Hidaka Masafumi 日高將文

… Alternative Names

HIDAKA Masafumi 日高將文

日高将文ヒダカマサフミ

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Researcher Number	00584848
Other IDs
Affiliation (Current)	2025: 東北大学, 農学研究科, 助教
Affiliation (based on the past Project Information) *help	2016 – 2024: 東北大学, 農学研究科, 助教 2012 – 2015: 東北大学, (連合)農学研究科(研究院), 助教 2014: 東北大学, (連合)農学研究科, 助教 2010 – 2011: 東北大学, 大学院・農学研究科, 助教
Review Section/Research Field	Principal Investigator Applied biochemistry / Basic Section 38050:Food sciences-related / Basic Section 38020:Applied microbiology-related / Applied microbiology Except Principal Investigator Applied microbiology / Biomolecular chemistry / Applied molecular and cellular biology
Keywords	Principal Investigator タンパク質工学 / バイオセンサー / 小角X線散乱 / イメージング / 放射光 / 構造解析 / 食品 / X線構造解析 / 微生物 / タンパク質発現・精製 … More / 転写因子 / X線結晶構造解析 / FRET / 一酸化窒素 / 結晶構造解析 … More Except Principal Investigator 共進化 / 共生 / 母乳オリゴ糖 / ビフィズス菌 / パッチクランプ記録法 / 新規医薬資源 / 電気生理 / 慢性疼痛 / テトロドトトキシン / ハイスループットスクリーニング / 医薬資源探索 / サキシトキシン / 神経障害性疼痛 / 構造決定 / 阻害剤探索 / 医薬資源 / スクリーニング / サブタイプ選択性 / クロイソカイメン / サキシトキシンン / テトロドトキシン / 電気生理実験 / 電位依存性ナトリウムチャネル / 酵素 / 酵素合成 / 酵素解析 / 母乳 / グリコシダーゼ / 糖質分解酵素 / 天然物資源 / 薬剤探索 / αシヌクレイン / Gas7 / 生活習慣病 / キネシン / リン酸化タウ / 機能調節剤 / 微小管関連タンパク質 / 微小管重合 / JNK / Pin1 / CAMKII / パクリタクセル / motility assay / コンデショナルノックアウトマウス / hGas7b / 肥満 / CREB / Gas7b / Pn1 / プロリン異性化酵素 / 微小管 / アルツハイマー病 / タンパク質・糖鎖工学 / 発生・分化制御 / 細胞機能 Less

Hierarchical structure analysis of food samples using synchrotron radiationPrincipal Investigator
- Principal Investigator
  
  日高將文
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Tohoku University
Approaches to transcription factor research in industrial microorganisms at molecular level.Principal Investigator
- Principal Investigator
  
  Hidaka Masafumi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Tohoku University
Elucidation of physiological role of nitrate/nitrite/NO dynamics and development of drugsPrincipal Investigator
- Principal Investigator
  
  Hidaka Masafumi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Tohoku University
Screening of the voltage-gated sodium channel blockers to discover the lead compounds for therapeutic purposes
- Principal Investigator
  
  Konoki Keiichi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Tohoku University
Human milk oligosaccharides as the bifidus factor: the mechanism underlying how bifidus flora is established in infant guts
- Principal Investigator
  
  Katayama Takane
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied microbiology
- Research Institution
  Kyoto University
Structure and function relationships of NasS-NasT, a novel two-component system in root nodule bacteriaPrincipal Investigator
- Principal Investigator
  
  Hidaka Masafumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied microbiology
- Research Institution
  Tohoku University
Milk oligosaccharides-mediated symbiosis and co-evolution between bifidobacteria and humans
- Principal Investigator
  
  KATAYAMA Takane
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied microbiology
- Research Institution
  Ishikawa Prefectural University
Visualization of structure and function change of phosphorylatad protein.Principal Investigator
- Principal Investigator
  
  HIDAKA Masafumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Tohoku University
Drug Discovery of Alzheimer Disease from Molecules- Regulating Microtubule Polymerization
- Principal Investigator
  
  UCHIDA Takafumi
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Tohoku University

All 2023 2021 2020 2019 2018 2016 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Synthesis of C12-keto saxitoxin derivatives with unusual inhibitory activity against voltage‐gated sodium channels.2020
- Author(s)
  Adachi, K., Yamada, T., Ishizuka, H., Oki, M., Tsunogae, S., Shimada, N., Chiba, O., Orihara, T., Hidaka, M., Hirokawa, T., Odagi, M., Konoki, K., Yotsu-Yamashita, M., Nagasawa, K.
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 26 Issue: 9 Pages: 2025-2033
- DOI
  10.1002/chem.201904184
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06406, KAKENHI-PROJECT-17H02199, KAKENHI-PROJECT-17H03809, KAKENHI-PUBLICLY-18H04387, KAKENHI-PROJECT-17H03052, KAKENHI-PROJECT-19K22266, KAKENHI-PUBLICLY-19H04636, KAKENHI-PROJECT-20H02921
[Journal Article] sNOOOpy, a Sensor for Physiological NO3－/NO2－ Employing a Bacterial Two-Component Regulatory System.2016
- Author(s)
  Hidaka M, Gotoh A, Shimizu T, Minamisawa K, Imamura H and Uchida T
- Journal Title
  
  Journal Biological Chemistry
  
  Volume: 291 Issue: 5 Pages: 2260-2269
- DOI
  10.1074/jbc.m115.687632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26660287, KAKENHI-PROJECT-26850042, KAKENHI-PUBLICLY-15H01401, KAKENHI-PROJECT-26252065, KAKENHI-PROJECT-26291027, KAKENHI-PROJECT-26252064
[Journal Article] A High-Throughput Screen for Inhibitors of the Prolyl Isomerase, Pin1, Identifies a Seaweed Polyphenol that Reduces Adipose Cell Differentiation2014
- Author(s)
  １．Mori T, Hidaka M , Ikuji H, Yoshizawa I, ToyoharaH, Okuda T, Uchida C, Asano T, Yotsu-Yamashita M and Uchida T
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20228006
[Journal Article] Alzheimer's Disease-Related Protein hGas7b Interferes with Kinesin Motility2012
- Author(s)
  Hidaka M, Uchida T
- Journal Title
  
  J Biochem
  
  Volume: 151 Pages: 593-598
- NAID
  10031166101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20228006
[Journal Article] Relationship between structure of Taxane derivatives and their microtubule polymerization activity2012
- Author(s)
  Hidaka M, Uchida T
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 76 Pages: 349-352
- NAID
  10030400057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20228006
[Journal Article] Alzheimer's Disease-Related Protein hGas7b Interferes with Kinesin Motility2012
- Author(s)
  Hidaka M
- Journal Title
  
  J Biochem
  
  Volume: (未定)(掲載確定) Issue: 6 Pages: 593-598
- DOI
  10.1093/jb/mvs038
- NAID
  10031166101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20228006
[Journal Article] 1,3-1,4-α-l-Fucosynthase That Specifically Introduces Lewis a/x Antigens into Type-1/2 Chains2012
- Author(s)
  Haruko Sakurama, Shinya Fushinobu, Masafumi Hidaka, Erina Yoshida, Yuji Honda, Hisashi Ashida, Motomitsu Kitaoka, Hidehiko Kumagai, Kenji Yamamoto, and Takane Katayama
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 287: Issue: 20 Pages: 16709-16719
- DOI
  10.1074/jbc.m111.333781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580119
[Journal Article] A dual inhibitor against prolyl isomerase Pinl and cyclophilin discovered by a novel real-time fluorescence detection method.2011
- Author(s)
  Mori, T, Hidaka M, Lin Y, Yoshizawa I, Okabe T, Egashira S, Kojima H, Nagano T, Koketsu M, Takamiya, M, Uchida T
- Journal Title
  
  Biochem.Biophys.Res.Commun. 406
  
  Pages: 439-443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20228006
[Presentation] 黄麹菌のデンプン分解酵素生産に関与する転写因子FlbCの大腸菌発現・精製系の構築2023
- Author(s)
  松畑達哉、小嶋慧、青西洋平、小川智久、二井勇人、五味勝也、日高將文
- Organizer
  日本農芸化学会東北支部第158回大会（東北大学）
- Data Source
  KAKENHI-PROJECT-20K05802
[Presentation] 黄麹菌の転写因子MalRの構造・機能解析に向けた発現系の構築2021
- Author(s)
  小嶋慧、小川智久、二井勇人、五味勝也、日高將文
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-20K05802
[Presentation] C11位炭素置換型サキシトキシン誘導体の合成と活性評価2019
- Author(s)
  〇安達栞菜，石塚　颯，山田智士，日高將文，広川貴次，小田木　陽，此木敬一，山下まり，長澤和夫
- Organizer
  第61回天然有機化合物討論会（広島国際会議場，広島市，2019年9月11-13日）
- Data Source
  KAKENHI-PROJECT-17H02199
[Presentation] テトロドトキシン類縁体に対する電位依存性ナトリウムチャネルの感受性評価2018
- Author(s)
  塚本匡顕, 千葉雪絵, 若森　実, 日高將文, 山田智士, 角替俊輔, 長　由扶子, 榊原　良, 今津拓也, 所　聖太, 佐竹佳樹, 安立昌篤, 西川俊夫, 山下まり, 此木敬一
- Organizer
  第60回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-17H02199
[Presentation] 微生物環境応答システムの速度論的解析と応用開発2016
- Author(s)
  日高將文、後藤愛那、清水泰希、南澤究、今村博臣、内田隆史
- Organizer
  日本農芸化学会年会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26850042
[Presentation] ポリフェノールによるプロリン異性化酵素(Pin1、Cyp)の活性制御2014
- Author(s)
  小坂啓太、生地紘子、日高將文、内田隆史
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  東京、明治大学
- Data Source
  KAKENHI-PROJECT-20228006
[Presentation] FRET法を用いたPin1構造変化の可視化2014
- Author(s)
  岡部恵美子、日高將文、内田隆史
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  神奈川県川崎市・明治大学
- Data Source
  KAKENHI-PROJECT-24780092
[Presentation] FRET法を用いたPin1構造変化の可視化2014
- Author(s)
  岡部恵美子、日高將文、内田隆史
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  東京、明治大学
- Data Source
  KAKENHI-PROJECT-20228006
[Presentation] Growth arrest specific protein b(Gas7b)によるリン酸化Tau量の調節機構2014
- Author(s)
  乗田理恵、清水泰希、秋山弘匡、広瀬恵子、後藤愛那、日高將文、内田隆史
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  東京、明治大学
- Data Source
  KAKENHI-PROJECT-20228006
[Presentation] FRETを用いた硝酸センサータンパク質の開発2014
- Author(s)
  後藤愛那日高將文岡部恵美子金井研太小坂啓太板倉学クリスチーナサンチェス南澤究内田隆史
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  東京, 明治大学
- Data Source
  KAKENHI-PROJECT-20228006
[Presentation] プロリン異性化酵素Pin1の脳関連キナーゼCaMKIIへの影響2013
- Author(s)
  金井研太、小坂啓太、堤貴明、後藤愛那、二井勇人、日高將文、内田隆史
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  仙台市, 東北大学
- Data Source
  KAKENHI-PROJECT-20228006
[Presentation] Visualization of Pin1 binding with c-Myc peptide by FRET-based indicators.2013
- Author(s)
  岡部恵美子、日高將文、内田隆史
- Organizer
  日本農芸化学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24780092
[Presentation] c-mycに作用し構造変化するPin1-FRET法の構築2013
- Author(s)
  岡部恵美子、日高將文、内田隆史
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  仙台市、東北大学
- Data Source
  KAKENHI-PROJECT-20228006
[Presentation] リン酸化Tauの微小管重合促進能を回復させる因子Pin1およびhGas72013
- Author(s)
  清水泰希、小坂啓太、林悠太、岡部恵美子、藤田彩子、後藤愛那、日高將文、内田隆史
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  仙台市、東北大学
- Data Source
  KAKENHI-PROJECT-20228006
[Presentation] Visualization of Pin1-phosphopeptide assiciation with FRET-based indicators.2012
- Author(s)
  岡部恵美子、日高將文、内田隆史
- Organizer
  日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24780092
[Presentation] Visualization of Pin1-phosphopeptide association with FRET-based indicators2012
- Author(s)
  岡部恵美子、日高将文、内田隆史
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡市、マリンメッセ
- Data Source
  KAKENHI-PROJECT-20228006
[Presentation] hGas7b Enhances Microtubule Polymerization but Blocks Kinesin Movement on Microtubule2010
- Author(s)
  Masafumi Hidaka, Tomoe Koga, Aina Goto, Hideo Higuchi, Takafumi Uchida
- Organizer
  4th Mechanobiology Workshop : Actin, The Cytoskeleton and the Nucleus
- Place of Presentation
  シンガポール
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PROJECT-20228006
[Presentation] hGas7b Enhances Microtubule Polymerization but Blocks Kinesin Movement on Microtubule2010
- Author(s)
  Masafumi Hidaka, et al
- Organizer
  4th Mechanobiology Workshop : Actin, The Cytoskeleton and the Nucleus
- Place of Presentation
  Singapore
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-20228006
[Presentation] Improvement of FRET based indicator for structural change of Pin1
- Author(s)
  岡部恵美子、日高將文、内田隆史
- Organizer
  日本分子生物学会
- Place of Presentation
  神奈川県横浜市・パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24780092

1. HIROSE Junko (40381917)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. KATAYAMA Takane (70346104)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. UCHIDA Takafumi (80312239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
4. UCHIDA Chiyoko (80312776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
5. YAMASHITA Mari (50192430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. HIROSE Keiko (90357872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OKUDA Toru (40328026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. Konoki Keiichi (40292825)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 二井勇人 (90447459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 栗原新 (20630966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 廣瀬恵子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hidaka Masafumi 日高 將文

HIDAKA Masafumi 日高 將文

日高 将文 ヒダカ マサフミ

Research Projects

Research Products

Co-Researchers

Hierarchical structure analysis of food samples using synchrotron radiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Approaches to transcription factor research in industrial microorganisms at molecular level.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of physiological role of nitrate/nitrite/NO dynamics and development of drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Screening of the voltage-gated sodium channel blockers to discover the lead compounds for therapeutic purposes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Human milk oligosaccharides as the bifidus factor: the mechanism underlying how bifidus flora is established in infant guts

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structure and function relationships of NasS-NasT, a novel two-component system in root nodule bacteriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Milk oligosaccharides-mediated symbiosis and co-evolution between bifidobacteria and humans

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Visualization of structure and function change of phosphorylatad protein.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Drug Discovery of Alzheimer Disease from Molecules- Regulating Microtubule Polymerization

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Synthesis of C12-keto saxitoxin derivatives with unusual inhibitory activity against voltage‐gated sodium channels.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] sNOOOpy, a Sensor for Physiological NO3－/NO2－ Employing a Bacterial Two-Component Regulatory System.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A High-Throughput Screen for Inhibitors of the Prolyl Isomerase, Pin1, Identifies a Seaweed Polyphenol that Reduces Adipose Cell Differentiation2014

Author(s)

Journal Title

Data Source

[Journal Article] Alzheimer's Disease-Related Protein hGas7b Interferes with Kinesin Motility2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Relationship between structure of Taxane derivatives and their microtubule polymerization activity2012

Hidaka Masafumi 日高將文

HIDAKA Masafumi 日高將文

日高将文ヒダカマサフミ

[Presentation] 黄麹菌のデンプン分解酵素生産に関与する転写因子FlbCの大腸菌発現・精製系の構築2023