Asahara Shun-ichiro 淺原俊一郎

… Alternative Names

ASAHARA Shun-ichiro 淺原俊一郎

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Researcher Number	00570342
Other IDs	https://orcid.org/0000-0001-6661-9402
Affiliation (Current)	2025: 神戸大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 神戸大学, 医学部附属病院, 助教 2018: 神戸大学, 医学(系)研究科(研究院), 助教 2018: 神戸大学, 医学部附属病院, 特定助教 2016 – 2018: 神戸大学, 医学研究科, 特命助教 2013 – 2015: 神戸大学, 医学(系)研究科(研究院), 研究員 2012: 神戸大学, 医学(系)研究科(研究院), 医学研究員
Review Section/Research Field	Principal Investigator Endocrinology / Basic Section 54040:Metabolism and endocrinology-related / Eating habits, studies on eating habits Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Basic Section 56060:Ophthalmology-related
Keywords	Principal Investigator 膵β細胞 / 2型糖尿病 / 2型糖尿病感受性遺伝子 / エピジェネティクス / 脱分化 / 可塑性 / 糖尿病 / ヒトiPS細胞 / セロトニン / 膵島 … More / mTORC1 / ２型糖尿病感受性遺伝子 / ヒト膵島 / iPS細胞 / インプリンティング / Kcnq1ot1 / 膵β細胞不全 … More Except Principal Investigator 膵β細胞 / 糖尿病 / in vivoイメージング / 糖尿病網膜症 / エクソソーム / 神経変性 / マウス / アクアポリン９ / 脱分化 / 膵島 / mTORC1 / 可塑性 / イメージング / 網膜変性 / neurovascular unit / アストロサイト Less

膵島の可塑性におけるセロトニンの機能解析Principal Investigator
- Principal Investigator
  
  淺原俊一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kobe University
膵β細胞由来エクソソームによる臓器連関機序の解明
- Principal Investigator
  
  木戸良明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kobe University
The Effect of Insulin Signaling on Plasticity in Pancreatic Beta Cells
- Principal Investigator
  
  Kido Yoshiaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kobe University
Roles of aquaporin9 in diabetic retinal neurodegeneration
- Principal Investigator
  
  Kusuhara Sentaro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Kobe University
Regulatory mechanism of mTORC1 activity in pancreatic beta cells in the development of type 2 diabetesPrincipal Investigator
- Principal Investigator
  
  Asahara Shun-ichiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kobe University
Functional analysis of type 2 diabetes susceptibility genes in human pancreatic beta cellsPrincipal Investigator
- Principal Investigator
  
  Asahara Shunichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Research Field
  
  Endocrinology
- Research Institution
  Kobe University
Roles of neurovascular unit in diabetic retinal neurodegeneration
- Principal Investigator
  
  Kusuhara Sentaro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Kobe University
Analysis of pathogenic mechanism by susceptibility genes of T2DM using human iPS cells.Principal Investigator
- Principal Investigator
  
  Asahara] Shun-ichiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Kobe University
Effect of type 2 diabetes susceptibility gene Kcnq1 gene region on pancreatic beta cellsPrincipal Investigator
- Principal Investigator
  
  Asahara Shun-ichiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Kobe University
Analysis of interaction between amino acids and pancreatic beta cell mass via epigenetic modulation.Principal Investigator
- Principal Investigator
  
  ASAHARA Shun-ichiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  Kobe University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Book

[Book] 糖尿病学20162016
- Author(s)
  淺原俊一郎、木戸良明
- Total Pages
  9
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-26461382
[Journal Article] l-Asparaginase regulates mTORC1 activity via a TSC2-dependent pathway in pancreatic beta cells2023
- Author(s)
  Seike M, Asahara SI, Inoue H, Kudo M, Kanno A, Yokoi A, Suzuki H, Kimura-Koyanagi M, Kido Y, Ogawa W.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 652 Pages: 121-130
- DOI
  10.1016/j.bbrc.2023.02.035
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08860, KAKENHI-PROJECT-20K08906, KAKENHI-PROJECT-22K08653, KAKENHI-PROJECT-23K07990, KAKENHI-PROJECT-21K08579
[Journal Article] Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea in diabetes2023
- Author(s)
  Watanabe H, Du W, Son J, Sui L, Asahara SI, Kurland IJ, Kuo T, Kitamoto T, Miyachi Y, de Cabo R, Accili D.
- Journal Title
  
  Sci Transl Med.
  
  Volume: 15 Issue: 681
- DOI
  10.1126/scitranslmed.abq4126
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08860
[Journal Article] A case of multiple glucagonomas with no clinical manifestations of excess glucagon despite hyperglucagonemia2023
- Author(s)
  Amano S, Suenaga S, Hamamoto K, Yada S, Tsuyama T, Shinoda S, Tanaka Y, Takemoto Y, Harada E, Tanabe K, Asahara S, Hoshii K, Takami T.
- Journal Title
  
  DEN Open
  
  Volume: 3 Issue: 1
- DOI
  10.1002/deo2.230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08860, KAKENHI-PROJECT-20K08887, KAKENHI-PROJECT-19K17434, KAKENHI-PROJECT-23K08011
[Journal Article] Chlorogenic Acid and Caffeine in Coffee Restore Insulin Signaling in Pancreatic Beta Cells2023
- Author(s)
  Ihara Y, Asahara SI, Inoue H, Seike M, Ando M, Kabutoya H, Kimura-Koyanagi M, Kido Y.
- Journal Title
  
  Kobe J Med Sci.
  
  Volume: 69
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08860
[Journal Article] Chlorogenic Acid and Caffeine in Coffee Restore Insulin Signaling in Pancreatic Beta Cells2023
- Author(s)
  Ihara Y, Asahara SI, Inoue H, Seike M, Ando M, Kabutoya H, Kimura-Koyanagi M, Kido Y.
- Journal Title
  
  Kobe J Med Sci.
  
  Volume: 69
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08579
[Journal Article] The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice2023
- Author(s)
  Inaba Yuka、Hashiuchi Emi、Watanabe Hitoshi、Kimura Kumi、Oshima Yu、Tsuchiya Kohsuke et al.
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 167-167
- DOI
  10.1038/s41467-023-35804-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19426, KAKENHI-PROJECT-22K19545, KAKENHI-PROJECT-21H04823, KAKENHI-PROJECT-20H03475, KAKENHI-PROJECT-20H04102, KAKENHI-PROJECT-20K05238, KAKENHI-PROJECT-20K08860, KAKENHI-PROJECT-23K24764, KAKENHI-PROJECT-20H03509, KAKENHI-PROJECT-21H02695, KAKENHI-PROJECT-23K24390
[Journal Article] Regulation of Pancreatic β-Cell Mass by Gene-Environment Interaction2022
- Author(s)
  Asahara SI, Inoue H, Kido Y.
- Journal Title
  
  Diabetes Metab J
  
  Volume: 46 Issue: 1 Pages: 38-48
- DOI
  10.4093/dmj.2021.0045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0438, KAKENHI-PROJECT-20K08860, KAKENHI-PROJECT-21K08579, KAKENHI-PROJECT-21K17684
[Journal Article] Roles of mTOR in the Regulation of Pancreatic β-Cell Mass and Insulin Secretion2022
- Author(s)
  Asahara S, Inoue H, Watanabe H, Kido Y.
- Journal Title
  
  Biomolecules
  
  Volume: 12 Issue: 5 Pages: 618-618
- DOI
  10.3390/biom12050614
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08860, KAKENHI-PROJECT-21K08579
[Journal Article] Oral administration of D-serine prevents the onset and progression of colitis in mice.2021
- Author(s)
  Takehito Asakawa, Michio Onizawa, Chikako Saito, Rie Hikichi, Daiki Yamada, Ai Minamidate, Tomoaki Mochimaru, Shun-ichiro Asahara, Yoshiaki Kido, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe.
- Journal Title
  
  Journal of Gastroenterolog.
  
  Volume: 56 Issue: 8 Pages: 732-745
- DOI
  10.1007/s00535-021-01792-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19K08461, KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-18KK0438, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-21H02897, KAKENHI-PROJECT-21H02898, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-20K08860, KAKENHI-PROJECT-21K08579
[Journal Article] Glutamate is an essential mediator in glutamine‐amplified insulin secretion2021
- Author(s)
  Han Guirong、Takahashi Harumi、Murao Naoya、Gheni Ghupurjan、Yokoi Norihide、Hamamoto Yoshiyuki、Asahara Shun‐ichiro、Seino Yutaka、Kido Yoshiaki、Seino Susumu
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: - Issue: 6 Pages: 920-930
- DOI
  10.1111/jdi.13497
- NAID
  120007097043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07400, KAKENHI-PROJECT-19K09026, KAKENHI-PROJECT-18KK0438, KAKENHI-PROJECT-18H02364, KAKENHI-PROJECT-21H02390, KAKENHI-PROJECT-20K08860, KAKENHI-PROJECT-21K08579
[Journal Article] Histone deacetylase 6 regulates insulin signaling in pancreatic β cells2021
- Author(s)
  Inoue H, Asahara SI, Sugiura Y, Kawada Y, Imai A, Hara C, Kanno A, Kimura-Koyanagi M, Kido Y.
- Journal Title
  
  Biochem Biophys Res Commun .
  
  Volume: 534 Pages: 896-901
- DOI
  10.1016/j.bbrc.2020.10.078
- NAID
  120007033584
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08860, KAKENHI-PROJECT-20K17535, KAKENHI-PROJECT-18KK0438
[Journal Article] Patch-seq shows the heterogeneity of pancreatic islet cells.2021
- Author(s)
  Asahara S
- Journal Title
  
  J Diabetes Investig.
  
  Volume: - Issue: 5 Pages: 691-693
- DOI
  10.1111/jdi.13514
- NAID
  120007032320
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08860, KAKENHI-PROJECT-18KK0438
[Journal Article] En face slab optical coherence tomography imaging successfully monitors progressive degenerative changes in the innermost layer of the diabetic retina2020
- Author(s)
  Katsuyama Atsuko、Kusuhara Sentaro、Asahara Shun-Ichiro、Nakai Shun-Ichiro、Mori Sotaro、Matsumiya Wataru、Miki Akiko、Kurimoto Takuji、Imai Hisanori、Kido Yoshiaki、Ogawa Wataru、Nakamura Makoto
- Journal Title
  
  BMJ Open Diabetes Research & Care
  
  Volume: 8 Issue: 1 Pages: e001120-e001120
- DOI
  10.1136/bmjdrc-2019-001120
- NAID
  120006863549
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09409, KAKENHI-PROJECT-18K09447, KAKENHI-PROJECT-18KK0438, KAKENHI-PROJECT-17H01966, KAKENHI-PROJECT-17K09882
[Journal Article] Sex difference in the association of obesity with personal or social background among urban residents in Japan2020
- Author(s)
  Asahara SI, Miura H, Ogawa W, Tamori Y.
- Journal Title
  
  PLoS One.
  
  Volume: 15 Issue: 11 Pages: e0242105-e0242105
- DOI
  10.1371/journal.pone.0242105
- NAID
  120006938919
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08860, KAKENHI-PROJECT-18KK0438
[Journal Article] GCN2 regulates pancreatic β-cell mass by sensing intracellular amino acid levels.2020
- Author(s)
  Kanno A, Asahara SI, Furubayashi A, Masuda K, Yoshitomi R, Suzuki E, Takai T, Kimura-Koyanagi M, Matsuda T, Bartolome A, Hirota Y, Yokoi N, Inaba Y, Inoue H, Matsumoto M, Inoue K, Abe T, Wei FY, Tomizawa K, Ogawa W, Seino S, Kasuga M, Kido Y.
- Journal Title
  
  JCI Insight.
  
  Volume: 5 Issue: 9 Pages: 128820-128820
- DOI
  10.1172/jci.insight.128820
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0438, KAKENHI-PROJECT-17H01966, KAKENHI-PROJECT-17K09831, KAKENHI-PROJECT-17K09882, KAKENHI-PROJECT-19K09192, KAKENHI-PROJECT-20K08860, KAKENHI-PROJECT-20K08906, KAKENHI-PROJECT-20K17535, KAKENHI-PUBLICLY-20H04943, KAKENHI-PROJECT-18H02364, KAKENHI-PROJECT-19H03713, KAKENHI-PROJECT-20H04102, KAKENHI-PROJECT-18KT0020
[Journal Article] Early administration of dapagliflozin preserves pancreatic β-cell mass through a legacy effect in a mouse model of type 2 diabetes2019
- Author(s)
  Kanno A, Asahara SI, Kawamura M, Furubayashi A, Tsuchiya S, Suzuki E, Takai T, Koyanagi-Kimura M, Matsuda T, Okada Y, Ogawa W, Kido Y.
- Journal Title
  
  J Diabetes Invest.
  
  Volume: 10 Issue: 3 Pages: 577-590
- DOI
  10.1111/jdi.12945
- NAID
  120006645694
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09882, KAKENHI-PROJECT-17H01966, KAKENHI-PROJECT-16K09803, KAKENHI-PROJECT-19K17963
[Journal Article] Neuronatin and glucose-induced stress in pancreatic β-cells.2019
- Author(s)
  Asahara SI
- Journal Title
  
  J Diabetes Invest.
  
  Volume: 10 Issue: 3 Pages: 574-576
- DOI
  10.1111/jdi.12993
- NAID
  120006645695
- Open Access
- Data Source
  KAKENHI-PROJECT-17K09882
[Journal Article] Association between mean platelet volume in the pathogenesis of type 2 diabetes mellitus and diabetic macrovascular complications in Japanese patients.2019
- Author(s)
  Inoue H, Saito M, Kouchi K, Asahara SI, Nakamura F, Kido Y.
- Journal Title
  
  J. Diab. Invest.
  
  Volume: - Issue: 4 Pages: 938-945
- DOI
  10.1111/jdi.13198
- NAID
  120006876706
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0438, KAKENHI-PROJECT-17H01966, KAKENHI-PROJECT-17K09882, KAKENHI-PROJECT-20K08860
[Journal Article] Docosahexaenoic Acid Reduces Palmitic Acid-Induced Endoplasmic Reticulum Stress in Pancreatic Β Cells.2018
- Author(s)
  Suzuki E, Matsuda T, Kawamoto T, Takahashi H, Mieda Y, Matsuura Y, Takai T, Kanno A, Koyanagi-Kimura M, Asahara SI, Inoue H, Ogawa W, Kido Y.
- Journal Title
  
  Kobe J Med Sci.
  
  Volume: 64
- NAID
  120006523798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09882
[Journal Article] Casein kinase 2 phosphorylates and stabilizes C/EBPβ in pancreatic β cells.2018
- Author(s)
  Takai T, Matsuda T, Matsuura Y, Inoue K, Suzuki E, Kanno A, Kimura-Koyanagi M, Asahara SI, Hatano N, Ogawa W, Kido Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 497 Issue: 1 Pages: 451-456
- DOI
  10.1016/j.bbrc.2018.02.108
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09803, KAKENHI-PROJECT-17K09882, KAKENHI-PROJECT-17H01966, KAKENHI-PROJECT-16K16277
[Journal Article] PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes.2018
- Author(s)
  Yano H, Sakai M, Matsukawa T, Yagi T, Naganuma T, Mitsushima M, Iida S, Inaba Y, Inoue H, Unoki-Kubota H, Kaburagi Y, Asahara S, Kido Y, Minami S, Kasuga M, Matsumoto M.
- Journal Title
  
  Sci Rep.
  
  Volume: 8 Issue: 1 Pages: 14290-14290
- DOI
  10.1038/s41598-018-32575-z
- NAID
  120006529679
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KT0020, KAKENHI-PROJECT-17K07266, KAKENHI-PROJECT-17K09882, KAKENHI-PROJECT-18K08534, KAKENHI-PUBLICLY-17H05499, KAKENHI-PROJECT-17H01966, KAKENHI-PROJECT-15H05678
[Journal Article] SGLT2 inhibitors and protection against pancreatic beta cell failure.2018
- Author(s)
  Asahara SI, Ogawa W.
- Journal Title
  
  Diabetol Int.
  
  Volume: 10 Issue: 1 Pages: 1-2
- DOI
  10.1007/s13340-018-0374-y
- Data Source
  KAKENHI-PROJECT-17K09882
[Journal Article] MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling.2018
- Author(s)
  2.Bartolomé A, García-Aguilar A, Asahara S, Kido Y, Guillén C, Pajvani UB, Benito M.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 印刷中 Issue: 23
- DOI
  10.1128/mcb.00441-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09882, KAKENHI-PROJECT-17H01966
[Journal Article] Histone deacetylase regulates insulin signaling via two pathways in pancreatic β cells.2017
- Author(s)
  Kawada Y, Asahara SI, Sugiura Y, Sato A, Furubayashi A, Kawamura M, Bartolome A, Terashi-Suzuki E, Takai T, Kanno A, Koyanagi-Kimura M, Matsuda T, Hashimoto N, Kido Y.
- Journal Title
  
  PLoS ONE
  
  Volume: 12 Issue: 9 Pages: e0184435-e0184435
- DOI
  10.1371/journal.pone.0184435
- NAID
  120006353753
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09803, KAKENHI-PROJECT-17K09882, KAKENHI-PROJECT-17H01966, KAKENHI-PROJECT-16K16277
[Journal Article] Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-Induced, Nonalcoholic Fatty Liver Disease.2017
- Author(s)
  Watanabe H, Inaba Y, Kimura K, Asahara SI, Kido Y, Matsumoto M, Motoyama T, Tachibana N, Kaneko S, Kohno M, Inoue H*.
- Journal Title
  
  J Nutr.
  
  Volume: 147 Issue: 1 Pages: 52-60
- DOI
  10.3945/jn.116.231662
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01373, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04851, KAKENHI-PROJECT-15H05678, KAKENHI-PROJECT-16J08117, KAKENHI-PROJECT-26282022, KAKENHI-PROJECT-26461382, KAKENHI-PROJECT-16K00849
[Journal Article] Centra insulin-action activates Kupffer cells by suppressing hepatic vagal activation through nicotinic alpha 7 acetylcholine receptor.2016
- Author(s)
  Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H
- Journal Title
  
  Cell reports
  
  Volume: 14 Issue: 10 Pages: 2362-2374
- DOI
  10.1016/j.celrep.2016.02.032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461382, KAKENHI-PROJECT-26560368, KAKENHI-PUBLICLY-15H01373, KAKENHI-PROJECT-15H04851, KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-15H05678, KAKENHI-PROJECT-25461352, KAKENHI-PROJECT-26670599, KAKENHI-PROJECT-26860693, KAKENHI-PROJECT-26860705, KAKENHI-PROJECT-26870672, KAKENHI-PROJECT-26282022, KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15K12698, KAKENHI-PROJECT-16K01815, KAKENHI-PROJECT-16K09767
[Journal Article] Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β cell mass via epigenetic modification of Cdkn1c.2015
- Author(s)
  Asahara S, Etoh H, Inoue H, Teruyama K, Shibutani Y, Ihara Y, Kawada Y, Bartolome A, Hashimoto N, Matsuda T, Koyanagi-Kimura M, Kanno A, Hirota Y, Hosooka T, Nagashima K, Nishimura W, Inoue H, Matsumoto M, Higgins MJ, Yasuda K, Inagaki N, Seino S, Kasuga M, Kido Y.
- Journal Title
  
  Proceedings of the National Acaddemy of Scienceof the United States of America
  
  Volume: 112(27) Issue: 27 Pages: 8332-8337
- DOI
  10.1073/pnas.1422104112
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461351, KAKENHI-PROJECT-26461382, KAKENHI-PUBLICLY-15H01373, KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-15H04851, KAKENHI-PROJECT-25461346, KAKENHI-PROJECT-25461352, KAKENHI-PROJECT-26670599, KAKENHI-PROJECT-26282022
[Journal Article] Regulation of pancreatic β cell mass by　cross-interaction between CCAAT enhancer binding protein β induced by endoplasmic reticulum stress and AMP-activated protein kinase activity.2015
- Author(s)
  Matsuda T, Takahashi H, Mieda Y, Shimizu S, Kawamoto T, Matsuura Y, Takai T, Suzuki E, Koyanagi-Kimura M, Asahara S, Bartolome A, Yokoi N, Inoue H, Ogawa W, Seino S, Kido Y
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 6 Pages: e0130757-e0130757
- DOI
  10.1371/journal.pone.0130757
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461382, KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-25461352
[Journal Article] Compensatory hyperinsulinemia in high-fat diet-induced obese mice is associated with enhanced insulin translation in islets2015
- Author(s)
  Kanno A, Asahara SI, Masuda K, Matsuda T, Kimura-Koyanagi M, Seino S, Ogawa W, Kido Y
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 458 Issue: 3 Pages: 681-686
- DOI
  10.1016/j.bbrc.2015.02.024
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-26461382, KAKENHI-PROJECT-25461352
[Journal Article] Contribution of insulin signaling to the regulation of pancreatic beta-cell mass during the catch-up growth period in a low birth weight mouse model2014
- Author(s)
  Yoshida Y, Fuchita M, Kimura-Koyanagi M, Kanno A, Matsuda T, Asahara S, Hashimoto N, Isagawa T, Ogawa W, Aburatani H, Noda T, Seino S, Kasuga M, Kido Y
- Journal Title
  
  Diabetology International
  
  Volume: 5 Pages: 43-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700826
[Journal Article] Pancreaticβcell failure mediated by mTORC1 hyperactivity and autophagic impairment2014
- Author(s)
  Bartolomé A, Kimura-Koyanagi M, Asahara S, Guillén C, Inoue H, Teruyama K, Shimizu S, Kanno A, García-Aguilar A, Koike M, Uchiyama Y, Benito M, Noda T, Kido Y
- Journal Title
  
  Diabetes
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700826
[Journal Article] Pancreatic β cell failure mediated by mTORC1 hyperactivity and autophagic impairment.2014
- Author(s)
  Bartolome A, Kimura-Koyanagi M, Asahara SI, Guillen C, Inoue H, Teruyama K, Shimizu S, Kanno A, Garcia-Aguilar A, Koike M, Uchiyama Y, Benito M, Noda T, Kido Y
- Journal Title
  
  Diabetes
  
  Volume: 未定 Issue: 9 Pages: 2996-3008
- DOI
  10.2337/db13-0970
- NAID
  40020504710
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24700826, KAKENHI-PROJECT-25460276, KAKENHI-PUBLICLY-26111519, KAKENHI-PROJECT-26461382
[Journal Article] Histidine augments the suppression of hepatic glucose production by central insulin action.2013
- Author(s)
  Kimura K, Nakamura Y, Inaba Y, Matsumoto M, Kido Y, Asahara S, Matsuda T, Watanabe H, Maeda A, Inagaki F, Mukai C, Takeda K, Akira S, Ota T, Nakabayashi H, Kaneko S, Kasuga M, Inoue H.
- Journal Title
  
  Diabetes
  
  Volume: 62 Issue: 7 Pages: 2266-77
- DOI
  10.2337/db12-1701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300274, KAKENHI-PUBLICLY-24116526, KAKENHI-PROJECT-24390003, KAKENHI-PROJECT-24591348, KAKENHI-PROJECT-24650487, KAKENHI-PROJECT-24700826, KAKENHI-PROJECT-24790009, KAKENHI-PUBLICLY-25105717, KAKENHI-PUBLICLY-25126709, KAKENHI-PUBLICLY-25126729, KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25861179
[Journal Article] Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin2013
- Author(s)
  Asahara S, Shibutani Y, Teruyama K, Inoue H, Kawada Y, Etoh H, Matsuda T, Kimura-Koyanagi M, Hashimoto N, Sakahara M, Fujimoto W, Takahashi H, Ueda S, Hosooka T, Satoh T, Inoue H, Matsumoto M, Aiba A, Kasuga M, Kido Y
- Journal Title
  
  Diabetologia
  
  Volume: 56 Pages: 1088-1097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700826
[Presentation] 2型糖尿病感受性遺伝子KCNQ1遺伝子領域による膵β細胞量調節機構の解明2020
- Author(s)
  原千佐子、淺原俊一郎、木戸良明
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18KK0438
[Presentation] 2型糖尿病感受性遺伝子Kcnq1遺伝子領域による膵β細胞量調節機構の解明2020
- Author(s)
  原千佐子、淺原俊一郎、木戸良明
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K08860
[Presentation] 2 型糖尿病モデルマウスを用いた早期診断のための新規バイオマーカーの探索2019
- Author(s)
  土屋　匠子、淺原　俊一郎、河村　真緒、林田　彩花、木戸　良明
- Organizer
  第56回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-18KK0438
[Presentation] 膵β細胞特異的TSC2ノックアウトマウスにおける膵β細胞不全発症機序の解明2019
- Author(s)
  伊東　春香、淺原　俊一郎、原　千佐子、木村　真希、神野　歩、高井　智子、木戸　良明
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18KK0438
[Presentation] SGLT2阻害薬早期導入における有用性ー臓器保護の観点を含めてー2019
- Author(s)
  淺原　俊一郎
- Organizer
  第56回日本臨床分子医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18KK0438
[Presentation] Early administration od dapagliflozin preserves pancreatic beta cell mass through an epigenetic modification in a mouse model of type2 diabetes2019
- Author(s)
  Asahara S
- Organizer
  International Congress of Diabetes and Metabolism
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0438
[Presentation] ヒトips細胞を用いた膵内分泌細胞への分化誘導2019
- Author(s)
  林田　彩花、淺原　俊一郎、土屋　匠子、武内　友香、遠山　春希、山田　瑞姫、木戸　良明
- Organizer
  第42日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18KK0438
[Presentation] Early administration od dapagliflozin preserves pancreatic beta cell mass through an epigenetic modification in a mouse model of type2 diabetes2019
- Author(s)
  Asahara S, Kannno A, Kido Y.
- Organizer
  79th American Diabetes Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0438
[Presentation] 2 型糖尿病モデルマウスを用いた早期診断のための新規バイオマーカーの探索2019
- Author(s)
  土屋　匠子、淺原　俊一郎、林田　彩花、武内　友香、河村　真緒、木戸　良明
- Organizer
  第42日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18KK0438
[Presentation] 膵β細胞の小胞体ストレス誘導性アポトーシスにおけるCK2βの役割2019
- Author(s)
  高井　智子、松田　友和、井上　佳歩、淺原　俊一郎、神野　歩、木村　真希、小川　渉、木戸　良明
- Organizer
  第56回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-18KK0438
[Presentation] 膵β細胞特異的TSC2ノックアウトマウスにおける膵β細胞不全発症機序の解明2019
- Author(s)
  伊東　春香、淺原　俊一郎、原　千佐子、伊藤　菜々子、鵜塚　仁菜、木村　真希、神野　歩、高井　智子、木戸　良明
- Organizer
  第42日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18KK0438
[Presentation] Identification of the regulatory mechanism of mTORC1 signaling activity in pancreatic β-cells in GCN2 knockout mice2019
- Author(s)
  KudoM, Kanno A, Asahara S, Kido Y
- Organizer
  79th American Diabetes Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0438
[Presentation] 2型糖尿病の病態把握におけるMPVの有用性に関する検討2019
- Author(s)
  井上　裕行、斉藤　真裕美、胡内　久美子、淺原　俊一郎、木戸　良明、中村　文彦
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18KK0438
[Presentation] GCN2欠損マウスの膵β細胞におけるmTORC1活性調節機構の解明2019
- Author(s)
  工藤　倫代、神野　歩、淺原　俊一郎、木戸　良明
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18KK0438
[Presentation] 脂肪酸が膵β細胞の小胞体に及ぼす影響2017
- Author(s)
  鈴木江美、松田友和、川本剛士、松浦有希、高井智子、神野歩、木村真希、淺原俊一郎、小川渉、木戸良明
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09882
[Presentation] 膵β細胞の小胞体ストレス誘導性アポトーシスにおけるCK2βの役割2017
- Author(s)
  井上佳歩、高井智子、松田友和、鈴木江美、神野歩、木村真希、淺原俊一郎、木戸良明
- Organizer
  第40回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K09882
[Presentation] ヒトiPS細胞を用いた2型糖尿病発症機序の解明2017
- Author(s)
  下野名奈子、淺原俊一郎、原瑞季、田中孝一、松田友和、木村真希、神野歩、高井智子、鈴木江美、青井貴之、木戸良明
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09882
[Presentation] 高脂肪食負荷GCN2欠損マウスの膵島におけるmTORC1シグナル調節機構の解明2017
- Author(s)
  古林鮎子、神野歩、増田勝久、吉富理紗、木村真希、松田友和、淺原俊一郎、木戸良明
- Organizer
  第40回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K09882
[Presentation] 膵β細胞の小胞体ストレス誘導性アポトーシスにおけるCK2βの役割2017
- Author(s)
  高井智子、松田友和、井上佳歩、松浦有希、鈴木江美、神野歩、木村真希、淺原俊一郎、小川渉、木戸良明
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09882
[Presentation] ヒトiPS細胞を用いた膵内分泌細胞への分化誘導法の確立2017
- Author(s)
  山田瑞姫、淺原俊一郎、下野名奈子、田中孝一、松田友和、木村真希、神野歩、高井智子、鈴木江美、青井貴之、木戸良明
- Organizer
  第40回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K09882
[Presentation] Effect of removal of glucotoxicity by SGLT2 inhibitor dapagliflozin on the gene expression in pancreatic beta cells2017
- Author(s)
  Asahara S, Ohashi Y,　Kido Y
- Organizer
  IDF2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09882
[Presentation] Analysis of Pathogenic Mechanism by Susceptibility Genes of T2DM Using Human iPS Cells2017
- Author(s)
  Shimono N, Asahara S, Kido Y
- Organizer
  77th Scientific Sessions of American Diabetes Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09882
[Presentation] Regulation of pancreatic beta cell mass through type 2 diabetes susceptibility genes2017
- Author(s)
  Shun-ichiro Asahara
- Organizer
  Asia Islet Biology & Incretin Symposium2017
- Place of Presentation
  カトリック大学校
- Year and Date
  2017-03-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461382
[Presentation] Regulation of pancreatic beta cell mass through type 2 diabetes susceptibility genes2016
- Author(s)
  淺原俊一郎
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  京都
- Year and Date
  2016-05-19
- Invited
- Data Source
  KAKENHI-PROJECT-26461382
[Presentation] Regulation of pancreatic beta cell mass through type 2 diabetes susceptibility genes2016
- Author(s)
  淺原俊一郎
- Organizer
  第59回日本糖尿病学会シンポジウム
- Place of Presentation
  京都国際会館
- Year and Date
  2016-05-19
- Invited
- Data Source
  KAKENHI-PROJECT-26461382
[Presentation] Pancreatic β-cell failure in Asian patients with type2 diabetes2016
- Author(s)
  Shun-ichiro Asahara
- Organizer
  3rd Annual meeting of DDES
- Place of Presentation
  EXCO convention center
- Year and Date
  2016-11-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461382
[Presentation] 2型糖尿病疾患感受性遺伝子による膵β細胞量調節機構2015
- Author(s)
  木戸良明、淺原俊一郎
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  山口
- Year and Date
  2015-05-21
- Invited
- Data Source
  KAKENHI-PROJECT-26461382
[Presentation] 膵β細胞における細胞周期調節因子p57の機能解析2015
- Author(s)
  原　瑞季、淺原俊一郎
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  山口
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26461382
[Presentation] Reduction in Pancreatic β-Cell Mass Caused by Enhanced Expression of Cdkn1c via Interaction between C/EBPβ and Epigenetic Control.2015
- Author(s)
  Asahara S
- Organizer
  75th Scientific Session of American Diabetes Association
- Place of Presentation
  ボストン
- Year and Date
  2015-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461382
[Presentation] 膵β細胞におけるヒストン脱アセチル化酵素HDACの機能解析2015
- Author(s)
  淺原　俊一郎
- Organizer
  第88回日本内分泌学会学術総会
- Place of Presentation
  東京
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26461382
[Presentation] 2型糖尿病感受性遺伝子GCN2は膵β細胞量の調節に関与する2013
- Author(s)
  神野歩、吉冨理紗、増田勝久、淺原俊一郎、松田友和、木村真希、渋谷由紀、春日雅人、清野進、木戸良明
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Year and Date
  2013-05-16
- Data Source
  KAKENHI-PROJECT-24700826
[Presentation] Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β -cell mass via epigenetic modification of Cdkn1c2013
- Author(s)
  Asahara S
- Organizer
  Beta Cell Workshop 2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24700826
[Presentation] 2型糖尿病感受性遺伝子GCN2は膵β細胞量の調節に関与する2013
- Author(s)
  神野歩、吉冨理紗、増田勝久、淺原俊一郎、松田友和、木村真希、渋谷由紀、春日雅人、清野進、木戸良明
- Organizer
  第28回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  宮崎
- Year and Date
  2013-02-14
- Data Source
  KAKENHI-PROJECT-24700826
[Presentation] 2型糖尿病発症におけるeIF2αキナーゼGCN2の機能解析2012
- Author(s)
  神野歩、吉冨理紗、淺原俊一郎、松田友和、木村真希、渋谷由紀、春日雅人、清野進、木戸良明
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-24700826
[Presentation] 2型糖尿病発症におけるelF2αキナーゼGCN2の機能解析2012
- Author(s)
  吉冨理紗、神野歩、淺原俊一郎、松田友和、木村真希、渋谷由紀、春日雅人、清野進、木戸良明
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-12
- Data Source
  KAKENHI-PROJECT-24700826
[Presentation] 膵β細胞におけるインスリンシグナルのエピジェネティクス制御の解析
- Author(s)
  川田有希奈、淺原俊一郎、佐藤綾香、橋本尚子、清野進、木戸良明
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本ホテルキャッスル
- Data Source
  KAKENHI-PROJECT-24700826
[Presentation] 膵β細胞のKcnq1遺伝子領域におけるエピジェネティクス制御機構の解析
- Author(s)
  淺原俊一郎
- Organizer
  第51回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2014-04-11 – 2014-04-12
- Data Source
  KAKENHI-PROJECT-26461382
[Presentation] Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass via epigenetic modification of Cdkn1c
- Author(s)
  Asahara SI, Etoh H, Inoue H, Teruyama K, Shibutani Y, Ihara Y, Bartolome A, Hashimoto N, Matsuda T, Kimura-Koyanagi M, Kanno A, Nagashima K, Nishimura W, Yasuda K, Inagaki N, Seino S, Kasuga M, Kido Y
- Organizer
  5th AASD
- Place of Presentation
  グランドヒルトンソウル
- Data Source
  KAKENHI-PROJECT-24700826
[Presentation] 膵β細胞のKcnq1遺伝子領域におけるエピジェネティクス制御機構の解析
- Author(s)
  淺原俊一郎
- Organizer
  第87回日本内分泌学会総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-26461382
[Presentation] Reduction in pancreatic β-cell mass caused by enhanced expression of Cdkn1c via interaction between C/EBPβ and epigenetic control
- Author(s)
  淺原俊一郎
- Organizer
  第75回アメリカ糖尿病学会
- Place of Presentation
  ボストンコンベンションセンター
- Year and Date
  2015-06-05 – 2015-06-09
- Data Source
  KAKENHI-PROJECT-26461382

1. Kusuhara Sentaro (40437463)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. Kido Yoshiaki (10335440)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 橘吉寿 (50373197)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NISHIMURA Wataru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. TAKAHASHI Harumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. TSUCHIYA Kohsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 渡辺守

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 永石宇治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 鬼澤道夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 齊藤詠子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 木村真希

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 井上啓

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
13. 清野進

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Asahara Shun-ichiro 淺原 俊一郎

ASAHARA Shun-ichiro 淺原 俊一郎

Research Projects

Research Products

Co-Researchers

膵島の可塑性におけるセロトニンの機能解析Principal Investigator

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膵β細胞由来エクソソームによる臓器連関機序の解明

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The Effect of Insulin Signaling on Plasticity in Pancreatic Beta Cells

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Roles of aquaporin9 in diabetic retinal neurodegeneration

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Regulatory mechanism of mTORC1 activity in pancreatic beta cells in the development of type 2 diabetesPrincipal Investigator

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Functional analysis of type 2 diabetes susceptibility genes in human pancreatic beta cellsPrincipal Investigator

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Roles of neurovascular unit in diabetic retinal neurodegeneration

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Analysis of pathogenic mechanism by susceptibility genes of T2DM using human iPS cells.Principal Investigator

Principal Investigator

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Effect of type 2 diabetes susceptibility gene Kcnq1 gene region on pancreatic beta cellsPrincipal Investigator

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Analysis of interaction between amino acids and pancreatic beta cell mass via epigenetic modulation.Principal Investigator

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[Book] 糖尿病学20162016

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[Journal Article] l-Asparaginase regulates mTORC1 activity via a TSC2-dependent pathway in pancreatic beta cells2023

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[Journal Article] Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea in diabetes2023

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Asahara Shun-ichiro 淺原俊一郎

ASAHARA Shun-ichiro 淺原俊一郎