Mihara Hirosi 三原弘

… Alternative Names

Mihara Hiroshi 三原弘

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Researcher Number	00612623
Other IDs	https://orcid.org/0000-0002-8427-2868
Affiliation (Current)	2025: 札幌医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 富山大学, 学術研究部医学系, 助教 2015 – 2018: 富山大学, 大学院医学薬学研究部(医学), 助教 2015: 富山大学, 大学院医学薬学研究部 (医学), 助教 2014: 富山大学, 大学病院, 診療助手
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator TRPV4 / 便秘症 / メチル化異常 / サイトカイン / 便秘 / 結腸上皮 / K. oxytoca / 酪酸 / TNFα / 上皮 … More / K.oxytoca / 腸球菌 / 大腸菌 / 腸内細菌 / 慢性便秘 / 上皮細胞 / 結腸 / メチル化 / 伸展 / ATP / 胃 / VNUT / ATP放出 / 伸展刺激 / 消化管上皮 … More Except Principal Investigator 細胞透過性 / NSAIDs / NSAIDｓ小腸潰瘍 / 細胞膜透過性 / NSAIDｓ / TRPV4阻害薬 / 細胞膜透過性亢進 / 非ステロイド系抗炎症薬 / TRPV4 / 透過性亢進 / 小腸潰瘍 / 非ステロイド系抗炎症剤 Less

Research for induction or normalization factor for colonic TRPV4 methylation aiming at curing constipationPrincipal Investigator
- Principal Investigator
  
  Mihara Hiroshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  University of Toyama
TRP ion channel related to the pathogenic mechanism of small intestinal ulceration induced by NSAIDs use
- Principal Investigator
  
  Sugiyama Toshiro
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Toyama
Molecular mechanism of luminal pressure reception and ATP release in gastrointestinal epitheliumPrincipal Investigator
- Principal Investigator
  
  Mihara Hiroshi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Toyama

All 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] 便秘症，腸内細菌とTRPV42021
- Author(s)
  三原　弘
- Journal Title
  
  Medical Science Digest
  
  Volume: 47 Pages: 526-7
- Data Source
  KAKENHI-PROJECT-19K08366
[Journal Article] 上部消化管疾患に迫る―形態と機能からの新たなるアプローチ―2020
- Author(s)
  二神生爾, 多田智裕, 渡邊嘉行, 三原弘, 山脇博士
- Journal Title
  
  Nippon Shokakibyo Gakkai Zasshi
  
  Volume: 117 Issue: 10 Pages: 876-887
- DOI
  10.11405/nisshoshi.117.876
- NAID
  130007925381
- ISSN
  0446-6586, 1349-7693
- Year and Date
  2020-10-10
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-19K08366
[Journal Article] 消化管上皮の圧受容と慢性炎症、そしてATP放出阻害という治療標的2019
- Author(s)
  三原　弘
- Journal Title
  
  BIO Clinica
  
  Volume: 34 Pages: 77-81
- Data Source
  KAKENHI-PROJECT-19K08366
[Journal Article] Transient receptor potential vanilloid 4 (TRPV4) regulation of ATP release by the ATP transporter VNUT: a novel therapeutic target for gastrointestinal baro-reception and chronic inflammation2019
- Author(s)
  Mihara H, Sugiyama T et al.
- Journal Title
  
  Digestion
  
  Volume: 99 Issue: 1 Pages: 6-11
- DOI
  10.1159/000504021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08947, KAKENHI-PROJECT-19K08366
[Journal Article] 消化管上皮の圧受容体と慢性炎症2018
- Author(s)
  三原　弘
- Journal Title
  
  Bio Clinica
  
  Volume: 33 Pages: 74-79
- Data Source
  KAKENHI-PROJECT-15K08947
[Journal Article] 消化管上皮の圧受容と慢性炎症2018
- Author(s)
  三原　弘
- Journal Title
  
  北隆館BIO Clinica
  
  Volume: 33 Pages: 46-51
- Data Source
  KAKENHI-PROJECT-26870214
[Journal Article] 機械刺激感受性TRPV4イオンチャネルのメチル化サイレンシングが直腸低感受性に関与している2018
- Author(s)
  三原　弘、
- Journal Title
  
  Pharma Medica
  
  Volume: 36 Pages: 119-120
- Data Source
  KAKENHI-PROJECT-15K08947
[Journal Article] Transient receptor potential vanilloid 4 (TRPV4) silencing in Helicobacter pylori-infected human gastric epithelium2017
- Author(s)
  Hiroshi Mihara, Nobuhiro Suzuki, Jibran Sualeh Muhammad, Sohachi Nanjo, Takayuki Ando, Haruka Fujinami, Shinya Kajiura, Ayumu Hosokawa,Toshiro Sugiyama
- Journal Title
  
  Helicobacter
  
  Volume: 22 Issue: 2
- DOI
  10.1111/hel.12361
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870214
[Journal Article] 消化管上皮の圧受容と慢性炎症2017
- Author(s)
  三原　弘
- Journal Title
  
  北隆館別冊BIO Clinica
  
  Volume: 6 Pages: 117-122
- Data Source
  KAKENHI-PROJECT-26870214
[Journal Article] Transient receptor potential vanilloid 4-dependent calcium influx and ATP release in mouse and rat gastric epithelia2016
- Author(s)
  Mihara H, Sugiyama , et al.
- Journal Title
  
  World J Gastroenterol.
  
  Volume: 22 Issue: 24 Pages: 5512-5519
- DOI
  10.3748/wjg.v22.i24.5512
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08947, KAKENHI-PROJECT-26870214
[Journal Article] Protease-Activated Receptor-2 Up-Regulates Transient Receptor Potential Vanilloid 4 Function in Mouse Esophageal Keratinocyte.2015
- Author(s)
  Suzuki N, Mihara H, Nishizono H, Tominaga M, Sugiyama T.
- Journal Title
  
  Dig Dis Sci.
  
  Volume: 60 Issue: 12 Pages: 3570-8
- DOI
  10.1007/s10620-015-3822-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870214
[Journal Article] 特集消化器疾患の病態生理H.Pylori 感染胃粘膜における TRPV4 メチル化.2015
- Author(s)
  三原弘、杉山敏郎.
- Journal Title
  
  Progress in Medicine　（ライフ・サイエンス）
  
  Volume: 35 Pages: 431-433
- Data Source
  KAKENHI-PROJECT-26870214
[Journal Article] Role of transient receptor potential vanilloid 4 activation in indomethacin-induced intestinal damage2014
- Author(s)
  Yamawaki H., Mihara H., Suzuki N., Nishizono H., Uchida K., Watanabe S., Tominaga M., Sugiyama T.
- Journal Title
  
  Am. J. Physiol. Gastrointest. Liver Physiol.
  
  Volume: 307 Issue: 1 Pages: G33-G40
- DOI
  10.1152/ajpgi.00105.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590873, KAKENHI-PROJECT-26460903, KAKENHI-PROJECT-26870214
[Journal Article] H.pylori感染症と胃運動異常．機能性消化管障害の病態と治療．2014
- Author(s)
  三原　弘
- Journal Title
  
  消化器内科
  
  Volume: 58 Pages: 184-8
- Data Source
  KAKENHI-PROJECT-26870214
[Presentation] 慢性便秘症の症状，粘膜関連腸内細菌と直腸上皮TRPV4発現・メチル化異常との関連2021
- Author(s)
  三原弘,南條宗八,藤浪斗,安田一朗,渡邊嘉行,及川律子,山本博幸,伊東文生
- Organizer
  第63回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-19K08366
[Presentation] 大腸菌培養上清による大腸TRPV4過剰発現とTNF-αの関連2021
- Author(s)
  三原弘,南條宗八,元尾伊織,安藤孝将,安田一朗, 内田邦敏
- Organizer
  第4回機能性腸疾患研究会
- Data Source
  KAKENHI-PROJECT-19K08366
[Presentation] 腸内細菌による結腸上皮の機械刺激感受性イオンチャネル（TRPV4）の発現変化の検討2020
- Author(s)
  三原　弘、小澤豊美、南條宗八、元尾伊織、安藤孝将、藤浪斗、安田一朗
- Organizer
  第22回日本神経消化器病学会神経消化器病学会
- Data Source
  KAKENHI-PROJECT-19K08366
[Presentation] LIPOPOLYSACCHARIDE O-ANTIGEN SPECIFIC TRANSIENT RECEPTOR POTENTIAL VANILLOID 4 (TRPV4)-DEPENDENT ATP RELEASE FROM COLON EPITHELIA2020
- Author(s)
  Hiroshi Mihara, Sohachi Nanjo, Kunitoshi Uchida, Iori Motoo, Takayuki Ando, Haruka Fujinami, Ichiro Yasuda
- Organizer
  Digestive Disease Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08366
[Presentation] Tryptase induces intestinal hyperpermeability via Up-regulated transient receptor potential vanilloid 4 (TRPV4) activation2020
- Author(s)
  Hiroshi　Mihara,　Mayo　Fuchino,　Ichiro　Yasuda
- Organizer
  日本消化器病学会週間2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08366
[Presentation] TRP研究会20202020
- Author(s)
  三原弘、内田邦敏、小泉修一、森山芳則
- Organizer
  胃腸上に発現するTRPV4 活性化のVNUT 阻害による制御及び、腸内細菌によるTRPV4 発現抑制に関する検討
- Data Source
  KAKENHI-PROJECT-19K08366
[Presentation] 第一世代ビスホスホネート製剤クロドロン酸による消化管上皮からのATP放出阻害作用2019
- Author(s)
  三原　弘
- Organizer
  第15回日本消化管学会総会学術集会コアシンポジウム3
- Data Source
  KAKENHI-PROJECT-15K08947
[Presentation] Transient Receptor Potential Vanilloid 4 (TRPV4)-Induced Atp Exocytosis from Stomach and Colon Epithelium in Human Cell Lines and Mouse2018
- Author(s)
  Mihara H, Sugiyama T　et al.
- Organizer
  Digestive Disease Week 2018, Washington DC
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08947
[Presentation] 機能性ディスペプシアにおけるTRPV4の関与2018
- Author(s)
  三原弘、杉山敏郎
- Organizer
  第 14 回日本消化管学会総会学術集会コアシンポジウム 3 「消化管機能性疾患の新展開」 -機能性ディスペプシアの病態・標的分子―
- Invited
- Data Source
  KAKENHI-PROJECT-26870214
[Presentation] 機能性ディスペプシアにおけるTRPV4の関与2018
- Author(s)
  三原　弘、杉山敏郎
- Organizer
  第14回日本消化管学会総会学術集会コアシンポジウム
- Data Source
  KAKENHI-PROJECT-15K08947
[Presentation] A mechanosensitive ion channel, TRPV4-methylation silencing in gastric epithelium2017
- Author(s)
  Hiroshi Mihara, Nobuhiro Suzuki, Jibran Sualeh Muhammad, Sohachi Nanjo, Takayuki Ando, Haruka Fujinami, Shinya Kajiura, Ayumu Hosokawa, Toshiro Sugiyama
- Organizer
  Congress of the Asian Neurogastroenterology and Motility Association
- Place of Presentation
  Osaka, Japan
- Year and Date
  2017-03-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870214
[Presentation] H. pylori infection directly induces methylation silencing of a gastric epithelial mechano-sensor, Transient Receptor Potential Vanilloid 4 in gastric epithelial cells2016
- Author(s)
  Hiroshi Mihara, Jibran Sualeh Muhammad, Sohachi Nanjo, Takayuki Ando, Toshiro Sugiyama
- Organizer
  Digestive Disease Week 2016
- Place of Presentation
  San Diego, California United States of America
- Year and Date
  2016-05-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870214
[Presentation] Gastrointestinal epithelia could be luminal sensors for chemical, hypo osmolality, acid, temperature and stretch via ATP release.2015
- Author(s)
  Mihara Hiroshi, Sualeh Muhammad Jibran, Suzuki Nobuhiro, Tabuchi Yoshiaki, Sugiyama Toshiro
- Organizer
  Digestive Disease Week 2015
- Place of Presentation
  Washington DC
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870214
[Presentation] 化合物，低浸透圧，酸，伸展，温度の各種刺激により胃上皮細胞から放出されたATPが胃内の情報を神経に伝達しうる．2014
- Author(s)
  三原　弘，Muhammad JS，鈴木庸弘，杉山敏郎，田渕圭章．
- Organizer
  第7回Japan-Functional Dyspepsia research society（J-FD研究会）
- Place of Presentation
  東京
- Year and Date
  2014-11-08
- Invited
- Data Source
  KAKENHI-PROJECT-26870214
[Presentation] TRPV4 活性化による胃上皮細胞からのATP 放出機構の破綻が，H. pylori 関連ディスペプシアの一因になり得る．
- Author(s)
  三原　弘，鈴木庸弘、Muhammad JS，山脇秀元，安藤孝将，藤浪　斗，細川　歩，杉山敏郎
- Organizer
  第16回日本神経消化器病学会，第8回機能性ディスペプシア研究会，第82回消化器心身医学研究会，第4回IBS研究会合同学術集会
- Place of Presentation
  東京
- Year and Date
  2014-11-06 – 2014-11-07
- Invited
- Data Source
  KAKENHI-PROJECT-26870214
[Presentation] What is the role of TRPV4 expressed in gastric epithelium?
- Author(s)
  Mihara H, Suzuki N, Ando T, Tominaga M, Sugiyama T.
- Organizer
  The 2nd International Symposium on Mechanobiology (ISMB 2014)
- Place of Presentation
  岡山
- Year and Date
  2014-05-20 – 2014-05-23
- Invited
- Data Source
  KAKENHI-PROJECT-26870214

1. SUGIYAMA Toshiro (00196768)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
2. UCHIDA Kunitoshi (20581135)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 南條宗八 (70649285)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. NISHIZONO Hirofumi (10502289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. TOMINAGA Makoto (90260041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. TABUCHI Yoshiaki (20322109)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. WATANABE Shiro (00222406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. KOIZUMI Schuichi (10280752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YAMAWAKI Hidemoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. SUZUKI Nobuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
11. KOZAWA Toyomi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Fujinami Haruka

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. ANDO Takayuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
14. Boudaka Ammar

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Muhammad Jibran Sualeh

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results

Mihara Hirosi 三原 弘

Mihara Hiroshi 三原 弘

Research Projects

Research Products

Co-Researchers

Research for induction or normalization factor for colonic TRPV4 methylation aiming at curing constipationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

TRP ion channel related to the pathogenic mechanism of small intestinal ulceration induced by NSAIDs use

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of luminal pressure reception and ATP release in gastrointestinal epitheliumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 便秘症，腸内細菌とTRPV42021

Author(s)

Journal Title

Data Source

[Journal Article] 上部消化管疾患に迫る―形態と機能からの新たなるアプローチ―2020

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] 消化管上皮の圧受容と慢性炎症、そしてATP放出阻害という治療標的2019

Author(s)

Journal Title

Data Source

[Journal Article] Transient receptor potential vanilloid 4 (TRPV4) regulation of ATP release by the ATP transporter VNUT: a novel therapeutic target for gastrointestinal baro-reception and chronic inflammation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 消化管上皮の圧受容体と慢性炎症2018

Author(s)

Journal Title

Data Source

[Journal Article] 消化管上皮の圧受容と慢性炎症2018

Author(s)

Journal Title

Data Source

[Journal Article] 機械刺激感受性TRPV4イオンチャネルのメチル化サイレンシングが直腸低感受性に関与している2018

Author(s)

Journal Title

Data Source

[Journal Article] Transient receptor potential vanilloid 4 (TRPV4) silencing in Helicobacter pylori-infected human gastric epithelium2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 消化管上皮の圧受容と慢性炎症2017

Author(s)

Journal Title

Data Source

[Journal Article] Transient receptor potential vanilloid 4-dependent calcium influx and ATP release in mouse and rat gastric epithelia2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protease-Activated Receptor-2 Up-Regulates Transient Receptor Potential Vanilloid 4 Function in Mouse Esophageal Keratinocyte.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 特集 消化器疾患の病態生理H.Pylori 感染胃粘膜における TRPV4 メチル化.2015

Author(s)

Journal Title

Data Source

Mihara Hirosi 三原弘

Mihara Hiroshi 三原弘

[Journal Article] 特集消化器疾患の病態生理H.Pylori 感染胃粘膜における TRPV4 メチル化.2015