Koike Atsushi 小池敦資

Researcher Number	00625725
Other IDs
Affiliation (Current)	2025: 大阪医科薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2025: 大阪医科薬科大学, 薬学部, 講師 2021 – 2023: 大阪医科薬科大学, 薬学部, 講師 2017 – 2020: 大阪薬科大学, 薬学部, 助教 2014 – 2015: 大阪薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Medical pharmacy / Natural medicines Except Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator マクロファージ / LPS / アポトーシス / プレニル化 / ゲラニルゲラニル転移酵素 / 急性増悪 / 肺線維症 / TLR / 薬物相互作用 / 細胞死 … More / ネクロトーシス / ナフトキノン骨格 / カスパーゼ阻害薬 / ネクロプトーシス / 自然免疫 / 天然化合物 / シコニン / 天然物 / 抗炎症 … More Except Principal Investigator 脂質 / エイコサノイド / 肥満 Less

骨格筋由来マイオカインを介した肺線維化制御機構の解明Principal Investigator
- Principal Investigator
  
  小池敦資
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Osaka Medical and Pharmaceutical University
ゲラニルゲラニル転移酵素による肺線維化の制御機構の解明Principal Investigator
- Principal Investigator
  
  小池敦資
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Regulation mechanism of obesity by eicosanoids
- Principal Investigator
  
  Fujimori Ko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Osaka Medical and Pharmaceutical University
  Osaka University of Pharmaceutical Sciences
Elucidation of the mechanisms of macrophage death by drug interaction through Toll-like receptor signalingPrincipal Investigator
- Principal Investigator
  
  Koike Atsushi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
A search of compounds with regulating activated macrophagesPrincipal Investigator
- Principal Investigator
  
  Koike Atsushi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Natural medicines
- Research Institution
  Osaka University of Pharmaceutical Sciences

All 2024 2023 2022 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Involvement of necroptotic cell death in macrophages in progression of bleomycin and LPS-induced acute exacerbation of idiopathic pulmonary fibrosis2024
- Author(s)
  Koike Atsushi、Hayashi Kaoruko、Fujimori Ko
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 972 Pages: 176572-176572
- DOI
  10.1016/j.ejphar.2024.176572
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06622
[Journal Article] Bicarbonate enhances the inflammatory response by activating JAK/STAT signalling in LPS + IFN-γ-stimulated macrophages2020
- Author(s)
  Kawakami Tomoya、Koike Atsushi、Maehara Toko、Hayashi Tetsuya、Fujimori Ko
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 010 Issue: 6 Pages: 1-9
- DOI
  10.1093/jb/mvaa010
- NAID
  40022260414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15529
[Journal Article] Pan-caspase inhibitors induce necroptosis via ROS-mediated activation of mixed lineage kinase domain-like protein and p38 in classically activated macrophages2019
- Author(s)
  Koike Atsushi、Hanatani Miho、Fujimori Ko
- Journal Title
  
  Experimental Cell Research
  
  Volume: 380 Issue: 2 Pages: 171-179
- DOI
  10.1016/j.yexcr.2019.04.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15529
[Journal Article] A Limonoid, 7-Deacetoxy-7-Oxogedunin (CG-1) from Andiroba (Carapa guianensis, Meliaceae) Lowers the Accumulation of Intracellular Lipids in Adipocytes via Suppression of IRS-1/Akt-Mediated Glucose Uptake and a Decrease in GLUT4 Expression2019
- Author(s)
  Matsumoto Chihiro、Koike Atsushi、Tanaka Reiko、Fujimori Ko
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 9 Pages: 1668-1668
- DOI
  10.3390/molecules24091668
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15529
[Journal Article] シコニン（shikonin）のマクロファージへの作用を介した新たな免疫調節の可能性2018
- Author(s)
  天野富美夫、小池敦資
- Journal Title
  
  漢方と最新治療
  
  Volume: 27 Pages: 53-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15529
[Journal Article] Cytotoxic effect of triptolide on LPS-treated macrophages through sustained phosphorylation of p38 MAP kinase and apoptosis2017
- Author(s)
  K. Kohama, A. Koike, F. Amano
- Journal Title
  
  International Biology Review
  
  Volume: 1 Pages: 1-22
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15529
[Journal Article] Triptolide Induces Cell Damage in Lipopolysaccharide (LPS)-Treated Macrophages in an LPS-Signaling Cascade-Dependent Manner2017
- Author(s)
  K. Kohama, A. Koike, F. Amano
- Journal Title
  
  Journal of Cytokaine Biology
  
  Volume: 2 Issue: 02 Pages: 1-6
- DOI
  10.4172/2576-3881.1000117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15529
[Journal Article] Induction of different activated phenotypes of mouse peritoneal macrophages grown in different tissue culture media.2017
- Author(s)
  T. Kawakami, A. Koike, F. Amano
- Journal Title
  
  Cytotechnology
  
  Volume: 69 Issue: 4 Pages: 631-642
- DOI
  10.1007/s10616-017-0073-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15529
[Journal Article] Simultaneous Addition of Shikonin and its Derivatives with Lipopolysaccharide Induces Rapid Macrophage Death2016
- Author(s)
  Atsushi Koike, Makio Shibano, Hideya Mori, Kiyoko Kohama, Ko Fujimori and Fumio Amano
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Pages: 1-8
- NAID
  130005155138
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860072
[Presentation] 肥満がブレオマイシン誘導性肺線維症に及ぼす影響の解析2024
- Author(s)
  小池敦資、林薫子、藤森功
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06622
[Presentation] 肺線維症急性増悪における炎症誘導機構の解析2023
- Author(s)
  林薫子、小池敦資、藤森功
- Organizer
  第69回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-22K06622
[Presentation] 薬剤誘導性肺線維症の急性増悪機構の解析2023
- Author(s)
  林薫子、小池敦資、藤森功
- Organizer
  第22回次世代を担う若手のためのファーマ・バイオフォーラム 2023
- Data Source
  KAKENHI-PROJECT-22K06622
[Presentation] 肺線維症急性増悪の炎症誘導におけるマクロファージの関与についての検討2022
- Author(s)
  林薫子、小池敦資、藤森功
- Organizer
  第68回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-22K06622
[Presentation] 肺線維症急性増悪における炎症誘導機構の解析2022
- Author(s)
  林薫子、小池敦資、藤森功
- Organizer
  第72回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-22K06622
[Presentation] 肺線維症急性増悪における炎症誘誘導機構の解析2022
- Author(s)
  小池敦資、林薫子、藤森功
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K06622
[Presentation] カスパーゼ阻害剤による炎症性マクロファージを標的とした細胞死誘導機構の解析2019
- Author(s)
  小池敦資、花谷南帆、藤森功
- Organizer
  第20回Pharmaco-Hematologyシンポジウム
- Data Source
  KAKENHI-PROJECT-17K15529
[Presentation] クロヅルTripterygium regeliiの活性化マクロファージに対する細胞死誘導活性成分の探索2019
- Author(s)
  福永悠介, 北廣優実, 小池敦資, 天野富美夫, 古平栄一, 芝野真喜雄
- Organizer
  日本生薬学会年会
- Data Source
  KAKENHI-PROJECT-17K15529
[Presentation] カスパーゼ阻害剤による炎症性マクロファージを標的とした細胞死誘導機構の解析2019
- Author(s)
  小池敦資
- Organizer
  日本薬学会第139回年会
- Data Source
  KAKENHI-PROJECT-17K15529
[Presentation] カスパーゼ阻害剤による炎症性マクロファージを標的とした細胞死誘導機構の解析2019
- Author(s)
  小池敦資、花谷南帆、藤森功
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K15529
[Presentation] Effects of statins on the inflammatory response of macrophage activation through the TLR3 signaling pathway2019
- Author(s)
  Atsushi Koike, Kaito Tsujinaka, Ko Fujimori
- Organizer
  2019 ASCB/EMBO Meeting Cell Biology for the 21st Century
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15529
[Presentation] スタチン系薬剤によるToll-like receptor 3を介した抗ウイルス作用抑制機構の解析2019
- Author(s)
  小池敦資、辻中海斗、藤森功
- Organizer
  第66回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-17K15529
[Presentation] スタチン系薬剤によるマクロファージのToll-like receptor 3を介した抗ウイルス作用抑制機構の解析2019
- Author(s)
  小池敦資、辻中海斗、藤森功
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K15529
[Presentation] Sodium bicarbonate is the factor in culture media that potentially regulates nitric oxide production in a mouse macrophage-like cell line, J774.1 cells, treated with LPS and IFNγ2017
- Author(s)
  T. Kawakami, A. Koike, F. Amano
- Organizer
  American Society of Cell Biology annual metting
- Data Source
  KAKENHI-PROJECT-17K15529
[Presentation] マクロファージ活性化に及ぼすピタバスタチンの影響2017
- Author(s)
  辻中海斗、小池敦資、天野富美夫
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-17K15529
[Presentation] マクロファージ活性化に及ぼすピタバスタチンの影響2017
- Author(s)
  辻中海斗、小池敦資、天野富美夫
- Organizer
  第67回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K15529
[Presentation] シコニンによるマクロファージを標的とした活性化抑制作用の解析2017
- Author(s)
  小池敦資、芝野真喜雄、天野富美夫
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-17K15529
[Presentation] マクロファージ活性化に及ぼす重炭酸ナトリウム濃度の影響2017
- Author(s)
  川上智也、小池敦資、天野富美夫
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-17K15529
[Presentation] 広域型カスパーゼ阻害剤zVAD-fmkによるLPS活性化マクロファージの細胞死誘導機構の解析2017
- Author(s)
  花谷南帆、小池敦資、天野富美夫
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-17K15529
[Presentation] 広域型カスパーゼ阻害剤が活性化マクロファージに特異的に誘導する細胞死の解析2017
- Author(s)
  花谷南帆、小池敦資、天野富美夫
- Organizer
  第67回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K15529
[Presentation] ピタバスタチンがマクロファージの活性化に及ぼす影響2017
- Author(s)
  辻中海斗、小池敦資、天野富美夫
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-17K15529
[Presentation] シコニンとLPSの併用によって誘導されるマクロファージ細胞死を抑制する化合物の探索2016
- Author(s)
  小池　敦資
- Organizer
  第136回日本薬学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26860072
[Presentation] シコニン含有生薬のエンドトキシンによる汚染とシコニン－エンドトキシンが誘導するマクロファージの細胞障害性の解析含有生薬のエンドトキシンによる汚染とシコニン－エンドトキシンが誘導するマクロファージの細胞障害性の解析2015
- Author(s)
  小池　敦資
- Organizer
  フォーラム2015　衛生薬学・環境トキシコロジー2015　衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸学院大学（兵庫県神戸市）
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-26860072
[Presentation] Simultaneous addition of shikonin derivatives and lipopolysaccharide induces rapid death of macrophages2015
- Author(s)
  小池　敦資
- Organizer
  ASCB annual meeting 2015
- Place of Presentation
  San Diego Convention Center (San Diego, USA)
- Year and Date
  2015-12-12
- Data Source
  KAKENHI-PROJECT-26860072
[Presentation] LPSとシコニンによって急速に誘導されるマクロファージの細胞障害性の解析2014
- Author(s)
  小池敦資
- Organizer
  フォーラム2014 衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば国際会議場
- Year and Date
  2014-09-20
- Data Source
  KAKENHI-PROJECT-26860072

1. Fujimori Ko (70425453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 前原都有子 (60825529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Koike Atsushi 小池 敦資

Research Projects

Research Products

Co-Researchers

骨格筋由来マイオカインを介した肺線維化制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ゲラニルゲラニル転移酵素による肺線維化の制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation mechanism of obesity by eicosanoids

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanisms of macrophage death by drug interaction through Toll-like receptor signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A search of compounds with regulating activated macrophagesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Involvement of necroptotic cell death in macrophages in progression of bleomycin and LPS-induced acute exacerbation of idiopathic pulmonary fibrosis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bicarbonate enhances the inflammatory response by activating JAK/STAT signalling in LPS + IFN-γ-stimulated macrophages2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Pan-caspase inhibitors induce necroptosis via ROS-mediated activation of mixed lineage kinase domain-like protein and p38 in classically activated macrophages2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Limonoid, 7-Deacetoxy-7-Oxogedunin (CG-1) from Andiroba (Carapa guianensis, Meliaceae) Lowers the Accumulation of Intracellular Lipids in Adipocytes via Suppression of IRS-1/Akt-Mediated Glucose Uptake and a Decrease in GLUT4 Expression2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] シコニン（shikonin）のマクロファージへの作用を介した新たな免疫調節の可能性2018

Author(s)

Journal Title

Data Source

[Journal Article] Cytotoxic effect of triptolide on LPS-treated macrophages through sustained phosphorylation of p38 MAP kinase and apoptosis2017

Author(s)

Journal Title

Data Source

[Journal Article] Triptolide Induces Cell Damage in Lipopolysaccharide (LPS)-Treated Macrophages in an LPS-Signaling Cascade-Dependent Manner2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Induction of different activated phenotypes of mouse peritoneal macrophages grown in different tissue culture media.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simultaneous Addition of Shikonin and its Derivatives with Lipopolysaccharide Induces Rapid Macrophage Death2016

Author(s)

Journal Title

NAID

Data Source

[Presentation] 肥満がブレオマイシン誘導性肺線維症に及ぼす影響の解析2024

Author(s)

Koike Atsushi 小池敦資

[Presentation] カスパーゼ阻害剤による炎症性マクロファージを標的とした細胞死誘導機構の解析2019