Kurihara Yuji 栗原裕司

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KURIHARA Yuji 栗原裕司

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Researcher Number	00634552
Other IDs
Affiliation (Current)	2025: 島根大学, 学術研究院医学・看護学系, 助教 2025: 名古屋市立大学, 医薬学総合研究院(薬学), 助教
Affiliation (based on the past Project Information) *help	2023: 島根大学, 学術研究院医学・看護学系, 助教 2021 – 2022: 名古屋市立大学, 医薬学総合研究院(薬学), 助教 2013 – 2017: 横浜市立大学, 生命医科学研究科, 特任助教 2012: 横浜市立大学, 医学(系)研究科(研究院), 特任助教
Review Section/Research Field	Principal Investigator General pharmacology / Basic Section 47040:Pharmacology-related / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator 神経科学 / 神経再生 / 薬理学 / 突起伸長 / 受容体制御 / 神経疾患 / アンタゴニスト / 神経再生阻害因子 / シグナル伝達

Analysis of the molecular mechanism underlying a promoting effect of LOTUS on neurite outgrowthPrincipal Investigator
- Principal Investigator
  
  KURIHARA Yuji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Shimane University
  Nagoya City University
Regulation of PirB, a receptor causing neurodegenerative diseasesPrincipal Investigator
- Principal Investigator
  
  KURIHARA Yuji
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Yokohama City University
Regulation of PirB, a functional receptor for axonal growth inhibitors, by LOTUSPrincipal Investigator
- Principal Investigator
  
  KURIHARA Yuji
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Yokohama City University
Mechanism of neurite outgrowth promoting effect of LOTUS, an antagonist for Nogo receptorPrincipal Investigator
- Principal Investigator
  
  KURIHARA Yuji
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General pharmacology
- Research Institution
  Yokohama City University

All 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Cerebrospinal fluid level of Nogo receptor 1 antagonist lateral olfactory tract usher substance (LOTUS) correlates inversely with the extent of neuroinflammation2018
- Author(s)
  Takahashi Keita、Takeuchi Hideyuki、Kurihara Yuji、Doi Hiroshi、Kunii Misako、Tanaka Kenichi、Nakamura Haruko、Fukai Ryoko、Tomita-Katsumoto Atsuko、Tada Mikiko、Higashiyama Yuichi、Joki Hideto、Koyano Shigeru、Takei Kohtaro、Tanaka Fumiaki
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 15 Issue: 1 Pages: 46-46
- DOI
  10.1186/s12974-018-1084-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16128, KAKENHI-PROJECT-16K19518, KAKENHI-PROJECT-16K21268, KAKENHI-PROJECT-18K07503, KAKENHI-PROJECT-18K15458
[Journal Article] The soluble form of LOTUS inhibits Nogo receptor-mediated signaling by interfering with the interaction between Nogo receptor type 1 and p75 neurotrophin receptor.2018
- Author(s)
  Kawakami Y, Kurihara Y, Saito Y, Fujita Y, Yamashita T, Takei K.
- Journal Title
  
  J Neurosci.
  
  Volume: 38 Issue: 10 Pages: 2589-2604
- DOI
  10.1523/jneurosci.0953-17.2018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21268
[Journal Article] Regulation of lateral olfactory tract development by Nogo-A, Nogo receptor-1 and LOTUS proteins.2017
- Author(s)
  Kurihara Y, Takei K.
- Journal Title
  
  Trends Dev Biol.
  
  Volume: 10 Pages: 41-47
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21268
[Journal Article] LOTUS overexpression accelerates neuronal plasticity after focal brain ischemia in mice.2017
- Author(s)
  Takase H, Kurihara Y, Yokoyama TA, Kawahara N, Takei K.
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 9 Pages: e0184258-e0184258
- DOI
  10.1371/journal.pone.0184258
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21268
[Journal Article] Blockade of chondroitin sulfate proteoglycans-induced axonal growth inhibition by LOTUS2017
- Author(s)
  Kurihara, Y., Saito, Y., and Takei, K.
- Journal Title
  
  Neuroscience
  
  Volume: 356 Pages: 265-274
- DOI
  10.1016/j.neuroscience.2017.05.034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01342, KAKENHI-PROJECT-16K21268
[Journal Article] Regulation of axonal regeneration by the level of function of endogenous Nogo receptor antagonist LOTUS2017
- Author(s)
  Hirokawa, T., Zou, Y., Kurihara, Y., Jiang, Z., Sakakibara, Y., Ito, H., Funakoshi, K., Kawahara, N., Goshima, Y., Strittmatter, S.M., and Takei, K.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 12119-12119
- DOI
  10.1038/s41598-017-12449-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03561, KAKENHI-PROJECT-16K21268
[Journal Article] Axonal branching in lateral olfactory tract is promoted by Nogo signaling2016
- Author(s)
  Iketani M, Yokoyama T, Kurihara Y, Strittmatter SM, Goshima Y, Kawahara N, Takei K
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 39586-39586
- DOI
  10.1038/srep39586
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03267, KAKENHI-PROJECT-26290024, KAKENHI-PROJECT-16K21268
[Journal Article] LOTUS, a potent blocker of Nogo receptor-1 causing inhibition of axonal growth.2015
- Author(s)
  Kurihara Y, Takei K.
- Journal Title
  
  Neural Regen Res.
  
  Volume: 10 Issue: 1 Pages: 46-48
- DOI
  10.4103/1673-5374.150652
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26870480
[Journal Article] Association of Cerebrospinal Fluid Levels of Lateral Olfactory Tract Usher Substance (LOTUS) With Disease Activity in Multiple Sclerosis2015
- Author(s)
  Takahashi K, Kurihara Y, Suzuki Y, Goshima Y, Tanaka F, Takei K.
- Journal Title
  
  JAMA Neurol
  
  Volume: 72 Issue: 2 Pages: 176-179
- DOI
  10.1001/jamaneurol.2014.3613
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293207, KAKENHI-PROJECT-26670444, KAKENHI-PROJECT-26870480
[Journal Article] LOTUS suppresses axon growth inhibition by blocking interaction between Nogo receptor-1 and all four types of its ligand.2014
- Author(s)
  Kurihara Y, Iketani M, Ito H, Nishiyama K, Sakakibara Y, Goshima Y, Takei K.
- Journal Title
  
  Molecular and Cellular Neuroscience
  
  Volume: 10 Pages: 211-218
- DOI
  10.1016/j.mcn.2014.07.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25830015, KAKENHI-PROJECT-26870480
[Journal Article] Regulation of neurite outgrowth mediated by localized phosphorylation of protein translational factor eEF2 in growth cones2013
- Author(s)
  Iketani M., Iizuka A., Sengoku K., Kurihara Y., Nakamura F., Sasaki Y., Sato Y., Yamane M., Matsushita M., Nairn A.C., Takamatsu K., Goshima Y., Takei K.
- Journal Title
  
  Dev. Neurosci
  
  Volume: 73 Issue: 3 Pages: 230-246
- DOI
  10.1002/dneu.22058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500336, KAKENHI-PROJECT-23500452, KAKENHI-PROJECT-24890187, KAKENHI-PUBLICLY-24111539, KAKENHI-PUBLICLY-24115713
[Journal Article] LOTUSによる神経回路形成機構2013
- Author(s)
  栗原裕司,竹居光太郎
- Journal Title
  
  Annual Review神経2013
  
  Volume: 2013年発行巻 Pages: 63-67
- URL
  http://www.chugaiigaku.jp/item/detail.php?id=1180
- Data Source
  KAKENHI-PROJECT-24890187
[Journal Article] LOTUSによる神経回路形成機構2013
- Author(s)
  栗原裕司
- Journal Title
  
  Annual Review 神経 2013
  
  Volume: 2013年発行巻
- Data Source
  KAKENHI-PROJECT-24890187
[Presentation] LOTUS, a neural circuit formation factor, blocks PirB-mediated axon growth inhibition.2017
- Author(s)
  Kurihara Y, Takei K.
- Organizer
  The 26th Biennial Meeting of the International Society for Neurochemistry and the European Society for Neurochemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21268
[Presentation] 神経回路形成因子LOTUSは神経突起伸長を促進する.2017
- Author(s)
  栗原裕司, 川上裕, 竹居光太郎.
- Organizer
  第60回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-16K21268
[Presentation] 神経回路形成因子LOTUSの軸索再生阻害因子PirBに対する拮抗作用.2017
- Author(s)
  栗原裕司, 竹居光太郎.
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16K21268
[Presentation] LOTUSはPirBのアンタゴニストとして機能する.2016
- Author(s)
  栗原裕司, 竹居光太郎.
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-16K21268
[Presentation] LOTUSはNogoにより誘起されるPirBの軸索伸長阻害を抑制する.2016
- Author(s)
  栗原裕司, 竹居光太郎.
- Organizer
  第59回日本神経化学会大会
- Place of Presentation
  福岡国際会議場（福岡県）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-16K21268
[Presentation] LOTUSはコンドロイチン硫酸プロテオグリカンにより誘起される軸索伸長阻害を抑制する.2014
- Author(s)
  栗原裕司, 齋藤優, 竹居光太郎.
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-26870480
[Presentation] LOTUSの神経突起伸長作用2013
- Author(s)
  栗原裕司,伊藤拓夢,池谷真澄,五嶋良郎,竹居光太郎
- Organizer
  第36回日本神経科学大会&第56回日本神経化学会大会
- Place of Presentation
  京都
- Year and Date
  2013-06-21
- Data Source
  KAKENHI-PROJECT-24890187
[Presentation] LOTUS functions as a potent antagonist for Nogo receptor2012
- Author(s)
  Kurihara Y, Iketani M, Ito H, Nishiyama K, Sakakibara Y, Goshima Y, Takei K
- Organizer
  The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry & The 55th Annual Meeting of the Japanese Society for Neurochemistry Kobe
- Place of Presentation
  Kobe
- Year and Date
  2012-10-01
- Data Source
  KAKENHI-PROJECT-24890187
[Presentation] Nogo受容体に対するLOTUSの拮抗作用2012
- Author(s)
  栗原裕司,池谷真澄,伊藤拓夢,西山邦幸,榊原裕介,五嶋良郎,竹居光太郎
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-24890187
[Presentation] Nogo受容体に対するLOTUSの拮抗作用
- Author(s)
  栗原　裕司
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋国際会議場（愛知県）
- Data Source
  KAKENHI-PROJECT-24890187
[Presentation] LOTUS functions as a potent antagonist for Nogo receptor
- Author(s)
  栗原　裕司
- Organizer
  第11回アジア太平洋神経化学会大会・第55回日本神経化学会大会
- Place of Presentation
  神戸コンベンションセンター（兵庫県）
- Data Source
  KAKENHI-PROJECT-24890187
[Presentation] LOTUSの神経突起伸長作用
- Author(s)
  栗原裕司，伊藤拓夢，池谷真澄，五嶋良郎，竹居光太郎
- Organizer
  第36回日本神経科学大会・第56回日本神経化学会大会
- Place of Presentation
  国立京都国際会館（京都）
- Data Source
  KAKENHI-PROJECT-24890187

1. Tanaka Fumiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. Doi Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 佐々木幸生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 五嶋良郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 國井美紗子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 田中健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 池谷真澄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 竹居光太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kurihara Yuji 栗原 裕司

KURIHARA Yuji 栗原 裕司

Research Projects

Research Products

Co-Researchers

Analysis of the molecular mechanism underlying a promoting effect of LOTUS on neurite outgrowthPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of PirB, a receptor causing neurodegenerative diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of PirB, a functional receptor for axonal growth inhibitors, by LOTUSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of neurite outgrowth promoting effect of LOTUS, an antagonist for Nogo receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cerebrospinal fluid level of Nogo receptor 1 antagonist lateral olfactory tract usher substance (LOTUS) correlates inversely with the extent of neuroinflammation2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The soluble form of LOTUS inhibits Nogo receptor-mediated signaling by interfering with the interaction between Nogo receptor type 1 and p75 neurotrophin receptor.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of lateral olfactory tract development by Nogo-A, Nogo receptor-1 and LOTUS proteins.2017

Author(s)

Journal Title

Data Source

[Journal Article] LOTUS overexpression accelerates neuronal plasticity after focal brain ischemia in mice.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Blockade of chondroitin sulfate proteoglycans-induced axonal growth inhibition by LOTUS2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of axonal regeneration by the level of function of endogenous Nogo receptor antagonist LOTUS2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Axonal branching in lateral olfactory tract is promoted by Nogo signaling2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LOTUS, a potent blocker of Nogo receptor-1 causing inhibition of axonal growth.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of Cerebrospinal Fluid Levels of Lateral Olfactory Tract Usher Substance (LOTUS) With Disease Activity in Multiple Sclerosis2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LOTUS suppresses axon growth inhibition by blocking interaction between Nogo receptor-1 and all four types of its ligand.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of neurite outgrowth mediated by localized phosphorylation of protein translational factor eEF2 in growth cones2013

Author(s)

Kurihara Yuji 栗原裕司

KURIHARA Yuji 栗原裕司