Masaki Yoshiaki 正木慶昭

Researcher Number	00578544
Other IDs
Affiliation (Current)	2025: 東京科学大学, 生命理工学院, 准教授
Affiliation (based on the past Project Information) *help	2023: 東京工業大学, 生命理工学院, 准教授 2016 – 2022: 東京工業大学, 生命理工学院, 助教 2015: 東京工業大学, 大学院生命理工学研究科, 助教 2014: 東京工業大学, 生命理工学研究科, 助教
Review Section/Research Field	Principal Investigator Bio-related chemistry / Basic Section 37010:Bio-related chemistry
Keywords	Principal Investigator アンチセンス核酸 / 化学修飾核酸 / 核酸医薬 / RNase H / 核酸化学 / オフターゲット効果 / RNaseH / 修飾核酸 / 分子動力学計算 / RNA … More / 核酸ータンパク質相互作用 / 核酸－タンパク質相互作用 / 核酸タンパク質相互作用 / 有機合成 / アンチセンス / DNA / 分子設計 / 二重鎖融解温度 Less

Control of nucleic acid-protein complex formation through strain and relaxationPrincipal Investigator
- Principal Investigator
  
  Masaki Yoshiaki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Tokyo Institute of Technology
Development of chemcial modifications optimized for oligonucleotide-protein complex formationPrincipal Investigator
- Principal Investigator
  
  Masaki Yoshiaki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Tokyo Institute of Technology
Deformability analysis for rational design of sugar-modified oligonucleotidesPrincipal Investigator
- Principal Investigator
  
  Masaki Yoshiaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Tokyo Institute of Technology

All 2024 2023 2022 2021 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book Patent

[Book] Synthesis of Therapeutic Oligonucleotides (38.Effects of 2´-O-Modifications on RNA Duplex Stability)2018
- Author(s)
  Masaki, Y.; Ohkubo, A.; Seio, K.; Sekine, M. (Obika, S. Sekine, M. eds)
- Total Pages
  284
- Publisher
  Springer Singapore
- ISBN
  9789811319112
- Data Source
  KAKENHI-PROJECT-17H04886
[Book] Chemical Biology of Nucleic Acids, fundamentals and clinical applications2014
- Author(s)
  Masaki, Y.; Yamada, T.; Saneyoshi, H.; Ohkubo, A.; Seio, K.; Sekine, M.
- Total Pages
  599
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26810086
[Journal Article] Alteration of target cleavage patterns and off-target reduction of antisense oligonucleotides incorporating 2-N-carbamoyl- or (2-pyridyl)guanine2023
- Author(s)
  Kanagawa Takayuki、Koyoma Aya、Masaki Yoshiaki、Seio Kohji
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 21 Issue: 25 Pages: 5214-5224
- DOI
  10.1039/d3ob00574g
- Data Source
  KAKENHI-PROJECT-20H02857
[Journal Article] Synthesis and Conformational Analyses of Cyclonucleoside Having 13-Membered Ring Bridging Nucleobase and 5′-Position via a Linker Containing Sulfonamide2023
- Author(s)
  Kanagawa Takayuki、Tachibana Shigetoshi、Masaki Yoshiaki、Seio Kohji
- Journal Title
  
  Organic Letters
  
  Volume: 25 Issue: 43 Pages: 7868-7872
- DOI
  10.1021/acs.orglett.3c03094
- Data Source
  KAKENHI-PROJECT-20H02857
[Journal Article] Oligodeoxynucleotides Modified with 2′-<i>O</i>-(Cysteinylaminobutyl)carbamoylethylribothymidine Residues for Native Chemical Ligation with Peptide at Internal Positions2022
- Author(s)
  Masaki Yoshiaki、Maruyama Atsuya、Yoshida Keita、Tomori Takahito、Kishimura Tomohiro、Seio Kohji
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 33 Issue: 2 Pages: 272-278
- DOI
  10.1021/acs.bioconjchem.1c00575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02857
[Journal Article] Quantification of synthetic errors during chemical synthesis of DNA and its suppression by non-canonical nucleosides2022
- Author(s)
  Masaki Yoshiaki、Onishi Yukiko、Seio Kohji
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1
- DOI
  10.1038/s41598-022-16222-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02857
[Journal Article] Synthesis of 2′-O-[3-(N-methylsulfamoyl)propan-1-yl]ribothymidine as a potentially applicable 2′-modified nucleoside for antisense oligonucleotides2022
- Author(s)
  Tomori Takahito、Uekusa Koya、Koyama Aya、Kanagawa Takayuki、Masaki Yoshiaki、Seio Kohji
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 73 Pages: 117002-117002
- DOI
  10.1016/j.bmc.2022.117002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02857, KAKENHI-PROJECT-20K21245
[Journal Article] Insertion of a methylene group into the backbone of an antisense oligonucleotide reveals the importance of deoxyribose recognition by RNase H2022
- Author(s)
  Masaki Yoshiaki、Tabira Ayano、Hattori Shihori、Wakatsuki Shunsuke、Seio Kohji
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 20 Issue: 45 Pages: 8917-8924
- DOI
  10.1039/d2ob01667b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02857, KAKENHI-PROJECT-21H02075, KAKENHI-PROJECT-20K21245
[Journal Article] Synthesis of 2′-O-alkylcarbamoylethyl-modified oligonucleotides with enhanced nuclease resistance that form isostable duplexes with complementary RNA2021
- Author(s)
  Tomohiro Kishimura, Takahito Tomori, Yoshiaki Masaki, Kohji Seio
- Journal Title
  
  Ｂioorganic ＆Medicinal Chemistry Ltters
  
  Volume: 35 Pages: 127779-127779
- DOI
  10.1016/j.bmcl.2021.127779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21245, KAKENHI-PROJECT-20H02857
[Journal Article] Modification of oligonucleotides with weak basic residues via the 2′-O-carbamoylethyl linker for improving nuclease resistance without loss of duplex stability and antisense activity2019
- Author(s)
  Masaki Yoshiaki、Yamamoto Keishi、Yoshida Keita、Maruyama Atsuya、Tomori Takahito、Iriyama Yusuke、Nakajima Hiroyuki、Kanaki Tatsuro、Seio Kohji
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 17 Issue: 19 Pages: 4835-4842
- DOI
  10.1039/c9ob00668k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04886
[Journal Article] Tolerance of N2-heteroaryl modifications on guanine bases in a DNA G-quadruplex2019
- Author(s)
  Masaki Yoshiaki、Inde Takeshi、Maruyama Atsuya、Seio Kohji
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 17 Issue: 4 Pages: 859-866
- DOI
  10.1039/c8ob03100b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04886
[Journal Article] Synthesis of 2'-O-(N-methylcarbamoylethyl) 5-methyl-2-thiouridine and its application to splice-switching oligonucleotides.2019
- Author(s)
  Masaki Y, Yamamoto K, Inde T, Yoshida K, Maruyama A, Nagata T, Tanihata J, Takeda S, Sekine M, Seio K
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 29 Issue: 2 Pages: 60-163
- DOI
  10.1016/j.bmcl.2018.12.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08726, KAKENHI-PROJECT-17H04886, KAKENHI-PROJECT-16H05221
[Journal Article] Application of 2′-O-(2-N-Methylcarbamoylethyl) Nucleotides in RNase H-Dependent Antisense Oligonucleotides2018
- Author(s)
  Masaki Yoshiaki、Iriyama Yusuke、Nakajima Hiroyuki、Kuroda Yusuke、Kanaki Tatsuro、Furukawa Satoshi、Sekine Mitsuo、Seio Kohji
- Journal Title
  
  Nucleic Acid Therapeutics
  
  Volume: 28 Issue: 5 Pages: 307-311
- DOI
  10.1089/nat.2018.0738
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04886
[Journal Article] Deformability Calculation for Estimation of the Relative Stability of Chemically Modified RNA Duplexes.2017
- Author(s)
  Masaki Y, Sekine M, Seio K.
- Journal Title
  
  Current Protocols in Nucleic Acid Chemistry
  
  Volume: 68 Issue: 1
- DOI
  10.1002/cpnc.25
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26810086
[Journal Article] Enzymatic synthesis and reverse transcription of RNAs incorporating 2 -O-carbamoyl uridine triphosphate2016
- Author(s)
  Masaki Y, Ito H, Oda Y, Yamazaki K, Tago N, Ohno K, Ishii N, Tsunoda H, Kanamori T, Ohkubo A, Sekine M, Seio K.
- Journal Title
  
  Chemical Communications
  
  Volume: 52 Issue: 87 Pages: 12889-12892
- DOI
  10.1039/c6cc05796a
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01062, KAKENHI-PROJECT-26288075, KAKENHI-PROJECT-15K13738, KAKENHI-PROJECT-26810086, KAKENHI-PROJECT-16K05840
[Journal Article] 7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding protein2016
- Author(s)
  Munefumi Tokugawa, Yoshiaki Masaki, Jan Christian Canggadibrata, Kazuhei Kaneko, Takashi Shiozawa, Takashi Kanamori, Morten Grøtli, L. Marcus Wilhelmsson, Mitsuo Sekine and Kohji Seio
- Journal Title
  
  Chemical Communications
  
  Volume: 52 Issue: 19 Pages: 3809-3812
- DOI
  10.1039/c5cc09700b
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26810086, KAKENHI-PUBLICLY-26119705, KAKENHI-PROJECT-26288075, KAKENHI-PROJECT-15K13738
[Journal Article] A New Microfluidic Phase-Transfer Reaction Using HPLC Guard Columns as the Reactor for the N3-Protection of Uridine Derivatives2015
- Author(s)
  Nobuhiro Tago, Yoshiaki Masaki, Hiroshi Nagasawa, Takashi Kanamori, Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine
- Journal Title
  
  Synlett
  
  Volume: 26 Issue: 18 Pages: 2578-2582
- DOI
  10.1055/s-0035-1560264
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26810086
[Journal Article] Synthesis and properties of oligonucleotides modified with 2'-O-(2-carboxyethyl)nucleotides and their carbamoyl derivatives.2014
- Author(s)
  Yamada T, Masaki Y, Okaniwa N, Kanamori T, Ohkubo A, Tsunoda H, Seio K, Sekine M
- Journal Title
  
  Org Biomol Chem.
  
  Volume: 12 Issue: 33 Pages: 6457-6464
- DOI
  10.1039/c4ob01260g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24550184, KAKENHI-PROJECT-25288074, KAKENHI-PROJECT-26810086
[Patent] 安全性の高い核酸配列の設計法2023
- Inventor(s)
  正木慶昭
- Industrial Property Rights Holder
  正木慶昭
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-002073
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-20H02857
[Patent] 毒性が低減されたアンチセンスオリゴヌクレオチド2019
- Inventor(s)
  正木慶昭他５名
- Industrial Property Rights Holder
  正木慶昭他５名
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17H04886
[Patent] 毒性が低減されたアンチセンスオリゴヌクレオチド2019
- Inventor(s)
  正木慶昭清尾康志井上敦入山友輔金木達朗中嶋宏之
- Industrial Property Rights Holder
  正木慶昭清尾康志井上敦入山友輔金木達朗中嶋宏之
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17H04886
[Patent] 毒性が低減されたアンチセンスオリゴヌクレオチド2018
- Inventor(s)
  正木慶昭清尾康志井上敦入山友輔金木達朗中嶋宏之
- Industrial Property Rights Holder
  正木慶昭清尾康志井上敦入山友輔金木達朗中嶋宏之
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-052578
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17H04886
[Presentation] Extended phosphate backbone of ASO reveals importance of deoxyribose recognition by RNase H2024
- Author(s)
  Tabira, A.; Httori, S.; Seio, K.; Masaki, Y.
- Organizer
  Supra FIBER International Summit for Nucleic Acids (S-FISNA)
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] 2´水酸基にスルホンアミド修飾またはスルホネート修飾を有する5-メチルウリジン誘導体の合成および二重鎖形成能の評価2024
- Author(s)
  瀧川駿太朗,友利貴人,植草宏哉,正木慶昭,清尾康志
- Organizer
  日本化学会第104春季年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] Estimation of synthetic errors toward long DNA chemical synthesis2024
- Author(s)
  Masaki, Y.; Onishi, Y.; Seio, K.
- Organizer
  Supra FIBER International Summit for Nucleic Acids (S-FISNA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] 7位にピリジル基を導入した7-デアザデオキシグアノシンを含むオリゴヌクレオチドの合成と性質2024
- Author(s)
  宮地健人, 羽生愛深, 清尾康志, 正木慶昭
- Organizer
  日本化学会第104春季年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] 細胞選択的送達を目指した糖リガンド修飾アンチセンス核酸の合成と性質2024
- Author(s)
  島村大輝, 有江嶺美, 金山朱里, 宮内彩, 清尾康志, 正木慶昭
- Organizer
  日本化学会第104春季年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] 置換基を導入した2´-O, 3´-C架橋アラビノフラノシルチミンを含むオリゴヌクレオチドの合成と性質2024
- Author(s)
  田平彩乃, 若月駿介, 清尾康志, 正木慶昭
- Organizer
  日本化学会第104春季年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] 5´位を増炭したスルホンアミド骨格を有するチミジンダイマーの合成と物性評価2024
- Author(s)
  立花茂載, 大西里絵, 正木慶昭, 清尾康志
- Organizer
  日本化学会第104春季年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] 光架橋ビオチンリンカーを有するグアノシンテトラリン酸類似体の合成2024
- Author(s)
  鈴木雄大, 須田雪音, 井分彩乃, 正木慶昭, 清尾康志
- Organizer
  日本化学会第104春季年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] スルホンアミド型バックボーンを導入したギャップマーの合成およびアンチセンス核酸としての性質2023
- Author(s)
  清尾康志, 大西里絵, 立花茂載, 正木慶昭
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] メチレン基のリン酸バックボーンへの挿入がRNase Hによるミスマッチを含む二重差切断に与える影響2023
- Author(s)
  田平彩乃, 服部詩萌里, 清尾康志, 正木慶昭
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] 2’-O-スルファモイルアルキル修飾を導入したオリゴヌクレオチドの合成と性質2022
- Author(s)
  植草宏哉, 友利貴人, 正木慶昭, 清尾康志
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] Synthesis and the structural analysis of a cyclic sulfonamide thymidine derivative2022
- Author(s)
  Tachibana, S.; Kanagawa, T.; Ohnishi, R.; Masaki, Y.; Seio, K.
- Organizer
  第49回国際核酸化学シンポジウム日本核酸化学会第6回年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] 5´-デオキシ-5´-ヒドロキシメチルチミジン及び3´-デオキシ-3´-ヒドロキシメチルチミジンを含むリン酸骨格を伸長したオリゴヌクレオチドの合成と性質2022
- Author(s)
  正木慶昭, 田平彩乃, 服部詩萌里, 清尾康志
- Organizer
  日本化学会第102春季年会2022
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] スルホンアミド骨格を含む人工核酸の合成とアンチセンス活性の評価2022
- Author(s)
  大西里絵, 清尾康志, 正木慶昭, 関谷彰太, 枝村亘
- Organizer
  日本化学会第102春季年会2022
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] Systemic comparison of DNA chemical synthesis conditions by next-generation sequencing2022
- Author(s)
  Masaki, Y.; Onishi, Y.; Seio, K.
- Organizer
  第49回国際核酸化学シンポジウム日本核酸化学会第6回年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] Synthesis of nucleoside and oligonucleotide derivatives incorporating 2’-O-sulfamoylpropyl or 2’-O-sulfamoylbutyl modifications2022
- Author(s)
  Uekusa, K.; Tomori, T.; Koyama, A.; Masaki, Y.; Seio, K.
- Organizer
  第49回国際核酸化学シンポジウム日本核酸化学会第6回年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] Synthesis and property of alkoxytrityl type protecting group having reactive moiety2022
- Author(s)
  Yagata, T.; Masaki, Y.; Onishi, Y.; Seio, K.
- Organizer
  第49回国際核酸化学シンポジウム日本核酸化学会第6回年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] スルホンアミド構造を有する環状チミジン誘導体の合成とその構造解析2022
- Author(s)
  金川峻幸, 立花茂載, 大西里絵, 正木慶昭, 清尾康志
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] 塩基部と5´位をスルホンアミド結合で架橋したチミジン誘導体の合成法の検討2022
- Author(s)
  金川峻幸, 立花茂載, 大西里絵, 正木慶昭, 清尾康志
- Organizer
  日本化学会第102春季年会2022
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] RNase H依存型アンチセンス核酸の安全性向上に向けた化学修飾の開発2022
- Author(s)
  正木慶昭, 田平彩乃, 金川峻幸, 若月駿介, 服部詩萌里, 小山彩, 井上敦, 清尾康志
- Organizer
  日本核酸医薬学会第7回年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] Synthesis and structural analysis of sulfonamide linkage-containing oligonucleotides for the development of antisense nucleic acids2022
- Author(s)
  Ohnishi, R.; Sekiya, S.; Edamura, W.; Tachibana, S.; Masaki, Y.; Seio, K.
- Organizer
  第49回国際核酸化学シンポジウム日本核酸化学会第6回年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] Effects of inserting methylene group in the interaction of RNase H and ASO2022
- Author(s)
  Tabira, A.; Masaki, Y.; Hattori, S.; Wakatsuki, S.; Seio, K.
- Organizer
  第49回国際核酸化学シンポジウム日本核酸化学会第6回年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] 塩基部修飾グアニン導入によるアンチセンス核酸の標的切断変化とオフターゲット抑制2022
- Author(s)
  金川峻幸, 小山彩, 正木慶明, 清尾康志
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] Synthesis of oligonucleotides with lipophilic residues via 2´-O-carbamoylethyl linker for providing 3´-exonuclease resistance and duplex stability2021
- Author(s)
  Takahito Tomori, Tomohiro Kishimura, Koya Uekusa, Aya Koyama, Yuki Erikawa, Yoshiaki Masaki, Kohji Seio
- Organizer
  The 48th International Symposium on Nucleic Acids Chemistry The 5th Annual Meeting of Japan Society of Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] 2'位に種々のカルバモイルエチル基を有する人工核酸の合成とアンチセンス核酸としての性質2021
- Author(s)
  清尾康志, 岸村智太, 友利貴人, 正木慶昭
- Organizer
  日本核酸医薬学会第6回年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] 2'-O-アルキルカルバモイルエチル型修飾を持つ人工核酸の合成および性質2021
- Author(s)
  岸村智太, 植草宏哉, 友利貴人, 正木慶昭, 清尾康志
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] 2'-O,3'-C架橋型 [3.3.0]ビシクロアラビノフラノシルチミン誘導体を含むオリゴヌクレオチドの合成と性質2021
- Author(s)
  若月駿介, 井上敦, 正木慶昭, 清尾康志
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] リン酸骨格を伸長した5'-デオキシ-5'-ヒドロキシメチルチミジンを含むオリゴヌクレオチドの合成と性質2021
- Author(s)
  服部詩萌里, 正木慶昭, 清尾康志
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-20H02857
[Presentation] Synthesis and properties of 2'-O-modified oligonucleotides having carbamoylethyl linker2019
- Author(s)
  Masaki, Y.; Yamamoto, K.; Yoshida, Y.; Maruyama, A.; Tomori, T.; Iriyama, Y.; Nakajima, H.; Kanaki, T.; Seio, K.
- Organizer
  日本核酸医薬学会第5回年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04886
[Presentation] 化学修飾によるアンチセンス核酸の RNaseH依存オフターゲット効果の抑制2019
- Author(s)
  正木慶昭，井上敦，入山友輔，金木達朗，中嶋宏之，清尾康志
- Organizer
  第13回バイオ関連化学シンポジウム2019
- Data Source
  KAKENHI-PROJECT-17H04886
[Presentation] 2',3'-糖部架橋型アラビノフラノシルチミン誘導体の効率的な合成研究2019
- Author(s)
  井上敦, 正木慶昭, 清尾康志
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-17H04886
[Presentation] (4)Tolerance of N2-heteroaryl modifications on guanine bases in G-quadruplex structure2019
- Author(s)
  Masaki, Y.; Inde, T.; Maruyama, A.; Seio, K.
- Organizer
  CISNAC 2019日本核酸化学会設立記念国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04886
[Presentation] RNaseH依存型アンチセンス核酸への応用に向けた化学修飾核酸の開発2018
- Author(s)
  正木慶昭, 井上敦, 入山友輔, 金木達朗, 中嶋宏之, 清尾康志
- Organizer
  日本核酸医薬学会第4回年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04886
[Presentation] Synthesis of oligodeoxyribonucleotides containing N2-heteroarylguanine residues and their properties in G-quadruplex structures2018
- Author(s)
  Masaki, Y.; Inde, T.; Maruyama, A.; Seio, Kohji
- Organizer
  XXIII International Roundtable on Nucleosides, Nucleotides & Nucleic Acids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04886
[Presentation] Application of 2´-O-carbamoylethyl-type modifications in antisense oligonucleotide2018
- Author(s)
  Masaki, Y.; Yamamoto, K.; Yoshida, K.; Iriyama, Y.; Nakajima, H.; Kanaki, T.; Tomori, T.; Seio, K.
- Organizer
  The 14th Annual Meeting of the Oligonucleotide Therapeutics Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04886
[Presentation] 2',3'-糖部架橋型化学修飾核酸の合成2018
- Author(s)
  井上敦, 正木慶昭, 清尾康志
- Organizer
  日本化学会第98回春季年会
- Data Source
  KAKENHI-PROJECT-17H04886
[Presentation] 2’-水酸基にカルバモイルエチル型修飾を有する人工核酸を用いたアンチセンス核酸の開発2017
- Author(s)
  清尾康志, 正木慶昭, 山本恵士, 印出健志, 入山友輔, 中島宏之, 金木達朗, 黒田雄介, 古川賢, 谷端淳, 永田哲也, 武田伸一, 関根光雄
- Organizer
  日本核酸医薬学会第3回年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04886
[Presentation] Relationship between deformability of sugar-modified RNA duplexes and their melting temperatures2017
- Author(s)
  Masaki, Y.; Sekine, M.; Seio, K.
- Organizer
  13th Annual Meeting of the Oligonucleotide Therapeutics Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04886
[Presentation] 糖部修飾オリゴヌクレオチドの変形能解析と二重鎖融解温度の関係2017
- Author(s)
  正木慶昭, 宮坂隆太, 山本恵士, 吉田圭汰, 関根光雄, 清尾康志
- Organizer
  日本核酸医薬学会第3回年会
- Data Source
  KAKENHI-PROJECT-17H04886
[Presentation] Deformability analysis of chemically modified RNA and its applicability for estimation of RNA duplex stability2016
- Author(s)
  Yoshiaki Masaki, Ryuta Miyasaka, Keishi Yamamoto, Keita Yoshida, Akihiro Ohkubo, Mitsuo Sekine, Kohji Seio.
- Organizer
  The 43rd International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  熊本大学
- Year and Date
  2016-09-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26810086
[Presentation] 糖部化学修飾RNA二重鎖の変形能と二重鎖融解温度の関係2016
- Author(s)
  正木慶昭, 吉田圭汰, 山本恵士, 関根光雄, 清尾康志
- Organizer
  第10回バイオ関連化学シンポジウム
- Place of Presentation
  石川県立音楽堂
- Year and Date
  2016-09-07
- Data Source
  KAKENHI-PROJECT-26810086
[Presentation] 2-(N-エチルカルバモイル)エチル構造を糖部に有する修飾核酸の合成と性質2016
- Author(s)
  山本　恵士・正木　慶昭・吉田　圭太・入山　友輔・中嶋　宏之・金木　達朗・関根　光雄・清尾　康志
- Organizer
  日本化学会　第96春季年会
- Place of Presentation
  同志社大学　京田辺キャンパス
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-26810086
[Presentation] Enhancement of exon skipping efficiency by using antisense oligonucleotides containing 2-thiothymidine derivatives2015
- Author(s)
  Masaki, Y.; Yamamoto, K.; Inde, T; Nagata, T.; Tanihata, J.; Iriyama, Y.; Takeda, S.; Sekine, M.; Seio, K.
- Organizer
  日本核酸医薬学会　第一回年会
- Place of Presentation
  京都テルサ
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-26810086
[Presentation] Enhancement of exon skipping by 2´-O-(N-methylcarbamoyl)ethyl (MCE) and/or nucleobase modified nucleosides incorporation into phosphorothioate oligonucleotides2015
- Author(s)
  Masaki, Y.; Yamamoto, K.; Inde, T; Nagata, T.; Tanihata, J.; Iriyama, Y.; Takeda, S.; Seio, K.; Sekine, M.
- Organizer
  11th of Annual Meeting of the Oligonucleotide Therapeutics Society
- Place of Presentation
  Leiden, the Netherlands
- Year and Date
  2015-10-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26810086
[Presentation] Synthesis and properties of oligonucleotide containing 2´-O-[2-(N-methylcarbamoyl)ethyl] modified 2-thioribothymidine2015
- Author(s)
  Yamamoto, K.,; Masaki, Y,; Ishii, A,; Inde, T,; Tanibata, J,; Nagata, T,; Kanamori, T,; Takeda, S,; Sekine, M,; Seio , K.
- Organizer
  第17回日本RNA学会年会
- Place of Presentation
  ホテルライフォート札幌
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-26810086
[Presentation] Effective N-benzoylation of uridine derivatives using a two-phase microfluidic system
- Author(s)
  Tago N.; Masaki Y.; Ohkubo A.; Nagasawa H.; Kanamori T.; Seio K.; Sekine M.
- Organizer
  The 41st International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  福岡（日本）
- Year and Date
  2014-11-05 – 2014-11-07
- Data Source
  KAKENHI-PROJECT-26810086
[Presentation] Synthesis of 2´-O-carbamoyl uridine triphosphate and its applicability to aptamer selection
- Author(s)
  Masaki, Y.; Ito, H.; Yamazaki, K.; Tsunoda, H.; Kanamori, T.; Ohkubo, A.; Seio, K.; Sekine, M.
- Organizer
  XXI Round Table on Nucleosides, Nucleotides and Nucleic Acids Chemical Biology of Nucleic Acids
- Place of Presentation
  Poznan (Poland)
- Year and Date
  2014-08-24 – 2014-08-28
- Data Source
  KAKENHI-PROJECT-26810086

1. TANIHATA Jun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 清尾康志

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 大窪章寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 武田伸一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Masaki Yoshiaki 正木 慶昭

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Control of nucleic acid-protein complex formation through strain and relaxationPrincipal Investigator

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Development of chemcial modifications optimized for oligonucleotide-protein complex formationPrincipal Investigator

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Deformability analysis for rational design of sugar-modified oligonucleotidesPrincipal Investigator

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[Book] Synthesis of Therapeutic Oligonucleotides (38.Effects of 2´-O-Modifications on RNA Duplex Stability)2018

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[Book] Chemical Biology of Nucleic Acids, fundamentals and clinical applications2014

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[Journal Article] Alteration of target cleavage patterns and off-target reduction of antisense oligonucleotides incorporating 2-N-carbamoyl- or (2-pyridyl)guanine2023

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[Journal Article] Synthesis and Conformational Analyses of Cyclonucleoside Having 13-Membered Ring Bridging Nucleobase and 5′-Position via a Linker Containing Sulfonamide2023

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[Journal Article] Oligodeoxynucleotides Modified with 2′-<i>O</i>-(Cysteinylaminobutyl)carbamoylethylribothymidine Residues for Native Chemical Ligation with Peptide at Internal Positions2022

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[Journal Article] Quantification of synthetic errors during chemical synthesis of DNA and its suppression by non-canonical nucleosides2022

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[Journal Article] Synthesis of 2′-O-[3-(N-methylsulfamoyl)propan-1-yl]ribothymidine as a potentially applicable 2′-modified nucleoside for antisense oligonucleotides2022

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[Journal Article] Insertion of a methylene group into the backbone of an antisense oligonucleotide reveals the importance of deoxyribose recognition by RNase H2022

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[Journal Article] Synthesis of 2′-O-alkylcarbamoylethyl-modified oligonucleotides with enhanced nuclease resistance that form isostable duplexes with complementary RNA2021

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[Journal Article] Modification of oligonucleotides with weak basic residues via the 2′-O-carbamoylethyl linker for improving nuclease resistance without loss of duplex stability and antisense activity2019

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[Journal Article] Tolerance of N2-heteroaryl modifications on guanine bases in a DNA G-quadruplex2019

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[Journal Article] Synthesis of 2'-O-(N-methylcarbamoylethyl) 5-methyl-2-thiouridine and its application to splice-switching oligonucleotides.2019

Author(s)

Masaki Yoshiaki 正木慶昭