Yamazaki Yuichi 山崎勇一

Researcher Number	00582404
Other IDs
Affiliation (Current)	2025: 群馬大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2023: 群馬大学, 医学部附属病院, 講師 2014 – 2023: 群馬大学, 医学部附属病院, 助教 2012 – 2013: 群馬大学, 医学(系)研究科(研究院), 助教 2011: 群馬大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology / Basic Section 47060:Clinical pharmacy-related / Basic Section 56030:Urology-related / Basic Section 53010:Gastroenterology-related / Environmental and hygienic pharmacy
Keywords	Principal Investigator 核内受容体CAR / 肝前駆細胞 / 胆管障害 / dysbiosis / 腸内フローラ / 胆管再生 / 胆管形成 / 胆管上皮細胞増殖 / 肝再生 / オーバル細胞増殖 … More Except Principal Investigator … More 核内受容体 / CAR / ＣＡＲ / サルコペニア / 加齢 / 薬物代謝 / 肝疾患 / リン酸化核内受容体 / 前立腺癌 / アンドロゲン受容体 / 酸化ストレス / ノックアウトマウス / アルコール性肝炎 / 転写共役活性化因子 / PDIP1 / 肝内胆管癌 / 化学発癌 / 胆管癌 / マイクロアレイ / 癌 / バイオテクノロジー / トランスレーショナルリサーチ / DSS腸炎 / PXR / 炎症性サイトカイン / ＤＳＳ腸炎 / ＰＸＲ / 核内レセプター / 炎症性腸疾患 / 動物 / 遺伝子 / 発現制御 / 病理学 / 脂質 Less

前立腺癌の去勢抵抗性獲得メカニズムとリン酸化核内受容体の病態解明
- Principal Investigator
  
  柿崎暁
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  独立行政法人国立病院機構高崎総合医療センター(臨床研究部)
Development of a drug metabolism capacity and interaction evaluation system for the elderly with sarcopenia and avoidance of adverse drug reaction risks.
- Principal Investigator
  
  戸島洋貴
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Gunma University
Verification of universal oxidative stress regulation ability by transcriptional coactivator PDIP1 and search for target molecules
- Principal Investigator
  
  Ken Sato
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Gunma University
腸内フローラの破綻時の胆管障害における核内受容体CAR/PXRの役割Principal Investigator
- Principal Investigator
  
  山崎勇一
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Gunma University
The role of nuclear receptor CAR in the pathogenesis of intrahepatic cholangiocellular carcinoma
- Principal Investigator
  
  Kakizaki Satoru
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Gunma University
The role of nuclear receptor CAR in hepatic progenitor cell-mediated bile duct epithelial cell proliferation, bile duct formation and regenerationPrincipal Investigator
- Principal Investigator
  
  Yamazaki Yuichi
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gunma University
The role of a transcriptional coactivator (PDIP1) that functions as a transcriptional coregulator of several nuclear receptors in the physiopathological process of the liver
- Principal Investigator
  
  SATO KEN
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gunma University
The role of nuclear receptors PXR/CAR in the pathogenesis of inflammatory bowel diseases.
- Principal Investigator
  
  Kakizaki Satoru
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gunma University
The role of nuclear receptor CAR in the liver regeneration and repair madiated by oval cell proliferation.Principal Investigator
- Principal Investigator
  
  Yamazaki Yuichi
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gunma University
The role of nuclear receptor coactivator PDIP1 in non-alcholic steatohepatitis
- Principal Investigator
  
  Sato Ken
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gunma University

All 2021 2019 2016 2015 2014 2013 2012 2011 2010

All Journal Article Presentation

[Journal Article] Correlative microscopy and block-face imaging (CoMBI) method for both paraffin-embedded and frozen specimens2021
- Author(s)
  Ishii Nobukazu、Tajika Yuki、Murakami Tohru、Galipon Josephine、Shirahata Hiroyoshi、Mukai Ryo、Uehara Daisuke、Kaneko Ryosuke、Yamazaki Yuichi、Yoshimoto Yuhei、Iwasaki Hirohide
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 13108-13108
- DOI
  10.1038/s41598-021-92485-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04895, KAKENHI-PROJECT-17K09453, KAKENHI-PROJECT-19K07241, KAKENHI-PROJECT-20H02932
[Journal Article] Constitutive androstane receptor and pregnane X receptor cooperatively ameliorate DSS-induced colitis.2019
- Author(s)
  Uehara D, Tojima H, Kakizaki S, Yamazaki Y, Horiguchi N, Takizawa D, Sato K, Yamada M, Uraoka T.
- Journal Title
  
  Dig Liver Dis.
  
  Volume: Feb;51(2) Issue: 2 Pages: 226-235
- DOI
  10.1016/j.dld.2018.10.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09339, KAKENHI-PROJECT-17K08387
[Journal Article] Expression of amino acid transporters (LAT1, ASCT2 and xCT) as clinical significance in hepatocellular carcinoma.2014
- Author(s)
  Namikawa M, Kakizaki S, Kaira K, Tojima H, Yamazaki Y, Horiguchi N, Sato K, Oriuchi N, Tominaga H, Sunose Y, Nagamori S, Kanai Y, Oyama T, Takeyoshi I, Yamada M.
- Journal Title
  
  Hepatol Res.
  
  Volume: in press Issue: 9 Pages: 1014-1022
- DOI
  10.1111/hepr.12431
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390217, KAKENHI-PROJECT-24591198, KAKENHI-PUBLICLY-25136714, KAKENHI-PROJECT-25460941, KAKENHI-PROJECT-25461801, KAKENHI-PROJECT-26461895
[Journal Article] MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in ob/ob mice.2014
- Author(s)
  Ohyama T, Sato K, Yamazaki Y, Hashizume H, Horiguchi N, Kakizaki S, Mori M, Kusano M, Yamada M.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 20 Issue: 43 Pages: 16227-35
- DOI
  10.3748/wjg.v20.i43.16227
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460941, KAKENHI-PROJECT-25460976
[Journal Article] Transforming growth factor-αactivates pancreatic stellate cells and may be involved in matrix metalloproteinase-1 upregulation2013
- Author(s)
  Tahara H, Sato K, Yamazaki Y, Ohyama T, Horiguchi N, Hashizume H, Kakizaki S, Takagi H, Ozaki I, Arai H, Hirato J, Jesenofsky R, Masamune A, Mori M
- Journal Title
  
  Lab Invest
  
  Volume: 93(6) Pages: 720-32
- Data Source
  KAKENHI-PROJECT-23590959
[Journal Article] DDCにより誘導される肝障害，肝前駆細胞，オーバル細胞増殖を介した肝再生，修復における核内受容体CARの役割2013
- Author(s)
  山崎勇一、柿崎暁、森昌朋、根岸正彦
- Journal Title
  
  消化器内科
  
  Volume: ５６巻第３号 Pages: 301310-301310
- Data Source
  KAKENHI-PROJECT-24590954
[Journal Article] Transforming growth factor-α activates pancreatic stellate cells and may be involved in matrix metalloproteinase-1 upregulation.2013
- Author(s)
  Tahara H, Sato K, Yamazaki Y, Ohyama T, Horiguchi N, Hashizume H, Kakizaki S, Takagi H, Ozaki I, Arai H, Hirato J, Jesenofsky R, Masamune A, Mori M.
- Journal Title
  
  Lab Invest
  
  Volume: 93 Pages: 720-732
- DOI
  10.1155/2013/458543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460941
[Journal Article] Transforming growth factor-αattenuates hepatic fibrosis : possible involvement of matrix metalloproteinase-12011
- Author(s)
  Ohyama T, Yamazaki Y, Sato K, Horiguchi N, Ichikawa T, Kakizaki S, Takagi H, Mori M
- Journal Title
  
  Liver Int
  
  Volume: 31(4) Pages: 572-84
- Data Source
  KAKENHI-PROJECT-23590959
[Presentation] 核内レセプターからみた肝疾患「核内レセプターCAR(constitutive androstane receptor)の肝疾患における役割」2016
- Author(s)
  柿崎暁,山崎勇一,Masahiko Negishi.
- Organizer
  第52回日本肝臓学会総会　（ワークショップ）
- Place of Presentation
  千葉市（日本）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-25460941
[Presentation] Development of new therapeutic agents for inflammatory bowel diseases targeting the nuclear receptor CAR/PXR.2016
- Author(s)
  Kakizaki S, Uehara D, Yamazaki Y, Horiguchi N, Inoue Y.
- Organizer
  GUMI&AMDE 2016(第3回群馬大学医療開発国際シンポジウム, 第８回先端マイクロデバイス工学国際会議）
- Place of Presentation
  桐生市（日本）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460941
[Presentation] IGFBP1 mediates pregnane X receptor-induced morphological changes and migration of hepatocellular carcinoma cells.2015
- Author(s)
  Yamazaki Y, Kodama S, Kakizaki S, et al.
- Organizer
  APDW2015(アジア太平洋消化器病学会）
- Place of Presentation
  台北市（台湾）
- Year and Date
  2015-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460941
[Presentation] 肝細胞癌株におけるIGFBP-1を介した核内受容体PXR活性化による形態変化、細胞遊走2015
- Author(s)
  山崎勇一、児玉進、柿崎暁、他
- Organizer
  第57回日本消化器病学会大会
- Place of Presentation
  グランドプリンスホテル新高輪（東京）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460941
[Presentation] マウスアルコール脂肪肝炎モデルにおける細胞特異的なSTAT3の役割2013
- Author(s)
  堀口昇男, 佐藤賢, 山崎勇一, ら
- Organizer
  アルコール医学生物学研究会学術集会
- Data Source
  KAKENHI-PROJECT-23590959
[Presentation] 臓器線維化(肝・膵を中心)研究・診療の最前線抗酸化作用を有するCa拮抗薬アゼルニジピンの肝線維化抑制効果とそのメカニズム臨床応用の可能性2012
- Author(s)
  大山達也, 佐藤賢, 山崎勇一, 堀口昇男, ら
- Organizer
  日本消化器病学会
- Data Source
  KAKENHI-PROJECT-23590959
[Presentation] MIF (マクロファージ遊走阻止因子)は高脂肪食による肝障害、脂質沈着(Steatosis)、および肝線維化を抑制する2012
- Author(s)
  堀口昇男, 佐藤賢, 山崎勇一, ら
- Organizer
  日本肝臓学会
- Data Source
  KAKENHI-PROJECT-23590959
[Presentation] 肝線維化の病態解明と治療への展開カルシウム拮抗薬アゼルニジピンによる肝線維化抑制臨床応用への展望2012
- Author(s)
  大山達也, 佐藤賢, 山崎勇一, 堀口昇男, ら
- Organizer
  日本肝臓学会
- Place of Presentation
  (共同演者)
- Data Source
  KAKENHI-PROJECT-23590959
[Presentation] NASH/NAFLDの病因・病態と予後NASHの肝線維化進行度別予後とNASH-HCC症例の予後2010
- Author(s)
  橋爪洋明, 佐藤賢, 山崎勇一, 堀口昇男, ら
- Organizer
  日本肝臓学会
- Place of Presentation
  (共同演者)
- Data Source
  KAKENHI-PROJECT-23590959

1. Kakizaki Satoru (80344935)

# of Collaborated Projects: 7 results

# of Collaborated Products: 8 results
2. 堀口昇男 (10550022)

# of Collaborated Projects: 5 results

# of Collaborated Products: 11 results
3. 戸島洋貴 (80807537)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. Sato Ken (40396619)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
5. YOSHINARI Kouichi (60343399)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. TAHARA Hiroki

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
7. SATOH tetsurou (40302484)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
8. 井上裕介 (90304302)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TAKIZAWA Daichi

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 井上貴子 (00431700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 植原大介 (70850139)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 柴田康博 (90344936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Yoshino Satoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Nakajima Yoshimi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Ohyama Tatsuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Gyao Bin

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NAGAMORI Shushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 山田英二郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 金子涼輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 金井好克

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamazaki Yuichi 山崎 勇一

Research Projects

Research Products

Co-Researchers

前立腺癌の去勢抵抗性獲得メカニズムとリン酸化核内受容体の病態解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a drug metabolism capacity and interaction evaluation system for the elderly with sarcopenia and avoidance of adverse drug reaction risks.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Verification of universal oxidative stress regulation ability by transcriptional coactivator PDIP1 and search for target molecules

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腸内フローラの破綻時の胆管障害における核内受容体CAR/PXRの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of nuclear receptor CAR in the pathogenesis of intrahepatic cholangiocellular carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of nuclear receptor CAR in hepatic progenitor cell-mediated bile duct epithelial cell proliferation, bile duct formation and regenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of a transcriptional coactivator (PDIP1) that functions as a transcriptional coregulator of several nuclear receptors in the physiopathological process of the liver

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of nuclear receptors PXR/CAR in the pathogenesis of inflammatory bowel diseases.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of nuclear receptor CAR in the liver regeneration and repair madiated by oval cell proliferation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of nuclear receptor coactivator PDIP1 in non-alcholic steatohepatitis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Correlative microscopy and block-face imaging (CoMBI) method for both paraffin-embedded and frozen specimens2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Constitutive androstane receptor and pregnane X receptor cooperatively ameliorate DSS-induced colitis.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of amino acid transporters (LAT1, ASCT2 and xCT) as clinical significance in hepatocellular carcinoma.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in ob/ob mice.2014

Yamazaki Yuichi 山崎勇一