YUI Naofumi 油井直史

Researcher Number	00633976
Other IDs	https://orcid.org/0000-0002-4262-4386
Affiliation (based on the past Project Information) *help	2016 – 2022: 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 2015: 東京医科歯科大学, 医歯(薬)学総合研究科, 非常勤講師
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / Kidney internal medicine
Keywords	Principal Investigator α平滑筋アクチン / 筋線維芽細胞 / 線維芽細胞 / ノックダウン / レンチウイルス / 非筋肉型ミオシン / 慢性腎臓病 / 細胞膜輸送体 / アクチン / ミオシン … More / 細胞骨格 / 腎臓線維化 / 心不全 / アクアポリン２ / 尿崩症 / アクアポリン2 / バソプレシン / 集合管 / 細胞内輸送 / 脱リン酸化 / リン酸化 / 水チャネル Less

Investigation of renal fibrosis molecular mechanisms focusing on membrane proteinsPrincipal Investigator
- Principal Investigator
  
  YUI Naofumi
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Tokyo Medical and Dental University
Identification of molecular mechanisms for AQP2 activation to deveplop its inhibitorPrincipal Investigator
- Principal Investigator
  
  YUI Naofumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Medical and Dental University

All 2022 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] LRBA is essential for urinary concentration and body water homeostasis2022
- Author(s)
  Hara Y, Ando F, Oikawa D, Ichimura K, Yanagawa H, Sakamaki Y, Nanamatsu A, Fujiki T, Mori S, Suzuki S, Yui N, Mandai S, Susa K, Mori T, Sohara E, Rai T, Takahashi M, Sasaki S, Kagechika H, Tokunaga F, Uchida S.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 30
- DOI
  10.1073/pnas.2202125119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-21K08249, KAKENHI-PROJECT-22K18385, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-21H02933, KAKENHI-PROJECT-18K08233, KAKENHI-PUBLICLY-21H00291, KAKENHI-PROJECT-23K24346
[Journal Article] Chlorpromazine Induces Basolateral Aquaporin-2 Accumulation via F-Actin Depolymerization and Blockade of Endocytosis in Renal Epithelial Cells.2020
- Author(s)
  Yui N, Bouley R, Terlouw A, Cheung PW, Brown D.
- Journal Title
  
  Cells
  
  Volume: 23 Issue: 4 Pages: 1057-1057
- DOI
  10.3390/cells9041057
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08233
[Journal Article] AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus2018
- Author(s)
  Ando Fumiaki、Mori Shuichi、Yui Naofumi、Morimoto Tetsuji、Nomura Naohiro、Sohara Eisei、Rai Tatemitsu、Sasaki Sei、Kondo Yoshiaki、Kagechika Hiroyuki、Uchida Shinichi
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1411-1411
- DOI
  10.1038/s41467-018-03771-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-15K09286, KAKENHI-PROJECT-18K08233, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-17H06656, KAKENHI-PROJECT-15K09301, KAKENHI-PROJECT-16K09642
[Journal Article] The proteasome inhibitor bortezomib attenuates renalfibrosis in mice via supression of TGF b12018
- Author(s)
  Zeniya M, Mori T, Yui N, Nomura N, Mandai S, Isobe K, Chiga M, Sohara E, Rai T, Uchida S.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 13086-13086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09286
[Journal Article] Ezrin directly interacts with AQP2 and promotes its endocytosis.2017
- Author(s)
  Li W, Jin WW, Tsuji K, Chen Y, Nomura N, Su L, Yui N, Arthur J, Cotecchia S, Paunescu TG, Brown D, Lu HAJ.
- Journal Title
  
  Journal of Cell Science
  
  Volume: 130 Pages: 2914-2914
- Data Source
  KAKENHI-PROJECT-15K09286
[Journal Article] Aquaporin-2 Ser-261 phosphorylation is regulated in combination with Ser-256 and Ser-269 phosphorylation2017
- Author(s)
  Naofumi Yui, Sei Sasaki, Shinichi Uchida
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 482 Issue: 4 Pages: 524-529
- DOI
  10.1016/j.bbrc.2016.11.118
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09286
[Journal Article] Ser-261 phospho-regulation is involved in pS256 and pS269-mediated apical translocation.2017
- Author(s)
  Yui N, Ando F, Sasaki S, Uchida S.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 490 Pages: 1039-1039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09286
[Journal Article] Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway.2016
- Author(s)
  Ando F, Sohara E, Morimoto T, Yui N, Nomura N, Kikuchi E, Takahashi D, Mori T, Vandewalle A, Rai T, Sasaki S, Kondo Y, Uchida S.
- Journal Title
  
  Nat Commun.
  
  Volume: 7 Issue: 1 Pages: 13636-13636
- DOI
  10.1038/ncomms13636
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K09286, KAKENHI-PROJECT-15K09301, KAKENHI-PROJECT-16K15467
[Journal Article] Bence-Jones Protein λ-type Multiple Myeloma Patient Withdrawn from Maintenance Hemodialysis after Long-term Bortezomib and Dexamethasone Therapy2016
- Author(s)
  Wakaba Yamaguchi, Naofumi Yui, Toshikage Nagao, Gaku Oshikawa, Mariko Negi, Soichiro Iimori, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida.
- Journal Title
  
  Intern. Med.
  
  Volume: 55 Issue: 3 Pages: 263-268
- DOI
  10.2169/internalmedicine.55.5310
- NAID
  130005122595
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09286
[Journal Article] Anemia mmanegement and morality risk in newly visiting patients with chronic kidney disease in Japan: The CKD-ROUTE study.2015
- Author(s)
  Soichiro Iimori, Shotaro Naito, Yumi Noda, Hidenori Nishida, Naofumi Yui, Tomokazu Okado, Sei Sasaki, Shinichi Uchida, Tatemitsu Rai.
- Journal Title
  
  Nephrology
  
  Volume: 20 Issue: 9 Pages: 601-608
- DOI
  10.1111/nep.12493
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09286
[Journal Article] Retroperitoneal Fibrosis in Chronic Kidney Disease2015
- Author(s)
  Yuki Yoshizaki, Naofumi Yui, Tomokazu Okado, Junichi Ishigami, Soichiro Iimori, Katsuyuki Oi, Eisei Sohara, Sei Sasaki, Tatemitsu Rai, Shinichi Uchida.
- Journal Title
  
  General Medicine
  
  Volume: 16 Issue: 2 Pages: 103-106
- DOI
  10.14442/general.16.103
- NAID
  130005078484
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09286
[Presentation] 腎臓線維芽細胞活性化における非筋肉型ミオシン 2A の重要性2020
- Author(s)
  油井　直史，名和　眞希子，内田　信一.
- Organizer
  日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08233
[Presentation] Derivatives of FMP-API-1/27 Robustly Activate AQP2 Water Channels Independently of Vasopressin2019
- Author(s)
  Ando, Fumiaki, Yui, Naofumi, Mandai, Shintaro, Isobe, Kiyoshi, Mori, Takayasu, Susa, Koichiro, Nomura, Naohiro, Sohara, Eisei, Rai, Tatemitsu, Uchida, Shinichi,
- Organizer
  American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08233
[Presentation] Epithelial Depolarization Induces AQP2 Up-regulation via Non-Canonical Ser-269 Phospho-Regulation Independently of Any Hormonal and Chemical Stimulation2018
- Author(s)
  Yui Naofumi、Ando Fumiaki、Sasaki Sei、Uchida Shinichi
- Organizer
  American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08233
[Presentation] Phosphorylation of Ser261 and Dephosphorylation of Ser269 Is Important for Urinary Excretion of AQP22018
- Author(s)
  Sasaki Sei、Sakai Masaki、Mizumura Hiroki、Matsumoto Tomoki、Noda Yumi、Yui Naofumi、Ishibashi Kenichi
- Organizer
  American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08233
[Presentation] AKAPs-PKA Disruptors Robustly Increase AQP2 Activity Independently of Vasopressin2018
- Author(s)
  Ando Fumiaki、Yui Naofumi、Nomura Naohiro、Rai Tatemitsu、Sasaki Sei、Uchida Shinichi
- Organizer
  American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08233
[Presentation] Quantification of singleand multi-site AQP2 phosphorylation2017
- Author(s)
  Yui N, Uchida S.
- Organizer
  51th Annual Meeting of American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09286
[Presentation] アクアポリン2の細胞内輸送調節における複合的リン酸化制御機構の解明2017
- Author(s)
  油井直史、佐々木成、内田信一
- Organizer
  日本腎臓学会
- Data Source
  KAKENHI-PROJECT-15K09286
[Presentation] 新規腎臓線維化改善薬としてのbortezomibの検討2017
- Author(s)
  銭谷慕子、森崇寧、油井直史、野村尚弘、千賀宗子、高橋大栄、蘇原映誠、頼建光、内田信一
- Organizer
  日本腎臓学会
- Data Source
  KAKENHI-PROJECT-15K09286
[Presentation] Regulated Ser-261 dephosphorylation combined with Ser-256 and Ser-269 phosphorylation in the C-terminus of aquaporin-2 water channel2016
- Author(s)
  Naofumi Yui, Sei Sasaki, Shinichi Uchida
- Organizer
  50th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Chicago, USA
- Year and Date
  2016-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09286
[Presentation] カルシニューリンは腎性尿崩症治療の標的分子である2016
- Author(s)
  安藤史顕、蘇原映誠、油井直史、野村尚弘、菊池絵梨子、高橋大栄、森崇寧、頼建光、佐々木成、内田信一
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜　横浜　神奈川
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K09286
[Presentation] The proteasome inhibitor bortezomib attenuate renal fibrosis in mice2016
- Author(s)
  Moko Zeniya, Takayasu Mori, Naohiro Nomura, Naofumi Yui, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
- Organizer
  50th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Chicago, USA
- Year and Date
  2016-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09286
[Presentation] Dephosphorylation at Ser-261 is a determinant for the regulated AQP2 apical accumulation2015
- Author(s)
  Naofumi Yui, Sei Sasaki, Shinichi Uchida
- Organizer
  American Society of Nephrology
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09286
[Presentation] バソプレッシン刺激によるアクアポリン２の活性化はGABAb受容体情報伝達機構により調節を受ける2015
- Author(s)
  谷田部淳一、高野梢、谷田部緑、油井直史、蘇原映誠、内田信一、渡辺毅、木村純子
- Organizer
  日本腎臓学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-06-07
- Data Source
  KAKENHI-PROJECT-15K09286
[Presentation] スニチニブによる腎症の一例2015
- Author(s)
  正田若菜、油井直史、工藤篤、大橋敦希、井上祐一、飯盛聡一郎、須佐紘一郎、森崇寧、佐藤文絵、野村尚弘、桑名仁、内藤省太郎、蘇原映誠、岡戸丈和、頼建光、内田信一
- Organizer
  日本腎臓学会東部学術大会
- Place of Presentation
  東京ミッドタウン　ホール＆カンファレンス（東京都港区）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-15K09286
[Presentation] Ser-269リン酸化AQP2の細胞内局在の時系列変化2015
- Author(s)
  油井直史、佐々木成、内田信一
- Organizer
  日本腎臓学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PROJECT-15K09286
[Presentation] Sunitinib-induced nephrotic syndrome and acute kidney injury in a malignant insulinoma patient: a case report2015
- Author(s)
  Shoda Wakana, Naofumi Yui, Shotaro Naito, Soichiro Iimori, Koichiro Susa, Takayasu Mori, Naohiro Nomura, Eisei Sohara, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida.
- Organizer
  American Society of Nephrology
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09286

1. 佐々木成

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 内田信一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 及川大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YUI Naofumi 油井 直史

Research Projects

Research Products

Co-Researchers

Investigation of renal fibrosis molecular mechanisms focusing on membrane proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of molecular mechanisms for AQP2 activation to deveplop its inhibitorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] LRBA is essential for urinary concentration and body water homeostasis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chlorpromazine Induces Basolateral Aquaporin-2 Accumulation via F-Actin Depolymerization and Blockade of Endocytosis in Renal Epithelial Cells.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The proteasome inhibitor bortezomib attenuates renalfibrosis in mice via supression of TGF b12018

Author(s)

Journal Title

Data Source

[Journal Article] Ezrin directly interacts with AQP2 and promotes its endocytosis.2017

Author(s)

Journal Title

Data Source

[Journal Article] Aquaporin-2 Ser-261 phosphorylation is regulated in combination with Ser-256 and Ser-269 phosphorylation2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ser-261 phospho-regulation is involved in pS256 and pS269-mediated apical translocation.2017

Author(s)

Journal Title

Data Source

[Journal Article] Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bence-Jones Protein &lambda;-type Multiple Myeloma Patient Withdrawn from Maintenance Hemodialysis after Long-term Bortezomib and Dexamethasone Therapy2016

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Anemia mmanegement and morality risk in newly visiting patients with chronic kidney disease in Japan: The CKD-ROUTE study.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Retroperitoneal Fibrosis in Chronic Kidney Disease2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] 腎臓線維芽細胞活性化における非筋肉型ミオシン 2A の重要性2020

Author(s)

Organizer

Data Source

[Presentation] Derivatives of FMP-API-1/27 Robustly Activate AQP2 Water Channels Independently of Vasopressin2019

Author(s)

Organizer

Data Source

YUI Naofumi 油井直史

[Journal Article] Bence-Jones Protein λ-type Multiple Myeloma Patient Withdrawn from Maintenance Hemodialysis after Long-term Bortezomib and Dexamethasone Therapy2016