Wang Linan 王立楠

… Alternative Names

Wang linan 王立楠

WANG Linan 王立楠

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Researcher Number	00589484
Affiliation (Current)	2025: 三重大学, 医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2025: 三重大学, 医学系研究科, 助教 2022 – 2023: 三重大学, 医学系研究科, 助教 2020 – 2021: 三重大学, 医学系研究科, 産学官連携講座助教 2017 – 2019: 三重大学, 医学系研究科, 特任助教(研究担当) 2016: 三重大学, 医学系研究科, 産学官連携研究員 … More 2014: 三重大学, 大学院医学系研究科, 特任助教(研究担当) 2012 – 2014: 三重大学, 医学(系)研究科(研究院), 特任助教(研究担当) 2010 – 2011: 三重大学, 大学院・医学系研究科, 特任助教 Less
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / General surgery / Basic Section 55020:Digestive surgery-related / Tumor therapeutics Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Respiratory organ internal medicine / General surgery
Keywords	Principal Investigator CAR-T / CEA / GITR / 免疫機能機構 / GITRリガンド / low Δψm/high mitomass / GSH前駆物質 / 幹細胞様メモリーT細胞(Tscm) / 疲弊抵抗性のCAR-T / GSH … More / ROS / N-acetyl-cysteine(NAC) / CAT-T細胞 / primary CD4T / TAA / CCR7 / CD62L / 腫瘍局所 / 代謝 / 疲弊マーカー / primaryCD4+ T細胞 / 癌胎児性抗原(CEA) / メラ抗原受容体(CAR) / naiveCD4T細胞 / primaryCD4+T細胞 / 固形がん / CAR-T細胞療法 / 抑制シグナル / PD-1 / 制御性T細胞 / :Gene Therapy / GITL / CAR / 癌胎児性抗原 / 複刺激シグナル分子 / がん治療 / T細胞受容体 / 胎児性癌抗原 / キメラ抗原受容体 / CAR-T細胞 / CEA-Tgマウス / scFv / TCR / T-body / NOG mouse / MAGE-A4 … More Except Principal Investigator キメラ抗原受容体 / 癌胎児性抗原 / 酸化ストレス / ミトコンドリア / 抗酸化因子 / T細胞輸注療法 / CAR-T / T細胞疲弊 / 抗酸化剤 / 細胞輸注療法 / 膵臓癌 / γδT細胞 / 疲弊抵抗性 / 移植片対宿主反応 / アロ反応性 / off-the-shelf / γδＴ細胞 / GITRシグナル / 固形がん / Ｔ細胞輸注療法 / 制御性Ｔ細胞 / 喘息 / 制御性T細胞 / キメラ抗原受容他 Less

CAR-T with memory property and resistance to immune suppression by introducing GITR ligandPrincipal Investigator
- Principal Investigator
  
  王立楠
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Mie University
疲弊抵抗性CAR-Tと腫瘍微小環境制御による固形がんに対するT細胞輸注療法
- Principal Investigator
  
  加藤琢磨
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Mie University
疲弊抵抗性CAR-Tと幹細胞様メモリーCAR-Tによるがん治療Principal Investigator
- Principal Investigator
  
  王立楠
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Mie University
Off-the-shelf immunotherapy with CAR-gamma delta T cells
- Principal Investigator
  
  Kato Takuma
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Mie University
Augmentation and mechanism of CAR-T cell therapy by naive CD4+ T cell helpPrincipal Investigator
- Principal Investigator
  
  WANG LINAN
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Mie University
Solid cancer treatment with CAR-T cells resistant to the immunosuppressive mechanism of cancer microenvironmentPrincipal Investigator
- Principal Investigator
  
  Wang linan
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Mie University
Therapeutic potintial of Tregs transduced with CEA specific CAR in sever asthma
- Principal Investigator
  
  KATO Takuma
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Mie University
A paradigm shift in T cell adaptive cell therapy using Th1/Th17 cells transduced chimeric antigen receptor
- Principal Investigator
  
  KATO Takuma
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Mie University
EFFICACY AND SAFETY OF T CELLS WITH CEA-SPECIFIC CHIMERIC ANTIGEN RECEPTOR FOR CANCER IMMUNOTHERAPYPrincipal Investigator
- Principal Investigator
  
  WANG Linan
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Mie University
Functional analysis of cancer-specific human T cells in NOG mice : Cell interaction of CD4, CD8 cellsPrincipal Investigator
- Principal Investigator
  
  WANG Linan
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General surgery
- Research Institution
  Mie University

All 2024 2023 2022 2021 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Exhaustion, rather than lack of infiltration and persistence, of CAR-T cells hampers the efficacy of CAR-T therapy in an orthotopic PDAC xenograft model2024
- Author(s)
  Yuta Takeuchi, Yizheng Wang, Katsunori Sasaki, Osamu Sato, Takahiro Tsuchikawa, Linan Wang, Yasunori Amaishi, Sachiko Okamoto, Junichi Mineno, Yoshifumi Hirokawa, Kanako C Hatanaka, Yutaka Hatanaka, Takuma Kato, Hiroshi Shiku, Satoshi Hirano
- Journal Title
  
  Biomed Pharmacoher
  
  Volume: 170 Pages: 116052-116052
- DOI
  10.1016/j.biopha.2023.116052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06714, KAKENHI-PROJECT-21K07189
[Journal Article] Preclinical evaluation of a novel CAR-T therapy utilizing a scFv antibody highly specific to MAGE-A4p230-239/HLA-A*02:01 complex2024
- Author(s)
  Linan Wang, Masahiro Matsumoto, Yasushi Akahori, Naohiro Seo, Kazuko Shirakura, Takuma Kato, Yoichi Katsumoto, Yoshihiro Miyahara, Hiroshi Shiku
- Journal Title
  
  Mol Ther
  
  Volume: 32 Issue: 3 Pages: 374-348
- DOI
  10.1016/j.ymthe.2024.01.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06714, KAKENHI-PROJECT-23K24180
[Journal Article] CAR-Modified Vγ9Vδ2 T Cells Propagated Using a Novel Bisphosphonate Prodrug for Allogeneic Adoptive Immunotherapy2023
- Author(s)
  Yizheng Wang, Linan Wang, Naohiro Seo, Satoshi Okumura, Tae Hayashi, Yasushi Akahori, Hiroshi Fujiwara, Yasunori Amaishi, Sachiko Okamoto, Junichi Mineno, Yoshimasa Tanaka, Takuma Kato, Hiroshi Shiku
- Journal Title
  
  Int J Mol Sci
  
  Volume: 24 Issue: 13 Pages: 10873-10873
- DOI
  10.3390/ijms241310873
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06714, KAKENHI-PROJECT-23K27455
[Journal Article] Tumor Growth Suppression of Pancreatic Cancer Orthotopic Xenograft Model by CEA-Targeting CAR-T Cells2023
- Author(s)
  Osamu Sato, Takahiro Tsuchikawa , Takuma Kato , Yasunori Amaishi , Sachiko Okamoto, Junichi Mineno , Yuta Takeuchi , Katsunori Sasaki, Toru Nakamura, Kazufumi Umemoto, Tomohiro Suzuki, Linan Wang, Yizheng Wang, Kanako C Hatanaka , Tomoko Mitsuhashi , Yutaka Hatanaka , Hiroshi Shiku , Satoshi Hirano
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 3 Pages: 1-18
- DOI
  10.3390/cancers15030601
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07674
[Journal Article] Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination.2018
- Author(s)
  Akahori Y, Wang L, Yoneyama M, Seo N, Okumura S, Miyahara Y, Amaishi Y, Okamoto S, Mineno J, Ikeda H, Maki T, Fujiwara H, Akatsuka Y, Kato T, Shiku H.
- Journal Title
  
  Blood. 2018 Sep 13;132(11):
  
  Volume: 132 Issue: 11 Pages: 1134-1145
- DOI
  10.1182/blood-2017-08-802926
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08341, KAKENHI-PROJECT-18K08361, KAKENHI-PROJECT-18K19474, KAKENHI-PROJECT-18K19584, KAKENHI-PROJECT-18H02872, KAKENHI-PROJECT-16K09533
[Journal Article] Efficient Tumor Regression by Adoptively Transferred CEA-Specific CAR-T Cells Associated with Symptoms of Mild Cytokine Release Syndrome.2016
- Author(s)
  Wang L, Ma N, Okamoto S, Amaishi Y, Sato E, Mineno J, Takesako K, Kato T and Shiku H.
- Journal Title
  
  OncoImmunology
  
  Volume: 5 Issue: 9 Pages: e1211218-e1211218
- DOI
  10.1080/2162402x.2016.1211218
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460813, KAKENHI-PROJECT-16K09533
[Journal Article] Alloantigen-specific CD4+ regulatory T cells induced in vivo by ultraviolet irradiation after alloantigen immunization require interleukin-10 for their induction and activation, and flexibly mediate bystander immunosuppression of allograft rejection2015
- Author(s)
  Hori T, Kuribayashi K, Saito K, Wang L, Torii M, Uemoto S, Kato T
- Journal Title
  
  Transpl Immunol
  
  Volume: in press Issue: 3 Pages: 1-8
- DOI
  10.1016/j.trim.2015.03.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670553
[Journal Article] Ultraviolet-induced alloantigen-specific immunosuppression in transplant immunity.2015
- Author(s)
  Hori T, Kuribayashi K, Saito K, Wang L, Torii M, Uemoto S, Iida T, Yagi S, Kato T.
- Journal Title
  
  World J Transplant
  
  Volume: 5 Issue: 1 Pages: 11-18
- DOI
  10.5500/wjt.v5.i1.11
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24501332, KAKENHI-PROJECT-24591877, KAKENHI-PROJECT-25670553, KAKENHI-PROJECT-25461967
[Journal Article] Induction of alloantigen-specific CD4+ T regulatory Type 1 cells by alloantigen immunization and ultraviolet-B irradiation: a pilot study in murine transplantation models with skin and cardiac allografts.2014
- Author(s)
  Hori T, Kuribayashi K, Saito K, Wang L, Torii M, Uemoto S, Kato T.
- Journal Title
  
  Ann Transplant
  
  Volume: 19 Pages: 519-36
- DOI
  10.12659/aot.890890
- NAID
  120005530947
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24501332, KAKENHI-PROJECT-25670553
[Journal Article] Establishment of animal models to analyze the kinetics and distribution of human tumor antigen-specific CD8+ T cells2013
- Author(s)
  Muraoka D, Nishikawa H, Noguchi T, Wang L, Harada N, Sato E, Luescher I, Nakayama E, Kato T, Shiku H
- Journal Title
  
  Vaccine
  
  Volume: 31(17) Issue: 17 Pages: 2110-2118
- DOI
  10.1016/j.vaccine.2013.02.056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300354, KAKENHI-PROJECT-24650259, KAKENHI-PROJECT-25430161, KAKENHI-PROJECT-25670553
[Journal Article] Endocrine disruptors found in food contaminants enhance allergic sensitization through an oxidative stress that promotes the development of allergic airway inflammation.2013
- Author(s)
  Kato T, Tada-Oikawa S, Wang L, Murata M, Kuribayashi K.
- Journal Title
  
  Toxicol Appl Pharmacol.
  
  Volume: 273 Issue: 1 Pages: 10-18
- DOI
  10.1016/j.taap.2013.08.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293149, KAKENHI-PROJECT-25305020, KAKENHI-PROJECT-25460798, KAKENHI-PROJECT-25670553
[Journal Article] T-cell receptor gene therapy targeting melanoma-associated antigen-A4 inhibits human tumor growth in non-obese diabetic/SCID/γc^<null> mice2012
- Author(s)
  Shirakura, Wang, et al
- Journal Title
  
  Cancer Science
  
  Volume: 103(1) Pages: 17-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890084
[Journal Article] T-cell receptor gene therapy targeting melanoma-associated antigen-A4 inhibits human tumor growth in non-obese diabetic/SCID/γcnull mice2012
- Author(s)
  Shirakura Y, Mizuno Y, Wang L, Imai N, Amaike C, Sato E, Ito M, Nukaya I, Mineno J, Takesako K, Ikeda H, Shiku H
- Journal Title
  
  Cancer Science
  
  Volume: 103 Pages: 17-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890084
[Journal Article] Intracellular Tumor-Associated Antigens Represent Effective Targets for Passive Immunotherapy2012
- Author(s)
  Noguchi T, Kato T, Wang L, Maeda Y, Ikeda H, Sato E, Knuth A, Gnjatic S, Ritter G, Sakaguchi S, Old LJ, Shiku H, Nishikawa H.
- Journal Title
  
  Cancer Science
  
  Volume: 72(7) Pages: 1672-1682
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890084
[Presentation] N-acetylcysteine trigger exhaustion resistant CAR-T cell for solid tumor immunotherapy2022
- Author(s)
  Yizheng Wang, Yasunori Amaishi, Sachiko Okamoto, Junichi Mineino,Takuma Kato and Hiroshi Shiku
- Organizer
  日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-20K07674
[Presentation] N-acetylcysteine renders CAR-T cells resistant to exhaustion for solid tumor immunotherapy2022
- Author(s)
  Yizheng Wang, Yasunori Amaishi, Sachiko Okamoto, Junichi Mineino,Takuma Kato and Hiroshi Shiku
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-20K07674
[Presentation] Potential for the use of gene-modified Vγ9Vδ2 T cells for cancer immunotherapy2021
- Author(s)
  Yizheng Wang, Linan Wang, Satoshi Okumura, Naohiro Seo, Sachiko Okamoto, Yasunori Amaishi, Junichi Mineno, Yoshimasa Tanaka, Takuma Kato and Hiroshi Shiku
- Organizer
  日本サイトカイン・インターフェロン学会
- Data Source
  KAKENHI-PROJECT-20K07674
[Presentation] Potential for the use of gene-modified Vγ9Vδ2 T cells for cancer immunotherapy2021
- Author(s)
  Yizheng Wang, Linan Wang, Satoshi Okumura, Naohiro Seo, Sachiko Okamoto, Yasunori Amaishi, Junichi Mineno, Yoshimasa Tanaka, Takuma Kato and Hiroshi Shiku
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-20K07674
[Presentation] Promising use of gene-modified γδ T cells for Cancer Immunotherapy2018
- Author(s)
  Okumura S, Kato T, Wang Y, Hayashi T, Shirakura K, Ikeda H, Wang L, Miyahara Y, Tanaka Y, Shiku H.
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-16K09533
[Presentation] Anti-tumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination2018
- Author(s)
  Akahori Y, Wang L, Yoneyama M, Seo N, Okumura S, Miyahara Y, Amaishi Y, Okamoto S, Mineno J, Ikeda H, Maki T, Fujiwara H, Akatsuka Y, Kato T, Shiku H.
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-16K09533
[Presentation] Anti-tumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination2018
- Author(s)
  Akahori Y, Wang L, Yoneyama M, Seo N, Okumura S, Miyahara Y, Amaishi Y, Okamoto S, Mineno J, Ikeda H, Maki T, Fujiwara H, Akatsuka Y, Kato T, Shiku H.
- Organizer
  日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-16K09533
[Presentation] T cells expressing CAR harbouring GITR signalling domain exhibit prolonged in vivo survival and resistance to immunosuppression that lead to efficient tumor eradication2017
- Author(s)
  Takuma Kato, Linan Wang, Sachiko Okamoto, Yasunori Amaishi, Naohiro Seo, Junichi Mineno, Kazutoh Takesako, and Hiroshi Shiku
- Organizer
  25th European Society for Gene and Cell Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09533
[Presentation] Efficient tumor eradication by CAR-T with GITR signal due to prolonged persistency and resistance to immunosuppression2017
- Author(s)
  Linan Wang, Takuma Kato, Sachiko Okamoto, Yasunori Amaishi, Naohiro Seo, Junichi Mineno, Kazutoh Takesako, and Hiroshi Shiku
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09533
[Presentation] T cells expressing CAR harboring GITR signaling domain exhibit prolonged in vivo survival and resistance to immunosuppression that lead to efficient tumor eradication2017
- Author(s)
  Takuma Kato, Linan Wang, Sachiko Okamoto, Yasunori Amaishi, Naohiro Seo, Junichi Mineno, Kazutoh Takesako, and Hiroshi Shiku
- Organizer
  日本遺伝子細胞治療学会
- Data Source
  KAKENHI-PROJECT-16K09533
[Presentation] Efficient tumor eradication by CAR-T with GITR signal due to prolonged persistency and resistance to immunosuppression2017
- Author(s)
  Linan Wang, Takuma Kato, Sachiko Okamoto, Yasunori Amaishi, Naohiro Seo, Junichi Mineno, Kazutoh Takesako, and Hiroshi Shiku
- Organizer
  第21回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K09533
[Presentation] Stromal cells modulated by IL-17A promote lung metastasis of breast cancer cells2017
- Author(s)
  Kanako Saito, Takuma Kato, Naohiro Seo, Linan Wang, Toshimichi Yoshida, Hiroshi Shiku, Naoyuki Katayama
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09533
[Presentation] Efficient Tumour Regression by Adoptively Transferred CEA-Specific CAR-T Cells Associated with Symptoms of Mild Cytokine Release Syndrome which can be treated by anti-IL-6 receptor without compromising its efficacy2016
- Author(s)
  Linan Wang, Ning Ma, Sachiko Okamoto, Yasunori Amaishi, Eiichi Sato, Naohiro Seo, Junichi Mineno, Kazutoh Takesako, Takuma Kato and Hiroshi Shiku
- Organizer
  日本がん免疫学会
- Place of Presentation
  大阪国際交流センター（大阪府・大阪市）
- Year and Date
  2016-07-27
- Data Source
  KAKENHI-PROJECT-16K09533
[Presentation] Efficient Tumour Regression by Adoptively Transferred CEA-Specific CAR-T Cells Associated with Symptoms of Mild Cytokine Release Syndrome which can be treated by anti-IL-6 receptor without compromising its efficacy2016
- Author(s)
  Linan Wang, Ning Ma, Sachiko Okamoto, Yasunori Amaishi, Eiichi Sato, Naohiro Seo, Junichi Mineno, Kazutoh Takesako, Takuma Kato and Hiroshi Shiku
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K09533
[Presentation] Efficacy and safety of T cells with CEA specific chimeric antigen receptor for cancer immunotherapy2013
- Author(s)
  王　立楠
- Organizer
  日本癌学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591899
[Presentation] 日本癌学会2013
- Author(s)
  王立楠、加藤琢磨、瀬尾尚宏、岡本幸子、天石泰典、峰野純一、竹迫一任、珠玖洋
- Organizer
  王立楠、加藤琢磨、瀬尾尚宏、岡本幸子、天石泰典、峰野純一、竹迫一任、珠玖洋
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25670553
[Presentation] 癌胎児性抗原（CEA）を標的としたキメラ抗原受容体導入T細胞輸注療法の有効性と安全性の検討2013
- Author(s)
  王立楠、加藤琢磨、瀬尾尚宏、岡本幸子、天石泰典、峰野純一、竹迫一任、珠玖洋
- Organizer
  日本がん免疫学会
- Place of Presentation
  ＡＮＡクラウンプラザホテル宇部
- Data Source
  KAKENHI-PROJECT-25670553
[Presentation] 機能制御性キメラ抗原レセプター（CAR）導入T細胞輸注療法の開発2013
- Author(s)
  天池千咲、池田裕明、王立楠、加藤琢磨、岡本幸子、天石泰典、峰野純一、竹迫一任、珠玖洋
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25670553
[Presentation] 癌胎児性抗原を標的としたキメラ抗原受容体導入T細胞輸注療法の有効性と安全性の検討2013
- Author(s)
  王　立楠
- Organizer
  日本がん免疫学会
- Place of Presentation
  山口
- Data Source
  KAKENHI-PROJECT-24591899
[Presentation] ヒトと同様の発現様式を示す癌胎児性抗原（CEA）トランスジェニックマウスを用いたCEA特異的キメラ抗原受容体導入T細胞輸注療法の有効性と安全性の検討
- Author(s)
  王立楠、加藤琢磨、瀬尾尚宏、岡本幸子、天石泰典、峰野純一、竹迫一任、珠玖洋
- Organizer
  日本がん免疫学会
- Place of Presentation
  ひめぎんホール、松山
- Year and Date
  2014-07-30 – 2014-08-01
- Data Source
  KAKENHI-PROJECT-25670553
[Presentation] Efficacy and safety of T cells with CEA-specific chimeric antigen receptor for cancer immunotherapy
- Author(s)
  L. Wang, T. Kato, N. Seo, S. Okamoto, Y. Amaishi, J. Mineno, K. Takesako, H. Shiku
- Organizer
  Cell Symposia: Cancer, inflammation, and Immunity
- Place of Presentation
  Stiges, Sapin
- Year and Date
  2015-06-14 – 2015-06-16
- Data Source
  KAKENHI-PROJECT-25670553
[Presentation] EFFICACY AND SAFETY OF T CELLS WITH CEA-SPECIFIC CHIMERIC ANTIGEN RECEPTOR FOR CANCER IMMUNOTHERAPY
- Author(s)
  Linan Wang, Takuma Kato, Naohiro Seo, Sachiko Okamoto, Yasunori Amaishi, Junichi Mineno, Kazutoh Takesako, and Hiroshi Shiku
- Organizer
  Keystone Symposia
- Place of Presentation
  Banff, Canada
- Year and Date
  2015-02-08 – 2015-02-13
- Data Source
  KAKENHI-PROJECT-25670553
[Presentation] EFICACY AND SAFETY OF T CELLS WITH CEA-SPECIFIC CHIMERIC ANTIGEN RECEPTOR FOR CANCER IMMUNOTHERAPY
- Author(s)
  Linan Wang, Takuma Kato, Naohiro Seo, Sachiko Okamoto, Yasunori Amaishi, Junichi Mineno, Kazutoh Takesako, and Hiroshi Shiku
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25670553
[Presentation] EFFICACY AND SAFETY OF T CELLS WITH CEA-SPECIFIC CHIMERIC ANTIGEN RECEPTOR FOR CANCER IMMUNOTHERAPY
- Author(s)
  Linan Wang, Takuma Kato, Naohiro Seo, Sachiko Okamoto, Yasunori Amaishi, Junichi Mineno, Kazutoh Takesako, and Hiroshi Shiku
- Organizer
  日本遺伝子治療学会
- Place of Presentation
  慈恵医科大学、東京
- Year and Date
  2014-07-06 – 2014-07-08
- Data Source
  KAKENHI-PROJECT-25670553

1. KATO Takuma (60224515)

# of Collaborated Projects: 9 results

# of Collaborated Products: 29 results
2. 宮原慶裕 (10582083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 西川博嘉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 馬寧

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 赤塚美樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 村田真理子子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 及川伸二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Wang Linan 王 立楠

Wang linan 王 立楠

WANG Linan 王 立楠

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CAR-T with memory property and resistance to immune suppression by introducing GITR ligandPrincipal Investigator

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疲弊抵抗性CAR-Tと腫瘍微小環境制御による固形がんに対するT細胞輸注療法

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疲弊抵抗性CAR-Tと幹細胞様メモリーCAR-Tによるがん治療Principal Investigator

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Off-the-shelf immunotherapy with CAR-gamma delta T cells

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Augmentation and mechanism of CAR-T cell therapy by naive CD4+ T cell helpPrincipal Investigator

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Solid cancer treatment with CAR-T cells resistant to the immunosuppressive mechanism of cancer microenvironmentPrincipal Investigator

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Therapeutic potintial of Tregs transduced with CEA specific CAR in sever asthma

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A paradigm shift in T cell adaptive cell therapy using Th1/Th17 cells transduced chimeric antigen receptor

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EFFICACY AND SAFETY OF T CELLS WITH CEA-SPECIFIC CHIMERIC ANTIGEN RECEPTOR FOR CANCER IMMUNOTHERAPYPrincipal Investigator

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Functional analysis of cancer-specific human T cells in NOG mice : Cell interaction of CD4, CD8 cellsPrincipal Investigator

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[Journal Article] Exhaustion, rather than lack of infiltration and persistence, of CAR-T cells hampers the efficacy of CAR-T therapy in an orthotopic PDAC xenograft model2024

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[Journal Article] Preclinical evaluation of a novel CAR-T therapy utilizing a scFv antibody highly specific to MAGE-A4p230-239/HLA-A*02:01 complex2024

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[Journal Article] CAR-Modified Vγ9Vδ2 T Cells Propagated Using a Novel Bisphosphonate Prodrug for Allogeneic Adoptive Immunotherapy2023

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Wang Linan 王立楠

Wang linan 王立楠

WANG Linan 王立楠