KAJITA MIHOKO 梶田美穂子

… Alternative Names

Kajita Mihoko 梶田美穂子

KAJITA Mihoko 梶田美穂子

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Researcher Number	00607442
Other IDs
Affiliation (Current)	2025: 立命館大学, 生命科学部, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 立命館大学, 生命科学部, 助教 2019 – 2020: 東京医科歯科大学, 難治疾患研究所, 日本学術振興会特別研究員 2018: 東京医科歯科大学, 難治疾患研究所, 特別研究員 2016 – 2017: 東京医科歯科大学, 難治疾患研究所, 特任助教 2015: 東京医科歯科大学, 難治疾患研究所, プロジェクト助教 2014: 北海道大学, 遺伝子病制御研究所, 助教 2011 – 2012: 北海道大学, 遺伝子病制御研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / 0901:Oncology and related fields / Hematology / Tumor biology / General medical chemistry
Keywords	Principal Investigator オルガノイド / 乳がん / マクロファージ / 組織常在性マクロファージ / filamin / がん抑制遺伝子 / がん遺伝子 / がん免疫 / がん予防 / IL-27 … More / 樹状細胞 / 免疫学 / interferon gamma / WSX1 / WSX-1 / dendritic cells / apical extrusion / Filamin / S1P / EPLIN / Caveolin / SILAC / EDAC / zebrafish / filamin A / vimentin / Src / 上皮細胞 / 癌 Less

発がんの初期段階に着目したがん免疫始動システムの解析Principal Investigator
- Principal Investigator
  
  梶田美穂子
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Ritsumeikan University
Analysis of the initiation of cancer immunity by tissue-resident macrophagesPrincipal Investigator
- Principal Investigator
  
  Kajita Mihoko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Ritsumeikan University
Analysis of the initiation system of cancer immunityPrincipal Investigator
- Principal Investigator
  
  Kajita Mihoko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical and Dental University
Analysis of the novel IL-27 signaling pathway involved in homeostasis of dendritic cellsPrincipal Investigator
- Principal Investigator
  
  KAJITA Mihoko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical and Dental University
Analysis of molecular mechanisms for the filamin-induced defensive force of normal epithelial cells against cancerPrincipal Investigator
- Principal Investigator
  
  Kajita Mihoko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tokyo Medical and Dental University
  Hokkaido University
Characterization of the interface between normal and transformed epithelial cells.Principal Investigator
- Principal Investigator
  
  KAJITA Mihoko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General medical chemistry
- Research Institution
  Hokkaido University

All 2024 2023 2022 2021 2020 2018 2017 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] C-terminal amino acids in the type I transmembrane domain of L-type lectin VIP36 affect γ-secretase susceptibility2024
- Author(s)
  Hua Zhihai、Watanabe Ryoma、Fukunaga Taku、Matsui Yojiro、Matsuoka Mayu、Yamaguchi Shoya、Tanabe Shun-ya、Yamamoto Miyu、Tamura-Kawakami Keiko、Takagi Junichi、Kajita Mihoko、Futai Eugene、Shirakabe Kyoko
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 696 Pages: 149504-149504
- DOI
  10.1016/j.bbrc.2024.149504
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06121, KAKENHI-PROJECT-21K07236
[Journal Article] Sequential oncogenic mutations influence cell competition2021
- Author(s)
  Kohashi Koki、Mori Yusuke、Narumi Rika、Kozawa Kei、Kamasaki Tomoko、Ishikawa Susumu、Kajita Mihoko、Kobayashi Rei、Tamori Yoichiro、Fujita Yasuyuki
- Journal Title
  
  Current Biology
  
  Volume: 31 Issue: 18 Pages: 3984-3995
- DOI
  10.1016/j.cub.2021.06.064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21411, KAKENHI-PROJECT-18KK0234, KAKENHI-PLANNED-21H05285, KAKENHI-PROJECT-21H05039, KAKENHI-PROJECT-19J40132, KAKENHI-PROJECT-20K07559, KAKENHI-PROJECT-21K07236
[Journal Article] CD86-based analysis enables observation of bona fide hematopoietic responses2020
- Author(s)
  Kanayama Masashi、Izumi Yuta、Yamauchi Yasuharu、Kuroda Shoko、Shin Takaei、Ishikawa Shun、Sato Taku、Kajita Mihoko、Ohteki Toshiaki
- Journal Title
  
  Blood
  
  Volume: 136 Issue: 10 Pages: 1144-1154
- DOI
  10.1182/blood.2020004923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19J40198, KAKENHI-PROJECT-18K07258
[Journal Article] Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine.2020
- Author(s)
  Sato T, Sase M, Ishikawa S, Kajita M, Asano J, Sato T, Mori Y, and Ohteki T.
- Journal Title
  
  Sci Rep
  
  Volume: 10 Issue: 1 Pages: 8308-8308
- DOI
  10.1038/s41598-020-64987-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H05028, KAKENHI-PROJECT-19H01024, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-19J40198, KAKENHI-PROJECT-18K07062, KAKENHI-PROJECT-18K07258
[Journal Article] The paxillin-plectin-EPLIN complex promotes apical elimination of RasV12-transformed cells by modulating HDAC6-regulated tubulin acetylation2018
- Author(s)
  Kasai Nobuhiro、Kadeer Ailijiang、Kajita Mihoko、Saitoh Sayaka、Ishikawa Susumu、Maruyama Takeshi、Fujita Yasuyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 2097-2097
- DOI
  10.1038/s41598-018-20146-1
- NAID
  120006456414
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-26114001, KAKENHI-PROJECT-26250026, KAKENHI-PROJECT-16K19571, KAKENHI-INTERNATIONAL-15K21757, KAKENHI-PLANNED-26114008, KAKENHI-PROJECT-18H02675
[Journal Article] Intrinsic autophagy is required for the maintenance of intestinal stem cells and for irradiation-induced intestinal regeneration.2017
- Author(s)
  Asano J, Sato T, Ichinose S, Kajita M, Onai N, Shimizu S, Ohteki T.
- Journal Title
  
  Cell reports
  
  Volume: 20 Issue: 5 Pages: 1050-1060
- DOI
  10.1016/j.celrep.2017.07.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05691, KAKENHI-PROJECT-15H04717, KAKENHI-PROJECT-16K19571, KAKENHI-PROJECT-17H01533
[Journal Article] Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes.2017
- Author(s)
  Shunsuke Kon, et al.
- Journal Title
  
  Nature Cell Biology
  
  Volume: 印刷中 Issue: 5 Pages: 530-541
- DOI
  10.1038/ncb3509
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01492, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-16J01233, KAKENHI-PROJECT-14J02366, KAKENHI-PROJECT-26293177, KAKENHI-PROJECT-15K15297, KAKENHI-PROJECT-15K08974, KAKENHI-PROJECT-16K19571, KAKENHI-PROJECT-15KT0072, KAKENHI-PROJECT-17K08561, KAKENHI-PROJECT-17K19507, KAKENHI-PROJECT-17K15589, KAKENHI-PROJECT-15KK0290, KAKENHI-PUBLICLY-17H05611, KAKENHI-ORGANIZER-26114001, KAKENHI-PLANNED-26114004, KAKENHI-PROJECT-17H01559, KAKENHI-PROJECT-26250026, KAKENHI-PROJECT-17H04016, KAKENHI-PROJECT-16K14709, KAKENHI-PROJECT-16K21106, KAKENHI-INTERNATIONAL-15K21757, KAKENHI-PLANNED-26114008, KAKENHI-PROJECT-17H03654
[Journal Article] Plectin is a novel regulator for apical extrusion of RasV12-transformed cells.2017
- Author(s)
  Kadeer, A., Maruyama, T., Kajita, M., Morita T., Sasaki, A., Ohoka, A., Ishikawa, S., Ikegawa, M., Shimada, T., and Fujita, Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 44328-44328
- DOI
  10.1038/srep44328
- NAID
  120006219881
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26114008, KAKENHI-PROJECT-26250026, KAKENHI-PROJECT-15J01725, KAKENHI-PROJECT-16K19571, KAKENHI-INTERNATIONAL-15K21757
[Journal Article] Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells.2017
- Author(s)
  S. Saitoh, T. Maruyama, Y. Yako, M. Kajita, Y. Fujioka, Y. Ohba, N. Kasai, N. Sugama, S. Kon, S. Ishikawa, T. Hayashi, T. Yamazaki, M. Tada and Y. Fujita.
- Journal Title
  
  Proc. Natl. Acad. Sci. U.S.A.
  
  Volume: 114 Issue: 12
- DOI
  10.1073/pnas.1602349114
- NAID
  120006346108
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01248, KAKENHI-ORGANIZER-26114001, KAKENHI-PLANNED-26114008, KAKENHI-PROJECT-26250026, KAKENHI-PROJECT-16H06227, KAKENHI-PROJECT-14J02366, KAKENHI-PROJECT-14J02420, KAKENHI-PROJECT-26293041, KAKENHI-PROJECT-15K15023, KAKENHI-PROJECT-15K18474, KAKENHI-PROJECT-16K19571, KAKENHI-INTERNATIONAL-15K21757, KAKENHI-PROJECT-15KK0290, KAKENHI-PROJECT-17K19507, KAKENHI-PUBLICLY-17H05611, KAKENHI-PROJECT-17H04016
[Journal Article] A role of the sphingosine-1-phosphate (S1P)- S1P receptor 2 pathway in Epithelial Defense Against Cancer (EDAC)2015
- Author(s)
  Yamamoto, S., Yako, Y., Fujioka, Y., Kajita, M., Kameyama, T., Kon, S., Ishikawa, S., Ohba, Y., Ohno, Y., Kihara, A., and Fujita, Y.
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 27（3） Issue: 3 Pages: 491-499
- DOI
  10.1091/mbc.e15-03-0161
- NAID
  120005740332
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-INTERNATIONAL-15K21757, KAKENHI-PLANNED-26114008, KAKENHI-PUBLICLY-26115701, KAKENHI-PROJECT-26250026, KAKENHI-PROJECT-15H05589, KAKENHI-PROJECT-14J02366, KAKENHI-PROJECT-26860254, KAKENHI-PROJECT-26870004, KAKENHI-ORGANIZER-26114001, KAKENHI-PUBLICLY-15H01248, KAKENHI-PROJECT-26293041, KAKENHI-PROJECT-15K15023, KAKENHI-PROJECT-15KK0290
[Journal Article] EPLIN is a crucial regulator for extrusion of RasV12-transformed cells.2015
- Author(s)
  Ohoka, A., Kajita, M., Ikenouchi, J., Yako, Y., Kitamoto, S., Kon, S., Ikegawa, M., Shimada, T., Ishikawa, S., and Fujita, Y.
- Journal Title
  
  Journal of Cell Science
  
  Volume: 128 Pages: 781-789
- DOI
  10.1242/jcs.163113
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14J02338, KAKENHI-PROJECT-14J02366, KAKENHI-PROJECT-24657131, KAKENHI-PROJECT-25711012, KAKENHI-PUBLICLY-26112713, KAKENHI-PROJECT-26250026, KAKENHI-PROJECT-26870004, KAKENHI-ORGANIZER-26114001
[Journal Article] EDAC: Epithelial defence against cancer- cell competition between normal and transformed epithelial cells in mammals.2015
- Author(s)
  Kajita, M. and Fujita, Y.
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 158(1) Issue: 1 Pages: 15-23
- DOI
  10.1093/jb/mvv050
- NAID
  40020522502
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-INTERNATIONAL-15K21757, KAKENHI-PLANNED-26114008, KAKENHI-PROJECT-26250026, KAKENHI-PROJECT-26870004, KAKENHI-ORGANIZER-26114001
[Journal Article] EDAC (Epithelial defence against cancer) -cell competition between normal and transformed epithelial cells in mammals.2015
- Author(s)
  Kajita, M. and Fujita, Y.
- Journal Title
  
  実験医学（増刊）
  
  Volume: 33 Pages: 128-134
- NAID
  40020522502
- Data Source
  KAKENHI-PROJECT-26870004
[Journal Article] Filamin acts as a key regulator in epithelial defence against transformed cells.2014
- Author(s)
  Kajita M., Sugimura, K., Ohoka, A., Burden, J., Suganuma, H., Ikegawa, M., Shimada, T., Kitamura, T., Shindoh, M., Ishikawa, S., Yamamoto, S., Saitoh, S., Yako, Y., Takahashi, R., Okajima, T., Kikuta, J., Maijima, Y., Ishii, M., Tada, M., and Fujita, Y.
- Journal Title
  
  Nature Communications
  
  Volume: 5 Issue: 1 Pages: 4428-4428
- DOI
  10.1038/ncomms5428
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J02366, KAKENHI-PROJECT-14J02420, KAKENHI-PROJECT-25286081, KAKENHI-PROJECT-25462912, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-26250026, KAKENHI-PROJECT-26870004, KAKENHI-PLANNED-26114008
[Journal Article] 正常上皮細胞と変異細胞間で生じる細胞競合~がん細胞をとりまく新たなheterogeneity~2013
- Author(s)
  梶田美穂子、藤田恭之
- Journal Title
  
  実験医学
  
  Volume: 31 Pages: 39-44
- Data Source
  KAKENHI-PROJECT-23890003
[Journal Article] 正常上皮細胞と変異細胞間で生じる細胞競合~がん細胞をとりまく新たな heterogeneity~2013
- Author(s)
  梶田美穂子、藤田恭之
- Journal Title
  
  実験医学
  
  Volume: Vol.31 No.1(Jan)
- Data Source
  KAKENHI-PROJECT-23890003
[Journal Article] Interactions between normal and transformed epithelial cells: their clinical applications2012
- Author(s)
  Kajita M, Fujita Y
- Journal Title
  
  Nihon Yakurigaku Zasshi
  
  Volume: 140(2) Pages: 76-80
- NAID
  10030987183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890003
[Presentation] 組織常在性マクロファージによる変異細胞の認識メカニズムの解析2023
- Author(s)
  田邉駿弥、梶田美穂子、元村一基、樗木俊聡、白壁恭子
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K07236
[Presentation] 組織常在性マクロファージによる変異細胞の認識メカニズムの解析2023
- Author(s)
  田邉駿弥、梶田美穂子、元村一基、白壁恭子
- Organizer
  第69回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-21K07236
[Presentation] 細胞外領域シェディング耐性のTREM2変異体の作製2022
- Author(s)
  梶田美穂子、菅波孝祥、浅原哲子、白壁恭子
- Organizer
  第27回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07236
[Presentation] Filamin acts as a key regulator in epithelial defense against transformed cells2014
- Author(s)
  Mihoko Kajita
- Organizer
  第３７回分子生物学会
- Place of Presentation
  パシフィコ横浜　（神奈川県・横浜市）
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-26870004
[Presentation] Interaction with surrounding normal epithelial cells influences signaling pathways and behavior of Src-transformed cells2012
- Author(s)
  Mihoko Kajita
- Organizer
  第71回日本癌学会
- Place of Presentation
  ホテルロイトン札幌（札幌市）
- Data Source
  KAKENHI-PROJECT-23890003
[Presentation] Epithelial defence against transformed cells via filamin-dependent vimentin reorganisation.2012
- Author(s)
  Mihoko Kajita
- Organizer
  北海道癌談話会
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2012-09-08
- Data Source
  KAKENHI-PROJECT-23890003
[Presentation] Interaction with Src-transformed cells influences signalling pathways and behaviour of surrounding normal epithelialcells.2012
- Author(s)
  Mihoko Kajita
- Organizer
  EMBO meeting
- Place of Presentation
  Nice Acropolis(フランス)
- Data Source
  KAKENHI-PROJECT-23890003
[Presentation] Interaction with Src-transformed cells influences signalling pathways and behaviour of surrounding normal epithelial cells2012
- Author(s)
  Mihoko Kajita
- Organizer
  The 4th EMBO meeting
- Place of Presentation
  Nice Acropolis (France)
- Data Source
  KAKENHI-PROJECT-23890003
[Presentation] Interaction with surrounding normal epithelial cells influences signaling pathways and behavior of Src-transformed cells.2012
- Author(s)
  Mihoko Kajita
- Organizer
  第71回日本癌学会
- Place of Presentation
  ホテルロイトン札幌(札幌市)
- Data Source
  KAKENHI-PROJECT-23890003
[Presentation] Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells2011
- Author(s)
  Mihoko Kajita
- Organizer
  第63回日本細胞生物学会
- Place of Presentation
  北海道大学(札幌市)
- Data Source
  KAKENHI-PROJECT-23890003
[Presentation] Epithelial defence against transformed cells via filamin-dependent vimentin reorganisation
- Author(s)
  Mihoko Kajita
- Organizer
  北海道癌談話会
- Place of Presentation
  北海道大学（札幌市）
- Data Source
  KAKENHI-PROJECT-23890003

1. FUTAI Eugene

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 藤田恭之

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
3. 清水重臣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 大場雄介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 樗木俊聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAJITA MIHOKO 梶田 美穂子

Kajita Mihoko 梶田 美穂子

KAJITA Mihoko 梶田 美穂子

Research Projects

Research Products

Co-Researchers

発がんの初期段階に着目したがん免疫始動システムの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the initiation of cancer immunity by tissue-resident macrophagesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the initiation system of cancer immunityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the novel IL-27 signaling pathway involved in homeostasis of dendritic cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of molecular mechanisms for the filamin-induced defensive force of normal epithelial cells against cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization of the interface between normal and transformed epithelial cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] C-terminal amino acids in the type I transmembrane domain of L-type lectin VIP36 affect γ-secretase susceptibility2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sequential oncogenic mutations influence cell competition2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD86-based analysis enables observation of bona fide hematopoietic responses2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The paxillin-plectin-EPLIN complex promotes apical elimination of RasV12-transformed cells by modulating HDAC6-regulated tubulin acetylation2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Intrinsic autophagy is required for the maintenance of intestinal stem cells and for irradiation-induced intestinal regeneration.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Plectin is a novel regulator for apical extrusion of RasV12-transformed cells.2017

Author(s)

KAJITA MIHOKO 梶田美穂子

Kajita Mihoko 梶田美穂子

KAJITA Mihoko 梶田美穂子