NISHIMICHI Norihisa 西道教尚

Researcher Number	00583486
Affiliation (based on the past Project Information) *help	2011 – 2019: 広島大学, 保健管理センター, 研究員
Review Section/Research Field	Principal Investigator Cell biology / Functional biochemistry / Living organism molecular science Except Principal Investigator Gastroenterology / Laboratory medicine
Keywords	Principal Investigator 炎症 / オステオポンチン / 抗体 / ゲノム編集 / 翻訳後修飾 / 線維化 / 重合 / 生理活性物質 / 蛋白質 / タンパク質 / 生理活性 / 生体分子 / 活性発現の分子機構 … More Except Principal Investigator … More 筋線維芽細胞 / 肝線維化 / 抗体医薬 / TGF-β / インテグリン / Fibrosis / α-SMA / Integrin α8β1 / 肝臓 / 線維化 / YAP1 / インテグリンα8β1 / YAP-1 / TGFβ / 肝線維症 / 抗体 / 重合体 / トランスグルタミナーゼ / ポリマー / 好中球 / ELISA / 重合 / オステオポンチン / モノクロナル抗体 / 阻害抗体 / 肺線維化 / 肝硬変 / 星細胞 / 線維症 Less

Mechanism and therapeutic application of a novel integrin blocking mAb that inhibit liver fibrosis in mice
- Principal Investigator
  
  Yokosaki Yasuyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Hiroshima University
Role of polymeric OPN on fibrosisPrincipal Investigator
- Principal Investigator
  
  Nishimichi Norihisa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Hiroshima University
Establishment of ELISA that detect polymeric OPN and its usefulness
- Principal Investigator
  
  Yokosaki Yasuyuki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Hiroshima University
The role of polymeric osteopontin on inflammationPrincipal Investigator
- Principal Investigator
  
  NISHIMICHI NORIHISA
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hiroshima University
Activated hepatic stellate cell specific antibody that attenuates liver fibrosis: mechanism of action and therapeutic use
- Principal Investigator
  
  YOKOSAKI Yasuyuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Hiroshima University
Characterization and expression analysis ofpolymeric osteopontinPrincipal Investigator
- Principal Investigator
  
  NISHIMICHI Norihisa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Hiroshima University

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book Patent

[Book] 月刊細胞 (2015 年4 月号)2015
- Author(s)
  西道教尚、川島永子、横崎恭之
- Total Pages
  52
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-25840034
[Journal Article] Culture time of vitrified/warmed zygotes before microinjection affects the production efficiency of CRISPR-Cas9-mediated knock-in mice2017
- Author(s)
  Nakagawa Y, Sakuma T, Nishimichi N, Yokosaki Y, Takeo T, Nakagata N, Yamamoto T
- Journal Title
  
  Biology Open
  
  Volume: - Pages: 706-713
- DOI
  10.1242/bio.025122
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18478, KAKENHI-PROJECT-17K11242, KAKENHI-PROJECT-15H04606, KAKENHI-PROJECT-15K07051, KAKENHI-PROJECT-17H04161
[Journal Article] Periostin promotes hepatic fibrosis in mice by modulating hepatic stellate cell activation via αv integrin interaction.2016
- Author(s)
  Sugiyama A, Kanno K, Nishimichi N, Yokosaki Y, Izuhara K, Ono J, Tazuma S.
- Journal Title
  
  J Gastroenteroln
  
  Volume: in press Issue: 12 Pages: 1161-1174
- DOI
  10.1007/s00535-016-1206-0
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670280, KAKENHI-PROJECT-16H05343, KAKENHI-PROJECT-26293174, KAKENHI-PROJECT-15K07051, KAKENHI-PROJECT-15K09553, KAKENHI-PROJECT-15K15372
[Journal Article] Ultra-superovulation for the CRISPR-Cas9-mediated production of gene-knockout, single- amino-acid-substituted, and floxed mice2016
- Author(s)
  Yoshiko Nakagawa, Tetsushi Sakuma, Norihisa Nishimichi, Yasuyuki Yokosaki, Noriyuki Yanaka, Toru Takeo, Naomi Nakagata and Takashi Yamamoto
- Journal Title
  
  Biology Open
  
  Volume: 5 Issue: 8 Pages: 1142-1148
- DOI
  10.1242/bio.019349
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04606, KAKENHI-PROJECT-26290070, KAKENHI-PROJECT-26293174, KAKENHI-PROJECT-26660112, KAKENHI-PROJECT-15K07051, KAKENHI-PROJECT-16K18478
[Journal Article] Epitopes in α8β1 and other RGD-binding integrins delineate classes of integrin-blocking antibodies and major binding loops in α subunits2015
- Author(s)
  Norihisa Nishimichi, Nagako Kawashima, Yasuyuki Yokosaki
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 13756-13767
- DOI
  10.1038/srep13756
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07051, KAKENHI-PROJECT-26670280, KAKENHI-PROJECT-26293174
[Journal Article] インテグリンを介した線維化調節機構2015
- Author(s)
  西道教尚、川島永子、横崎恭之
- Journal Title
  
  細胞
  
  Volume: 47 Pages: 180-183
- Data Source
  KAKENHI-PROJECT-26670280
[Journal Article] Role of Integrin-α8 in Bleomycin-Induced Lung Injury2015
- Author(s)
  Chi F. Hung, Nick M. Mark, Yu-Hua Chow, Norihisa Nishimichi, Yasuyuki Yokosaki, Lynn M. Schnapp
- Journal Title
  
  Annals of the American Thoracic Society
  
  Volume: 12 Issue: Supplement 1 Pages: S74-S74
- DOI
  10.1513/annalsats.201406-256mg
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670280, KAKENHI-PROJECT-26293174
[Journal Article] Generation of intracellular single-chain antibodies directed against polypeptide GalNAc-transferase using a yeast two-hybrid system2012
- Author(s)
  Ma L, Koyota K, Myoen Y, Yamashita T, Yatabe N, Koizumi Y, Aosasa M, Nishimichi N, Matsuda H, Sugiyama T
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 418 Issue: 4 Pages: 628-633
- DOI
  10.1016/j.bbrc.2012.01.062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700913, KAKENHI-PROJECT-23710257
[Journal Article] Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta12011
- Author(s)
  Nishimichi N, Hayashita-Kinoh H, Chen C, Matsuda H, Sheppard D, Yokosaki Y
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 286 Pages: 11170-11178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710257
[Journal Article] Matsuda H, Sheppard D, Yokosaki Y. Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrinα9β12011
- Author(s)
  Nishimichi N, Kinoh-HayashitaH, Chen C, Matsuda H, Sheppard D, Yokosaki Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Issue: 13 Pages: 11170-11178
- DOI
  10.1074/jbc.m110.189258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590996, KAKENHI-PROJECT-23710257
[Patent] インテグリン α8β1 の機能を阻害する事による線維化の抑制2013
- Inventor(s)
  西道教尚ほか 1 名
- Industrial Property Rights Holder
  国立大学法人広島大学
- Filing Date
  2013-03-28
- Overseas
- Data Source
  KAKENHI-PROJECT-23710257
[Patent] インテグリンα8β1の機能を阻害する事による線維化の抑制2013
- Inventor(s)
  横崎恭之、西道教尚
- Industrial Property Rights Holder
  広島大学
- Industrial Property Rights Type
  特許
- Filing Date
  2013-03-28
- Overseas
- Data Source
  KAKENHI-PROJECT-24659367
[Patent] インテグリンα8β1 の機能を阻害する事による線維化の抑制2013
- Inventor(s)
  西道教尚ほか1名
- Industrial Property Rights Holder
  国立大学法人広島大学
- Industrial Property Rights Type
  特許
- Filing Date
  2013-03-28
- Overseas
- Data Source
  KAKENHI-PROJECT-23710257
[Patent] インテグリン α8β1 の機能を阻害する事による線維化の抑制2012
- Inventor(s)
  西道教尚ほか 1 名
- Industrial Property Rights Holder
  国立大学法人広島大学
- Filing Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-23710257
[Presentation] 試験管内親和性成熟によるインテグリンα11β1 阻害抗体の活性改変2019
- Author(s)
  Norihisa Nishimichi, Mikage Otani, Mari Harada and Yasuyuki Yokosaki
- Organizer
  分子生物学会
- Data Source
  KAKENHI-PROJECT-17H04161
[Presentation] α-シヌクレインのミクログリア内取り込みはインテグリンα9β1との結合を介したエンドサイトーシスである2018
- Author(s)
  伊藤益美、西道教尚、大谷水景、原田真里、横崎恭之
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H04161
[Presentation] インテグリンα11β1機能阻害モノクローナル抗体の樹立と活性評価2018
- Author(s)
  西道教尚、伊藤益美、大谷水景、横崎恭之
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H04161
[Presentation] インテグリン阻害抗体の脱着・解離効果の有無とそのエピトープからの予測,2018
- Author(s)
  大谷水景、西道教尚、伊藤益美、吉栖正生、横崎恭之
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H04161
[Presentation] α-シヌクレインのミクログリア内取り込みはインテグリンα9β1との結合を介する2017
- Author(s)
  伊藤益美、西道教尚、大谷水景、横崎恭之
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K07051
[Presentation] 筋線維芽細胞分化におけるインテグリンα8β1とTGF-βの役割2017
- Author(s)
  西道教尚、伊藤真澄、大谷水景、横崎恭之
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K07051
[Presentation] インテグリンα9β1阻害抗体の医薬としての有用性を規定する作用様式2017
- Author(s)
  大谷水景、西道教尚、伊藤益美、横崎恭之
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K07051
[Presentation] Identification of conformational epitopes for integrin blocking mAbs against α3 and α5 subunits.2017
- Author(s)
  Otani M, Nishimichi N, Ito M, Hanaoka M, Yoshizumi M, Yokosaki Y.
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04161
[Presentation] Integrin α8β1 promotes tissue fibrosis via differentiation of myofibroblast -a potent therapeutic target on fibrosis-2017
- Author(s)
  Nishimichi N, Kanno K, Sentani K, Sugiyama A, Ito M, Otani M, Hanaoka M, Yasui W, Yokosaki Y.
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04161
[Presentation] Epitopes of Anti-Integrin 81 Blocking mAbs Disclosed Difficulty in Generation of the mAbs in Mammals.2016
- Author(s)
  Norihisa Nishimichi, Nagako Kawashima, Yasuyuki Yokosaki
- Organizer
  Keystone Symposia
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2016-03-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670280
[Presentation] Epitopes of Anti-Fibrotic Monoclonal Antibodies against Integrin 81 Explained Long Term Lacking of the mAb2016
- Author(s)
  Norihisa Nishimichi, Nagako Kawashima, Yasuyuki Yokosaki
- Organizer
  American Thoracic Society 2016 International Meeting
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2016-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670280
[Presentation] Localization of integrin α9β1 binding site in transglutaminase-catalyzed polymeric osteopontin2015
- Author(s)
  Yokosaki Yasuyuki, Norihisa Nishimichi
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-12
- Data Source
  KAKENHI-PROJECT-15K07051
[Presentation] 糖尿病患者における心不全へのインテグリンα8β1の関与2015
- Author(s)
  阿賀康弘、西道教尚、横崎恭之
- Organizer
  BMB 2015 (生化学会・分子生物学会合同年会)
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26670280
[Presentation] インテグリンα8β1 は筋線維芽細胞分化を誘導して組織線維化を促進する2015
- Author(s)
  西道教尚、菅野啓司、杉山晶子、仙谷和弘、安井弥、横崎恭之
- Organizer
  BMB 2015 (生化学会・分子生物学会合同年会)
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26670280
[Presentation] Periostin stimulates hepatic stellate cells via interaction with integrins: Novel functional roles for periostin in hepatic fibrosis.2015
- Author(s)
  Akiko Sugiyama, Keishi Kanno, Norihisa Nishimichi, Yasuyuki Yokosaki, Susumu Tazuma.
- Organizer
  American Association for the Study of Liver Disease
- Place of Presentation
  Boston, MA, USA
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670280
[Presentation] Localization of integrin binding site in transglutaminase-catalyzed polymeric osteopontin2015
- Author(s)
  Yasuyuki Yokosaki, Norihisa Nishimichi.
- Organizer
  BMB 2015 (生化学会・分子生物学会合同年会)
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-26670280
[Presentation] Inhibition Of Pulmonary Fibrosis By Integrin α8β1 Blocking Antibody and TGFβ-Independent Myofibroblast Differentiation By α8β1 Mediated Signal2014
- Author(s)
  Y. Yokosaki, N. Nishimichi, K. Kanno, K. Sentani
- Organizer
  American Thoracic Society 2014 International Meeting
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-24659367
[Presentation] α8β1 Integrin And Mechanical Traction Are Necessary For Activation Of TGFβ In Fibroblasts2014
- Author(s)
  N.M. Mark, C. Hung, Y-H. Chow, K. Kennewick, S. Lewis, N. Nishimichi, Y. Yokosaki, B. Hinz, L.M. Schnapp
- Organizer
  American Thoracic Society 2014 International Meeting
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-24659367
[Presentation] インテグリンα8β1モノクローナル抗体の認識部位の同定2014
- Author(s)
  西道教尚、横崎恭之
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-25840034
[Presentation] Myofibroblast Differentiation Mediated By Integrin α8β1.2014
- Author(s)
  Norihisa Nishimichi, Keishi Kanno, Akiko Sugiyama, Yasuyuki Yokosaki
- Organizer
  Keystone Symposia
- Place of Presentation
  Keystone, CO, USA
- Data Source
  KAKENHI-PROJECT-24659367
[Presentation] 新しい肺線維化抑制薬シーズインテグリンα8β1阻害抗体2014
- Author(s)
  横崎恭之、西道教尚、仙谷和弘、菅野啓司、安井弥
- Organizer
  第54日本呼吸器学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24659367
[Presentation] A possible therapeutic agent for pulmonary fibrosis: antibody against integrin α8β1.2013
- Author(s)
  Yokosaki Y, Nishimichi N, Kanno K, Senatani K, Yasui W.
- Organizer
  European Respiratory Society
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-24659367
[Presentation] osteopontin-polymerization-blocking antibody attenuates septic inflammation induced by LPS in mice2013
- Author(s)
  横崎恭之、西道教尚
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25840034
[Presentation] オステオポンチン重合化と全身性炎症反応症候群2013
- Author(s)
  西道教尚、横崎恭之
- Organizer
  第45回日本結合組織学会学術大会、第60回マトリックス研究会大会合同学術大会
- Place of Presentation
  和歌山県立医科大学
- Data Source
  KAKENHI-PROJECT-25840034
[Presentation] A possible therapeutic agent for pulmonary fibrosis : antibody against integrinα8β12013
- Author(s)
  Yokosaki Y, Nishimichi N, Kanno K, Senatani K, Yasui W.
- Organizer
  European Respiratory Society
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-24659367
[Presentation] Role of α8β1 integrin in TGF-β activation by lung fibroblasts2013
- Author(s)
  Nick Mark, Chi Hung C, Yu-Hua Chow, Norihisa Nishimichi, Lynn Schnapp, Yasuyuki Yokosaki.
- Organizer
  American Thoracic Society 2013 International Meeting
- Place of Presentation
  Philadelphia, PA, USA
- Data Source
  KAKENHI-PROJECT-24659367
[Presentation] osteopontin-polymerization-blocking antibody attenuates septic inflammation induced by LPS in mice2013
- Author(s)
  西道教尚、横崎恭之
- Organizer
  第５回トランスグルタミナーゼ研究会＆日本ポリアミン学会合同学術集会
- Place of Presentation
  キャンパスイノベーションセンター (東京都港区芝浦)
- Data Source
  KAKENHI-PROJECT-25840034
[Presentation] Role ofα8β1 integrin in TGF-βactivation by lung fibroblasts2013
- Author(s)
  Nick Mark, Chi Hung C, Yu-Hua Chow, Norihisa Nishimichi, Lynn Schnapp, Yasuyuki Yokosaki
- Organizer
  American Thoracic Society 2013 International Meeting
- Place of Presentation
  Philadelphia, PA, USA
- Data Source
  KAKENHI-PROJECT-24659367
[Presentation] 全身性炎症反応症候群(SIRS) に対するオステオポンチン重合阻害抗体の効果2012
- Author(s)
  西道教尚ほか
- Organizer
  第15回トランスグルタミナーゼ研究会学術集会
- Place of Presentation
  九州大学理学部生物学科第二会議室
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-23710257
[Presentation] Integrinα8β1 as a new therapeutic target for tissue fibrosis. American Thoracic Society2012
- Author(s)
  Norihisa Nishimichi, Keishi Kanno, Neil C. Henderson, Dean Sheppard, Yasuyuki Yokosaki
- Organizer
  2012 International Meeting
- Place of Presentation
  San Francisco, CA, USA
- Data Source
  KAKENHI-PROJECT-24659367
[Presentation] 全身性炎症反応症候群(SIRS)に対するオステオポンチン重合阻害抗体の効果2012
- Author(s)
  西道教尚、横崎恭之 (西道教尚)
- Organizer
  第15回トランスグルタミナーゼ研究会学術集会
- Place of Presentation
  九州大学理学部生物学科第二会議室
- Data Source
  KAKENHI-PROJECT-23710257
[Presentation] インテグリンα8β1 は活性化肝星細胞に発現し肝線維化を促進する2012
- Author(s)
  西道教尚、菅野啓司、仙谷和弘、安井弥、横崎恭之
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24659367
[Presentation] Integrin α8β1 As A New Therapeutic Target For Tissue Fibrosis2012
- Author(s)
  Norihisa Nishimichi, Keishi Kanno, Neil C. Henderson, Dean Sheppard, Yasuyuki Yokosaki
- Organizer
  American Thoracic Society, 2012 International Meeting
- Place of Presentation
  San Francisco, CA, USA
- Data Source
  KAKENHI-PROJECT-24659367
[Presentation] インテグリンα8β1は活性化肝星細胞に発現し肝線維化を促進する2012
- Author(s)
  西道教尚、菅野啓司、仙谷和弘、安井弥、横崎恭之
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24659367
[Presentation] インテグリンα8β1 機能阻害モノクローナル抗体の認識部位の同定2012
- Author(s)
  西道教尚、横崎恭之
- Organizer
  第85回日本生化学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24659367
[Presentation] インテグリンα8β1機能阻害モノクローナル抗体の認識部位の同定2012
- Author(s)
  西道教尚、横崎恭之
- Organizer
  第85回日本生化学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24659367
[Presentation] オステオポンチン投与後のオリゴマー化とそれに続く好中球集積2011
- Author(s)
  西道教尚ほか
- Organizer
  第52回日本生化学会中国・四国支部総会
- Place of Presentation
  広島大学医学部広仁会館
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-23710257
[Presentation] トランスグルタミナーゼ重合によるオステオポンチンの蛋白結合部位形成と機能獲得2011
- Author(s)
  西道教尚ほか
- Organizer
  第4回トランスグルタミナーゼ研究会&日本ポリアミン学会合同学術集会
- Place of Presentation
  京都工芸繊維大学60 周年記念館
- Year and Date
  2011-09-20
- Data Source
  KAKENHI-PROJECT-23710257
[Presentation] トランスグルタミナーゼ重合によるオステオポンチンの蛋白結合部位形成と機能獲得2011
- Author(s)
  西道教尚、横崎恭之
- Organizer
  第４回トランスグルタミナーゼ研究会＆日本ポリアミン学会合同学術集会
- Place of Presentation
  京都工芸繊維大学　60周年記念館
- Data Source
  KAKENHI-PROJECT-23710257
[Presentation] α8β1 Integrin And Mechanical Traction Are Necessary For Activation Of TGF-β In Fibroblasts
- Author(s)
  N.M. Mark, C. Hung, Y.-H. Chow, K. Kennewick, S. Lewis, N. Nishimichi, Y. Yokosaki, B. Hinz, L.M. Schnapp.
- Organizer
  American Thoracic Society
- Place of Presentation
  サンディエゴ、アメリカ合衆国
- Year and Date
  2014-05-16 – 2014-05-21
- Data Source
  KAKENHI-PROJECT-26670280
[Presentation] Inhibition Of Pulmonary Fibrosis By Integrin α8β1 Blocking Antibody And TGFβ-Independent Myofibroblast Differentiation By α8β1 Mediated Signal
- Author(s)
  Yokosaki Y, Nishimichi N, Kanno K, Sentani K.
- Organizer
  American Thoracic Society
- Place of Presentation
  サンディエゴ、アメリカ合衆国
- Year and Date
  2014-05-16 – 2014-05-21
- Data Source
  KAKENHI-PROJECT-26670280
[Presentation] 新しい肺線維化抑制薬シーズインテグリンα8β1阻害抗体
- Author(s)
  横崎恭之、西道教尚、仙谷和弘、菅野啓司、安井弥
- Organizer
  日本呼吸器学会
- Place of Presentation
  大阪
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-26670280
[Presentation] インテグリンα8β1 モノクローナル抗体の認識部位の同定
- Author(s)
  西道教尚、横崎恭之
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26670280
[Presentation] Periostin stimulates hepatic stellate cells via interaction with integrins: Novel functional roles for periostin in hepatic fibrosis.
- Author(s)
  Akiko Sugiyama, Keishi Kanno, Norihisa Nishimichi, Yasuyuki Yokosaki, Susumu Tazuma
- Organizer
  American Association for the Study of Liver Disease
- Place of Presentation
  ボストン、アメリカ合衆国
- Year and Date
  2014-11-07 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-26670280

1. YOKOSAKI Yasuyuki (80210607)

# of Collaborated Projects: 4 results

# of Collaborated Products: 40 results
2. SENTANI Kazuhiro (30508164)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. KANNO Keishi (30448237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. 外丸祐介 (90309352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 佐久間哲史 (90711143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 茶山一彰 (00211376)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KOIZUMI Yukio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 松田治男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 中潟直己

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 山本卓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 中川佳子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NISHIMICHI Norihisa 西道 教尚

Research Projects

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Co-Researchers

Mechanism and therapeutic application of a novel integrin blocking mAb that inhibit liver fibrosis in mice

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Role of polymeric OPN on fibrosisPrincipal Investigator

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Establishment of ELISA that detect polymeric OPN and its usefulness

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The role of polymeric osteopontin on inflammationPrincipal Investigator

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Activated hepatic stellate cell specific antibody that attenuates liver fibrosis: mechanism of action and therapeutic use

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Characterization and expression analysis ofpolymeric osteopontinPrincipal Investigator

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[Book] 月刊細胞 (2015 年4 月号)2015

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[Journal Article] Culture time of vitrified/warmed zygotes before microinjection affects the production efficiency of CRISPR-Cas9-mediated knock-in mice2017

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[Journal Article] Periostin promotes hepatic fibrosis in mice by modulating hepatic stellate cell activation via αv integrin interaction.2016

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[Journal Article] Ultra-superovulation for the CRISPR-Cas9-mediated production of gene-knockout, single- amino-acid-substituted, and floxed mice2016

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[Journal Article] Epitopes in α8β1 and other RGD-binding integrins delineate classes of integrin-blocking antibodies and major binding loops in α subunits2015

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[Journal Article] インテグリンを介した線維化調節機構2015

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[Journal Article] Role of Integrin-α8 in Bleomycin-Induced Lung Injury2015

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[Journal Article] Generation of intracellular single-chain antibodies directed against polypeptide GalNAc-transferase using a yeast two-hybrid system2012

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[Journal Article] Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta12011

NISHIMICHI Norihisa 西道教尚