. Fraser, Chris Hoi Houng Chan
- Organizer
  International Society for Mechanical Circulatory Support (ISMCS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] せん断速度が血小板凝集サイズに与える影響2019
- Author(s)
  井上雅喬,Ki Katrina, 村重智崇,Simmonds Michael, 渡邉宣夫,Tansley Geoff,　Fraser John, Chan Chris
- Organizer
  LIFE2019日本機械学会福祉工学シンポジウム2019第35回ライフサポート学会大会第19回日本生活支援工学会大会
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] Mechanical characteristics of Blood cells2019
- Author(s)
  Nobuo Watanabe
- Organizer
  International Conference on Mechanical, Electrical and Medical Intelligent System 2019 (ICMEMIS 2019)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] The effect of shear stress and exposure time on the formation size of platelet aggregation2019
- Author(s)
  Chris Hoi Houng Chan, Masataka Inoue, Katrina K Ki, Tomotaka Murashige, John F Fraser, Nobuo Watanabe, Geoff Tansley
- Organizer
  The American Society for Artificial Internal Organs (ASAIO) San Francisco.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] 観察点移動機構を有するせん断流れ発生撮影装置を用いたラット新鮮血中の赤血球観察2019
- Author(s)
  池田直生、井上雅喬、浅井森介、吉田脩人、渡邉宣夫
- Organizer
  第42回日本バイオレオロジー学会年会第27回福岡県臨床工学会合同大会
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] Image analysis to detect erythrocyte damage induced by high shear stress2019
- Author(s)
  Masataka Inoue，Masaya Hakozaki ，Jarod T. Horobin，Antony P. McNamee，Geoff D. Tansley, John F. Fraser, Michael J. Simmonds，Shuto Yoshida, Masahiro Shibata, Nobuo Watanabe
- Organizer
  Life Engineering Symposium 2019 (LE2019) 34th Biological and Physiological Engineering
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] Abrupt change of shear stress as additional hemolysis factor2019
- Author(s)
  Nobuo Watanabe and Reina Ioka
- Organizer
  ESAO Congress Sept 3-7 2019 Hannover, Germany.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] The threshold shear stress for mechanical damage as evaluated by hemolysis, red blood cell deformability and platelet activation using a novel shearing device2019
- Author(s)
  Kosuke Igarashi, Tomotaka Murashige, Katrina Ki, Michael J. Simmonds, Geoff Tansley, John F. Fraser, Nobuo Watanabe, Chris H. H. Chan
- Organizer
  The 8th Meeting of the International Federation for Artificial Organs (IFAO 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] Study to evaluate erythrocyte’s membrane oxidation during shear stress loading by centrifugal blood pump2019
- Author(s)
  Yuki Udono　Yugo Kato, Koji Fukui, Nobuo Watanabe
- Organizer
  International Society for Mechanical Circulatory Support (ISMCS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] 密度別に区分した赤血球に対する膜酸化量の測定評価2019
- Author(s)
  鵜殿裕輝、福井浩二、渡邉宣夫
- Organizer
  第42回日本バイオレオロジー学会年会第27回福岡県臨床工学会合同大会
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] 画像解析による高せん断応力下の損傷赤血球検知法の提案2019
- Author(s)
  井上雅喬, 箱﨑雅也, Jarod T. Horobin, Antony P. McNamee, Geoff D. Tansley, John F. Fraser, Michael J. Simmonds, 渡邉宣夫
- Organizer
  第57回日本人工臓器学会大会（JSAO 2019）
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] The effect of shear stress and exposure time on the formation size of platelet aggregation2019
- Author(s)
  Chris Hoi Houng Chan, Masataka Inoue, Katrina K Ki, Tomotaka Murashige, John F Fraser, Nobuo Watanabe, Geoff Tansley
- Organizer
  The American Society for Artificial Internal Organs (ASAIO)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] Discussion about high shear stress induced erythrocyte’s damage and lysis -Interpretation of hemolysis in cardiovascular devices based on our visualized erythrocytes’ behaviors2018
- Author(s)
  N. Watanabe, T. Shimada, N. Ikeda, M. Hakozaki, K. Igarashi
- Organizer
  Joint Meeting of The European Society for Clinical Hemorheology and Microcirculation The International Society for Clinical Hemorheology The International Society of Biorheology 2-6 July 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] Visualisation of the erythrocyte damage process induced by sublethal shear stress2018
- Author(s)
  M. Hakozaki, M. J. Simmonds, J. T. Horobin, A. P. McNamee, T. Shimada, R. Hara, N. Watanabe
- Organizer
  ESAO 2018 Madrid Spain.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] 観察点移動機構を有する血液細胞流動撮影装置の構築とその妥当性検証2018
- Author(s)
  池田直生 , 井上雅喬 , 箱﨑雅也 , 五十嵐公輔 , 渡邉宣夫
- Organizer
  第41 回日本バイオレオロジー学会年会
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] Visualized erythrocyte’s shear induced damage process under high shear flow2017
- Author(s)
  N. Watanabe, T Shimada, M Hakozaki, R Hara
- Organizer
  44th ESAO and 7th IFAO Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01370
[Presentation] 流れに対するコラーゲン繊維の傾斜角度と血小板の粘着容易さの関係性評価方法の検討2016
- Author(s)
  大石麻代，花房昭彦，町村幸夫，吉田脩右，渡邉宣夫
- Organizer
  第３９回日本バイオレオロジー学会年会
- Place of Presentation
  東海大学校友会館（東京都千代田区霞ヶ関：霞ヶ関ビル35階）
- Year and Date
  2016-06-18
- Data Source
  KAKENHI-PROJECT-26750150

1. 福井浩二 (80399807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. 迫田大輔 (40588670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 長岡英気 (30526463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 坪子侑佑 (40809399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Watanabe Nobuo 渡邉 宣夫

Research Projects

Research Products

Co-Researchers

Prolonged ex vivo heart perfusion incorporating ventricular assist device to preserve the myocardial function

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of blood cell's response to constant and fluctuating shear stressesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Multidisciplinary basic studies on the shear stress related functional deterioration and damage phenomenon of erythrocytes and plateletsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of Platelet Adhesion Behavior using Manufacturing technique, Confocal Microscopy, and Image AnalysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] In vitro comparative study of activated clotting time in fresh human whole blood with various levels of coagulability using two devices2022

Author(s)

Journal Title

Data Source

[Journal Article] In vitro comparative study of activated clotting time in fresh human whole blood with various levels of coagulability using two devices2022

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Direct observation of deformation of individual red blood cells in oscillatory fluid flow produced using a generator of precise sinusoidal shear flow2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discrete responses of erythrocytes, platelets, and von Willebrand factor to shear2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Erythrocyte morphological symmetry analysis to detect sublethal trauma in shear flow2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preliminary study of the effect of hemolysis on platelet aggregation through microscopic observation under physiological shear flow2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Shear‐dependent platelet aggregation size2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Shear-stress mediated nitric oxide production within red blood cells: A dose-response2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intravital Observation of Microvascular Remodeling During Chronic Exposure to Hypoxia in Mice2018

Author(s)

Journal Title

Data Source

[Journal Article] Visualization of erythrocyte deformation induced by supraphysiological shear stress2018

Author(s)

Journal Title

DOI

Watanabe Nobuo 渡邉宣夫

[Presentation] せん断流れに起因した血液損傷の解明　‐画像解析を用いた赤血球損傷および血小板凝集評価‐2020