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Hayakawa Kunihiro  早川 国宏

… Alternative Names

HAYAKAWA Kunihiro  早川 国宏

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Researcher Number 00573007
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-8053-746X
Affiliation (Current) 2025: 順天堂大学, 大学院医学研究科, 准教授
Affiliation (based on the past Project Information) *help 2023: 順天堂大学, 大学院医学研究科, 准教授
2021 – 2022: 順天堂大学, 大学院医学研究科, 特任助教
2020: 順天堂大学, 医学(系)研究科(研究院), 特任助教
2015 – 2016: 順天堂大学, 医学(系)研究科(研究院), 博士研究員
2014: 順天堂大学, 医学(系)研究科(研究院), 研究員 … More
2012: 国立国際医療研究センター, 免疫病理, 研究員
2012: 独立行政法人国立国際医療研究センター, その他部局等, その他
2011 – 2012: 独立行政法人国立国際医療研究センター, その他部局等, 研究員
2011: 国立国際医療研究センター(研究所), 免疫病理研究部, 研究員
2010: 国立国際医療研究センター, 研究所・免疫病理研究部, 研究員 Less
Review Section/Research Field
Principal Investigator
Basic Section 49030:Experimental pathology-related / Experimental pathology / Immunology
Except Principal Investigator
Immunology
Keywords
Principal Investigator
自己免疫疾患 / 免疫寛容 / 環境要因 / 腸内細菌叢 / SLE / 炎症応答 / 炎症 / 全身性エリテマトーデス / 関節リウマチ / miRNA … More / T細胞 / 活性化T細胞 / IL-2 / T細胞 / 免疫学 … More
Except Principal Investigator
自己免疫 / 正の選択 / シグナル伝達 / 分化 / T細胞 / 胸腺 / リンパ球 Less
  • Research Projects

    (4 results)
  • Research Products

    (38 results)
  • Co-Researchers

    (8 People)
  •  Analysis of autoimmune dysregulation caused by changes in intestinal microbiota due to environmental factorsPrincipal Investigator

    • Principal Investigator
      Hayakawa Kunihiro
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Juntendo University
  •  Investigation of the autoimmune diseases pathogenesis through microRNA exhaustive analysisPrincipal Investigator

    • Principal Investigator
      Hayakawa Kunihiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Juntendo University
  •  新規胸腺特異的遺伝子ISC22のT細胞分化・活性化における機能の解析Principal Investigator

    • Principal Investigator
      早川 国宏
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Immunology
    • Research Institution
      Research Institute, International Medical Center of Japan
  •  Function of novel molecule Gasp exclusively expressed in the thymus

    • Principal Investigator
      SUZUKI Harumi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Research Institute, International Medical Center of Japan

All 2024 2022 2021 2020 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

  • [Journal Article] Type 1 interferon suppresses expression and glucocorticoid induction of glucocorticoid-induced leucine zipper (GILZ)2022

    • Author(s)
      Dankers Wendy、Northcott Melissa、Bennett Taylah、D’Cruz Akshay、Sherlock Rochelle、Gearing Linden J.、Hertzog Paul、Russ Brendan、Miceli Iolanda、Scheer Sebastian、Fujishiro Maki、Hayakawa Kunihiro、Ikeda Keigo、Morand Eric F.、Jones Sarah A.
    • Journal Title

      Frontiers in Immunology

      Volume: 13 Pages: 1034880-1034880

    • DOI

      10.3389/fimmu.2022.1034880

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07428, KAKENHI-PROJECT-22K09365, KAKENHI-PROJECT-22H04366
  • [Journal Article] Exposure of female NZBWF1 mice to imiquimod-induced lupus nephritis at an early age via a unique mechanism that differed from spontaneous onset2022

    • Author(s)
      Hayakawa Kunihiro、Fujishiro Maki、Yoshida Yuko、Kataoka Yuko、Sakuma Shota、Nishi Takuya、Ikeda Keigo、Morimoto Shinji、Takamori Kenji、Sekigawa Iwao
    • Journal Title

      Clinical and Experimental Immunology

      Volume: uxac012 Issue: 1 Pages: 33-46

    • DOI

      10.1093/cei/uxac012

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09608, KAKENHI-PROJECT-21H04255, KAKENHI-PROJECT-20K07428, KAKENHI-PROJECT-22K09365, KAKENHI-PROJECT-22H04366, KAKENHI-PROJECT-18K08415, KAKENHI-PROJECT-23K20320
  • [Journal Article] Metformin repositioning in rheumatoid arthritis2021

    • Author(s)
      Matsuoka Yuki、 Morimoto Shinji、 Fujishiro Maki、 Hayakawa Kunihiro、 Kataoka Yuko、 Suzuki Satoshi、 Ikeda Keigo、 Takamori Kenji、 Yamaji Ken、 Tamura Naoto
    • Journal Title

      Clinical and Experimental Rheumatology

      Volume: 39 Pages: 763-768

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07428
  • [Journal Article] Social defeat stress exacerbates atopic dermatitis through downregulation of DNA methyltransferase 1 and upregulation of C?C motif chemokine receptor 7 in skin dendritic cells2020

    • Author(s)
      Yoshida Yuko、Hayakawa Kunihiro、Fujishiro Maki、Ikeda Keigo、Tsushima Hiroshi、Hirai Takuya、Kawasaki Mikiko、Tominaga Mitsutoshi、Suga Yasushi、Takamori Kenji、Watanabe Yoshifumi、Sekigawa Iwao、Morimoto Shinji
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 529 Issue: 4 Pages: 1073-1079

    • DOI

      10.1016/j.bbrc.2020.06.157

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08415, KAKENHI-PROJECT-19K09608, KAKENHI-PROJECT-20K07428, KAKENHI-PROJECT-18K07396, KAKENHI-PROJECT-23K20320
  • [Journal Article] Metformin repositioning in rheumatoid arthritis2020

    • Author(s)
      Matsuoka, Yuki; Morimoto, Shinji; Fujishiro, Maki; Hayakawa, Kunihiro; Kataoka, Yuko; Suzuki, Satoshi; Ikeda, Keigo; Takamori, Kenji; Yamaji, Ken; Tamura, Naoto
    • Journal Title

      Clinical and experimental rheumatology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07428
  • [Journal Article] The effectiveness of new triple combination therapy using synthetic disease-modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study.2017

    • Author(s)
      Hirai T, Ikeda K, Fujishiro M, Tsushima H, Hayakawa K, Suzuki S, Yamaguchi A, Nozawa K, Morimoto S, Takasaki Y, Ogawa H, Takamori K, Tamura N, Sekigawa I
    • Journal Title

      Clin Rheumatol

      Volume: 36 Issue: 1 Pages: 51-58

    • DOI

      10.1007/s10067-016-3458-8

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860265, KAKENHI-PROJECT-15K08107, KAKENHI-PROJECT-16K08997
  • [Journal Article] Inhibition of each module of connective tissue growth factor as a potential therapeutic target for rheumatoid arthritis.2015

    • Author(s)
      Miyashita T, Morimoto S, Fujishiro M, Hayakawa K, Suzuki S, Ikeda K, Miyazawa K, Morioka M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y.
    • Journal Title

      Autoimmunity

      Volume: 49(2) Issue: 2 Pages: 109-14

    • DOI

      10.3109/08916934.2015.1113405

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08107, KAKENHI-PROJECT-26860265, KAKENHI-PROJECT-25460727
  • [Journal Article] Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis.2014

    • Author(s)
      Suzuki S, Morimoto S, Fujishiro M, Kawasaki M, Hayakawa K, Miyashita T, Ikeda K, Miyazawa K, Yanagida M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y
    • Journal Title

      Autoimmunity

      Volume: - Issue: 4 Pages: 251-8

    • DOI

      10.3109/08916934.2014.976631

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26860265, KAKENHI-PROJECT-15K08107
  • [Journal Article] Differential requirement for RhoH in development of TCRαβ CD8αα IELs and other types of T cells.2013

    • Author(s)
      Oda, H.
    • Journal Title

      Immunol Lett.

      Volume: 151 Issue: 1-2 Pages: 1-9

    • DOI

      10.1016/j.imlet.2013.02.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390098, KAKENHI-PROJECT-23790554, KAKENHI-PROJECT-24790491
  • [Journal Article] Differential requirement for RhoH in development of TCRab CD8aa IELs and other types of T cells2013

    • Author(s)
      Oda H, Tamehiro N, Patrich MS, Hayakawa K and Suzuki H
    • Journal Title

      Immunol. Lett.

      Volume: 151 Pages: 1-9

    • Data Source
      KAKENHI-PROJECT-22390098
  • [Journal Article] Selective abrogation of BiP/GRP78 blunts activation of NF-KB through the ATF6 branch of the UPR: involvement of C/EBP13 and mTOR-dependent dephosphorylation of Akt2011

    • Author(s)
      Nakajima S, Hiramatsu N, Hayakawa K, Saito Y, Kato H, Huang T, Yao J, Paton AW, Paton JC, Kitamura M
    • Journal Title

      Mol Cell Biol

      Volume: 31 Pages: 1710-1718

    • Data Source
      KAKENHI-PROJECT-22390098
  • [Journal Article] Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion-triggered PERK-eIF2a pathway2011

    • Author(s)
      Tagawa Y, Hiramatsu N, Kato H, Sakoh T, Nakajima S, Hayakawa K, Saito Y, Johno H, Takahashi S, Gu L, Yao J, Kitamura M
    • Journal Title

      Toxicology

      Volume: 287 Pages: 105-112

    • Data Source
      KAKENHI-PROJECT-22390098
  • [Journal Article] ER stress depresses NF-kB activation in mesangial cells through preferential induction of C/EBPb2010

    • Author(s)
      Hayakawa, K., et al.
    • Journal Title

      J Am Soc Nephrol

      Volume: 21 Pages: 73-81

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390098
  • [Presentation] Analysis of the relationship between changes in the gut microbiota and the production of autoantibodies2024

    • Author(s)
      Kunihiro Hayakawa, Maki Fujishiro
    • Organizer
      第52回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07428
  • [Presentation] マウス新生児期における肝臓由来FGF21の神経系への作用2022

    • Author(s)
      芳田祐子、及川茉那、早川国宏、渡辺恵史
    • Organizer
      日本薬学会 第142年会
    • Data Source
      KAKENHI-PROJECT-20K07428
  • [Presentation] 末梢血細胞分画変動及びB細胞内シグナルへの影響から検証したべリムマブの役割2022

    • Author(s)
      西卓也、藤城真樹、早川国宏、鈴木智、池田圭吾、森本真司、山路健、田村直人
    • Organizer
      第66回日本リウマチ学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-20K07428
  • [Presentation] Modification by Liver-derived Fibroblast growth factor (FGF) 21 of the b-klotho protein (KLB) expression in the central nerve system.2021

    • Author(s)
      Yoshida Y, Oikawa M, Hayakawa K, Watanabe Y
    • Organizer
      第50回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07428
  • [Presentation] Imiquimod induced lupus nephritis in NZBWF1 mice is developed through a unique mechanism different from spontaneous onset.2021

    • Author(s)
      Hayakawa K, Fujishiro M, Yoshida Y, Kataoka Y, Sakuma S, Nishi T, Ikeda K, Morimoto S, Sekigawa I
    • Organizer
      第50回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07428
  • [Presentation] The investigation of the Connective Tissue Growth Factor in the pathogenesis of imiquimod-induced psoriasis-like dermatitis mice.2016

    • Author(s)
      Hayakawa K, Fujishiro M, Yoshida Y, Tsushima H, Hirai T, Ikeda K, Morimoto M, Sekigawa I
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄県宜野湾市
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-26860265
  • [Presentation] 関節リウマチ炎症局所の脂質メディエーターの測定方法の確立とその役割の検討2016

    • Author(s)
      早川国宏、藤城真樹、芳田祐子、宮下知子、津島浩、平井琢也、池田圭吾、森本真司、関川巖
    • Organizer
      第60回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-04-21
    • Data Source
      KAKENHI-PROJECT-26860265
  • [Presentation] SLEモデルマウスおよびJAK阻害薬を用いたインターフェロンと転写制御因子の調節に関わる検討2016

    • Author(s)
      池田圭吾、早川国宏、藤城真樹、川崎美紀子、平井琢也、津島浩、森本真司、髙﨑芳成、関川巖
    • Organizer
      第60回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-04-21
    • Data Source
      KAKENHI-PROJECT-26860265
  • [Presentation] The implication of the Connective Tissue Growth Factor (CTGF) in the pathogenesis of psoriasis.2015

    • Author(s)
      Hayakawa K, Fujishiro M, Masuzawa M, Yoshida Y, Miyashita T, Ikeda K, Morimoto S, Sekigawa I
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター (北海道・札幌市)
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-26860265
  • [Presentation] 関節リウマチ発症におけるCTGF各moduleの関与について2015

    • Author(s)
      宮下知子、森本真司、藤城真樹、早川国宏、池田圭吾、関川巖、高崎芳成
    • Organizer
      第59回日本リウマチ学会総会・学術集会
    • Place of Presentation
      名古屋国際会議場 (愛知県・名古屋市)
    • Year and Date
      2015-04-23
    • Data Source
      KAKENHI-PROJECT-26860265
  • [Presentation] Pan JAK Inhibitor Tofacitinib Ameliorate Autoimmunity and Nephritis in Lupus Prone Mice Via Inhibition of Interferon Signaling Pathway.2015

    • Author(s)
      Ikeda K, Hayakawa K, Fujishiro M, Kawasaki M, Hiari T, Morimoto S, Takasaki Y, Sekigawa I
    • Organizer
      2015 American College of Rheumatorogy Annual Meeting
    • Place of Presentation
      San Francisco (アメリカ)
    • Year and Date
      2015-11-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860265
  • [Presentation] The novel gene ISC22 is involved in TCR-mediated IL-2 production in mature T cells2012

    • Author(s)
      早川国宏, 鈴木春巳
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-12-06
    • Data Source
      KAKENHI-PROJECT-22390098
  • [Presentation] The novel gene ISC22 is involved in TCR-mediated IL-2 production in mature T cells.2012

    • Author(s)
      Hayakawa K, Suzuki H
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23790554
  • [Presentation] ESET (SETDB1) modulates H3K9 methylation of developing thymocytes and is indispensable for T cell development.2012

    • Author(s)
      Takikita S, Hayakawa K, Suzuki H
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23790554
  • [Presentation] Functional analysis of a Tcell-specificgene ISC222011

    • Author(s)
      早川国宏、鈴木春巳
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-22390098
  • [Presentation] Functionalan alysis of histone methyltransferase ESET/SETDB1 in T cell development2011

    • Author(s)
      Shoichi Takikita, Kunihiro Hayakawa, Harumi Suzuki
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ (千葉県)
    • Data Source
      KAKENHI-PROJECT-23790554
  • [Presentation] T細胞における低分子タンパク質RhoHの機能解析2011

    • Author(s)
      為廣 紀正、早川 国宏、小田 浩代、鈴木 春巳
    • Organizer
      第21回 Kyoto T Cell Conference
    • Place of Presentation
      京都平安ホテル (京都府)
    • Data Source
      KAKENHI-PROJECT-23790554
  • [Presentation] T細胞特異的発現遺伝子ISC22の解析/ Functional analysis of a T cell-specific gene ISC222011

    • Author(s)
      早川 国宏、鈴木 春巳
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ (千葉県)
    • Data Source
      KAKENHI-PROJECT-23790554
  • [Presentation] 老齢RhoH欠損マウスにおいて自然発症する皮膚炎/Aging RhoH deficient mice exhibit spontaneous skin inflammation2011

    • Author(s)
      Norimasa Tamehiro, Kunihiro Hayakawa, Hiroyo Oda, Harumi Suzuki
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ (千葉県)
    • Data Source
      KAKENHI-PROJECT-23790554
  • [Presentation] 新規遺伝子ISC22のT細胞分化における機能の解析2010

    • Author(s)
      早川国宏、Michael S. Patrick、小田浩代、鈴木春巳
    • Organizer
      第20回KTCC
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22390098
  • [Presentation] Gasp (Themis) is critically required for thymocyte positive selection2010

    • Author(s)
      Patrick MS, Oda H, Hayakawa K, Eshima K, Suzuki H
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Data Source
      KAKENHI-PROJECT-22390098
  • [Presentation] The novel protein Gasp (Themis) is critically required for thymocyte positive selection by regulating ERK activation2010

    • Author(s)
      Patrick MS, Hayakawa K, Oda H, Suzuki H
    • Organizer
      第20回KTCC
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22390098
  • [Presentation] Functional analysis of novel T cell-specific gene ISC222010

    • Author(s)
      Hayakawa K, Patrick MS, Oda H, Suzuki H
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Data Source
      KAKENHI-PROJECT-22390098
  • [Presentation] インスリン用成長因子系阻害による新規関節リウマチ治療の可能性の検討

    • Author(s)
      鈴木智、森本真司、藤城真樹、宮下知子、川崎美紀子、早川国宏、池田圭吾、関川巖、高崎芳成
    • Organizer
      日本リウマチ学会総会・学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Data Source
      KAKENHI-PROJECT-26860265
  • [Presentation] JAK阻害剤tofacitinibはCD4陽性T細胞のIFNシグナルに加えCD28シグナルの抑制を介して全身性エリテマトーデスの活動性を抑制しうる

    • Author(s)
      池田圭吾、藤城真樹、早川国宏、川崎美紀子、森本真司、高崎芳成、関川巖
    • Organizer
      日本リウマチ学会総会・学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Data Source
      KAKENHI-PROJECT-26860265
  • 1.  SUZUKI Harumi (70235985)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 2.  SEKIGAWA Iwao
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  FUJISHIRO Maki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  SUZUKI Satoshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  MIYASHITA Tomoko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  高崎 芳成
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  池田 圭吾
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 8.  森本 真司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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