ITOH MICHIKO 伊藤美智子

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ITO Michiko 伊藤美智子

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Researcher Number	00581860
Other IDs
Affiliation (Current)	2025: 東京医科大学, 医学部, 主任教授 2025: 東京科学大学, その他の部局等, 非常勤講師
Affiliation (based on the past Project Information) *help	2023: 東京医科大学, 医学部, 主任教授 2021 – 2022: 名古屋大学, 環境医学研究所, 特任准教授 2019 – 2020: 名古屋大学, 環境医学研究所, 客員研究者 2018: 東京医科歯科大学, 大学院医歯学総合研究科, ジョイントリサーチ講座准教授 2017: 東京医科歯科大学, 大学院医歯学総合研究科, 特任准教授 … More 2016: 東京医科歯科大学, 大学院医歯学総合研究科, ジョイントリサーチ講座助教 2015: 東京医科歯科大学, 医歯(薬)学総合研究科, 特別研究員 2014: 東京医科歯科大学, 大学院医歯学総合研究科, 日本学術振興会特別研究員 2012 – 2013: 東京医科歯科大学, 医歯(薬)学総合研究科, 寄附講座教員 2011: 東京医科歯科大学, 難治疾患研究所, 寄附研究部門教員 2010: 東京医科歯科大学, 難治疾患研究所, 特任助教 Less
Review Section/Research Field	Principal Investigator Metabolomics / Basic Section 54040:Metabolism and endocrinology-related / Basic Section 49030:Experimental pathology-related / Experimental pathology
Keywords	Principal Investigator マクロファージ / 慢性炎症 / 細胞死 / crown-like structure / リソソーム / コレステロール / 線維芽細胞 / Crown-like structure / 肥満 / 肝細胞癌 … More / NASH / 貪食 / 線維化 / 死細胞 / 非アルコール性脂肪性肝炎 / 脂肪組織 / メタボリックシンドローム / インスリン抵抗性 Less

Pathophysiological role of lipid stress induced by dead cell clearance in the development of NASHPrincipal Investigator
- Principal Investigator
  
  伊藤美智子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Tokyo Medical University
  Nagoya University
Cell death-induced inflammation and the development of NASH and hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  ITOH Michiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Nagoya University
Molecular mechanism of hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitisPrincipal Investigator
- Principal Investigator
  
  ITOH Michiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Medical and Dental University
Pathophysiological role of macrophages and leptin in the development of non-alcoholic steatohepaititisPrincipal Investigator
- Principal Investigator
  
  Itoh Michiko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Tokyo Medical and Dental University
Pathophysiological role of adipo-hepatic axis in the development of non-alcoholic steatohepatitisPrincipal Investigator
- Principal Investigator
  
  ITOH MICHIKO
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Tokyo Medical and Dental University
Pathophysiological role of macrophages in development of NASHPrincipal Investigator
- Principal Investigator
  
  ITO Michiko
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Metabolomics
- Research Institution
  Tokyo Medical and Dental University

[Book] Innovative Medicine - Basic Research and Development2015
- Author(s)
  Yoshihiro Ogawa, Takayoshi Suganami, Michiko Itoh, Miyako Tanaka
- Total Pages
  339
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-26860692
[Book] 疾患モデルの作成と利用-糖尿病・肥満/感染症2012
- Author(s)
  伊藤美智子, 他
- Total Pages
  230
- Publisher
  エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-24790916
[Book] そうだったんだ!脂肪酸2012
- Author(s)
  伊藤美智子, 他
- Total Pages
  178
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-24790916
[Journal Article] Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH2023
- Author(s)
  Itoh Michiko、Tamura Atsushi、Kanai Sayaka、Tanaka Miyako、Kanamori Yohei、Shirakawa Ibuki、Ito Ayaka、Oka Yasuyoshi、Hidaka Isao、Takami Taro、Honda Yasushi、Maeda Mitsuyo、Saito Yasuyuki、Murata Yoji、Matozaki Takashi、Nakajima Atsushi、Kataoka Yosky、Ogi Tomoo、Ogawa Yoshihiro、Suganami Takayoshi
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 220 Issue: 11
- DOI
  10.1084/jem.20220681
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19524, KAKENHI-PROJECT-22K08504, KAKENHI-PROJECT-22K08667, KAKENHI-PROJECT-22K11700, KAKENHI-PROJECT-21K08526, KAKENHI-PROJECT-22K19458, KAKENHI-PROJECT-19KK0249, KAKENHI-PROJECT-20H00629, KAKENHI-PUBLICLY-22H04806, KAKENHI-PUBLICLY-23H04776, KAKENHI-PROJECT-21H04807
[Journal Article] Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models2023
- Author(s)
  Matsukawa Toshiya、Yagi Takashi、Uchida Tohru、Sakai Mashito、Mitsushima Masaru、Naganuma Takao、Yano Hiroyuki、Inaba Yuka、Inoue Hiroshi、Yanagida Keisuke、Uematsu Masaaki、Nakao Kazuki、Nakao Harumi、Aiba Atsu、Nagashima Yoji、Kubota Tetsuya、Kubota Naoto
- Journal Title
  
  JCI Insight
  
  Volume: 8 Issue: 17
- DOI
  10.1172/jci.insight.161282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08640, KAKENHI-PROJECT-22K08667, KAKENHI-PROJECT-21K08243, KAKENHI-PROJECT-21K08542, KAKENHI-PROJECT-21K08579, KAKENHI-PROJECT-22K19545, KAKENHI-PROJECT-22K17790, KAKENHI-PROJECT-23K24390, KAKENHI-PROJECT-23K24764, KAKENHI-PROJECT-23K27996
[Journal Article] Novel Therapeutic Potentials of Taxifolin for Obesity-Induced Hepatic Steatosis, Fibrogenesis, and Tumorigenesis2023
- Author(s)
  Inoue Takayuki、Fu Bin、Nishio Miwako、Tanaka Miyako、Kato Hisashi、Tanaka Masashi、Itoh Michiko、Yamakage Hajime、Ochi Kozue、Ito Ayaka、Shiraki Yukihiro、Saito Satoshi、Ihara Masafumi、Nishimura Hideo、Kawamoto Atsuhiko、Inoue Shian、Saeki Kumiko、Enomoto Atsushi、Suganami Takayoshi、Satoh-Asahara Noriko
- Journal Title
  
  Nutrients
  
  Volume: 15 Issue: 2 Pages: 350-350
- DOI
  10.3390/nu15020350
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08526, KAKENHI-PROJECT-21K08571, KAKENHI-PROJECT-22K07456, KAKENHI-PROJECT-22K08667, KAKENHI-PROJECT-22K11700, KAKENHI-PROJECT-22K11720, KAKENHI-PROJECT-22K19524, KAKENHI-PROJECT-22K19723, KAKENHI-PROJECT-21K17557, KAKENHI-PROJECT-19KK0249, KAKENHI-PUBLICLY-21H05625, KAKENHI-PROJECT-20H03447, KAKENHI-PROJECT-21H02835, KAKENHI-PROJECT-19K07905, KAKENHI-PROJECT-19K07927, KAKENHI-PUBLICLY-22H04806
[Journal Article] Iron-rich Kupffer cells exhibit phenotypic changes during the development of liver fibrosis in NASH.2021
- Author(s)
  Kanamori Y, Tanaka M, Itoh M, Ochi K, Ito A, Hidaka I, Sakaida I, Ogawa Y, Suganami T
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 2 Pages: 2102032-2102032
- DOI
  10.1016/j.isci.2020.102032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07475, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-18J00710, KAKENHI-PROJECT-18K08508, KAKENHI-PROJECT-19K16539, KAKENHI-PUBLICLY-20H04944, KAKENHI-PUBLICLY-20H05503, KAKENHI-PROJECT-20H03447, KAKENHI-PROJECT-19H01054
[Journal Article] Role of chronic inflammation in the pathogenesis of nonalcoholic steatohepatitis: lessons from a unique mouse model using melanocortin receptor-deficient mice2021
- Author(s)
  Itoh M, Suganami T, Ogawa Y.
- Journal Title
  
  Endocr J
  
  Volume: 68 Issue: 7 Pages: 743-749
- DOI
  10.1507/endocrj.EJ21-0002
- NAID
  130008068276
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07475, KAKENHI-PROJECT-19H01054
[Journal Article] The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model.2021
- Author(s)
  Yoshioka N, Tanaka M, Ochi K, Watanabe A, Ono K, Sawada M, Ogi T, Itoh M, Ito A, Shiraki Y, Enomoto A, Ishigami M, Fujishiro M, Ogawa Y, Suganami T.
- Journal Title
  
  Biomed Pharmacother
  
  Volume: 140 Pages: 111738-111738
- DOI
  10.1016/j.biopha.2021.111738
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07475, KAKENHI-PROJECT-19K11765, KAKENHI-PROJECT-18H03372, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-18H05429, KAKENHI-PUBLICLY-20H04944, KAKENHI-PUBLICLY-20H05503, KAKENHI-PROJECT-19H01054, KAKENHI-PROJECT-20H03447, KAKENHI-PROJECT-20K06871, KAKENHI-PROJECT-21K08526, KAKENHI-PROJECT-19KK0249
[Journal Article] Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis?associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects2020
- Author(s)
  Kawakubo M, Tanaka M, Ochi K, Watanabe A, Saka-Tanaka M, Kanamori Y, Yoshioka N, Yamashita S, Goto M, Itoh M, Shirakawa I, Kanai S, Suzuki H, Sawada M, Ito A, Ishigami M, Fujishiro M, Arima H, Ogawa Y, Suganami T
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 983-983
- DOI
  10.1038/s41598-020-57935-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08508, KAKENHI-PROJECT-19K07475, KAKENHI-PROJECT-19K16539, KAKENHI-PUBLICLY-18H05039, KAKENHI-PLANNED-18H05429, KAKENHI-PROJECT-19H01054, KAKENHI-PROJECT-18J00710
[Journal Article] Chronic inflammation as a molecular basis of nonalcoholic steatohepatitis : role of macrophages and fibroblasts in the liver2020
- Author(s)
  Itoh M, Ogawa Y, Suganami T
- Journal Title
  
  Nagoya Journal of Medical Science
  
  Volume: 82 Issue: 3 Pages: 391-397
- DOI
  10.18999/nagjms.82.3.391
- NAID
  120006881540
- ISSN
  2186-3326
- URL
  https://nagoya.repo.nii.ac.jp/records/30409
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07475, KAKENHI-PUBLICLY-20H04944, KAKENHI-PUBLICLY-20H05503, KAKENHI-PROJECT-20H03447
[Journal Article] Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis2019
- Author(s)
  Asakawa M, Itoh M, Suganami T, Sakai T, Kanai S, Shirakawa I, Yuan X, Hatayama T, Shimada S, Akiyama Y, Fujiu K, Inagaki Y, Manabe I, Yamaoka S, Yamada T, Tanaka S, Ogawa Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 9 Issue: 1 Pages: 19601-19601
- DOI
  10.1038/s41598-019-56039-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07143, KAKENHI-PROJECT-19K07475, KAKENHI-PROJECT-19K22627, KAKENHI-PUBLICLY-18H05039, KAKENHI-PROJECT-19H01054, KAKENHI-PROJECT-19H01055, KAKENHI-PROJECT-17H04166, KAKENHI-PROJECT-18H02859, KAKENHI-PROJECT-16K08647, KAKENHI-PROJECT-17K01840, KAKENHI-PROJECT-18K19575
[Journal Article] Obeticholic acid protects against hepatocyte death and liver fibrosis in a murine model of nonalcoholic steatohepatitis.2018
- Author(s)
  T. Goto, M. Itoh, T. Suganami, S. Kanai, I. Shirakawa, T. Sakai, M. Asakawa,T. Yoneyama, T. Kai, Y. Ogawa.
- Journal Title
  
  Sci. Rep.
  
  Volume: 8 Issue: 1 Pages: 8157-8157
- DOI
  10.1038/s41598-018-26383-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05500, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-16H05171, KAKENHI-PROJECT-16KT0110, KAKENHI-PROJECT-16K08732, KAKENHI-PROJECT-17K19686
[Journal Article] Fatty Acid Binding Protein 4 (FABP4) Overexpression in Intratumoral Hepatic Stellate Cells within Hepatocellular Carcinoma with Metabolic Risk Factors2018
- Author(s)
  Chiyonobu Norimichi、Shimada Shu、Akiyama Yoshimitsu、Mogushi Kaoru、Itoh Michiko、Akahoshi Keiichi、Matsumura Satoshi、Ogawa Kosuke、Ono Hiroaki、Mitsunori Yusuke、Ban Daisuke、Kudo Atsushi、Arii Shigeki、Suganami Takayoshi、Yamaoka Shoji、Ogawa Yoshihiro、Tanabe Minoru、Tanaka Shinji
- Journal Title
  
  Am. J. Pathol.
  
  Volume: 188 Issue: 5 Pages: 1213-1224
- DOI
  10.1016/j.ajpath.2018.01.012
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0110, KAKENHI-PROJECT-16K08732, KAKENHI-PROJECT-17K10689, KAKENHI-PROJECT-16H02670, KAKENHI-PROJECT-16H05171, KAKENHI-PROJECT-16K08647, KAKENHI-PROJECT-16K10476, KAKENHI-PROJECT-17K10652, KAKENHI-PROJECT-18K06198, KAKENHI-PROJECT-18K08798, KAKENHI-PROJECT-18K19575, KAKENHI-PUBLICLY-17H05500
[Journal Article] Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH2018
- Author(s)
  Shiba Kumiko、Tsuchiya Kyoichiro、Komiya Chikara、Miyachi Yasutaka、Mori Kentaro、Shimazu Noriko、Yamaguchi Shinobu、Ogasawara Naomi、Katoh Makoto、Itoh Michiko、Suganami Takayoshi、Ogawa Yoshihiro
- Journal Title
  
  Sci. Rep.
  
  Volume: 8 Issue: 1 Pages: 2362-2362
- DOI
  10.1038/s41598-018-19658-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16KT0110, KAKENHI-PROJECT-16K08732, KAKENHI-PROJECT-17K19686, KAKENHI-PUBLICLY-17H05500, KAKENHI-PROJECT-16H05171, KAKENHI-PROJECT-16K15234
[Journal Article] Evaluation of hepatic function using dynamic contrast-enhanced magnetic resonance imaging in melanocortin 4 receptor-deficient mice as a model of nonalcoholic steatohepatitis.2018
- Author(s)
  T. Yamada, Y. Kashiwagi, T. Rokugawa, H. Kato, H. Konishi, T. Hamada, R. Nagai, Y. Masago, M. Itoh, T. Suganami, Y. Ogawa, H. Watabe, K. Abe.
- Journal Title
  
  Magn. Reson. Immaging
  
  Volume: 57 Pages: 210-217
- DOI
  10.1016/j.mri.2018.11.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05500, KAKENHI-PROJECT-16H05171, KAKENHI-PROJECT-16KT0110, KAKENHI-PROJECT-19K07475
[Journal Article] Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis.2017
- Author(s)
  C. Komiya, M. Tanaka, K. Tsuchiya, N. Shimazu, K. Mori, S. Furuke, Y. Miyachi, K. Shiba, S. Yamaguchi, K. Ikeda, K. Ochi, K. Nakabayashi, K. Hata, M. Itoh, T. Suganami, Y. Ogawa.
- Journal Title
  
  Sci. Rep.
  
  Volume: 7 Issue: 1 Pages: 44754-44754
- DOI
  10.1038/srep44754
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01371, KAKENHI-PROJECT-16H05171, KAKENHI-PROJECT-16KT0110, KAKENHI-PROJECT-15K09423, KAKENHI-PROJECT-16K08732, KAKENHI-PROJECT-16K15234
[Journal Article] CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis2017
- Author(s)
  Itoh Michiko、Suganami Takayoshi、Kato Hideaki、Kanai Sayaka、Shirakawa Ibuki、Sakai Takeru、Goto Toshihiro、Asakawa Masahiro、Hidaka Isao、Sakugawa Hiroshi、Ohnishi Koji、Komohara Yoshihiro、Asano Kenichi、Sakaida Isao、Tanaka Masato、Ogawa Yoshihiro
- Journal Title
  
  JCI Insight
  
  Volume: 2 Issue: 22 Pages: 1-16
- DOI
  10.1172/jci.insight.92902
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16KT0110, KAKENHI-PROJECT-16K08732, KAKENHI-PROJECT-16K19823, KAKENHI-PUBLICLY-17H05500, KAKENHI-PLANNED-26110006, KAKENHI-PROJECT-16H05171, KAKENHI-PROJECT-17H04068, KAKENHI-PROJECT-16K15234, KAKENHI-PROJECT-16K19331
[Journal Article] Eicosapentaenoic acid ameliorates non-alcoholic steatohepatitis in a novel mouse model using Melanocortin 4 receptor-deficient mice.2015
- Author(s)
  K. Konuma, M. Itoh, T. Suganami, S. Kanai, N. Nakagawa, T. Sakai, H. Kawano, M. Hara, S. Kojima, Y. Izumi, Y. Ogawa.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 3 Pages: e0121528-e0121528
- DOI
  10.1371/journal.pone.0121528
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J40047, KAKENHI-PUBLICLY-25126705, KAKENHI-PROJECT-26860692, KAKENHI-PUBLICLY-15H01371, KAKENHI-PUBLICLY-26102742
[Journal Article] Hepatic crown-like structure : a unique histological feature in non-alcoholic steatohepatitis in mice and humans2013
- Author(s)
  M. Itoh, H. Kato, T. Suganami, K. Konuma, Y. Marumoto, S. Terai, H. Sakugawa, S. Kanai, M. Hamaguchi, T. Fukaishi, S. Aoe, K. Akiyoshi, Y. Komohara, M. Takeya, I. Sakaida, Y. Ogawa
- Journal Title
  
  PLoS ONE
  
  Volume: 8 Issue: 12 Pages: e82163-e82163
- DOI
  10.1371/journal.pone.0082163
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117007, KAKENHI-PROJECT-24790916, KAKENHI-PUBLICLY-25126705, KAKENHI-PROJECT-25670439
[Journal Article] n-3多価不飽和脂肪酸と糖代謝改善, 動脈硬化改善のメカニズム2013
- Author(s)
  伊藤美智子, 菅波孝祥, 小川佳宏
- Journal Title
  
  内分泌・糖尿病・代謝内科
  
  Volume: 36 Pages: 502-506
- Data Source
  KAKENHI-PROJECT-24790916
[Journal Article] 中枢神経系を介するレプチンの炎症・免疫調節作用2013
- Author(s)
  伊藤美智子, 田中都, 菅波孝祥, 小川佳宏
- Journal Title
  
  BIO Clinica
  
  Volume: 28 Pages: 45-48
- Data Source
  KAKENHI-PROJECT-24790916
[Journal Article] 脂肪酸の質的・量的変化がもたらす慢性炎症とメタボリックシンドローム2012
- Author(s)
  伊藤美智子, 菅波孝祥, 小川佳宏
- Journal Title
  
  実験医学
  
  Volume: 30 Pages: 418-422
- Data Source
  KAKENHI-PROJECT-24790916
[Journal Article] Melanocortin-4 receptor-deficient mice as a novel mouse model of non-alcoholic steatohepatitis2011
- Author(s)
  M. Itoh, T. Suganami, N. Nakagawa, M. Tanaka, Y. Yamamoto, Y. Kamei, S. Terai, I. Sakaida, Y. Ogawa
- Journal Title
  
  Am. J. Pathol
  
  Volume: 179 Pages: 2454-2463
- Data Source
  KAKENHI-PROJECT-22890052
[Journal Article] Adipose tissue remodeling as homeostatic inflammation2011
- Author(s)
  Itoh M, Suganami T, Hachiya R, Ogawa Y
- Journal Title
  
  International Journal of Inflammation
  
  Volume: 2011 Pages: 720926-720926
- DOI
  10.4061/2011/720926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J40078, KAKENHI-PLANNED-21117007, KAKENHI-PROJECT-21689026, KAKENHI-PROJECT-22890052
[Journal Article] Melanocortin-4 receptor-deficient mice as a novel mouse model of non-alcoholic steatohepatitis2011
- Author(s)
  M. Itoh, T. Suganami, N. Nakagawa, M. Tanaka, Y. Yamamoto, Y. Kamei, S. Terai, I. Sakaida, Y. Ogawa
- Journal Title
  
  Am. J. Pathol.
  
  Volume: 179 Issue: 5 Pages: 2454-2463
- DOI
  10.1016/j.ajpath.2011.07.014
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117007, KAKENHI-PROJECT-22390150, KAKENHI-PROJECT-22890052, KAKENHI-PUBLICLY-23126508
[Journal Article] Adipose tissue inflammation as homeostatic inflammation2011
- Author(s)
  M. Itoh, T. Suganami, R. Hachiya, Y. Ogawa
- Journal Title
  
  Int. J. Inflamm
  
  Volume: 2011 Pages: 720926-720926
- Data Source
  KAKENHI-PROJECT-22890052
[Journal Article] Anti-obesity effectof eicosapentaenoic acid in high-fat/high-sucrose diet induced obesity : importance of hepatic lipogenesis2010
- Author(s)
  A. Sato, H. Kawano, T. Notsu, M. Ohta, M. Nakakuki, K. Mizuguchi, M. Itoh, T. Suganami, Y. Ogawa
- Journal Title
  
  Diabetes
  
  Volume: 59 Pages: 2495-2504
- Data Source
  KAKENHI-PROJECT-22890052
[Journal Article] Anti-obesity effect of eicosapentaenoic acid in high-fat/high-sucrose diet induced obesity : importance of hepatic lipogenesis2010
- Author(s)
  A.Sato, H.Kawano, T.Notsu, M.Ohta, M.Nakakuki, K.Mizuguchi, M.Itoh, T.Suganami, Y.Ogawa
- Journal Title
  
  Diabetes
  
  Volume: 59 Pages: 2495-2504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890052
[Patent] 非アルコール性脂肪肝炎治療用医薬組成物2020
- Inventor(s)
  田村篤志, 由井伸彦, 菅波孝祥, 伊藤美智子
- Industrial Property Rights Holder
  田村篤志, 由井伸彦, 菅波孝祥, 伊藤美智子
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-139225
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K07475
[Patent] 非アルコール性脂肪肝炎モデル動物の製造方法2015
- Inventor(s)
  小川佳宏、菅波孝祥、伊藤美智子
- Industrial Property Rights Holder
  小川佳宏、菅波孝祥、伊藤美智子
- Industrial Property Rights Type
  特許
- Filing Date
  2015-06-18
- Data Source
  KAKENHI-PROJECT-26860692
[Presentation] 非アルコール性脂肪性肝炎の病態を駆動するマクロファージ活性化機構2023
- Author(s)
  金井紗綾香、伊藤美智子、田中都、白川伊吹、菅波孝祥
- Organizer
  日本生化学会中部支部地方会
- Data Source
  KAKENHI-PROJECT-22K08667
[Presentation] 細胞死を起点とするNASHの病態理解と医学応用ー医工連携を通してー2023
- Author(s)
  伊藤美智子、菅波孝祥
- Organizer
  第44回日本肥満学会・第41回肥満症治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08667
[Presentation] NASHにおけるマクロファージの脂質代謝変容とリソソームストレス2023
- Author(s)
  伊藤美智子、菅波孝祥
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08667
[Presentation] NASH病態形成における脂肪毒性の理解と医学応用2023
- Author(s)
  伊藤美智子、菅波孝祥
- Organizer
  第9回肝臓と糖尿病・代謝研究会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08667
[Presentation] NASH発症におけるマクロファージのリソソーム機能障害と病態生理的意義の解明2022
- Author(s)
  伊藤美智子、金井紗綾香、白川伊吹、田中都、小川佳宏、菅波孝祥
- Organizer
  第43回日本肥満学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08667
[Presentation] Role of cholesterol metabolism in macrophages in the pathogenesis of non-alcoholic steatohepatitis2022
- Author(s)
  伊藤美智子、菅波孝祥
- Organizer
  第26回日本心血管内分泌代謝学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08667
[Presentation] The role of cholesterol overload in macrophages as a novel molecular mechanism of non-alcoholic steatohepatitis.2022
- Author(s)
  伊藤美智子、菅波孝祥
- Organizer
  第100回日本生理学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08667
[Presentation] 中枢MC4Rシグナルによる肝臓の炎症慢性化機構2022
- Author(s)
  付友紀子、伊藤美智子、田中都、Fu Bin、越智梢、吉岡直輝、菅波孝祥
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K08667
[Presentation] マクロファージの脂質代謝障害に着目したNASH発症機構の解明2022
- Author(s)
  伊藤美智子、田村篤志、金井紗綾香、白川伊吹、田中都、金森耀平、小川佳宏、菅波孝祥
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K08667
[Presentation] 新規NASHマウスモデルの開発と病態形成機構の解明2021
- Author(s)
  伊藤美智子、菅波孝祥、小川佳宏
- Organizer
  第41回日本肥満学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07475
[Presentation] 死細胞を起点とする慢性炎症と非アルコール脂肪性肝炎2021
- Author(s)
  伊藤美智子、小川佳宏、菅波孝祥
- Organizer
  第36回日本糖尿病合併症学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07475
[Presentation] NASHマウスモデルの確立を通じた病態解析・治療戦略開発への挑戦2021
- Author(s)
  伊藤美智子、小川佳宏、菅波孝祥
- Organizer
  第64回日本糖尿病学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07475
[Presentation] NASH発症におけるマクロファージのコレステロール代謝障害と機能変容2021
- Author(s)
  伊藤美智子、田村篤志、金井紗綾香、白川伊吹、田中都、金森耀平、小川佳宏、菅波孝祥
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07475
[Presentation] Role of cholesterol metabolism in macrophages in the pathogenesis of non-alcoholic steatohepatitis2021
- Author(s)
  Michiko Itoh, Takayoshi Suganami
- Organizer
  第98回日本生理学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07475
[Presentation] NASH発症における死細胞貪食・処理の病態生理的意義2021
- Author(s)
  伊藤美智子、田中都、小川佳宏、菅波孝祥
- Organizer
  日本Cell Death学会第29回学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07475
[Presentation] NASH発症過程における死細胞貪食障害の病態生理的意義2021
- Author(s)
  伊藤美智子、金井紗綾香、金森耀平、田中都、松元亮、宮原裕二、小川佳宏、菅波孝祥
- Organizer
  第41回日本肥満学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07475
[Presentation] マクロファージにおける脂質代謝障害に着目したNASH発症機構の解明2021
- Author(s)
  伊藤美智子、金井紗綾香、田村篤志、白川伊吹、金森耀平、田中都、松元亮、宮原裕二、小川佳宏、菅波孝祥
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07475
[Presentation] 新規マウスモデルの確立による非アルコール性脂肪性肝炎の病態生理の解明2020
- Author(s)
  伊藤美智子
- Organizer
  第93回日本内分泌学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07475
[Presentation] 死細胞に対する細胞応答に基づくNASH発症機構の解明2019
- Author(s)
  伊藤美智子、菅波孝祥、金井紗綾香、白川伊吹、酒井建、後藤俊宏、浅川雅博、小川佳宏
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07475
[Presentation] 代謝ストレスに対する細胞応答とNASH・肝癌発症機構2019
- Author(s)
  伊藤美智子、菅波孝祥、小川佳宏
- Organizer
  第6回肝臓と糖尿病・代謝研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07475
[Presentation] マクロファージによるメタボリックシンドロームの制御機構2019
- Author(s)
  菅波孝祥, 田中　都, 伊藤美智子,小川佳宏
- Organizer
  第92回日本生化学会
- Data Source
  KAKENHI-PROJECT-19K07475
[Presentation] NASH肝線維芽細胞はFGF9産生を介して腫瘍形成を促進する2019
- Author(s)
  浅川雅博、伊藤美智子、菅波孝祥、酒井建、金井紗綾香、白川伊吹、畑山朋美、田中真二、山田哲也、小川佳宏
- Organizer
  第40回日本肥満学会
- Data Source
  KAKENHI-PROJECT-19K07475
[Presentation] 細胞死を核とする炎症慢性化機構と生活習慣病2019
- Author(s)
  菅波孝祥、田中　都、伊藤美智子、小川佳宏
- Organizer
  第40回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-19K07475
[Presentation] NASH発症に重要なマクロファージサブセットの同定2018
- Author(s)
  伊藤美智子、菅波孝祥、加藤秀昭、金井紗綾香、白川伊吹、酒井建、後藤俊宏、浅川雅博、小川佳宏
- Organizer
  第91回日本内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08732
[Presentation] CD11c-positive macrophages drive obesity-induced liver fibrosis in a murine model of NASH2018
- Author(s)
  Michiko Itoh
- Organizer
  第47回日本免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K08732
[Presentation] 死細胞を起点とするNASH発症機構の解明ー新規マウスモデルの確立を通してー2018
- Author(s)
  伊藤美智子、菅波孝祥、小川佳宏
- Organizer
  第39回日本肥満学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K08732
[Presentation] 死細胞とマクロファージの相互作用に注目したNASH発症機構の解2018
- Author(s)
  伊藤美智子、菅波孝祥、加藤秀昭、金井紗綾香、白川伊吹、酒井建、後藤俊宏、浅川雅博、小川佳宏
- Organizer
  第61回日本糖尿病学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08732
[Presentation] 細胞死を起点とする非アルコール性脂肪性肝炎発症機構の解明2017
- Author(s)
  伊藤美智子、菅波孝祥、金井紗綾香、白川伊吹、小川佳宏
- Organizer
  第31回日本糖尿病・肥満動物学会
- Place of Presentation
  はまぎんホールヴィアマーレ（神奈川県横浜市）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-16K08732
[Presentation] 細胞死を起点とするマクロファージの形質変化と非アルコール性脂肪性肝炎2017
- Author(s)
  伊藤美智子、菅波孝祥、金井紗綾香、白川伊吹、小川佳宏
- Organizer
  第54回日本臨床分子医学会
- Data Source
  KAKENHI-PROJECT-16K08732
[Presentation] 非アルコール性脂肪性肝炎の病態形成におけるhepatic crown-like structureの病態生理的意義2017
- Author(s)
  伊藤美智子、菅波孝祥、金井紗綾香、白川伊吹、小川佳宏
- Organizer
  第90回日本内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08732
[Presentation] NASH発症過程におけるマクロファージの形質変化-hepatic crown-like structureに注目して-2017
- Author(s)
  伊藤美智子、菅波孝祥、金井紗綾香、白川伊吹、酒井健、後藤俊宏、浅川雅博、日高勲、坂井田功、小川佳宏
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-16K08732
[Presentation] Hepatocyte death-triggered CD11c-positive macrophage accumulation induces liver fibrosis in a murine model of non-alcoholic steatohepatitis.2017
- Author(s)
  Michiko Itoh, Takayoshi Suganami, Sayaka Kanai, Ibuki Shirakawa, Takeru Sakai, Toshihiro Goto, Masahiro Asakawa, Isao Hidaka, Isao Sakaida, Yoshihiro Ogawa
- Organizer
  AASLD The Liver Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08732
[Presentation] 非アルコール性脂肪性肝炎の病態形成におけるhepatic crown-like structureの病態生理的意義2016
- Author(s)
  伊藤美智子、菅波孝祥、小川佳宏
- Organizer
  第37回日本炎症・再生医学会
- Place of Presentation
  京都市勧業館みやこめっせ（京都府京都市）
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-16K08732
[Presentation] 新しいマウスモデルを用いたNASH発症機構の解明と医学応用2016
- Author(s)
  伊藤美智子、菅波孝祥、小川佳宏
- Organizer
  第37回日本肥満学会
- Place of Presentation
  東京ファッションタウンビル（東京都江東区）
- Year and Date
  2016-10-07
- Invited
- Data Source
  KAKENHI-PROJECT-16K08732
[Presentation] NASHモデルマウスにおけるテネグリプチンの肝保護効果の検討2015
- Author(s)
  酒井建、伊藤美智子、菅波孝祥、金井紗綾香、小川佳宏
- Organizer
  日本肥満学会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26860692
[Presentation] 臓器間ネットワークによる異所性脂肪蓄積の新たな分子機構2015
- Author(s)
  菅波孝祥、田中都、伊藤美智子、小川佳宏
- Organizer
  日本内分泌学会学術総会
- Place of Presentation
  ホテルニューオータニ東京（東京都千代田区）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26860692
[Presentation] hepatic crown-like structureに注目したNASH発症機構の解析2015
- Author(s)
  伊藤美智子、加藤秀昭、金井紗綾香、菅波孝祥、小川佳宏
- Organizer
  日本肥満学会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26860692
[Presentation] NASHの病勢を反映する病理組織マーカー：hepatic crown-like structureの意義2014
- Author(s)
  伊藤美智子、菅波孝祥、小沼邦葉、丸本芳雄、寺井崇二、坂井田功、小川佳宏
- Organizer
  第28回日本糖尿病・肥満動物学会
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-24790916
[Presentation] NASH に対するEPA の予防・治療効果の検討-新規NASH モデルを用いて-(口演)2014
- Author(s)
  小沼邦葉, 伊藤美智子, 他
- Organizer
  第28回日本糖尿病・肥満動物学会
- Place of Presentation
  宮崎
- Year and Date
  2014-02-15
- Data Source
  KAKENHI-PROJECT-24790916
[Presentation] NASH の病勢を反映する病理組織マーカー(口演) hepatic crown-like structure の意義2014
- Author(s)
  伊藤美智子, 他
- Organizer
  第28回日本糖尿病・肥満動物学会
- Place of Presentation
  宮崎
- Year and Date
  2014-02-14
- Data Source
  KAKENHI-PROJECT-24790916
[Presentation] NASH発症におけるhepatic crown-like structureの意義2013
- Author(s)
  伊藤美智子、菅波孝祥、小沼邦葉、丸本芳雄、寺井崇二、佐久川廣、坂井田功、小川佳宏
- Organizer
  第34回日本肥満学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790916
[Presentation] NASH 発症におけるhepatic crown-like structure の意義(口演)2013
- Author(s)
  伊藤美智子, 他
- Organizer
  第34回日本肥満学会
- Place of Presentation
  東京
- Year and Date
  2013-10-12
- Data Source
  KAKENHI-PROJECT-24790916
[Presentation] NASHの発症・進展と脂肪組織炎症-新しいNASHモデル・MC4R欠損マウスを用いて-2011
- Author(s)
  伊藤美智子、菅波孝祥、田中都、亀井康富、小川佳宏
- Organizer
  第32回日本肥満学会
- Place of Presentation
  淡路島
- Data Source
  KAKENHI-PROJECT-22890052
[Presentation] MC4R欠損マウスを用いた新規NASHモデルの確立2011
- Author(s)
  伊藤美智子、菅波孝祥、中川信貴、田中都、亀井康富、小川佳宏
- Organizer
  第84回日本内分泌学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22890052
[Presentation] Melanocortin-4 receptor-deficient mice as a novel mouse model of non-alcoholic steatohepatitis.2011
- Author(s)
  M.Itoh, T.Suganami, N.Nakagawa, M.Tanaka, Y.Yamamoto, Y.Kamei, Y.Ogawa
- Organizer
  Keystone symposia : Type 2 diabetes, insulin resistance and metabolic dysfunction and obesity
- Place of Presentation
  Keystone, Colorado, USA
- Year and Date
  2011-01-13
- Data Source
  KAKENHI-PROJECT-22890052
[Presentation] Melanocortin-4 receptor-deficient mice as a novel mouse model of non-alcoholic steatohepatitis2011
- Author(s)
  M. Itoh, T. Suganami, N. Nakagawa, M. Tanaka, Y. Yamamoto, Y. Kamei, Y. Ogawa
- Organizer
  Keystonesymposia : Type 2 diabetes, insulin resistance and metabolic dysfunction and obesity. Keystone
- Place of Presentation
  Colorado, USA
- Data Source
  KAKENHI-PROJECT-22890052
[Presentation] 新しいNASHモデルとしてのMC4R欠損マウス2010
- Author(s)
  伊藤美智子、菅波孝祥、中川信貴、田中都、亀井康富、小川佳宏
- Organizer
  第31回日本肥満学会
- Place of Presentation
  前橋
- Data Source
  KAKENHI-PROJECT-22890052
[Presentation] 新しいNASHモデルとしてのMC4R欠損マウス2010
- Author(s)
  伊藤美智子、菅波孝祥、中川信貴、田中都、亀井康富、小川佳宏
- Organizer
  日本肥満学会
- Place of Presentation
  前橋
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-22890052
[Presentation] NASH発症過程におけるマクロファージの動態解析―hepatic crown-like structureに注目して
- Author(s)
  伊藤美智子、加藤秀昭、菅波孝祥、小沼邦葉、酒井建、小川佳宏
- Organizer
  日本肥満学会
- Place of Presentation
  フェニックスシーガイアコンベンションセンター（宮崎県宮崎市）
- Year and Date
  2014-10-24 – 2014-10-25
- Data Source
  KAKENHI-PROJECT-26860692

1. SUGANAMI takayoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
2. KUBOTA Tetsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 小川佳宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 田中都

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 山岡昇司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ITOH MICHIKO 伊藤 美智子

ITO Michiko 伊藤 美智子

Research Projects

Research Products

Co-Researchers

Pathophysiological role of lipid stress induced by dead cell clearance in the development of NASHPrincipal Investigator

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Cell death-induced inflammation and the development of NASH and hepatocellular carcinomaPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Molecular mechanism of hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitisPrincipal Investigator

Principal Investigator

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Research Institution

Pathophysiological role of macrophages and leptin in the development of non-alcoholic steatohepaititisPrincipal Investigator

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Pathophysiological role of adipo-hepatic axis in the development of non-alcoholic steatohepatitisPrincipal Investigator

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Pathophysiological role of macrophages in development of NASHPrincipal Investigator

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[Book] Innovative Medicine - Basic Research and Development2015

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[Book] 疾患モデルの作成と利用-糖尿病・肥満/感染症2012

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[Book] そうだったんだ!脂肪酸2012

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[Journal Article] Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH2023

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[Journal Article] Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models2023

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[Journal Article] Novel Therapeutic Potentials of Taxifolin for Obesity-Induced Hepatic Steatosis, Fibrogenesis, and Tumorigenesis2023

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[Journal Article] Iron-rich Kupffer cells exhibit phenotypic changes during the development of liver fibrosis in NASH.2021

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[Journal Article] Role of chronic inflammation in the pathogenesis of nonalcoholic steatohepatitis: lessons from a unique mouse model using melanocortin receptor-deficient mice2021

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ITOH MICHIKO 伊藤美智子

ITO Michiko 伊藤美智子