Ohashi Akiko 大橋晶子

… Alternative Names

OHASHI Akiko 大橋晶子

大橋晶子オオハシアキコ

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Researcher Number	00571019
Other IDs
Affiliation (Current)	2025: 日本大学, 歯学部, 講師
Affiliation (based on the past Project Information) *help	2019 – 2021: 日本大学, 歯学部, 助教 2016 – 2017: 日本大学, 歯学部, 助教 2010: 日本大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 57020:Oral pathobiological science-related / Functional basic dentistry Except Principal Investigator Kidney internal medicine
Keywords	Principal Investigator テトラヒドロビオプテリン / 活性酸素 / 一酸化窒素 / 輸送体 / 浸透圧 / TRPチャネル / 一酸化窒素合成酵素 / 酸化ストレス / 血管障害 / モノアミン … More / 脳・神経 / 生理活性 / 脳神経疾患 / 薬理学 / 抗うつ薬 / モノアミン合成 / テトラヒドロビオプテリン補充 / モノアミン合成促進 / ドーパミン / セロトニン … More Except Principal Investigator 腎臓 / 細胞膜輸送 / 尿酸降下薬 / 腎臟 / トランスポーター / テトラヒドロビオプテリン Less

Development of new therapeutic agents for diabetic complications including periodontal diseasePrincipal Investigator
- Principal Investigator
  
  OHASHI Akiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Nihon University
Mechanism of increase in brain-aromatic monoamines after peripheral administration of sepiapterinPrincipal Investigator
- Principal Investigator
  
  OHASHI Akiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Nihon University
ベンズブロマロン感受性を指標とした腎尿細管テトラヒドロビオプテリン輸送体の探索
- Principal Investigator
  
  安西尚彦
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyorin University

All 2022 2021 2020 2019 2017 2016 2011 2010

All Journal Article Presentation

[Journal Article] p53 deficiency promotes bone regeneration by functional regulation of mesenchymal stromal cells and osteoblasts.2022
- Author(s)
  Nagashima T, Ninomiya T, Nakamura Y, Nishimura S, Ohashi A, Aoki J, Mizogguchi T, Tonogi M, Takahashi T
- Journal Title
  
  J Bone Miner Metab
  
  Volume: - Issue: 3 Pages: 434-447
- DOI
  10.1007/s00774-022-01314-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10079, KAKENHI-PROJECT-19K22727, KAKENHI-PROJECT-20K18682, KAKENHI-PROJECT-20H03853, KAKENHI-PROJECT-19H03833, KAKENHI-PROJECT-21K09941, KAKENHI-PROJECT-21K19615, KAKENHI-PROJECT-20K09999
[Journal Article] セピアプテリンの末梢投与による脳内セロトニン代謝回転の亢進2022
- Author(s)
  大橋晶子，永島利通，酒井嶺，外木守雄，佐藤秀一，髙橋富久
- Journal Title
  
  日大歯学
  
  Volume: 96 Pages: 11-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10079
[Journal Article] テトラヒドロビオプテリンの薬理作用と臨床応用について2020
- Author(s)
  大橋晶子，髙橋富久
- Journal Title
  
  日大歯学
  
  Volume: 94 Pages: 55-63
- NAID
  40022498703
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10079
[Journal Article] Forced expression of mouse progerin attenuates the osteoblast differentiation interrupting beta-catenin signal pathway in vitro.2019
- Author(s)
  Tsukune Naoya, Naito Masako, Ohashi Akiko, Ninomiya Tadashi, Sato Shuichi, Takahashi Tomihisa
- Journal Title
  
  Cell Tissue Res
  
  Volume: 375 Issue: 3 Pages: 655-664
- DOI
  10.1007/s00441-018-2930-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09625, KAKENHI-PROJECT-19K10079
[Journal Article] CRISPR/Cas9-mediated in vivo gene editing reveals that neuronal 5-HT1A receptors in the dorsal raphe nucleus contribute to body temperature regulation in mice2019
- Author(s)
  Nishitani Naoya、Ohmura Yu、Nagayasu Kazuki、Shibui Norihiro、Kaneko Shuji、Ohashi Akiko、Yoshida Takayuki、Yamanaka Akihiro、Yoshioka Mitsuhiro
- Journal Title
  
  Brain Research
  
  Volume: 1719 Pages: 243-252
- DOI
  10.1016/j.brainres.2019.06.009
- NAID
  120006885155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07545, KAKENHI-PROJECT-19K10079, KAKENHI-PROJECT-19K17078, KAKENHI-PROJECT-18KK0223, KAKENHI-PUBLICLY-19H04976, KAKENHI-PROJECT-16K10182, KAKENHI-PROJECT-18K14919, KAKENHI-PUBLICLY-18H05124, KAKENHI-PUBLICLY-19H05016, KAKENHI-PROJECT-18H02523
[Journal Article] Organic anion transporters, OAT1 and OAT3, are crucial biopterin transporters involved in bodily distribution of tetrahydrobiopterin and exclusion of its excess2017
- Author(s)
  Ohashi Akiko、Mamada Kaori、Harada Tomonori、Naito Masako、Takahashi Tomihisa、Aizawa Shin、Hasegawa Hiroyuki
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 435 Issue: 1-2 Pages: 97-108
- DOI
  10.1007/s11010-017-3060-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08161, KAKENHI-PROJECT-16K20429
[Journal Article] Tetrahydrobiopterin activates brown adipose tissue and regulates systemic energy metabolism2017
- Author(s)
  Oguri Yasuo、Fujita Yoshihito、Abudukadier Abulizi、Ohashi Akiko、Goto Tsuyoshi、Furuya Futoshi、Obara Akio、Fukushima Toru、Matsuo Naomi、Kim Minji、Hosokawa Masaya、Kawada Teruo、Hasegawa Hiroyuki、Inagaki Nobuya
- Journal Title
  
  JCI Insight
  
  Volume: 2 Issue: 9 Pages: 91981-91981
- DOI
  10.1172/jci.insight.91981
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09826, KAKENHI-PROJECT-16J09973, KAKENHI-PROJECT-16K20429
[Journal Article] Tetrahydrobiopterin Supplementation: Elevation of Tissue Biopterin Levels Accompanied by a Relative Increase in Dihydrobiopterin in the Blood and the Role of Probenecid-Sensitive Uptake in Scavenging Dihydrobiopterin in the Liver and Kidney of Rats.2016
- Author(s)
  Ohashi A, Saeki Y, Harada T, Naito M, Takahashi T, Aizawa S, Hasegawa H.
- Journal Title
  
  PLoS One.
  
  Volume: 11 Issue: 10 Pages: e0164305-e0164305
- DOI
  10.1371/journal.pone.0164305
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11462, KAKENHI-PROJECT-16K20429
[Journal Article] Membrane transport of sepiapterin and dihydrobiopterin by equilibrative nucleoside transporters : a plausible gateway for the salvage pathway of tetrahydrobiopterin biosynthesis.2011
- Author(s)
  Ohashi A
- Journal Title
  
  Mol Genet Metab
  
  Volume: 102 Pages: 18-28
- NAID
  110009489788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659216
[Presentation] BH4の褐色脂肪組織への分化制御機構の解析，および胎生期における役割の検討.2021
- Author(s)
  南野寛人，藤田義人，小栗靖生，大橋晶子，後藤剛，川原崎聡子，古谷太志，磯村望，武居晃平，李瀛，河田照雄，長谷川宏幸，稲垣暢也
- Organizer
  第34回日本プテリジン研究会
- Data Source
  KAKENHI-PROJECT-19K10079
[Presentation] Dynamic change of tetrahydrobiopterin and dihydrobiopterin in plasma and erythrocytes2020
- Author(s)
  大橋晶子，髙橋富久
- Organizer
  第62回歯科基礎医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K10079
[Presentation] Maternal Supplementation of Tetrahydrobiopterin Regulates Differentiation of Fetal Brown Adipose Tissue and Contributes to Offspring Metabolic Health2020
- Author(s)
  HIROTO MINAMINO, YOSHIHITO FUJITA, YASUO OGURI, TSUYOSHI GOTO, AKIKO OHASHI, FUTOSHI FURUYA, NOZOMI ISOMURA, TAKESUE KOHEI, YING LI, SATOKO KAWARASAKI, TERUO KAWADA, HIROYUKI HASEGAWA and NOBUYA INAGAKI
- Organizer
  American Diabetes Association's 80th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10079
[Presentation] Lamin Aの遺伝子変異体のprogerinの発現が骨芽細胞分化に与える影響2019
- Author(s)
  髙橋富久，大橋晶子，二宮禎
- Organizer
  第61回歯科基礎医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K10079
[Presentation] Tetrahydrobiopterin Is Required for Brown Adipose Tissue Development and Differentiation2019
- Author(s)
  Minamino H, Fujita Y, Oguri Y, Goto T, Ohashi A, Furuya F, Isomura N, Kawarasaki S, Kawada T, Hasegawa H, Inagaki N
- Organizer
  The 11th Scientific Meeting of the Asian Association for the Study of Diabetes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10079
[Presentation] Tetrahydrobiopterin Regulates Developmental Differentiation of Brown Adipose Tissue2019
- Author(s)
  Minamino H, Fujita Y, Oguri Y, Goto T, Ohashi A, Furuya F, Isomura N, Kawarasaki S, Kawada T, Hasegawa H, Inagaki N
- Organizer
  79th American Diabetes Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10079
[Presentation] モノアミン産生細胞におけるテトラヒドロビオプテリンの2つの効果2019
- Author(s)
  大橋晶子，原田智則，二宮禎，藤原恭子，髙橋富久，長谷川宏之
- Organizer
  日本ビタミン学会第71回大会
- Data Source
  KAKENHI-PROJECT-19K10079
[Presentation] マウス歯根膜細胞のLRP1発現による抜歯窩修復への寄与2019
- Author(s)
  二宮禎，中村純基，永島利通，大橋晶子，高橋富久
- Organizer
  第61回歯科基礎医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K10079
[Presentation] セピアプテリンの末梢投与による脳内トリプトファンレベルの変動2017
- Author(s)
  大橋晶子，原田智紀，内藤昌子，髙橋富久，相澤信，長谷川宏幸
- Organizer
  日本ビタミン学会第69回大会
- Data Source
  KAKENHI-PROJECT-16K20429
[Presentation] テトラヒドロビオプテリンの尿中排出への有機陰イオン輸送体の関与2017
- Author(s)
  大橋晶子，内藤昌子，髙橋富久
- Organizer
  第59回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-16K20429
[Presentation] 有機陰イオン輸送体はBH4の尿中排出に関わる2017
- Author(s)
  大橋晶子，内藤昌子，髙橋富久，原田智紀，長谷川宏幸
- Organizer
  第31回日本プテリジン研究会
- Data Source
  KAKENHI-PROJECT-16K20429
[Presentation] 細胞外のテトラヒドロビオプテリンがセロトニン生合成活性に与える影響2016
- Author(s)
  大橋晶子, 原田智紀, 内藤昌子, 髙橋富久, 相澤信, 長谷川宏幸
- Organizer
  第20回活性アミンに関するワークショップ
- Place of Presentation
  ホテルマークワンつくば研究学園(茨城県つくば市)
- Data Source
  KAKENHI-PROJECT-16K20429
[Presentation] 肥満細胞におけるテトラヒドロビオプテリンによるセロトニン生合成の促進2016
- Author(s)
  大橋晶子, 笠原正彰, 内藤昌子, 髙橋富久
- Organizer
  第58回歯科基礎医学会学術大会
- Place of Presentation
  札幌コンベンションセンター(北海道札幌市)
- Year and Date
  2016-08-24
- Data Source
  KAKENHI-PROJECT-16K20429
[Presentation] セピアプテリンの末梢投与による脳内カテコールアミン生合成の促進2016
- Author(s)
  大橋晶子, 内藤昌子, 髙橋富久, 原田智紀, 長谷川宏幸
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山国際会議場(富山県富山市)
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K20429
[Presentation] テトラヒドロビオプテリン輸送体の探索:アフリカツメガエル卵母細胞発現系を用いた既知輸送体のビオプテリン輸送能の検討2010
- Author(s)
  大橋晶子
- Organizer
  日本ビタミン学会第62回大会
- Place of Presentation
  盛岡
- Year and Date
  2010-06-12
- Data Source
  KAKENHI-PROJECT-21659216

1. 安西尚彦 (70276054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. JUTABHA Promsuk (90541748)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. NAITO Masako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. OHMURA Yu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 相沢信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 二宮禎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 藤田義人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohashi Akiko 大橋 晶子

OHASHI Akiko 大橋 晶子

大橋 晶子 オオハシ アキコ

Research Projects

Research Products

Co-Researchers

Development of new therapeutic agents for diabetic complications including periodontal diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of increase in brain-aromatic monoamines after peripheral administration of sepiapterinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ベンズブロマロン感受性を指標とした腎尿細管テトラヒドロビオプテリン輸送体の探索

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] p53 deficiency promotes bone regeneration by functional regulation of mesenchymal stromal cells and osteoblasts.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] セピアプテリンの末梢投与による脳内セロトニン代謝回転の亢進2022

Author(s)

Journal Title

Data Source

[Journal Article] テトラヒドロビオプテリンの薬理作用と臨床応用について2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Forced expression of mouse progerin attenuates the osteoblast differentiation interrupting beta-catenin signal pathway in vitro.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CRISPR/Cas9-mediated in vivo gene editing reveals that neuronal 5-HT1A receptors in the dorsal raphe nucleus contribute to body temperature regulation in mice2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Organic anion transporters, OAT1 and OAT3, are crucial biopterin transporters involved in bodily distribution of tetrahydrobiopterin and exclusion of its excess2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tetrahydrobiopterin activates brown adipose tissue and regulates systemic energy metabolism2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tetrahydrobiopterin Supplementation: Elevation of Tissue Biopterin Levels Accompanied by a Relative Increase in Dihydrobiopterin in the Blood and the Role of Probenecid-Sensitive Uptake in Scavenging Dihydrobiopterin in the Liver and Kidney of Rats.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Membrane transport of sepiapterin and dihydrobiopterin by equilibrative nucleoside transporters : a plausible gateway for the salvage pathway of tetrahydrobiopterin biosynthesis.2011

Author(s)

Journal Title

NAID

Data Source

[Presentation] BH4の褐色脂肪組織への分化制御機構の解析，および胎生期における役割の検討.2021

Author(s)

Organizer

Data Source

[Presentation] Dynamic change of tetrahydrobiopterin and dihydrobiopterin in plasma and erythrocytes2020

Author(s)

Organizer

Data Source

[Presentation] Maternal Supplementation of Tetrahydrobiopterin Regulates Differentiation of Fetal Brown Adipose Tissue and Contributes to Offspring Metabolic Health2020

Author(s)

Organizer

Ohashi Akiko 大橋晶子

OHASHI Akiko 大橋晶子

大橋晶子オオハシアキコ