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Ohigashi Izumi  大東 いずみ

… Alternative Names

大東 いずみ  オオヒガシ イズミ

OHIGASHI Izumi  大東 いずみ

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Researcher Number 00596588
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-6432-5355
Affiliation (Current) 2025: 徳島大学, 先端酵素学研究所, 教授
Affiliation (based on the past Project Information) *help 2022 – 2023: 徳島大学, 先端酵素学研究所, 教授
2021: 徳島大学, 先端酵素学研究所, 准教授
2016 – 2019: 徳島大学, 先端酵素学研究所(プロテオ), 准教授
2015: 徳島大学, 疾患プロテオゲノム研究センター, 講師
2012 – 2014: 徳島大学, 疾患プロテオゲノム研究センター, 特任助教
2011: 徳島大学, 疾患ゲノム研究センター, 特任助教
Review Section/Research Field
Principal Investigator
Immunology / Basic Section 48040:Medical biochemistry-related
Except Principal Investigator
Immunology / Basic Section 59040:Nutrition science and health science-related
Keywords
Principal Investigator
胸腺 / 胸腺上皮細胞 / 獲得免疫 / 細胞分化 / 胸腺髄質上皮細胞 / 自己免疫 / 発現制御 / CCL21 / がん / ケモカイン … More / 上皮細胞 / プロテオームプロファイリング / 生殖機能 / 精巣 / プロテアソーム / プロテオーム / β5t / 髄質上皮細胞 / 自己免疫寛容性 / 免疫寛容 … More
Except Principal Investigator
胸腺 / Tリンパ球 / 膵beta細胞 / Prss53 / 膵島 / ミトコンドリア / 膵β細胞 / レパトア / 正の選択 / 免疫学 / 胸腺微小環境 / Tリンパ球レパトア形成 / 胸腺上皮細胞 / レパトア形成 / 獲得免疫 Less
  • Research Projects

    (8 results)
  • Research Products

    (136 results)
  • Co-Researchers

    (13 People)
  •  自己免疫疾患とガンの病態に関与するケモカインCCL21の発現制御メカニズムの研究Principal Investigator

    • Principal Investigator
      大東 いずみ
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      The University of Tokushima
  •  膵β細胞特異的Prss53の分子メカニズム

    • Principal Investigator
      水澤 典子
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      The University of Tokushima
  •  The mechanism regulating the development of thymic epithelial cellsPrincipal Investigator

    • Principal Investigator
      OHIGASHI Izumi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokushima
  •  Positive selection of T cells in the thymic cortex

    • Principal Investigator
      TAKAHAMA Yousuke
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokushima
  •  Molecular mechanism of the development of thymic epithelial cellsPrincipal Investigator

    • Principal Investigator
      OHIGASHI Izumi
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokushima
  •  Development and developmental potential of beta5t-expressing thymic epithelial cellsPrincipal Investigator

    • Principal Investigator
      OHIGASHI Izumi
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokushima
  •  Molecular basis for the thymic microenvironments that characterize the immune system

    • Principal Investigator
      TAKAHAMA Yousuke
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokushima
  •  The challenge for the development of therapy for autoimmune disorder by the establishment of artificial thymic medullary organPrincipal Investigator

    • Principal Investigator
      OHIGASHI Izumi
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Immunology
    • Research Institution
      The University of Tokushima

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

  • [Book] Encyclopedia of Immunobiology2016

    • Author(s)
      Ohigashi I, Takahama Y.
    • Total Pages
      3126
    • Publisher
      Elsevier
    • Data Source
      KAKENHI-PROJECT-15K19130
  • [Journal Article] The role of thymic epithelium in thymus development and age-related thymic involution2024

    • Author(s)
      Fujimori Sayumi、Ohigashi Izumi
    • Journal Title

      The Journal of Medical Investigation

      Volume: 71 Pages: 23-39

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K06900
  • [Journal Article] Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium2024

    • Author(s)
      Ohigashi Izumi、White Andrea J、Yang Mei-Ting、Fujimori Sayumi、Tanaka Yu、Jacques Alison、Kiyonari Hiroshi、Matsushita Yosuke、Turan Sevilay、Kelly Michael C、Anderson Graham、Takahama Yousuke
    • Journal Title

      eLife

      Volume: 12

    • DOI

      10.7554/elife.92552

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06900
  • [Journal Article] Large-scale isolation of mouse thymic epithelial cells2023

    • Author(s)
      Ohigashi I, Matsuda-Lennikov M, Takahama Y.
    • Journal Title

      Methods in Molecular Biology

      Volume: 2580 Pages: 189-197

    • DOI

      10.1007/978-1-0716-2740-2_11

    • ISBN
      9781071627396, 9781071627402
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06900
  • [Journal Article] Endogenous CCL21-Ser deficiency reduces B16-F10 melanoma growth by enhanced antitumor immunity2023

    • Author(s)
      Fujie Ryonosuke、Kurowarabe Kaoru、Yamada Yuki、Fujiwara Kakeru、Nakatani Hayato、Tsutsumi Kenta、Hayashi Ryota、Kawahata Hinami、Miyamoto Megumi、Ozawa Madoka、Katakai Tomoya、Takahama Yousuke、Ohigashi Izumi、Hayasaka Haruko
    • Journal Title

      Heliyon

      Volume: 9 Issue: 8 Pages: e19215-e19215

    • DOI

      10.1016/j.heliyon.2023.e19215

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06823, KAKENHI-PROJECT-22K06900, KAKENHI-PROJECT-21H02653
  • [Journal Article] CCL21‐Ser expression in melanoma cells recruits CCR7+ naive T cells to tumor tissues and promotes tumor growth2023

    • Author(s)
      Miyamoto Megumi、Kawato Yuki、Fujie Ryonosuke、Kurowarabe Kaoru、Fujiwara Kakeru、Nobusawa Reika、Hayashi Ryota、Iida Kei、Ohigashi Izumi、Hayasaka Haruko
    • Journal Title

      Cancer Science

      Volume: 114 Issue: 9 Pages: 3509-3522

    • DOI

      10.1111/cas.15902

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06823, KAKENHI-PROJECT-22K06900
  • [Journal Article] Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla2023

    • Author(s)
      Lucas Beth、White Andrea J.、Klein Fabian、Veiga-Villauriz Clara、Handel Adam、Bacon Andrea、Cosway Emilie J.、James Kieran D.、Parnell Sonia M.、Ohigashi Izumi、Takahama Yousuke、Jenkinson William E.、Hollander Georg A.、Lu Wei-Yu、Anderson Graham
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1

    • DOI

      10.1038/s41467-023-37589-4

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06900
  • [Journal Article] Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift2022

    • Author(s)
      Zhang Y, Garcia-Ibanez L, Ulbricht C, Lok LSC, Pike JA, Mueller-Winkler J, Dennison TW, Ferdinand JR, Burnett CJM, Yam-Puc JC, Zhang L, Alfaro RM, Takahama Y, Ohigashi I, Brown G, Kurosaki T, Tybulewicz VLJ, Rot A, Hauser AE, Clatworthy MR, Toellner KM.
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 2460-2460

    • DOI

      10.1038/s41467-022-29978-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06900, KAKENHI-PROJECT-22H00450
  • [Journal Article] Tissue-specific proteasomes in generation of MHC class I peptides and CD8+ T cells2022

    • Author(s)
      Matsuda-Lennikov M, Ohigashi I, Takahama Y.
    • Journal Title

      Current Opinion in Immunology

      Volume: 77 Pages: 102217-102217

    • DOI

      10.1016/j.coi.2022.102217

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06900
  • [Journal Article] Identification of protease serine S1 family member 53 as a mitochondrial protein in murine islet beta cells2021

    • Author(s)
      Noriko Mizusawa, Nagakatsu Harada, Takeo Iwata, Izumi Ohigashi, Mitsuo Itakura & Katsuhiko Yoshimoto
    • Journal Title

      Islets

      Volume: 14(1) Issue: 1 Pages: 1-13

    • DOI

      10.1080/19382014.2021.1982325

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K11698
  • [Journal Article] PITHD1 is a proteasome-interacting protein essential for male fertilization2020

    • Author(s)
      Kondo Hiroyuki、Matsumura Takafumi、Kaneko Mari、Inoue Kenichi、Kosako Hidetaka、Ikawa Masahito、Takahama Yousuke、Ohigashi Izumi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 295 Issue: 6 Pages: 1658-1672

    • DOI

      10.1074/jbc.ra119.011144

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-19H05749, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-17K08884
  • [Journal Article] TCR Affinity for In Vivo Peptide-Induced Thymic Positive Selection Fine-Tunes TCR Responsiveness of Peripheral CD8+ T Cells2019

    • Author(s)
      Khanom Umme Shahina、Ohigashi Izumi、Fujimori Sayumi、Kondo Kenta、Takada Kensuke、Takahama Yousuke
    • Journal Title

      The Journal of Immunology

      Volume: 203 Issue: 4 Pages: 881-887

    • DOI

      10.4049/jimmunol.1900097

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-17H03928, KAKENHI-PROJECT-17K08884, KAKENHI-PROJECT-18K19253
  • [Journal Article] Thymoproteasome and peptidic self2019

    • Author(s)
      Takahama Y, Ohigashi I, Murata S, Tanaka K.
    • Journal Title

      Immunogenetics

      Volume: 71 Issue: 3 Pages: 217-221

    • DOI

      10.1007/s00251-018-1081-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08884, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-26000014
  • [Journal Article] Trans-omics impact of thymoproteasome in cortical thymic epithelial cells.2019

    • Author(s)
      Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin A, Hoffmann V, Kozai M, Matsushita Y, Uda S, Motosugi R, Hamazaki J, Kubota H, Murata S, Tanaka K, Katagiri T, Kosako H, Takahama Y
    • Journal Title

      Cell Reports

      Volume: 29 Issue: 9 Pages: 2901-2916

    • DOI

      10.1016/j.celrep.2019.10.079

    • NAID

      120006894616

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07062, KAKENHI-PLANNED-17H06419, KAKENHI-PUBLICLY-18H04801, KAKENHI-PLANNED-18H05500, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18H02431, KAKENHI-PROJECT-17K08884, KAKENHI-PROJECT-26000014, KAKENHI-PLANNED-16H06577
  • [Journal Article] Thymus machinery for T-cell selection2019

    • Author(s)
      Kondo K, Ohigashi I, Takahama Y
    • Journal Title

      International Immunology

      Volume: 31 Issue: 3 Pages: 119-125

    • DOI

      10.1093/intimm/dxy081

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08884, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-17K15727
  • [Journal Article] Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth2019

    • Author(s)
      Cowan Jennifer E.、Malin Justin、Zhao Yongge、Seedhom Mina O.、Harly Christelle、Ohigashi Izumi、Kelly Michael、Takahama Yousuke、Yewdell Jonathan W.、Cam Maggie、Bhandoola Avinash
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 5498-5498

    • DOI

      10.1038/s41467-019-13465-y

    • NAID

      120006949467

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-17K08884
  • [Journal Article] Cellularity of thymic epithelial cells in the postnatal mouse.2018

    • Author(s)
      Sakata M, Ohigashi I, Takahama Y.
    • Journal Title

      J Immunol.

      Volume: 200 Issue: 4 Pages: 1382-1388

    • DOI

      10.4049/jimmunol.1701235

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Journal Article] Cellularity of Thymic Epithelial Cells in the Postnatal Mouse.2018

    • Author(s)
      Sakata M, Ohigashi I, Takahama Y.
    • Journal Title

      The Journal of Immunology

      Volume: 200 Pages: 1382-1388

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Journal Article] Formation of the intrathymic dendritic cell pool requires CCL21-mediated recruitment of CCR7+ progenitors to the thymus2018

    • Author(s)
      Cosway EJ, Ohigashi I, Schauble K, Parnell SM, Jenkinson WE, Luther S, Takahama Y, Anderson G.
    • Journal Title

      The Journal of Immunology

      Volume: 201 Issue: 2 Pages: 516-523

    • DOI

      10.4049/jimmunol.1800348

    • NAID

      120006937667

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08884, KAKENHI-PROJECT-16H02630
  • [Journal Article] A distinct subset of fibroblastic stromal cells constitutes the cortex-medulla boundary subcompartment of the lymph node2018

    • Author(s)
      Takeuchi A, Ozawa M, Kanda Y, Kozai M, Ohigashi I, Kurosawa Y, Rahman MA, Kawamura T, Shichida Y, Umemoto E, Miyasaka M, Ludewig B, Takahama Y, Nagasawa T, Katakai T.
    • Journal Title

      Frontiers in Immunology

      Volume: 9 Pages: 2196-2196

    • DOI

      10.3389/fimmu.2018.02196

    • NAID

      120006937683

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08884, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-16H05204, KAKENHI-PLANNED-18H05417
  • [Journal Article] Essential role of CCL21 in establishment of central self-tolerance in T cells.2017

    • Author(s)
      Kozai M, Kubo Y, Katakai T, Kondo H, Kiyonari H, Schaeuble K, Luther SA, Ishimaru N, Ohigashi I, Takahama Y.
    • Journal Title

      Journal of Experimental Medicine

      Volume: 214 Issue: 7 Pages: 1925-1935

    • DOI

      10.1084/jem.20161864

    • NAID

      120006312717

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08884, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-16H02690, KAKENHI-PROJECT-16H05204, KAKENHI-PROJECT-16K15287
  • [Journal Article] Generation of diversity in thymic epithelial cells.2017

    • Author(s)
      Takahama Y, Ohigashi I, Baik S, Anderson G.
    • Journal Title

      Nat Rev Immunol

      Volume: 印刷中 Issue: 5 Pages: 295-305

    • DOI

      10.1038/nri.2017.12

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-15K19130, KAKENHI-PROJECT-17K08884, KAKENHI-PROJECT-16H02630
  • [Journal Article] Foxn1-β5t transcriptional axis controls CD8+ T cell production in the thymus.2017

    • Author(s)
      Uddin MM, Ohigashi I, Motosugi R, Nakayama T, Sakata M, Hamazaki J, Nishito Y, Rode I, Tanaka K, Takemoto T, Murata S, Takahama Y.
    • Journal Title

      Nat Commun

      Volume: 8 Issue: 1 Pages: 14419-14419

    • DOI

      10.1038/ncomms14419

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-15K19130, KAKENHI-PROJECT-16K08228, KAKENHI-PROJECT-26000014
  • [Journal Article] A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production2017

    • Author(s)
      Ohigashi I, Ohte Y, Setoh K, Nakase H, Maekawa A, Kiyonari H, Hamazaki Y, Sekai M, Sudo T, Tabara Y, Sawai H, Omae Y, Yuliwulandari R, Tanaka Y, Mizokami M, Inoue H, Kasahara M, Minato N, Tokunaga K, Tanaka K, Matsuda F, Murata S, Takahama Y.
    • Journal Title

      JCI Insight

      Volume: 2 Issue: 10 Pages: 1-14

    • DOI

      10.1172/jci.insight.93664

    • NAID

      120006733720

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08884, KAKENHI-PROJECT-15K19125, KAKENHI-PUBLICLY-15H01154, KAKENHI-PLANNED-24111008, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-17H04123, KAKENHI-PROJECT-15K15151, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-15H04716
  • [Journal Article] Flow cytometry analysis of thymic epithelial cells and their subpopulation2016

    • Author(s)
      Ohigashi I, Takahama Y
    • Journal Title

      Methods in Molecular Biology

      Volume: 1323 Pages: 65-73

    • DOI

      10.1007/978-1-4939-2809-5_5

    • ISBN
      9781493928088, 9781493928095
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K19130, KAKENHI-PLANNED-24111004, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-16H02630
  • [Journal Article] Dynamic spatio-temporal contribution of single b5t+ cortical epithelial precursors to the thymus medulla2016

    • Author(s)
      Mayer CE, Zuklys S, Zhanybekova S, Ohigashi I, Teh HY, Sansom SN, Shikama-Dorn N, Hafen K, Macaulay IC, Deadman ME, Ponting CP, Takahama Y, Hollander GA.
    • Journal Title

      European Journal of Immunology

      Volume: 46 Issue: 4 Pages: 846-856

    • DOI

      10.1002/eji.201545995

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19130, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-16H02630
  • [Journal Article] Development and developmental potential of cortical thymic epithelial cells2016

    • Author(s)
      Ohigashi I, Kozai M, Takahama Y
    • Journal Title

      Immunological Reviews

      Volume: 271 Pages: 10-22

    • NAID

      120006727049

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K19130
  • [Journal Article] Development and developmental potential of cortical thymic epithelial cells.2016

    • Author(s)
      Ohigashi I, Kozai M, Takahama Y.
    • Journal Title

      Immunol Rev

      Volume: 271 Issue: 1 Pages: 10-22

    • DOI

      10.1111/imr.12404

    • NAID

      120006727049

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-16H02630
  • [Journal Article] Adult thymic medullary epithelium is maintained and regenerated by lineage-restricted cells rather than bipotent progenitors2015

    • Author(s)
      Ohigashi I, Zuklys S, Sakata M, Mayer CE, Hamazaki Y, Minato N, Hollander GA, Takahama Y.
    • Journal Title

      Cell Rep.

      Volume: 13 Issue: 7 Pages: 1432-43

    • DOI

      10.1016/j.celrep.2015.10.012

    • NAID

      120006727050

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15151, KAKENHI-PROJECT-15K19130, KAKENHI-PUBLICLY-25111505, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-24590580, KAKENHI-PUBLICLY-15H01154, KAKENHI-PLANNED-24111008
  • [Journal Article] Serial progression of cortical and medullary thymic epithelial microenvironments2014

    • Author(s)
      Alves NL, Takahama Y, Ohigashi I, Ribeiro AR, Baik S, Anderson G, Jenkinson WE.
    • Journal Title

      Eur J Immunol.

      Volume: 44 Issue: 1 Pages: 16-22

    • DOI

      10.1002/eji.201344110

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249025, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-25860361
  • [Journal Article] Increased number of Hassall's corpuscles in myasthenia gravis patients with thymic hyperplasia2014

    • Author(s)
      Matsui N, Ohigashi I, Tanaka K, Nagayama Y, Kondo K, Kitagawa T, Yamashita S, Nomura Y, Takahama Y, Kaji R.
    • Journal Title

      J Neuroimmunol

      Volume: 269 Issue: 1-2 Pages: 56-61

    • DOI

      10.1016/j.jneuroim.2014.01.011

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23249025, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-25860361, KAKENHI-PROJECT-25870477
  • [Journal Article] Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.2014

    • Author(s)
      Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.
    • Journal Title

      J Immunol

      Volume: 192 Issue: 2 Pages: 630-640

    • DOI

      10.4049/jimmunol.1302550

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249025, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PUBLICLY-25111516, KAKENHI-PROJECT-25860361
  • [Journal Article] CCRL1 marks heterogeneity in cortical and medullary thymic epithelial cells.2014

    • Author(s)
      Ohigashi I, Takahama Y.
    • Journal Title

      Eur J Immunol

      Volume: 44 Issue: 10 Pages: 2872-2875

    • DOI

      10.1002/eji.201445091

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249025, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-25860361
  • [Journal Article] Development and function of thymic cortical epithelial cells.2014

    • Author(s)
      Takada K, Ohigashi I, Kasai M, Nakase H, Takahama Y.
    • Journal Title

      Curr Top Microbiol Immunol

      Volume: 373 Pages: 1-17

    • DOI

      10.1007/82_2013_322

    • ISBN
      9783642402517, 9783642402524
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249025, KAKENHI-PROJECT-23659246, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-24790475, KAKENHI-PUBLICLY-25111507, KAKENHI-PROJECT-25860361, KAKENHI-PROJECT-26460576
  • [Journal Article] Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells2013

    • Author(s)
      Ohigashi I, Saulius Z, Sakata M (他6名)
    • Journal Title

      Proceedings of the National Academy of Sciences USA

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659241
  • [Journal Article] Development and function of cortical thymic epithelial cells2013

    • Author(s)
      Takada K, Ohigashi I (他3名)
    • Journal Title

      Current Topics Microbiology and Immunology

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659241
  • [Journal Article] TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development2013

    • Author(s)
      Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak MJ, Zuklys S, Sharrow SO, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander G, Takahama Y, Hodes RJ.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 110 Issue: 52 Pages: 21107-21112

    • DOI

      10.1073/pnas.1314859111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249025, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PUBLICLY-25111516, KAKENHI-PROJECT-25860361
  • [Journal Article] Lymphotoxin beta receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells2013

    • Author(s)
      Lkhagvasuren E, Sakata M, Ohigashi I, Takahama Y.
    • Journal Title

      J Immunol

      Volume: 190 Issue: 10 Pages: 5110-5117

    • DOI

      10.4049/jimmunol.1203203

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249025, KAKENHI-PROJECT-23659241, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004
  • [Journal Article] Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.2013

    • Author(s)
      Ohigashi, I., Zuklys, S., Sakata, M., Mayer, GE., Zhanybekova. S., Murata, S., Tanaka, K., Hollander, G., and Takahama, Y.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 110 Issue: 24 Pages: 9885-9890

    • DOI

      10.1073/pnas.1301799110

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23249025, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-25860361
  • [Journal Article] The development of T lymphocytes in fetal thymus organ culture2013

    • Author(s)
      Nitta T, Ohigashi I, Takahama Y.
    • Journal Title

      Methods Mol Biol

      Volume: 946 Pages: 85-102

    • DOI

      10.1007/978-1-62703-128-8_6

    • ISBN
      9781627031271, 9781627031288
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249025, KAKENHI-PROJECT-23659241, KAKENHI-PROJECT-23790540, KAKENHI-PLANNED-24111004
  • [Journal Article] Thymic nurse cells provide microenvironment for secondary TCRα rearrangement in cortical thymocytes2012

    • Author(s)
      Nakagawa Y
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Issue: 50 Pages: 20572-20577

    • DOI

      10.1073/pnas.1213069109

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249025, KAKENHI-PROJECT-23659241, KAKENHI-PROJECT-23790540, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004
  • [Journal Article] Effects of RANKL on the thymic medulla.2011

    • Author(s)
      大東いずみ
    • Journal Title

      European Journal of Immunology

      Volume: 41巻 Pages: 1822-1827

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659241
  • [Journal Article] Effects of RANKL on the thymic medulla2011

    • Author(s)
      Ohigashi I
    • Journal Title

      European Journal of Immunology

      Volume: 41 Issue: 7 Pages: 1822-1827

    • DOI

      10.1002/eji.201141480

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059010, KAKENHI-PROJECT-23249025, KAKENHI-PROJECT-23790540
  • [Presentation] ケモカインCCL21を発現する胎仔期の胸腺髄質上皮細胞は自己抗原発現髄質上皮細胞への分化活性を有する2023

    • Author(s)
      大東いずみ、White Andrea J.、Yang Mei-Ting、藤森さゆ美、Anderson Graham、高浜洋介
    • Organizer
      第46回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-22K06900
  • [Presentation] Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in thymus medulla epithelium2023

    • Author(s)
      Ohigashi I, White A, Yang MT, Fujimori S, Anderson G, Takahama Y
    • Organizer
      ThymOz 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06900
  • [Presentation] Role of β-catenin in mouse thymic epithelial cells for postnatal thymic development2023

    • Author(s)
      藤森さゆ美、高田慎治、高浜洋介、大東いずみ
    • Organizer
      The 18th International Symposium of the Institute Network for Biomedical Sciences
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06900
  • [Presentation] ケモカインCCL21を発現する胸腺髄質上皮細胞は自己抗原発現髄質上皮細胞への分化活性を有する2023

    • Author(s)
      大東いずみ、White Andrea J、Yang Mei-Ting、藤森さゆ美、Anderson Graham、高浜洋介
    • Organizer
      第32回 Kyoto T Cell Conference
    • Data Source
      KAKENHI-PROJECT-22K06900
  • [Presentation] Role of β-catenin in thymic epithelial cells for postnatal thymic development and involution2023

    • Author(s)
      Fujimori S, Takada S, Takahama Y, Ohigashi I
    • Organizer
      ThymOz 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06900
  • [Presentation] Ccl21a 欠損マウスでの抗腫瘍免疫応答亢進における制御性 T 細胞の関与2022

    • Author(s)
      藤江 亮之介、藤原 翔、黒蕨 馨、大東 いずみ, 早坂 晴子
    • Organizer
      第45回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-22K06900
  • [Presentation] 胸腺プロテアソームは負の選択非依存的にCD8+T細胞の至適産生を制御する2022

    • Author(s)
      大東いずみ、Frantzeskakis Melina, 高浜洋介
    • Organizer
      第45回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-22K06900
  • [Presentation] Fine-tuning of beta-catenin in mouse thymic epithelial cells is required for postnatal T-cell development2022

    • Author(s)
      藤森さゆ美、大東いずみ、高浜洋介、高田慎治
    • Organizer
      第45回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-22K06900
  • [Presentation] Trans-omics profiling of thymic epithelial cells2019

    • Author(s)
      Ohigashi I
    • Organizer
      The 4th Symposium of the inter-university research network for trans-omics medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] 胸腺上皮細胞特異的なWnt/β-cateninシグナル経路活性制御の影響2019

    • Author(s)
      藤森さゆ美、大東いずみ、高田慎治、高浜洋介
    • Organizer
      第18回 四国免疫フォーラム
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] CD8T細胞の正の選択におけるペプチドスイッチ仮説の検証2019

    • Author(s)
      村松直美、大東いずみ、高浜洋介
    • Organizer
      第29回 Kyoto T cell conference
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] 胸腺上皮細胞のオミクスプロファイリング2019

    • Author(s)
      大東いずみ、小迫英尊、高濱洋介
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] マウス胸腺上皮細胞の分化にはβ-catenin依存性経路の精緻な制御が必要である2019

    • Author(s)
      藤森さゆ美、大東いずみ、高濱洋介、高田慎治
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] 新規プロテアソーム会合因子PITHD1は精子形成を制御する2019

    • Author(s)
      近藤博之、松村貴史、小迫英尊、伊川正人、高濱洋介、大東いずみ
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] 胸腺上皮細胞のオミクスプロファイリング2019

    • Author(s)
      大東いずみ、高浜洋介
    • Organizer
      第29回 Kyoto T cell conference
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] CD8T細胞の正の選択におけるペプチドスイッチ仮説の検証2019

    • Author(s)
      村松直美、大東いずみ、高濱洋介
    • Organizer
      第29回 Kyoto T Cell Conference
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] マウス胸腺上皮細胞の分化にはβ-catenin依存性経路の精緻な制御が必要である2019

    • Author(s)
      藤森さゆ美、大東いずみ、高浜洋介、高田慎治、
    • Organizer
      第42回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] 胸腺上皮細胞のオミクスプロファイリング2019

    • Author(s)
      大東いずみ、小迫英尊、高浜洋介
    • Organizer
      第42回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] 胸腺上皮細胞のオミクスプロファイリング2019

    • Author(s)
      大東いずみ、高濱洋介
    • Organizer
      第29回 Kyoto T Cell Conference
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] Trans-omics impact of thymoproteasome in cortical thymic epithelial cells2019

    • Author(s)
      大東いずみ、田中優、近藤健太、藤森さゆ美、Amy Palin、近藤博之、 小迫英尊、高濱洋介
    • Organizer
      EMBO Workshop ThymE: T cell and thymus biology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] 新規プロテアソーム会合因子PITHD1は精子形成を制御する2019

    • Author(s)
      近藤博之、松村貴史、小迫英尊、伊川正人、高浜洋介、大東いずみ
    • Organizer
      第42回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] Role of β-catenin in thymic epithelial progenies of β5t positive progenitors2019

    • Author(s)
      Fujimori S, Ohigashi I, Takahama Y, Takada S
    • Organizer
      ThymE: T cell and thymus biology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] Role of β-catenin in thymic epithelial progenies of β5t positive progenitors2019

    • Author(s)
      藤森さゆ美、大東いずみ、高濱洋介、高田慎治
    • Organizer
      EMBO Workshop ThymE: T cell and thymus biology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] 胸腺上皮細胞特異的なWnt/β-cateninシグナル経路活性制御の影響2019

    • Author(s)
      藤森さゆ美、大東いずみ、高田慎治、高濱洋介
    • Organizer
      第18回四国免疫フォーラム
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] Trans-omics impact of thymoproteasome in cortical thymic epithelial cells2019

    • Author(s)
      Ohigashi I, Tanaka Y, kondo K, Fujimori S, Palin A, Kondo H, Kosako H, Takahama Y
    • Organizer
      ThymE: T cell and thymus biology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] T細胞の自己免疫寛容確立におけるCCL21の役割2018

    • Author(s)
      大東いずみ、高浜洋介
    • Organizer
      第37回胸腺研究会
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] ヒト胸腺を用いた胸腺上皮細胞の解析2018

    • Author(s)
      松井尚子、大東いずみ、山本遥平、中川英刀、近藤和也、高濱洋介
    • Organizer
      第37回日本胸腺研究会
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] T細胞の自己寛容性確立におけるCCL21の役割2018

    • Author(s)
      大東いずみ、高濱洋介
    • Organizer
      第37回日本胸腺研究会
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] ヒト胸腺を用いた胸腺上皮細胞の解析2018

    • Author(s)
      松井尚子、大東いずみ、山本遥平、中川英刀、近藤和也、高浜洋介
    • Organizer
      第37回胸腺研究会
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] 胸腺皮質上皮細胞で高発現する新規分子の機能解析2018

    • Author(s)
      大東いずみ
    • Organizer
      第28回 Kyoto T cell Conference
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] Affinity required for positive selection to generate functional CD8+ T cells in vivo2018

    • Author(s)
      Umme Shahina Khanom, Kenta Kondo, Izumi Ohigashi and Yousuke Takahama
    • Organizer
      第17回四国免疫フォーラム
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] Peptide-induced positive selection of CD8+ T cells in vivo2018

    • Author(s)
      Umme Shahina Khanom、近藤健太、高田健介、大東いずみ、高濱洋介
    • Organizer
      第17回四国免疫フォーラム
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] Human PSMB11 polymorphisms that affect thymoproteasome processing and CD8+ T cell generation2018

    • Author(s)
      Ohigashi I, Takahama Y
    • Organizer
      The 8th ThymOz
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] Human PSMB11 polymorphisms that affect thymoproteasome processing and CD8+ T cell generation2018

    • Author(s)
      大東いずみ、高濱洋介
    • Organizer
      ThymOz-8
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] マウス胸腺上皮細胞特異的なWnt/b-cateninシグナル経路活性化による胸腺形成異常2018

    • Author(s)
      藤森さゆ美、大東いずみ、高田慎治、髙濵洋介
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] 胸腺皮質上皮細胞で高発現する新規分子の機能解析2018

    • Author(s)
      近藤博之、高濱洋介、大東いずみ
    • Organizer
      第28回 Kyoto T Cell Conference
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] プロテアソームに会合する新規分子 PITHD1 の機能解析2018

    • Author(s)
      近藤博之、松村貴史、小迫英尊、伊川正人、高濱洋介、大東いずみ
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] プロテアソームに会合する新規分子PITHD1の機能解析2018

    • Author(s)
      近藤博之、松村貴史、小迫英尊、伊川正人、髙濵洋介、大東いずみ
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] Enforced activation of β-catenin signaling in mouse thymic epithelial cells induces thymic dysplasia2018

    • Author(s)
      藤森さゆ美、大東いずみ、高田慎治、高濱洋介
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] Foxn1-binding cis-regulatory element required for optimal CD8+ T cell production in the thymus2017

    • Author(s)
      大東いずみ、Uddin Myn、竹本龍也、高濱洋介
    • Organizer
      11th International Symposium of The Institute Network “Frontiers in Biomedical Sciences”
    • Place of Presentation
      徳島大学(徳島県・徳島市)
    • Year and Date
      2017-01-26
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] CCL21 regulates T-cell self-tolerance in thymic medulla2017

    • Author(s)
      香西美奈、大東いずみ、高濱洋介
    • Organizer
      11th International Symposium of The Institute Network “Frontiers in Biomedical Sciences”
    • Place of Presentation
      徳島大学(徳島県・徳島市)
    • Year and Date
      2017-01-26
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] Essential role of CCL21 in establishment of central self-tolerance in T cells2017

    • Author(s)
      近藤博之、大東いずみ、高濱洋介
    • Organizer
      Kyoto T Cell Conference
    • Place of Presentation
      芝蘭会館(京都府・京都市)
    • Year and Date
      2017-03-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] マウス胸腺皮質上皮細胞亜集団におけるWnt/beta-cateninシグナル経路の活性化2017

    • Author(s)
      藤森さゆ美、大東いずみ、竹本龍也、高田慎治、高浜洋介
    • Organizer
      第40回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] 免疫ステルス獲得における異種細胞間相互作用2017

    • Author(s)
      大東いずみ、高濱洋介
    • Organizer
      第1回免疫ステルス公開シンポジウム
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] A human Psmb11 polymorphism affects molecular processing of thymoproteasome and thymic production of CD8+ T cells2017

    • Author(s)
      大東いずみ、高濱洋介
    • Organizer
      Kyoto T Cell Conference
    • Place of Presentation
      芝蘭会館(京都府・京都市)
    • Year and Date
      2017-03-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] ヒト胸腺を用いた胸腺上皮細胞の解析2017

    • Author(s)
      松井尚子、大東いずみ、Uddin Muhammad Myn、佐坂開人、山本遥平、古川貴大、近藤和也、中川英刀、梶 龍兒、高浜洋介
    • Organizer
      第29回日本神経免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] Activation of Wnt/β-catenin signaling in thymic epithelial progenitors2017

    • Author(s)
      藤森さゆ美、大東いずみ、竹本龍也、高浜洋介、高田慎治
    • Organizer
      Kyoto T Cell Conference
    • Place of Presentation
      芝蘭会館(京都府・京都市)
    • Year and Date
      2017-03-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] T細胞の自己寛容性確立におけるCCL21の役割2017

    • Author(s)
      大東いずみ、石丸直澄、片貝智哉、高濱洋介
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] Foxn1-binding cis-regulatory element required for optimal CD8+ T cell production in the thymus2017

    • Author(s)
      Izumi Ohigashi, Myn Uddin, Tatsuya Takemoto, Yousuke Takahama
    • Organizer
      11th International Symposium of the institute network
    • Place of Presentation
      徳島大学藤井記念ホール(徳島県・徳島市)
    • Year and Date
      2017-01-26
    • Data Source
      KAKENHI-PROJECT-15K19130
  • [Presentation] 胸腺髄質上皮細胞の再生におけるβ5t陽性上皮前駆細胞の寄与2017

    • Author(s)
      大東いずみ、高濱洋介
    • Organizer
      日本胸腺研究会
    • Place of Presentation
      芝蘭会館(京都府・京都市)
    • Year and Date
      2017-02-04
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] Essential role of CCL21 in establishment of central tolerance in T cells2017

    • Author(s)
      Ohigashi I, Ishimaru N, Katakai T, Takahama Y
    • Organizer
      第40回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K08884
  • [Presentation] メラノーマ組織に形成される高内皮細静脈様血管の検出2017

    • Author(s)
      藤原翔、森空悟、大東いずみ、高浜洋介、早坂晴子
    • Organizer
      第26回日本がん転移学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] マウス胸腺皮質上皮細胞亜集団におけるWnt/β-cateninシグナル経路の活性化2017

    • Author(s)
      藤森さゆ美、大東いずみ、竹本龍也、高浜洋介、高田慎治
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] Foxn1-β5t transcriptional axis controls CD8+ T cell production in the thymus2017

    • Author(s)
      Myn Uddin、大東いずみ、高濱洋介
    • Organizer
      IMMUNOLOGY 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] CCL21 regulates T-cell self-tolerance in thymic medulla2017

    • Author(s)
      Mina Kozai, Izumi Ohigashi, Yousuke Takahama
    • Organizer
      11th International Symposium of the institute network
    • Place of Presentation
      徳島大学藤井記念ホール(徳島県・徳島市)
    • Year and Date
      2017-01-26
    • Data Source
      KAKENHI-PROJECT-15K19130
  • [Presentation] CCL21Ser欠損マウスにおけるT細胞異常2017

    • Author(s)
      近藤博之、大東いずみ、高濱洋介
    • Organizer
      第16回四国免疫フォーラム
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] 胸腺におけるCD8+ T細胞生成を制御するFoxn1結合シス制御領域の同定2016

    • Author(s)
      大東いずみ, 竹本龍也, 高浜洋介
    • Organizer
      第39回分子生物学学会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Data Source
      KAKENHI-PROJECT-15K19130
  • [Presentation] CCL21欠損マウスの自己寛容確立異常2016

    • Author(s)
      香西美奈、大東いずみ、高濱洋介
    • Organizer
      四国免疫フォーラム
    • Place of Presentation
      高知大学(高知県・高知市)
    • Year and Date
      2016-06-25
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] The spatio-temporal activation of Wnt/β-catenin signaling in the thymic epithelial cells in mouse thymus2016

    • Author(s)
      Sayumi Fujimori, Izumi Ohigashi, Tatsuya Takemoto, Yousuke Takahama, Shinji Takada
    • Organizer
      第39回分子生物学学会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Data Source
      KAKENHI-PROJECT-15K19130
  • [Presentation] 胸腺におけるCD8+ T細胞生成を制御するFoxn1結合シス制御領域の同定2016

    • Author(s)
      大東いずみ、竹本龍也、高濱洋介
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-12-06
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] Foxn1-binding cis-regulatory element required for optimal CD8+ T cell production in the thymus2016

    • Author(s)
      Myn UDDIN、大東いずみ、高濱洋介
    • Organizer
      日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター、ラグナガーデンホテル(沖縄県・宜野湾市)
    • Year and Date
      2016-12-07
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] Foxn1-binding cis-regulatory element required for optimal CD8+ T cell production in the thymus2016

    • Author(s)
      Ohigashi Izumi
    • Organizer
      5th Bizan symposium
    • Place of Presentation
      徳島大学日亜メディカルホール(徳島県・徳島市)
    • Year and Date
      2016-03-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19130
  • [Presentation] Foxn1-binding cis-regulatry element for optimal CD8+ T cell production in the thymus2016

    • Author(s)
      Myn Uddin、大東いずみ、高濱洋介
    • Organizer
      Kyoto T Cell Conference
    • Place of Presentation
      延暦寺会館(滋賀県・大津市)
    • Year and Date
      2016-05-20
    • Data Source
      KAKENHI-PROJECT-16H02630
  • [Presentation] Foxn1-binding cis-regulatory element for optimal CD8+ T cell production in the thymus2016

    • Author(s)
      Myn Uddin, Izumi Ohigashi, Yousuke Takahama
    • Organizer
      第26回 Kyoto T cell Conference
    • Place of Presentation
      延暦寺会館(京都府・京都市)
    • Data Source
      KAKENHI-PROJECT-15K19130
  • [Presentation] Adult thymus medullary epithelium is maintained and regenerated by lineage restricted cells rather than bipotent progenitors2015

    • Author(s)
      Ohigashi I, Takahama Y
    • Organizer
      第4回眉山国際免疫シンポジウム
    • Place of Presentation
      徳島大学藤井節郎記念ホール(徳島市)
    • Year and Date
      2015-01-29
    • Data Source
      KAKENHI-PROJECT-25860361
  • [Presentation] The differentiation potential of β5t+ thymic epithelial progenitors2015

    • Author(s)
      Ohigashi Izumi, Takahama Yousuke
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-15K19130
  • [Presentation] 成体の胸腺髄質上皮は髄質系列細胞によって維持・再生される2015

    • Author(s)
      大東いずみ、髙濵洋介
    • Organizer
      Kyoto T cell Conference 第25回学術集会
    • Place of Presentation
      京都大学芝蘭会館(京都府・京都市)
    • Year and Date
      2015-05-15
    • Data Source
      KAKENHI-PROJECT-15K19130
  • [Presentation] 胸腺上皮細胞におけるミトコンドリアの役割2015

    • Author(s)
      金 鳳柱、大東 いずみ、高浜 洋介
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-03-22
    • Data Source
      KAKENHI-PROJECT-23249025
  • [Presentation] 胸腺皮質上皮細胞で高発現される機能未知新規遺伝子の研究:ノックアウトマウスと特異的抗体の作製によるアプローチ2014

    • Author(s)
      近藤博之、大東いずみ、高浜洋介
    • Organizer
      2014感染免疫クラスター・ミニリトリート
    • Place of Presentation
      ルネッサンスリゾートナルト(徳島県・徳島市)
    • Year and Date
      2014-10-30
    • Data Source
      KAKENHI-PROJECT-23249025
  • [Presentation] Role of mitochondria in thymic epithelial cells2014

    • Author(s)
      KIM Bongju, OHIGASHI Izumi, TAKAHAMA Yousuke
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都国際会館(京都府・京都市)
    • Year and Date
      2014-12-11
    • Data Source
      KAKENHI-PROJECT-23249025
  • [Presentation] mTECs derived from embryonic and postnatal beta5t+ progenitors2014

    • Author(s)
      Izumi Ohigashi, Saulius Zuklys, Georg Hollander, Yousuke Takahama
    • Organizer
      ThymOz VII An International Workshop on T Lymphocytes
    • Place of Presentation
      ヘロンアイランドリゾート(オーストラリア・クイーンランド)
    • Year and Date
      2014-04-03
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249025
  • [Presentation] Defective T cell tolerance in CCL21 knockout mice2014

    • Author(s)
      KOZAI Mina, OHIGASHI Izumi, TAKAHAMA Yousuke
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都国際会館(京都府・京都市)
    • Year and Date
      2014-12-10
    • Data Source
      KAKENHI-PROJECT-23249025
  • [Presentation] 髄質上皮細胞の維持と再生におけるβ5t陽性前駆細胞の寄与2014

    • Author(s)
      大東いずみ、高浜洋介
    • Organizer
      第24回 Kyoto T Cell Conference
    • Place of Presentation
      京都平安ホテル(京都府・京都市)
    • Year and Date
      2014-05-16
    • Data Source
      KAKENHI-PROJECT-23249025
  • [Presentation] β5t+ progenitors contribute to the maintenance and regeneration of medullary thymic epithelial cells2014

    • Author(s)
      Ohigashi I, Takahama Y
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都国際会議場(京都市)
    • Year and Date
      2014-12-11
    • Data Source
      KAKENHI-PROJECT-25860361
  • [Presentation] β5t+ progenitors contribute to the maintenance and regeneration of medullary thymic epithelial cells2014

    • Author(s)
      OHIGASHI Izumi, TAKAHAMA Yousuke
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都国際会館(京都府・京都市)
    • Year and Date
      2014-12-11
    • Data Source
      KAKENHI-PROJECT-23249025
  • [Presentation] Seeking transcriptional mechanisms for regulation of β5t expression2014

    • Author(s)
      Myn UDDIN, Izumi OHIGASHI, Yousuke TAKAHAMA
    • Organizer
      2014感染免疫クラスター・ミニリトリート
    • Place of Presentation
      ルネッサンスリゾートナルト(徳島県・徳島市)
    • Year and Date
      2014-10-31
    • Data Source
      KAKENHI-PROJECT-23249025
  • [Presentation] 髄質上皮細胞の維持と再生におけるβ5t陽性前駆細胞の寄与2014

    • Author(s)
      大東いずみ、高浜洋介
    • Organizer
      第24回 Kyoto T Cell Conference
    • Place of Presentation
      京都平安ホテル(京都市)
    • Year and Date
      2014-05-16
    • Data Source
      KAKENHI-PROJECT-25860361
  • [Presentation] Serial development of cortical and medullary thymic epithelia2013

    • Author(s)
      Takahama Yousuke, Ohigashi Izumi
    • Organizer
      Fourth Synthetic Immunology WorkshopEngineering in Immunity
    • Place of Presentation
      京都大学楽友会館(京都府)
    • Data Source
      KAKENHI-PROJECT-25860361
  • [Presentation] 胸腺皮質上皮細胞特異的β5t遺伝子座にCreをノックインしたマウスの作製2012

    • Author(s)
      大東いずみ
    • Organizer
      第22回Kyoto T cell conference
    • Place of Presentation
      和順会館(京都府)
    • Year and Date
      2012-07-06
    • Data Source
      KAKENHI-PROJECT-23659241
  • [Presentation] Analysis of cortical and medullary bifurcation mechanisms in thymic epithelial cells using cortical thymic epithelial cell-specific β5t-Cre knock-in mice2012

    • Author(s)
      大東いずみ
    • Organizer
      第41回日本免疫学会総会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2012-12-05
    • Data Source
      KAKENHI-PROJECT-23659241
  • [Presentation] 免疫不全を呈するヒトCD3eトランスジェニックマウス系統tge26におけるトランスジーン挿入部位の同定2011

    • Author(s)
      大東いずみ
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Data Source
      KAKENHI-PROJECT-23659241
  • [Presentation] 免疫不全を呈するヒトCD3εトランスジェニックマウス系統tgε26におけるトランスジーン挿入部位の同定2011

    • Author(s)
      Izumi Ohigashi
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-27
    • Data Source
      KAKENHI-PROJECT-23249025
  • [Presentation] Development and developmental potential of 5t-expressing thymic epithelial cells

    • Author(s)
      Takahama Yousuke, Ohigashi Izumi
    • Organizer
      KTCC 2013 International Workshop on T Lymphocytes
    • Place of Presentation
      京都大学芝蘭会館(京都府)
    • Data Source
      KAKENHI-PROJECT-25860361
  • [Presentation] Developmental potential of β5t-expressing

    • Author(s)
      Ohigashi Izumi, Takahama Yousuke
    • Organizer
      第3回眉山国際免疫シンポジウム
    • Place of Presentation
      徳島大学藤井節郎記念ホール(徳島県)
    • Data Source
      KAKENHI-PROJECT-25860361
  • [Presentation] 胸腺皮質上皮細胞特異的β5tおよび髄質上皮細胞に発現するCCL21aの発現トレーサー実験による胸腺上皮細胞分化機構の解析

    • Author(s)
      大東 いずみ, 高浜洋介
    • Organizer
      第37回日本リンパ学会総会
    • Place of Presentation
      アクロス福岡(福岡県)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25860361
  • [Presentation] 胸腺皮質上皮細胞特異的β5t および髄質上皮細胞に発現するCCL21aの発現トレーサー実験による胸腺上皮細胞分化機構の解析

    • Author(s)
      大東いずみ
    • Organizer
      第37回日本リンパ学会総会
    • Place of Presentation
      アクロス福岡(福岡県)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249025
  • [Presentation] Development and developmental potential of β 5t-expressing thymic epithelial cells

    • Author(s)
      Ohigashi Izumi
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Data Source
      KAKENHI-PROJECT-23249025
  • [Presentation] Analysis of cortical and medullary bifurcation mechanisms in thymic epithelial cells using cortical thymic epithelial cell-specific β5t-Cre knock-in mice

    • Author(s)
      大東いずみ
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Data Source
      KAKENHI-PROJECT-23659241
  • [Presentation] 胸腺皮質上皮細胞特異的β5t遺伝子座にCreをノックインしたマウスの作製

    • Author(s)
      大東いずみ
    • Organizer
      第22回Kyoto T Cell Conference
    • Place of Presentation
      和順会館 (京都府)
    • Data Source
      KAKENHI-PROJECT-23249025
  • [Presentation] Analysis of cortical and medullary bifurcation mechanisms in thymic epithelial cells using cortical thymic epithelial cell-specific β5t-Cre knock-in mice

    • Author(s)
      OHIGASHI Izumi
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場 (兵庫県)
    • Data Source
      KAKENHI-PROJECT-23249025
  • [Presentation] Development and developmental potential of β5t-expressing thymic epithelial cells

    • Author(s)
      Izumi Ohigashi
    • Organizer
      The Third Bizan Immunology Symposium at The University of Tokushima (BISUT3) “Immune System Development, Deviation, and Regulation”
    • Place of Presentation
      徳島大学 (徳島県)
    • Data Source
      KAKENHI-PROJECT-23249025
  • [Presentation] Development and developmental potential of5t-expressing thymic epithelial cells

    • Author(s)
      Ohigashi Izumi, Sakata Mie, Takahama Yousuke
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25860361
  • [Presentation] 胸腺皮質上皮細胞特異的β5t遺伝子座にCreをノックインしたマウスの作製

    • Author(s)
      大東いずみ
    • Organizer
      Kyoto T cell Conference
    • Place of Presentation
      和順会館(京都府)
    • Data Source
      KAKENHI-PROJECT-23659241
  • 1.  TAKAHAMA Yousuke (20183858)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 64 results
  • 2.  TAKADA Kensuke (40570073)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 9 results
  • 3.  NITTA Takeshi (30373343)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  水澤 典子 (80254746)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  岩田 武男 (10350399)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  SAKATA Mie
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  UDDIN Myn
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 8.  HAYASAKA Haruko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 9.  濱崎 純
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  伊川 正人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  濱崎 洋子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  村田 茂穂
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  田中 啓二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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