Hodatsu Akihiko 寳達明彦

Researcher Number	00623662
Affiliation (based on the past Project Information) *help	2015 – 2016: 金沢大学, 医学系, 協力研究員 2014: 金沢大学, 大学病院, 特任助教 2013: 金沢大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Cardiovascular medicine Except Principal Investigator Laboratory medicine
Keywords	Principal Investigator 遺伝子変異 / ゼブラフィッシュ / 肥大型心筋症 Except Principal Investigator 機能解析 / 次世代シークエンサー / 全エクソーム解析 / 遺伝性不整脈 / 遺伝子改変ゼブラフィッシュ / Crispr/Cas9システム / モルフォリノ / 次世代シークエンス / ゼブラフィッシュ

Genetic analysis for inherited arrhythmia and functional study using zebrafish model
- Principal Investigator
  
  Hayashi Kenshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kanazawa University
Analysis of the pathogenesis in hypertophic cardiomyopathy by using zebrafish models.Principal Investigator
- Principal Investigator
  
  Hodatsu Akihiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kanazawa University

All 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Whole exome sequencing combined with integrated variant annotation prediction identifies a causative myosin essential light chain variant in hypertrophic cardiomyopathy.2016
- Author(s)
  Nomura A, Tada H, Teramoto R, Konno T, Hodatsu A, Won HH, Kathiresan S, Ino H, Fujino N, Yamagishi M, Hayashi K.
- Journal Title
  
  J Cardiol.
  
  Volume: 2 Issue: 2 Pages: 133-9
- DOI
  10.1016/j.jjcc.2015.09.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460670, KAKENHI-PROJECT-26460742, KAKENHI-PROJECT-25460648, KAKENHI-PROJECT-25860589, KAKENHI-PROJECT-15K09134
[Journal Article] Right ventricular hypertrophy is associated with cardiovascular events in hypertrophic cardiomyopathy: evidence from study with magnetic resonance imaging.2015
- Author(s)
  Nagata Y, Konno T, Fujino N, Hodatsu A, Nomura A, Hayashi K, Nakamura H, Kawashiri MA, Yamagishi M.
- Journal Title
  
  Can J Cardiol.
  
  Volume: 31 Issue: 6 Pages: 702-708
- DOI
  10.1016/j.cjca.2014.12.036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-15K09134, KAKENHI-PROJECT-26460670, KAKENHI-PROJECT-26460742, KAKENHI-PROJECT-15H04783, KAKENHI-PROJECT-25670295, KAKENHI-PROJECT-25860589
[Journal Article] Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation.2015
- Author(s)
  Hayashi K, Konno T, Tada H, Tani S, Liu L, Fujino N, Nohara A, Hodatsu A, Tsuda T, Tanaka Y, Kawashiri MA, Ino H, Makita N, Yamagishi M.
- Journal Title
  
  Circ Arrhythm Electrophysiol.
  
  Volume: 8 Issue: 5 Pages: 1095-1104
- DOI
  10.1161/circep.114.002519
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-26460670, KAKENHI-PROJECT-15K15311, KAKENHI-PROJECT-15H04823, KAKENHI-PROJECT-25460648, KAKENHI-PROJECT-25860589, KAKENHI-PROJECT-24390199
[Journal Article] Electrocardiographic QRS Fragmentation as a Marker for Myocardial Fibrosis in Hypertrophic Cardiomyopathy.2015
- Author(s)
  Konno T, Hayashi K, Fujino N, Oka R, Nomura A, Nagata Y, Hodatsu A, Sakata K, Furusho H, Takamura M, Nakamura H, Kawashiri MA, Yamagishi M.
- Journal Title
  
  J Cardiovasc Electrophysiol.
  
  Volume: 26 Issue: 10 Pages: 1081-1087
- DOI
  10.1111/jce.12742
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-15K09134, KAKENHI-PROJECT-26460670, KAKENHI-PROJECT-26460742, KAKENHI-PROJECT-25670295, KAKENHI-PROJECT-25860589
[Journal Article] Fragmented QRS Predicts Heart Failure Progression in Patients With Hypertrophic Cardiomyopathy2014
- Author(s)
  Nomura A, Konno T, Fujita T, Tanaka Y, Nagata Y, Tsuda T, Hodatsu A, Sakata K, Nakamura H, Kawashiri MA, Fujino N, Yamagishi M, Hayashi K.
- Journal Title
  
  Circ J
  
  Volume: 79 Issue: 1 Pages: 136-143
- DOI
  10.1253/circj.CJ-14-0822
- NAID
  130004704014
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591041, KAKENHI-PROJECT-24790748, KAKENHI-PROJECT-26460670, KAKENHI-PROJECT-26460742, KAKENHI-PROJECT-15K09134
[Journal Article] Compound heterozygosity deteriorates phenotypes of hypertrophic cardiomyopathy with founder MYBPC3 mutation: evidence from patients and zebrafish models.2014
- Author(s)
  Hodatsu A, Konno T, Hayashi K, Funada A, Fujita T, Nagata Y, Fujino N, Kawashiri MA, Yamagishi M.
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 307 Issue: 11 Pages: 1594-604
- DOI
  10.1152/ajpheart.00637.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591041, KAKENHI-PROJECT-24790748, KAKENHI-PROJECT-25860589, KAKENHI-PROJECT-26460670, KAKENHI-PROJECT-26460742
[Journal Article] High sensitivity of late gadolinium enhancement for predicting microscopic myocardial scarring in biopsied specimens in hypertrophic cardiomyopathy.2014
- Author(s)
  Konno T，Hayashi K，Fujino N，Nagata Y，Hodatsu A，Masuta E，Sakata K，Nakamura H，Kawashiri M，Yamagishi M.
- Journal Title
  
  PLoS One.
  
  Volume: 9 Issue: 7 Pages: e101465-e101465
- DOI
  10.1371/journal.pone.0101465
- NAID
  120006460361
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591041, KAKENHI-PROJECT-24790748, KAKENHI-PROJECT-25460830, KAKENHI-PROJECT-25670295, KAKENHI-PROJECT-26460670, KAKENHI-PROJECT-26460742
[Journal Article] Increased extent of myocardial fibrosis in genotyped hypertrophic cardiomyopathy with ventricular tachyarrhythmias.2014
- Author(s)
  Fujita T, Konno T, Yokawa J, Masuta E, Nagata Y, Fujino N, Funada A, Hodatsu A, Kawashiri MA, Yamagishi M, Hayashi K.
- Journal Title
  
  J Cardiol.
  
  Volume: in press Issue: 1 Pages: 63-68
- DOI
  10.1016/j.jjcc.2014.10.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591041, KAKENHI-PROJECT-25460648, KAKENHI-PROJECT-15K09134, KAKENHI-PROJECT-26460742, KAKENHI-PROJECT-25860589
[Presentation] Hypertrophic Cardiomyopathy.2015
- Author(s)
  Kenshi Hayashi, Noboru Fujino, Tetsuo Konno, Kenji Sakata, Takashi Fujita, Akihiko Hodatsu, Akihiro Nomura, Toyonobu Tsuda, Yoji Nagata, Yoshihiro Tanaka, Masa-aki Kawashiri, Masakazu Yamagishi.
- Organizer
  2015 8TH APHRS SCIENTIFIC SESSIONS
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2015-11-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460670
[Presentation] Functional Characterization of Rare Variants Associated with Lone Atrial Fibrillation.2014
- Author(s)
  Kenshi Hayashi, Noboru Fujino, Tetsuo Konno, Akihiko Hodatsu, Toyonobu Tsuda, Yoshihiro Tanaka, Masa-aki Kawashiri, Hidekazu Ino, and Masakazu Yamagishi.
- Organizer
  ESC CONGRESS 2014
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2014-09-02
- Data Source
  KAKENHI-PROJECT-26460670
[Presentation] Prognostic Significance of Sarcomere Gene Mutations and Myocardial Fibrosis in Hypertrophic Cardiomyopathy.2014
- Author(s)
  Kenshi Hayashi, Noboru Fujino, Tetsuo Konno, Kenji Sakata, Takashi Fujita, Akihiko Hodatsu, Akihiro Nomura, Toyonobu Tsuda, Yoji Nagata, Yoshihiro Tanaka, Masa-aki Kawashiri, Masakazu Yamagishi.
- Organizer
  7th Asia-Pacific Heart Rhythm Society Scientific Session
- Place of Presentation
  New Delhi, India
- Year and Date
  2014-10-31
- Data Source
  KAKENHI-PROJECT-26460670
[Presentation] A founder mutation of the myosin binding protein-C gene in hypertrophic cardiomyopathy and adverse outcomes with compound heterozygosity
- Author(s)
  Akihiko Hodatsu, Tetsuo Konno, Kenshi Hayashi, Takashi Fujita, Yoji Nagata, Noboru Fujino, Masa-aki Kawashiri, Masakazu Yamagishi
- Organizer
  European society of Cardiology Congress 2014
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2014-08-30 – 2014-09-03
- Data Source
  KAKENHI-PROJECT-25860589
[Presentation] Impact of Mutation Dosage on Phenotypes in Hypertrophic Cardiomyopathywith MYBPC3 Mutations; Evidence from Zebrafish Models.
- Author(s)
  Akihiko Hodatsu, Tetsuo Konno, Kenshi Hayashi, Yoji Nagata, Ryota Teramoto, Noboru Fujino, Masa-aki Kawashiri, Masakazu Yamagishi
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2015-04-24 – 2015-04-26
- Data Source
  KAKENHI-PROJECT-25860589
[Presentation] Impact of Compound Heterozygosity on Phenotypes of hypertrophic cardiomyopathy with MYBPC3 mutasions; Evidence from zebrafish models.
- Author(s)
  Akihiko Hodatsu, Tetsuo Konno, Kenshi Hayashi, Ryota Teramoto, Yoji Nagata, Noboru Fujino, Masa-aki Kawashiri, Masakazu Yamagishi
- Organizer
  American College of Cardiology 64th Annual Scientific Session
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-03-14 – 2015-03-16
- Data Source
  KAKENHI-PROJECT-25860589

1. SEGUCHI OSAMU (60570869)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. Hayashi Kenshi (00422642)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. SEKINE Akihiro (30425631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. AIBA Takeshi (40574348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 藤野陽 (40361993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 清水渉 (50399606)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TSUDA Toyonobu

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. TANAKA Yoshihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 川尻剛照

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
10. 野原淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 多田隼人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hodatsu Akihiko 寳達 明彦

Research Projects

Research Products

Co-Researchers

Genetic analysis for inherited arrhythmia and functional study using zebrafish model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the pathogenesis in hypertophic cardiomyopathy by using zebrafish models.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Whole exome sequencing combined with integrated variant annotation prediction identifies a causative myosin essential light chain variant in hypertrophic cardiomyopathy.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Right ventricular hypertrophy is associated with cardiovascular events in hypertrophic cardiomyopathy: evidence from study with magnetic resonance imaging.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Electrocardiographic QRS Fragmentation as a Marker for Myocardial Fibrosis in Hypertrophic Cardiomyopathy.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fragmented QRS Predicts Heart Failure Progression in Patients With Hypertrophic Cardiomyopathy2014

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Compound heterozygosity deteriorates phenotypes of hypertrophic cardiomyopathy with founder MYBPC3 mutation: evidence from patients and zebrafish models.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High sensitivity of late gadolinium enhancement for predicting microscopic myocardial scarring in biopsied specimens in hypertrophic cardiomyopathy.2014

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Increased extent of myocardial fibrosis in genotyped hypertrophic cardiomyopathy with ventricular tachyarrhythmias.2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] Hypertrophic Cardiomyopathy.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Functional Characterization of Rare Variants Associated with Lone Atrial Fibrillation.2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Prognostic Significance of Sarcomere Gene Mutations and Myocardial Fibrosis in Hypertrophic Cardiomyopathy.2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] A founder mutation of the myosin binding protein-C gene in hypertrophic cardiomyopathy and adverse outcomes with compound heterozygosity

Author(s)

Hodatsu Akihiko 寳達明彦