Imajo Masamichi 今城正道

… Alternative Names

今城正道イマジョウマサミチ

IMAJO Masamichi 今城正道

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Researcher Number	00633934
Other IDs
Affiliation (Current)	2025: 北海道大学, 化学反応創成研究拠点 , 特任准教授
Affiliation (based on the past Project Information) *help	2025: 北海道大学, 化学反応創成研究拠点, 特任准教授 2022 – 2023: 北海道大学, 化学反応創成研究拠点, 特任准教授 2019 – 2020: 北海道大学, 化学反応創成研究拠点, 特任准教授 2013 – 2018: 京都大学, 生命科学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 48040:Medical biochemistry-related / Cell biology / Developmental biology
Keywords	Principal Investigator オルガノイド培養 / 腸上皮幹細胞 / 幹細胞 / 腸上皮 / 合成ハイドロゲル / ERK / EGFR / オルガノイド / YAP / 癌 … More / 基質電荷 / 大腸癌 / 胎児化 / 腸上皮細胞 / 環境刺激応答 / 細胞増殖 / 生体イメージング / 細胞分化 / 腫瘍形成 / 細胞ダイバーシティー / 環境応答 / 組織幹細胞 / ハイドロゲル / 感染応答 / 分泌系細胞分化 / Atoh1 / ERK MAP kinase / 環境刺激 / シグナル伝達 / β-カテニン / Myc / beta-catenin / オルガノイド培養法 / Wntシグナル / Hippoシグナル / 肝芽腫 / 肝芽細胞 / noggin / EGF / Notch / Eph/ephrinシグナル伝達 / 生体内遺伝子導入法 / Hippoシグナル伝達 / パターン形成 / Eph-ephrinシグナル / パネート細胞 / ephrin-Eph signaling / ニッチ / 細胞移動 Less

基質電荷による幹細胞性制御機構の解明Principal Investigator
- Principal Investigator
  
  今城正道
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Hokkaido University
腸上皮幹細胞の胎児化による大腸癌発生機構の解明Principal Investigator
- Principal Investigator
  
  今城正道
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Hokkaido University
Elucidation of molecular mechanisms underlying intestinal stem cell responses to environmental stimuli and their physiological significancePrincipal Investigator
- Principal Investigator
  
  Imajo Masamichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Hokkaido University
  Kyoto University
細胞ダイバーシティーを基盤とした腸上皮組織の恒常性維持機構の解明Principal Investigator
- Principal Investigator
  
  今城正道
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Hokkaido University
  Kyoto University
Analysis on molecular mechanisms regulating fetal liver stem cells, hepatoblasts, by using a novel organoid culture systemPrincipal Investigator
- Principal Investigator
  
  Imajo Masamichi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Kyoto University
Regulatory mechanisms and physiological significance of stem cell migration in the adult tissuesPrincipal Investigator
- Principal Investigator
  
  IMAJO Masamichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  Kyoto University

All 2024 2023 2022 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Generation of Fetal Intestinal Organoids and Their Maturation into Adult Intestinal Cells2023
- Author(s)
  Masamichi Imajo, Akira Hirota, Shinya Tanaka
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 2650 Pages: 133-140
- DOI
  10.1007/978-1-0716-3076-1_11
- ISBN
  9781071630754, 9781071630761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06874, KAKENHI-PROJECT-19H01171
[Journal Article] Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction2023
- Author(s)
  Tanikawa Satoshi、Ebisu Yuki、Seldacik Tomas、Semba Shingo、Nonoyama Takayuki、Kurokawa Takayuki、Hirota Akira、Takahashi Taiga、Yamaguchi Kazushi、Imajo Masamichi、Kato Hinako、Nishimura Takuya、Tanei Zen-ichi、Tsuda Masumi、Nemoto Tomomi、Gong Jian Ping、Tanaka Shinya
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 2233-2233
- DOI
  10.1038/s41598-023-28870-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05669, KAKENHI-PROJECT-21H03802, KAKENHI-PROJECT-21K19878, KAKENHI-PROJECT-19K20656, KAKENHI-PROJECT-22K06874, KAKENHI-PROJECT-19H01171, KAKENHI-PROJECT-23K21134
[Journal Article] Hemagglutinating Virus of Japan Envelope (HVJ-E)-Guided Gene Transfer to the Intestinal Epithelium2020
- Author(s)
  Masamichi Imajo
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: Intestinal Stem Cells Pages: 285-291
- DOI
  10.1007/978-1-0716-0747-3_19
- ISBN
  9781071607466, 9781071607473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06929
[Journal Article] Divergent Dynamics and Functions of ERK MAP Kinase Signaling in Development, Homeostasis and Cancer: Lessons from Fluorescent Bioimaging2019
- Author(s)
  Yu Muta, Michiyuki Matsuda, Masamichi Imajo*
- Journal Title
  
  Cancers
  
  Volume: 11 Issue: 4 Pages: 513-513
- DOI
  10.3390/cancers11040513
- NAID
  120006879513
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06929, KAKENHI-PUBLICLY-18H05100, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-22KJ2230
[Journal Article] Analysis of Retinoic Acid Receptor Signaling in Colorectal Cancer2019
- Author(s)
  Masamichi Imajo
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 2019 Pages: 85-93
- DOI
  10.1007/978-1-4939-9585-1_6
- ISBN
  9781493995844, 9781493995851
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H05100
[Journal Article] Analysis of Retinoic Acid Receptor Signaling in Colorectal Cancer2019
- Author(s)
  Masamichi Imajo
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: - Pages: 85-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06929
[Journal Article] Dynamic ERK signaling regulation in intestinal tumorigenesis2018
- Author(s)
  Yu Muta, Michiyuki Matsuda, Masamichi Imajo*
- Journal Title
  
  Mol. Cell. Oncol.
  
  Volume: 5 Issue: 5 Pages: 1506684-1506684
- DOI
  10.1080/23723556.2018.1506684
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06929, KAKENHI-PUBLICLY-18H05100, KAKENHI-PLANNED-15H05949
[Journal Article] Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine2018
- Author(s)
  Muta Yu、Fujita Yoshihisa、Sumiyama Kenta、Sakurai Atsuro、Taketo M. Mark、Chiba Tsutomu、Seno Hiroshi、Aoki Kazuhiro、Matsuda Michiyuki、Imajo Masamichi
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 2174-2174
- DOI
  10.1038/s41467-018-04527-8
- NAID
  120006488609
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0069, KAKENHI-PROJECT-18K06929, KAKENHI-PUBLICLY-18H04754, KAKENHI-PUBLICLY-18H05100, KAKENHI-PROJECT-18H02444, KAKENHI-PLANNED-15H05949, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-18H02490
[Journal Article] Antagonistic Interactions between Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and Retinoic acid Receptor Signaling in Colorectal Cancer Cells2017
- Author(s)
  2.Masamichi Imajo, Kunio Kondoh, Takuya Yamamoto, Kei Nakayama, May Nakajima-Koyama, Eisuke Nishida
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 37 Issue: 15
- DOI
  10.1128/mcb.00012-17
- NAID
  120006334857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K21106
[Journal Article] Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes.2017
- Author(s)
  Shunsuke Kon, et al.
- Journal Title
  
  Nature Cell Biology
  
  Volume: 印刷中 Issue: 5 Pages: 530-541
- DOI
  10.1038/ncb3509
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01492, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-16J01233, KAKENHI-PROJECT-14J02366, KAKENHI-PROJECT-26293177, KAKENHI-PROJECT-15K15297, KAKENHI-PROJECT-15K08974, KAKENHI-PROJECT-16K19571, KAKENHI-PROJECT-15KT0072, KAKENHI-PROJECT-17K08561, KAKENHI-PROJECT-17K19507, KAKENHI-PROJECT-17K15589, KAKENHI-PROJECT-15KK0290, KAKENHI-PUBLICLY-17H05611, KAKENHI-ORGANIZER-26114001, KAKENHI-PLANNED-26114004, KAKENHI-PROJECT-17H01559, KAKENHI-PROJECT-26250026, KAKENHI-PROJECT-17H04016, KAKENHI-PROJECT-16K14709, KAKENHI-PROJECT-16K21106, KAKENHI-INTERNATIONAL-15K21757, KAKENHI-PLANNED-26114008, KAKENHI-PROJECT-17H03654
[Journal Article] Live imaging of extracellular signal-regulated kinase and protein kinase A activities during thrombus formation in mice expressing biosensors based on Foerster resonance energy transfer2017
- Author(s)
  Takuya Hiratsuka,Takeshi Sano,Hisashi Kato,Naoki Komatsu,Masamichi Imajo,Yuji Kamioka,Kenta Sumiyama,Fumiaki Banno,Toshiyuki Miyata,Michiyuki Matsuda
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 印刷中 Issue: 7 Pages: 1487-1499
- DOI
  10.1111/jth.13723
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21109, KAKENHI-PROJECT-16K09834, KAKENHI-PROJECT-16K09835, KAKENHI-PROJECT-16K21106
[Journal Article] A highly sensitive FRET biosensor for AMPK exhibits heterogenous AMPK responses among cells and organs2017
- Author(s)
  1.Yumi Konagaya, Kenta Terai, Yusuke Hirao, Kanako Takakura, Masamichi Imajo, Yuji Kamioka, Norio Sasaoka, Akira Kakizuka, Kenta Sumiyama, Tomoichiro Asano, Michiyuki Matsuda
- Journal Title
  
  Cell Reports
  
  Volume: 21 Issue: 9 Pages: 2628-2638
- DOI
  10.1016/j.celrep.2017.10.113
- NAID
  120006366781
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21106, KAKENHI-PROJECT-16H05151, KAKENHI-PROJECT-16H06280
[Journal Article] Dual role of YAP and TAZ in renewal of the intestinal epithelium2015
- Author(s)
  Imajo M, Ebisuya M & Nishida E
- Journal Title
  
  Nature Cell Biology
  
  Volume: 17 Issue: 1 Pages: 7-19
- DOI
  10.1038/ncb3084
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25111712, KAKENHI-PROJECT-25870363, KAKENHI-PLANNED-26114004
[Journal Article] HOXA5 counteracts stem cell traits by inhibiting Wnt signaling in colorectal cancer2015
- Author(s)
  Ordonez-Moran P. et al.
- Journal Title
  
  Cancer Cell
  
  Volume: 28 Issue: 6 Pages: 815-829
- DOI
  10.1016/j.ccell.2015.11.001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26114004, KAKENHI-PROJECT-25870363
[Journal Article] 腸上皮恒常性におけるHippoシグナル伝達経路の役割2015
- Author(s)
  今城正道、西田栄介
- Journal Title
  
  実験医学
  
  Volume: 33 Pages: 2926-2933
- Data Source
  KAKENHI-PROJECT-25870363
[Journal Article] HVJ-E-mediated gene transfer into the intestinal epithelium2014
- Author(s)
  Masamichi Imajo, Miki Ebisuya, Eisuke Nishida
- Journal Title
  
  Protocol Exchange
  
  Volume: 該当しない
- DOI
  10.1038/protex.2014.049
- Open Access
- Data Source
  KAKENHI-PROJECT-25870363
[Presentation] 合成ハイドロゲルによるオルガノイドの制御と臓器新生2024
- Author(s)
  今城正道, 陳策文, Jian Ping Gong, 田中伸哉
- Organizer
  第113回日本病理学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06874
[Presentation] 細胞機能の新たな制御軸-基質電荷の影響の解明と癌・組織再生研究への展開2023
- Author(s)
  今城正道
- Organizer
  第40回分子病理学研究会　クラークシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22K06874
[Presentation] Application of synthetic hydrogel technology to the control of cancer and pluripotent stem cells2023
- Author(s)
  Masamichi Imajo, Akira Hirota, Jian-Ping Gong, Shinya Tanaka
- Organizer
  The 6th ICReDD International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06874
[Presentation] 細胞外基質の電荷による細胞機能の制御機構と生物学的意義の解明2022
- Author(s)
  今城正道、廣田聡、Gong Jian Ping、田中伸哉
- Organizer
  第74回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-22K06874
[Presentation] Substrate charge regulates stemness of cancer and pluripotent stem cells via metabolic control of pluripotency factors2022
- Author(s)
  Masamichi Imajo, Akira Hirota, Ryosuke Miyazaki, Jean-Ping Gong, Shinya Tanaka
- Organizer
  The 40th Sapporo International Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06874
[Presentation] Dynamic regulation of ERK signaling in intestinal homeostasis and cancer2020
- Author(s)
  Masamichi Imajo, Yu Muta, Michiyuki Matsuda
- Organizer
  Establishing International Research Network of Mathematical Concology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06929
[Presentation] 分子活性のゆらぎによる腸上皮細胞ダイバーシティーの制御2020
- Author(s)
  今城正道
- Organizer
  新学術領域「細胞ダイバース」第3回若手ワークショップ
- Data Source
  KAKENHI-PROJECT-18K06929
[Presentation] 腸上皮における細胞増殖シグナルの動態とその生理的意義2019
- Author(s)
  今城正道、牟田優、松田道行
- Organizer
  文部科学省科学研究費補助金　新学術領域（研究領域提案型）細胞社会ダイバーシティーの統合的解明と制御　第３回公開シンポジウム「1細胞統合解析を駆使した組織内ダイバーシティー解明への挑戦」
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H05100
[Presentation] Alterations of ERK activity dynamics underlying tumor-specific traits in the intestinal epithelium2019
- Author(s)
  Masamichi Imajo, Yu Muta, Michiyuki Matsuda
- Organizer
  The 38th Sapporo International Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06929
[Presentation] 腸上皮における細胞増殖シグナルの動態とその生理的意義2019
- Author(s)
  今城正道, 牟田優, 松田道行
- Organizer
  文部科学省科学研究費補助金新学術領域研究（研究領域提案型）細胞社会ダイバーシティーの統合的解明と制御第3回公開シンポジウム「1細胞統合解析を駆使した組織内ダイバーシティー解明への挑戦」
- Invited
- Data Source
  KAKENHI-PROJECT-18K06929
[Presentation] Alterations of ERK activity dynamics underlying tumor-specific traits in the intestinal epithelium2019
- Author(s)
  Masamichi Imajo, Yu Muta, Michiyuki Matsuda
- Organizer
  The 38th Sapporo International Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H05100
[Presentation] Composite regulation of ERK activity dynamics underlying tumor-specific traits in the intestine2018
- Author(s)
  今城正道、牟田優、松田道行
- Organizer
  第70回日本細胞生物学会　第51回日本発生生物学会　合同大会
- Data Source
  KAKENHI-PUBLICLY-18H05100
[Presentation] Composite regulation of ERK activity dynamics underlying tumor-specific traits in the intestine2018
- Author(s)
  今城正道、牟田優、松田道行
- Organizer
  第70回日本細胞生物学会　第51回日本発生生物学会　合同大会
- Data Source
  KAKENHI-PROJECT-18K06929
[Presentation] 炎症性シグナルの制御におけるHippo経路の新たな役割と分子機構の解明2017
- Author(s)
  今城正道、牟田優、松田道行
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-16K21106
[Presentation] Molecular mechanisms controlling intestinal stem cell functions and their alterations in intestinal tumorigenesis2017
- Author(s)
  Masamichi Imajo, Yu Muta, Michiyuki Matsuda
- Organizer
  The 16th Joint Mini-Symposium 2017 of National Taiwan University, Kyoto University, and the University of Tsukuba
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21106
[Presentation] 炎症応答の制御におけるHippo経路の新たな役割と分子機構の解明2017
- Author(s)
  今城正道、牟田優、松田道行
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K21106
[Presentation] Novel role of Yes-associated protein as a regulator of inflammation2017
- Author(s)
  Masamichi Imajo, Yu Muta, Michiyuki Matsuda
- Organizer
  The EMBO Workshop, The Hippo pathway across species and disciplines
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21106
[Presentation] 新規オルガノイド培養法を用いた肝芽腫発生機構の解析2016
- Author(s)
  今城正道、松田道行
- Organizer
  第68回細胞生物学会大会
- Place of Presentation
  京都テルサ、京都府京都市、日本
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16K21106
[Presentation] 組織幹細胞の制御におけるHippo経路の新たな役割2015
- Author(s)
  今城正道
- Organizer
  第8回Symphony
- Place of Presentation
  ホテルメトロポリタンエドモント飯田橋 (東京都千代田区)
- Year and Date
  2015-09-26
- Invited
- Data Source
  KAKENHI-PROJECT-25870363
[Presentation] 腸上皮の幹細胞依存的な更新におけるHippo経路の役割2015
- Author(s)
  今城正道、西田栄介
- Organizer
  第38回日本分子生物学会年会　第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド (兵庫県神戸市)
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-25870363
[Presentation] 生体内遺伝子導入法により解明された腸上皮幹細胞機能の新たな制御機構2014
- Author(s)
  今城正道、西田栄介
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良県新公会堂
- Year and Date
  2014-06-13
- Invited
- Data Source
  KAKENHI-PROJECT-25870363

1. EBISUYA Miki

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2. AOKI Kazuhiro

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3. 小松直貴

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4. 高橋泰伽

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5. 根本知己

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Imajo Masamichi 今城 正道

今城 正道 イマジョウ マサミチ

IMAJO Masamichi 今城 正道

Research Projects

Research Products

Co-Researchers

基質電荷による幹細胞性制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腸上皮幹細胞の胎児化による大腸癌発生機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular mechanisms underlying intestinal stem cell responses to environmental stimuli and their physiological significancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞ダイバーシティーを基盤とした腸上皮組織の恒常性維持機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Analysis on molecular mechanisms regulating fetal liver stem cells, hepatoblasts, by using a novel organoid culture systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulatory mechanisms and physiological significance of stem cell migration in the adult tissuesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Generation of Fetal Intestinal Organoids and Their Maturation into Adult Intestinal Cells2023

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[Journal Article] Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction2023

Author(s)

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DOI

Data Source

[Journal Article] Hemagglutinating Virus of Japan Envelope (HVJ-E)-Guided Gene Transfer to the Intestinal Epithelium2020

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Divergent Dynamics and Functions of ERK MAP Kinase Signaling in Development, Homeostasis and Cancer: Lessons from Fluorescent Bioimaging2019

Author(s)

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DOI

NAID

Data Source

[Journal Article] Analysis of Retinoic Acid Receptor Signaling in Colorectal Cancer2019

Author(s)

Journal Title

DOI

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[Journal Article] Analysis of Retinoic Acid Receptor Signaling in Colorectal Cancer2019

Author(s)

Journal Title

Data Source

[Journal Article] Dynamic ERK signaling regulation in intestinal tumorigenesis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine2018

Imajo Masamichi 今城正道

今城正道イマジョウマサミチ

IMAJO Masamichi 今城正道