Ishimoto Kenji 石本憲司

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ISHIMOTO Kenji 石本憲司

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Researcher Number	00572984
Other IDs
Affiliation (based on the past Project Information) *help	2023: 大阪大学, 大学院薬学研究科, 招へい教員 2021 – 2023: 大阪大学, 大学院薬学研究科, 特任講師(常勤) 2018 – 2021: 大阪大学, 薬学研究科, 特任講師(常勤) 2017: 大阪大学, 薬学研究科(研究院), 助教 2016: 大阪大学, 薬学研究科, 招へい教員 … More 2015: 東京大学, 先端科学技術研究センター, 研究員 2015: 大阪大学, 薬学研究科(研究院), 招へい教員 2014: 大阪大学, 薬学研究科(研究院), 特任講師(常勤) 2012: 大阪大学, 医学部附属病院, 助教 2012: 大阪大学, 医学部附属病院, 特任助教(常勤) 2011: 大阪大学, 医学(系)研究科(研究院), 特任研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Pathological medical chemistry / Biological pharmacy Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Eating habits
Keywords	Principal Investigator ポリフェノール / 免疫沈降法 / 細胞内局在 / 肥満 / 脂肪酸酸化 / トリグリセリド生合成 / Lipin1 / エピガロカテキンガレート (EGCg) / アレルギー / 安全性試験 … More / アレルギー性鼻炎 / 体内動態評価 / 腸内細菌代謝物 / 機能性食品素材 / エピガロカテキンガレート（EGCg） / ポリフェノール類 / 薬物動態 / 非晶質化 / 難水溶性ポリフェノール / 薬食同源 / 予防効果 / 体内動態 / 予防戦略 / 機能性食品開発 / 難水溶性 / ナリンゲニン / シリビニン / NAFLD/NASH / 非晶質固体分散体 / 脂質代謝制御因子 / 核移行シグナル（NLS） / 核移行シグナル (NLS) / トリグリセリド合成 / 脂質代謝 / 細胞内光クロスリンク法 / タンパク質分解制御 / ユビキチン―プロテアソーム / ユビキチン-プロテアソーム / プロテオミクス / 細部内局在 / 脂質代謝調節因子 … More Except Principal Investigator 核内受容体 / PPAR / 分子代謝学 / LPIN / 脂質代謝 / 早期診断技術 / 薬物送達技術 / タイトジャンクション / 血液脳関門 / 認知症 / 分子病態学 / リガンド / PGAM5 / 立体構造解析 / NASH / 活性化剤 / 転写制御 / SETDB1 / 蛋白質　分解 / PPARα活性化剤 / 翻訳後修飾 Less

Proposal of effective utilization of polyphenols as functional food ingredients for realization of a healthy longevity societyPrincipal Investigator
- Principal Investigator
  
  石本憲司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Osaka University
Building the foundation for preventive medical strategies against dementia to realize a sustainable super-aging society
- Principal Investigator
  
  TACHIBANA Keisuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Osaka University
Preparation and evaluation of amorphous of poorly water-soluble polyphenols for prevention of NAFLD / NASHPrincipal Investigator
- Principal Investigator
  
  Ishimoto Kenji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Osaka University
Development of NASH therapeutics by regulating energy expenditure and inflammation through the lipid sensor PPAR
- Principal Investigator
  
  Keisuke TACHIBANA
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Osaka University
Analysis of the transcriptional regulatory mechanism of nuclear receptors via posttranslational modification of the nuclear receptors and localization of the interacting factors
- Principal Investigator
  
  Keisuke Tachibana
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits
- Research Institution
  Osaka University
The search of novel factors that control the subcellular localization of Lipin1Principal Investigator
- Principal Investigator
  
  Ishimoto Kenji
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
  Osaka University
Strategy for the prevention of obesity by the regulation of Lipin1Principal Investigator
- Principal Investigator
  
  ISHIMOTO Kenji
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka University

[Book] 血管生物医学事典(日本血管生物医学会編)2011
- Author(s)
  石本憲司,土井健史
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-23790087
[Journal Article] Suppressive effect of black tea polyphenol theaflavins in a mouse model of ovalbumin-induced food allergy2023
- Author(s)
  Ishimoto K, Konishi Y, Otani S, Maeda S, Ago Y, Hino N, Suzuki M, Nakagawa S.
- Journal Title
  
  J Nat Med.
  
  Volume: in press Issue: 3 Pages: 604-609
- DOI
  10.1007/s11418-023-01686-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K11578, KAKENHI-PROJECT-21K06560, KAKENHI-PROJECT-20H03392
[Journal Article] Exploring Compounds to be used as Cosmetic Agents that Activate Peroxisome Proliferator‐Activated Receptor Alpha2022
- Author(s)
  Tachibana Keisuke、Fukuda Syohei、Fukushima Jun、Ishimoto Kenji、Sakata Masahiro、Nishimori Yasutomo、Doi Takefumi
- Journal Title
  
  International Journal of Cosmetic Science
  
  Volume: - Issue: 2 Pages: 189-200
- DOI
  10.1111/ics.12767
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03190, KAKENHI-PROJECT-21H03354
[Journal Article] Examination of dissolution ratio of β-carotene in water for practical application of β-carotene amorphous solid dispersion2022
- Author(s)
  Ishimoto K, Nakamura Y, Otani S, Miki S, Maeda S, Iwamoto T, Konishi Y, Ago Y, Nakagawa S.
- Journal Title
  
  J Food Sci Technol.
  
  Volume: 59 Issue: 1 Pages: 114-122
- DOI
  10.1007/s13197-021-04991-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K11578
[Journal Article] Physicochemical and Biochemical Evaluation of Amorphous Solid Dispersion of Naringenin Prepared Using Hot-Melt Extrusion2022
- Author(s)
  Ishimoto Kenji、Shimada Yukiko、Ohno Akane、Otani Shuichi、Ago Yukio、Maeda Soya、Lin Bangzhong、Nunomura Kazuto、Hino Nobumasa、Suzuki Masayuki、Nakagawa Shinsaku
- Journal Title
  
  Frontiers in Nutrition
  
  Volume: 9 Pages: 850103-850103
- DOI
  10.3389/fnut.2022.850103
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06560, KAKENHI-PROJECT-20H03392, KAKENHI-PROJECT-20K11578
[Journal Article] Tea crude extracts effectively inactivate severe acute respiratory syndrome coronavirus 22022
- Author(s)
  Ishimoto K, Hatanaka N, Otani S, Maeda S, Xu B, Yasugi M, Moore JE, Suzuki M, Nakagawa S, Yamasaki S.
- Journal Title
  
  Lett Appl Microbiol.
  
  Volume: 74 Issue: 1 Pages: 2-7
- DOI
  10.1111/lam.13591
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11578
[Journal Article] Generation of KS-133 as a novel bicyclic peptide with a potent and selective VIPR2 antagonist activity that counteracts cognitive decline in a mouse model of psychiatric disorders2021
- Author(s)
  Sakamoto K, Chen L, Miyaoka T, Yamada M, Masutani T, Ishimoto K, Hino N, Nakagawa S, Asano S, Ago Y
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 12 Pages: 751587-751587
- DOI
  10.3389/fphar.2021.751587
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03392, KAKENHI-PROJECT-20K09905, KAKENHI-PROJECT-20K11578, KAKENHI-PROJECT-21K06560, KAKENHI-PROJECT-21K19714
[Journal Article] Structural Basis for PPARα Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives.2020
- Author(s)
  Yoshida T, Oki H, Doi M, Fukuda S, Yuzuriha T, Tabata R, Ishimoto K, Kawahara K, Ohkubo T, Miyachi H, Doi T, Tachibana K.
- Journal Title
  
  Scientific Reports
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03190
[Journal Article] Development of a Ligand Screening Tool Using Full-Length Human Peroxisome Proliferator-Activated Receptor-Expressing Cell Lines to Ameliorate Metabolic Syndrome2019
- Author(s)
  Tachibana Keisuke、Ishimoto Kenji、Takahashi Rika、Kadono Hirokazu、Awaji Takuya、Yuzuriha Tomohiro、Tanaka Toshiya、Hamakubo Takao、Sakai Juro、Kodama Tatsuhiko、Aoki Shunji、Doi Takefumi
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 67 Issue: 3 Pages: 199-202
- DOI
  10.1248/cpb.c18-00627
- NAID
  130007605823
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2019-03-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03190, KAKENHI-PROJECT-16K13044
[Journal Article] Lipin-1 is a novel substrate of protein phosphatase PGAM52019
- Author(s)
  Okuno Hiroko、Okuzono Haruna、Hayase Ayaka、Kumagai Fumiko、Tanii Shohei、Hino Nobumasa、Okada Yoshiaki、Tachibana Keisuke、Doi Takefumi、Ishimoto Kenji
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 509 Issue: 4 Pages: 886-891
- DOI
  10.1016/j.bbrc.2019.01.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19403, KAKENHI-PROJECT-18H03190, KAKENHI-PROJECT-17K19487
[Journal Article] Structural development of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives as human peroxisome proliferator-activated receptor alpha (PPARα)-selective agonists2019
- Author(s)
  Miyachi Hiroyuki、Yuzuriha Tomohiro、Tabata Ryotaro、Fukuda Syohei、Nunomura Kazuto、Lin Bangzhong、Kobayashi Tadayuki、Ishimoto Kenji、Doi Takefumi、Tachibana Keisuke
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 29 Issue: 16 Pages: 2124-2128
- DOI
  10.1016/j.bmcl.2019.06.062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03190
[Journal Article] Discovery of peroxisome proliferator?activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line2018
- Author(s)
  Tachibana Keisuke、Yuzuriha Tomohiro、Tabata Ryotaro、Fukuda Syohei、Maegawa Takashi、Takahashi Rika、Tanimoto Keiichi、Tsujino Hirofumi、Nunomura Kazuto、Lin Bangzhong、Matsuura Yoshiharu、Tanaka Toshiya、Hamakubo Takao、Sakai Juro、Kodama Tatsuhiko、Kobayashi Tadayuki、Ishimoto Kenji、Miyachi Hiroyuki、Doi Takefumi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 26 Pages: 10333-10343
- DOI
  10.1074/jbc.ra118.002077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03190, KAKENHI-PROJECT-16K13044, KAKENHI-PROJECT-16H06390
[Journal Article] Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase2017
- Author(s)
  Ishimoto Kenji、Hayase Ayaka、Kumagai Fumiko、Kawai Megumi、Okuno Hiroko、Hino Nobumasa、Okada Yoshiaki、Kawamura Takeshi、Tanaka Toshiya、Hamakubo Takao、Sakai Juro、Kodama Tatsuhiko、Tachibana Keisuke、Doi Takefumi
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 488 Issue: 1 Pages: 159-164
- DOI
  10.1016/j.bbrc.2017.04.159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19487, KAKENHI-PROJECT-16H06390, KAKENHI-PUBLICLY-16H01382, KAKENHI-PROJECT-15H02896, KAKENHI-PROJECT-16F16725, KAKENHI-PROJECT-16K13042, KAKENHI-PROJECT-16K21142
[Journal Article] Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity.2016
- Author(s)
  Ishimoto K, Kawamata N, Uchihara Y, Okubo M, Fujimoto R, Gotoh E, Kakinouchi K, Mizohata E, Hino N, Okada Y, Mochizuki Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Inoue T, Tachibana K, Doi T
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 10 Pages: e0165766-e0165766
- DOI
  10.1371/journal.pone.0165766
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H02896, KAKENHI-PROJECT-15H04644, KAKENHI-PROJECT-25282230, KAKENHI-PROJECT-26293014, KAKENHI-PROJECT-16K21142, KAKENHI-PROJECT-16H06390
[Journal Article] Expression of the Robo4 receptor in endothelial cells is regulated by two AP-1 protein complexes.2015
- Author(s)
  Okada Y, Naruse H, Tanaka T, Funahashi N, Regan ER, Yamakawa K, Hino N, Ishimoto K, Doi T, Aird WC.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 467(4) Issue: 4 Pages: 987-991
- DOI
  10.1016/j.bbrc.2015.10.029
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16537, KAKENHI-PROJECT-26870346, KAKENHI-PROJECT-26293014
[Journal Article] Analysis of the subcellular localization of the human histone methyltransferase SETDB12015
- Author(s)
  Tachibana K, Gotoh E, Kawamata N, Ishimoto K, Uchihara Y, Iwanari H, Sugiyama A, Kawamura T, Mochizuki Y, Tanaka T, Sakai J, Hamakubo T, Kodama T, Doi T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 465 Issue: 4 Pages: 725-731
- DOI
  10.1016/j.bbrc.2015.08.065
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22229009, KAKENHI-PROJECT-25220205, KAKENHI-PROJECT-15H02896, KAKENHI-PROJECT-15H04644, KAKENHI-PROJECT-26560395, KAKENHI-PROJECT-25860253, KAKENHI-PROJECT-26870346, KAKENHI-PUBLICLY-26116708
[Journal Article] Loss of hepatic HIF-1α accelerates lipid accumulation by inhibiting peroxisomal fatty acid oxidation in nonalcoholic fatty liver disease.2015
- Author(s)
  Arai T, Kato Y, Ishimoto K, Kanai M, Shinjo S, Sayama K, Suzuki T, Doi T, Johnson RS, Suematsu M, Goda N.
- Journal Title
  
  J Hepatol.
  
  Volume: Feb
- DOI
  10.1016/j.jhep.2015.01.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870346
[Journal Article] Endothelial cell-specific expression of roundabout 4 is regulated by differential DNA methylation of the proximal promoter2014
- Author(s)
  Okada, Y., Funahashi, N., Tanaka, T., Nishiyama, Y., Yuan, L., Shirakura, K., Turjman, A. S., Kano, Y., Naruse, H., Suzuki, A., Sakai, M., Zhixia, J., Kitajima, K., Ishimoto, K., Hino, N., Kondoh, M., Mukai, Y., Nakagawa, S., Garcia-Cardena, G., Aird, W. C., Doi, T.
- Journal Title
  
  Arterioscler Thromb. Vasc. Biol.
  
  Volume: 34 Issue: 7 Pages: 1531-1538
- DOI
  10.1161/atvbaha.114.303818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670023, KAKENHI-PROJECT-25670056, KAKENHI-PROJECT-26293014, KAKENHI-PROJECT-26713007, KAKENHI-PROJECT-26870346
[Journal Article] Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis2012
- Author(s)
  Yamaguchi, S., Yamane, T., Takahashi-Niki, K., Kato, I., Niki, T., Goldberg, M. S., Shen, J., Ishimoto, K., Doi, T., Iguchi-Ariga, S. M. M., Ariga, H.
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Issue: 5 Pages: e38144-e38144
- DOI
  10.1371/journal.pone.0038144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390014, KAKENHI-PROJECT-22300119, KAKENHI-PROJECT-23790087, KAKENHI-PROJECT-23790970, KAKENHI-PROJECT-24390013, KAKENHI-PROJECT-24650191, KAKENHI-PUBLICLY-23117502
[Journal Article] Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms.2011
- Author(s)
  Yamasaki D, Kawabe N, Nakamura H, Tachibana K, Ishimoto K, Tanaka T, Aburatani H, Sakai J, Hamakubo T, Kodama T, Doi T.
- Journal Title
  
  Eur. J. Cell Biol.
  
  Volume: 90(8) Pages: 657-664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790087
[Journal Article] Lipin 1 in lipid metabolism.2011
- Author(s)
  Ishimoto K.
- Journal Title
  
  Yakugaku Zasshi
  
  Volume: 131(8) Pages: 1189-1194
- NAID
  130001075907
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790087
[Journal Article] Human mannose-binding lectin 2 is directly regulated by peroxisome proliferator-activated receptors (PPARs) via a peroxisome proliferator responsive element.
- Author(s)
  Tachibana K, Takeuchi K, Inada H, Sugimoto K, Ishimoto K, Yamashita M, Maegawa T, Yamasaki D, Osada S, Tanaka T, Rakugi H, Hamakubo T, Sakai J, Kodama T, Doi T.
- Journal Title
  
  J. Biochem.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790087
[Patent] ピラゾロピリジン誘導体およびその使用2016
- Inventor(s)
  土井健史, 橘敬祐, 小林直之, 杠智博, 石本憲司, 宮地弘幸
- Industrial Property Rights Holder
  国立大学法人大阪大学、国立大学法人岡山大学
- Industrial Property Rights Type
  特許
- Filing Date
  2016-11-11
- Overseas
- Data Source
  KAKENHI-PROJECT-15H02896
[Presentation] 経皮感作による食物アレルギーモデルマウスにおけるシリコン製剤の抗アレルギー作用の検討（その２）2024
- Author(s)
  田谷まる美、竹内ほのか、石本憲司、樋野展正、塚本智仁、小林悠輝、小林光、中川晋作
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K10889
[Presentation] 経皮感作による食物アレルギーモデルマウスにおけるシリコン製剤の抗アレルギー作用の検討2024
- Author(s)
  竹内ほのか、田谷まる美、石本憲司、樋野展正、塚本智仁、柿沼千早、小林悠輝、小林光、中川晋作
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K10889
[Presentation] 食物アレルギーモデルマウスにおけるシリコン製剤の抗アレルギー作用に関する検討2023
- Author(s)
  竹内ほのか、南佑斉、石本憲司、樋野展正、塚本智仁、小林悠輝、小林光、中川晋作
- Organizer
  第39回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23K10889
[Presentation] 血管作動性腸管ペプチド受容体2遺伝子のコピー数多型モデルマウスは超音波発声の変化と社会性行動の低下を示す2023
- Author(s)
  吾郷由希夫、片平海雅、陳露、宮岡辰典、北川航平、横山玲、竹内修斗, 山田めゐ、金子皓、石本憲司、塚本智仁、樋野展正、中澤敬信、橋本均、中川晋作
- Organizer
  第53回日本神経精神薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K10889
[Presentation] 神経ペプチド受容体VIPR2遺伝子のコピー数変異モデルマウスは超音波発声の変化と社会性行動の低下を示す2023
- Author(s)
  片平海雅、陳露、宮岡辰典、北川航平、竹内修斗、山田めゐ、金子皓、石本憲司、塚本智仁、樋野展正、中澤敬信、橋本均、中川晋作、吾郷由希夫
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K10889
[Presentation] SARS-CoV-2に不可逆的に結合し不活性化する次世代型ACE2-Fcの開発2023
- Author(s)
  樋野展正、高田理沙、徳納渚沙、小野慎子、大竹和正、尾上遥南、鈴木喬介、西浦崇史、塚本智仁、石本憲司、松浦善治、坂本健作、吉岡靖雄、中川晋作
- Organizer
  第39回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23K10889
[Presentation] 機能性食品開発を目指した非晶質化β-カロテンの機能性評価2022
- Author(s)
  河本茉侑, 石本憲司, 金子瑞季, 樋野展正, 中川晋作.
- Organizer
  第38回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20K11578
[Presentation] 機能性食品の創出を目指した非晶質ナリンゲニンの消化管吸収性と機能性評価2021
- Author(s)
  石本憲司，島田有希子，大野茜，大谷修一，前田壮矢，吾郷由希夫，中川晋作
- Organizer
  第37年会日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20K11578
[Presentation] 機能性食品を指向した非晶質シリビニンの溶解性と消化管吸収2020
- Author(s)
  岩本泰樹, 大谷修一, 石本憲司, 吾郷由希夫, 中川晋作
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-20K11578
[Presentation] 生活習慣病治療薬開発を目指した新規PPAR alpha作動薬としてのピラゾロピリジン誘導体の開発2019
- Author(s)
  橘敬祐, 福田昭平, 杠智博, 田畑遼太朗, 布村一人, 林邦忠, 小林直之, 石本憲司, 宮地弘幸, 土井健史
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H03190
[Presentation] Development Of Novel Non-fibrate Peroxisome Proliferator-activated Receptor Ligand For Treating Nonalcoholic Steatohepatitis2018
- Author(s)
  Keisuke TACHIBANA, Tomohiro YUZURIHA, Ryotaro TABATA, Syohei FUKUDA, Kazuto NUNOMURA, Bangzhong LIN, Tadayuki KOBAYASHI, Masuo KONDOH, Kenji ISHIMOTO, Hiroyuki MIYACHI, Takefumi DOI
- Organizer
  CRS Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03190
[Presentation] Development of novel non-fibrate PPARα activator for metabolic diseases2018
- Author(s)
  Keisuke TACHIBANA, Tomohiro YUZURIHA, Ryotaro TABATA, Syohei FUKUDA, Kazuto NUNOMURA, Tadayuki KOBAYASHI, Kenji ISHIMOTO, Hiroyuki MIYACHI, Takefumi DOI
- Organizer
  4th International Symposium of Medicinal Sciences
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02896
[Presentation] 脂質異常症治療薬の開発を目指した新規PPARα活性化化合物の薬効と毒性の評価2017
- Author(s)
  田畑遼太朗, 橘敬祐, 杠智博, 前川貴志, 福田昭平, 石本憲司, 小林直之, 田中十志也, 児玉龍彦, 宮地弘幸, 土井健史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-15H02896
[Presentation] 核内受容体PPARα発現細胞株を用いたリガンドスクリーニング系の構築と新規活性化剤の探索2017
- Author(s)
  橘敬祐, 田畑遼太朗, 杠智博, 福田昭平, 前川貴志, 石本憲司, 布村一人, 小林直之, 宮地弘幸, 土井健史
- Organizer
  第21回　日本心血管内分泌代謝学会学術総会
- Data Source
  KAKENHI-PROJECT-15H02896
[Presentation] 心血管イベントの残余リスクの軽減を目指した新規核内受容体PPARα作働薬の開発2016
- Author(s)
  橘敬祐, 杠智博, 田畑遼太朗, 前川貴志, 福田昭平, 石本憲司, 小林直之, 宮地弘幸, 土井健史
- Organizer
  第1回黒潮カンファレンス
- Place of Presentation
  千葉
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-15H02896
[Presentation] 核内受容体PPARαを標的とした新規脂質異常症治療薬の開発2016
- Author(s)
  田畑遼太朗, 橘敬祐, 杠智博, 前川貴志, 福田昭平, 石本憲司, 小林直之, 田中十志也, 児玉龍彦, 宮地弘幸, 土井健史
- Organizer
  第15回次世代を担う若手ファーマ・バイオフォーラム2016
- Place of Presentation
  大阪
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-15H02896
[Presentation] 脂質代謝制御因子Lipin1と分解メカニズムの解明2015
- Author(s)
  奥野紘子, 石本憲司, 熊谷文子, 早瀬絢香, 樋野展正, 橘敬祐, 川村猛, 田中十志也, 児玉龍彦, 土井健史
- Organizer
  第16回 Pharmaco-Hematologyシンポジウム
- Place of Presentation
  東京
- Year and Date
  2015-06-13
- Data Source
  KAKENHI-PROJECT-15H02896
[Presentation] 脂質代謝制御因子Lipin1と分解メカニズムの解明2015
- Author(s)
  奥野紘子，石本憲司，熊谷文子，早瀬絢香，樋野展正，橘敬祐，川村猛，田中十志也，児玉龍彦，土井健史
- Organizer
  第16回　Pharmaco-Hematologyシンポジウム
- Place of Presentation
  東京
- Year and Date
  2015-06-13
- Data Source
  KAKENHI-PROJECT-26870346
[Presentation] 脂質異常症治療薬を目指した核内受容体PPARαの新規活性化化合物の開発2015
- Author(s)
  杠智博, 橘敬祐, 前川貴志, 田畑遼太朗, 石本憲司, 小林直之, 田中十志也, 児玉龍彦, 宮地弘幸, 土井健史
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15H02896
[Presentation] ユビキチンリガーゼによる脂質代謝調節因子 Lipin1 の分解機構の解析2014
- Author(s)
  早瀬絢香，石本憲司，熊谷文子，橘敬祐，川村猛，田中十志也，浜窪隆雄，酒井寿郎，児玉龍彦，土井健史
- Organizer
  第64回　日本薬学会近畿支部総会・大会
- Place of Presentation
  京都
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26870346
[Presentation] 核内受容体 PPARδの恒常的転写活性化領域への結合因子の解析2013
- Author(s)
  藤田泰聖,樋野展正,上原光太郎,前川貴志,熊谷文子,石本憲司,橘敬祐,土井健史
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790087
[Presentation] 脂質代謝調節因子Lipin1 タンパク質の分解制御機構の解析2012
- Author(s)
  熊谷文子,石本憲司,河井恵,橘敬祐,川村猛,田中十志也,浜窪隆雄,酒井寿郎,児玉龍彦,土井健史
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23790087
[Presentation] ヒト核内受容体 PPARαによる生体防御レクチン MBL2 の発現制御機構の解析2012
- Author(s)
  橘敬祐,竹内健太郎,稲田大彦,杉本研,石本憲司,田中十志也,楽木宏実,浜窪隆雄,酒井寿郎,児玉龍彦,沢村達也,土井健史
- Organizer
  第121回日本薬理学会近畿支部会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-23790087
[Presentation] 脂質代謝因子 Lipin1の細胞内局在を制御する相互作用因子の探索2011
- Author(s)
  河井恵,石本憲司,橘敬祐,山崎大典,川村猛,田中十志也,浜窪隆雄,酒井寿郎,児玉龍彦,土井健史
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790087
[Presentation] 転写制御因子を介したミトコンドリアの脂肪酸酸化制御の解析2011
- Author(s)
  山下雅礼,橘敬祐,杉本研,秋山恵麻,石本憲司,山崎大典,岩成宏子,田中十志也,望月康弘,楽木宏実,酒井寿郎,浜窪隆雄,児玉龍彦,土井健史
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790087
[Presentation] Protein purification and generation of antibody for structure analysis of SETDB1.2011
- Author(s)
  Eiko Gotoh, Keisuke Tachibana, Yoshie Uchihara, Natsuko Kawamata, Kenji Ishimoto, Daisuke Yamasaki, Takefumi Doi.
- Organizer
  The 4th Global COE International Symposium on Physiome and Systems Biology for Integrated Life Sciences and Predictive Medicine
- Place of Presentation
  Osaka
- Data Source
  KAKENHI-PROJECT-23790087
[Presentation] 肥満解消を目指したLipin1遺伝子の発現制御機構の解明2011
- Author(s)
  石本　憲司
- Organizer
  第61回日本薬学会近畿支部総会・大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790087
[Presentation] ヒストンメチル化酵素 SETDB1 はメチル基供与体 SAM の輸送体になり得るか?2011
- Author(s)
  橘敬祐,後藤英子,内原佳恵,川又那津子,石本憲司,山崎大典,岩成宏子,望月康弘,酒井寿郎,浜窪隆雄,児玉龍彦,土井健史
- Organizer
  第6回トランスポーター研究会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23790087
[Presentation] Functional analysis of the roles of posttranslational modification of PPAR delta in regulating transcriptional activity.2011
- Author(s)
  Keisuke Tachibana, Kotaro Uehara, Takashi Maegawa, Masanori Yamashita, Fumiko Kumagai, Taisei Fujita, Kenji Ishimoto, Daisuke Yamasaki, Takefumi Doi.
- Organizer
  The 4th Global COE International Symposium on Physiome and Systems Biology for Integrated Life Sciences and Predictive Medicine
- Place of Presentation
  Osaka
- Data Source
  KAKENHI-PROJECT-23790087
[Presentation] Global proteomic analysis of lipin1 involved in lipid metabolism2011
- Author(s)
  Kenji Ishimoto
- Organizer
  The 4th Global COE International Symposium on Physiome and Systems Biology for Integrated Life Sciences and Predictive Medicine
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23790087
[Presentation] ヒストンメチル化酵素 SETDB1 の細胞内局在の解析2011
- Author(s)
  後藤英子,橘敬祐,内原佳恵,川又那津子,石本憲司,岩成宏子,川村猛,望月康弘,酒井寿郎,浜窪隆雄,児玉龍彦,土井健史
- Organizer
  第84回日本生化学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23790087
[Presentation] Global proteomic analysis of lipin1 involved in lipid metabolism2011
- Author(s)
  Kenji Ishimoto, Megumi Kawai, Keisuke Tachibana, Daisuke Yamasaki, Takefumi Doi
- Organizer
  The 4th Global COE International Symposium on Physiome and Systems Biology for Integrated Life Sciences and Predictive Medicine
- Place of Presentation
  Osaka
- Data Source
  KAKENHI-PROJECT-23790087
[Presentation] 肥満解消を目指した Lipin1 遺伝子の発現制御機構の解明2011
- Author(s)
  石本憲司,中村太樹,河井恵,橘敬祐,土井健史
- Organizer
  第61回日本薬学会近畿支部総会・大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790087

1. Keisuke Tachibana (30432446)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
2. 土井健史 (00211409)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
3. 吉田卓也 (00294116)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 樋野展正 (90469916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. OKADA Yoshiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. AGO Yukio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 有賀寛芳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 舟橋伸昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 川村猛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 酒井寿郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishimoto Kenji 石本 憲司

ISHIMOTO Kenji 石本 憲司

Research Projects

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Co-Researchers

Proposal of effective utilization of polyphenols as functional food ingredients for realization of a healthy longevity societyPrincipal Investigator

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Building the foundation for preventive medical strategies against dementia to realize a sustainable super-aging society

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Preparation and evaluation of amorphous of poorly water-soluble polyphenols for prevention of NAFLD / NASHPrincipal Investigator

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Development of NASH therapeutics by regulating energy expenditure and inflammation through the lipid sensor PPAR

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Analysis of the transcriptional regulatory mechanism of nuclear receptors via posttranslational modification of the nuclear receptors and localization of the interacting factors

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The search of novel factors that control the subcellular localization of Lipin1Principal Investigator

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Strategy for the prevention of obesity by the regulation of Lipin1Principal Investigator

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[Book] 血管生物医学事典(日本血管生物医学会編)2011

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[Journal Article] Suppressive effect of black tea polyphenol theaflavins in a mouse model of ovalbumin-induced food allergy2023

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[Journal Article] Exploring Compounds to be used as Cosmetic Agents that Activate Peroxisome Proliferator‐Activated Receptor Alpha2022

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[Journal Article] Examination of dissolution ratio of β-carotene in water for practical application of β-carotene amorphous solid dispersion2022

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[Journal Article] Physicochemical and Biochemical Evaluation of Amorphous Solid Dispersion of Naringenin Prepared Using Hot-Melt Extrusion2022

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[Journal Article] Tea crude extracts effectively inactivate severe acute respiratory syndrome coronavirus 22022

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[Journal Article] Generation of KS-133 as a novel bicyclic peptide with a potent and selective VIPR2 antagonist activity that counteracts cognitive decline in a mouse model of psychiatric disorders2021

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Ishimoto Kenji 石本憲司

ISHIMOTO Kenji 石本憲司