KOBAYASHI EIJI 小林英士

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Kobayashi Eiji 小林英士

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Researcher Number	00632530
Other IDs
Affiliation (Current)	2025: 金沢大学, 医学系, 協力研究員
Affiliation (based on the past Project Information) *help	2023: 金沢大学, 附属病院, 助教 2022: 金沢大学, 医学系, 助教 2021: 金沢大学, 附属病院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related / 0905:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator エクソソーム / 上咽頭癌 / Epstein-Barrウイルス / 頭頸部癌 / ファルネシル化 / 細胞間情報伝達 / PD-1/PD-L1系 / Epstein Barrウイルス / PD-L-1 / PD-L1

Explication of mechanism of exosome-formation on nasopharyngeal carcinoma through protein farnesylationPrincipal Investigator
- Principal Investigator
  
  小林英士
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kanazawa University
Explication of resistance to PD-1 blockade on nasopharyngeal car cinoma through the mechanism of protein sorting to exosomesPrincipal Investigator
- Principal Investigator
  
  Kobayashi Eiji
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0905:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Kanazawa University

All 2024 2023 2022

All Journal Article Presentation Book

[Book] 分子標的薬が適応となる耳鼻咽喉科疾患2022
- Author(s)
  小林英士、吉崎智一
- Total Pages
  4
- Publisher
  東京医学社
- ISBN
  9784885635502
- Data Source
  KAKENHI-PROJECT-21K20946
[Journal Article] Lymph node metastasis regulation by peritumoral tonsillar tissue mitochondria-related pathway activation in oropharyngeal cancer2024
- Author(s)
  Wakisaka Naohiro、Moriyama-Kita Makiko、Kondo Satoru、Kobayashi Eiji、Ueno Takayoshi、Nakanishi Yosuke、Endo Kazuhira、Sugimoto Hisashi、Yoshizaki Tomokazu
- Journal Title
  
  PLOS ONE
  
  Volume: 19 Issue: 2 Pages: e0299750-e0299750
- DOI
  10.1371/journal.pone.0299750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15883, KAKENHI-PROJECT-20K21648, KAKENHI-PROJECT-23K21477
[Journal Article] Recent Advances in Assessing the Clinical Implications of Epstein-Barr Virus Infection and Their Application to the Diagnosis and Treatment of Nasopharyngeal Carcinoma2023
- Author(s)
  Yoshizaki Tomokazu、Kondo Satoru、Dochi Hirotomo、Kobayashi Eiji、Mizokami Harue、Komura Shigetaka、Endo Kazuhira
- Journal Title
  
  Microorganisms
  
  Volume: 12 Issue: 1 Pages: 14-14
- DOI
  10.3390/microorganisms12010014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15883
[Journal Article] Peritumoral SPARC expression induced by exosomes from nasopharyngeal carcinoma infected Epstein‐Barr virus: A poor prognostic marker2023
- Author(s)
  Dochi Hirotomo, Kondo Satoru, Komura Shigetaka, Moriyama‐Kita Makiko, Komori Takeshi, Nanbo Asuka, Sakaguchi Miako, Fukuyo Masaki, Hamabe‐Horiike Toshihide, Tanaka Mariko, Mizokami Harue, Kano Makoto, Kitagawa Yuki, Kobayashi Eiji, Hirai Nobuyuki, Ueno Takayoshi, Nakanishi Yosuke, et. al.
- Journal Title
  
  International Journal of Cancer
  
  Volume: 154 Issue: 5 Pages: 895-911
- DOI
  10.1002/ijc.34777
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15883, KAKENHI-PROJECT-22K07043, KAKENHI-PROJECT-22K07164, KAKENHI-PROJECT-22K19553, KAKENHI-PROJECT-21K16840
[Journal Article] Protein Farnesylation on Nasopharyngeal Carcinoma, Molecular Background and Its Potential as a Therapeutic Target2022
- Author(s)
  Kobayashi Eiji、Kondo Satoru、Dochi Hirotomo、Moriyama-Kita Makiko、Hirai Nobuyuki、Komori Takeshi、Ueno Takayoshi、Nakanishi Yosuke、Hatano Miyako、Endo Kazuhira、Sugimoto Hisashi、Wakisaka Naohiro、Yoshizaki Tomokazu
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 12 Pages: 2826-2826
- DOI
  10.3390/cancers14122826
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21648, KAKENHI-PROJECT-21K20946, KAKENHI-PROJECT-23K21477
[Journal Article] EBV genome variations enhance clinicopathological features of nasopharyngeal carcinoma in a non-endemic region2022
- Author(s)
  Kondo, Satoru; Okuno, Yusuke; Murata, Takayuki; Dochi, Hirotomo; Wakisaka, Naohiro; Mizokami, Harue; Moriyama-Kita, Makiko; Kobayashi, Eiji; Kano, Makoto; Komori, Takeshi; Hirai, Nobuyuki; Ueno, Takayoshi; Nakanishi, Yosuke; Endo, Kazuhira; Sugimoto, Hisashi; Kimura, Hiroshi; Yoshizaki, Tomokazu
- Journal Title
  
  Cancer Science
  
  Volume: －
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K20946
[Journal Article] EBV genome variations enhance clinicopathological features of nasopharyngeal carcinoma in a non‐endemic region2022
- Author(s)
  Kondo Satoru、Okuno Yusuke、Murata Takayuki、Dochi Hirotomo、Wakisaka Naohiro、Mizokami Harue、Moriyama‐Kita Makiko、Kobayashi Eiji、Kano Makoto、Ueno Takayoshi、et al.
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 7 Pages: 2446-2456
- DOI
  10.1111/cas.15381
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21648, KAKENHI-PROJECT-21K19557, KAKENHI-PROJECT-21K20946, KAKENHI-PROJECT-23K21477, KAKENHI-PROJECT-23K24140
[Journal Article] Estrogen induces the expression of <scp>EBV</scp> lytic protein <scp>ZEBRA</scp> , a?marker of poor prognosis in nasopharyngeal carcinoma2022
- Author(s)
  Dochi H、Kondo S、Murata T、Fukuyo M、Nanbo A、Wakae K、Jiang P、Hamabe T、Tanaka M、Nishiuchi T、Mizokami H、Moriyama M、Kobayashi E、Hirai N、Komori T、Ueno T、Nakanishi Y、Hatano M、Endo K、Sugimoto H、Wakisaka N、Juang H、Muramatsu M、Kaneda A、Yoshizaki T
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 8 Pages: 2862-2877
- DOI
  10.1111/cas.15440
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07164, KAKENHI-PROJECT-20K21648, KAKENHI-PROJECT-21K19557, KAKENHI-PROJECT-21K20946, KAKENHI-PROJECT-23K21477
[Journal Article] 頭頸部癌に対する化学放射線療法症例における全身性炎症反応とサルコペニア評価の意義2022
- Author(s)
  遠藤一平、小林英士、平井信行、小森岳、中西庸介、近藤悟、吉崎智一
- Journal Title
  
  金沢大学十全医学会雑誌
  
  Volume: 131 Pages: 32-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K20946
[Presentation] Clinical effectiveness of nivolumab and its prognostic factors related to tumor immunity2023
- Author(s)
  Kobayashi E, Sugimoto H, Yoshizaki T
- Organizer
  The 8th Conference of the Asian Society of Head and Neck Surgery (ASHNO2023)
- Data Source
  KAKENHI-PROJECT-23K15883
[Presentation] Effectiveness of nivolumab for sinonasal carcinomas2023
- Author(s)
  Kobayashi E, Ueno T, Yoshizaki T
- Organizer
  ERS 2023
- Data Source
  KAKENHI-PROJECT-23K15883
[Presentation] エクソソームの上咽頭癌転移・浸潤能への関与とLiquid Biopsyへの応用の展望2023
- Author(s)
  小林英士、上野貴雄、近藤悟、吉崎智一
- Organizer
  第6回CTC臨床応用研究会
- Data Source
  KAKENHI-PROJECT-21K20946
[Presentation] 当科における甲状腺分化癌の術後再発期間についての検討2022
- Author(s)
  小林英士、近藤悟、吉崎智一
- Organizer
  第80回日本癌学会
- Data Source
  KAKENHI-PROJECT-21K20946
[Presentation] 当科におけるNivolumabの使用成績および腫瘍免疫に関連した予後因子の検討2022
- Author(s)
  小林英士、吉崎智一
- Organizer
  第1回日本耳鼻咽喉科免疫アレルギー感染症学会
- Data Source
  KAKENHI-PROJECT-21K20946
[Presentation] Clinical outcomes of Nivolumab its prognostic factors related to tumor immunity in head and neck malignancies2022
- Author(s)
  Eiji Kobayashi, Satoru Kondo, Hisashi Sugimoto, Tomokazu Yoshizaki
- Organizer
  18th Japan-Korea Joint Meeting of Otorhinolaryngology - Head and Neck Surgery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20946
[Presentation] 外側側頭骨切除術施行時の前方視野確保おける、万能開口器の有用性2022
- Author(s)
  小林英士、杉本寿史、吉崎智一
- Organizer
  第22回耳鼻咽喉科手術支援システム・ナビ研究会
- Data Source
  KAKENHI-PROJECT-21K20946
[Presentation] C-Terminal Farnesylation of UCH-L1 Plays a Role in Transport of Epstain-Barr Virus Primary Oncoprotein LMP1 to Exosomes2022
- Author(s)
  Eiji Kobayashi, Satoru Kondo, Christopher B Whitehurst, Tomokazu Yoshizaki, Joseph S Pagano, Julia Shakelford
- Organizer
  19th International Symposium on Epstein-Barr Virus and associated disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20946

1. FUKUYO Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 脇坂尚宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 小林一三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOBAYASHI EIJI 小林 英士

Kobayashi Eiji 小林 英士

Research Projects

Research Products

Co-Researchers

Explication of mechanism of exosome-formation on nasopharyngeal carcinoma through protein farnesylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Explication of resistance to PD-1 blockade on nasopharyngeal car cinoma through the mechanism of protein sorting to exosomesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 分子標的薬が適応となる耳鼻咽喉科疾患2022

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Lymph node metastasis regulation by peritumoral tonsillar tissue mitochondria-related pathway activation in oropharyngeal cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recent Advances in Assessing the Clinical Implications of Epstein-Barr Virus Infection and Their Application to the Diagnosis and Treatment of Nasopharyngeal Carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peritumoral SPARC expression induced by exosomes from nasopharyngeal carcinoma infected Epstein‐Barr virus: A poor prognostic marker2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protein Farnesylation on Nasopharyngeal Carcinoma, Molecular Background and Its Potential as a Therapeutic Target2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EBV genome variations enhance clinicopathological features of nasopharyngeal carcinoma in a non-endemic region2022

Author(s)

Journal Title

Data Source

[Journal Article] EBV genome variations enhance clinicopathological features of nasopharyngeal carcinoma in a non‐endemic region2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Estrogen induces the expression of <scp>EBV</scp> lytic protein <scp>ZEBRA</scp> , a?marker of poor prognosis in nasopharyngeal carcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 頭頸部癌に対する化学放射線療法症例における全身性炎症反応と サルコペニア評価の意義2022

Author(s)

Journal Title

Data Source

[Presentation] Clinical effectiveness of nivolumab and its prognostic factors related to tumor immunity2023

Author(s)

Organizer

Data Source

[Presentation] Effectiveness of nivolumab for sinonasal carcinomas2023

Author(s)

Organizer

Data Source

[Presentation] エクソソームの上咽頭癌転移・浸潤能への関与とLiquid Biopsyへの応用の展望2023

Author(s)

Organizer

Data Source

[Presentation] 当科における甲状腺分化癌の術後再発期間についての検討2022

Author(s)

Organizer

Data Source

[Presentation] 当科におけるNivolumabの使用成績および腫瘍免疫に関連した予後因子の検討2022

Author(s)

Organizer

KOBAYASHI EIJI 小林英士

Kobayashi Eiji 小林英士

[Journal Article] 頭頸部癌に対する化学放射線療法症例における全身性炎症反応とサルコペニア評価の意義2022