Koga Motokazu 古賀資和

… Alternative Names

KOGA Motokazu 古賀資和

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Researcher Number	00637233
Other IDs
Affiliation (Current)	2025: 横浜市立大学, 医学研究科, 客員研究員
Affiliation (based on the past Project Information) *help	2023: 横浜市立大学, 医学部, 助教 2021 – 2023: 横浜市立大学, 医学研究科, 客員研究員 2020: 横浜市立大学, 医学部, 客員研究員 2019 – 2020: 横浜市立大学, 医学部, 助教 2018: 横浜市立大学, 附属病院, 助教 2015 – 2017: 横浜市立大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 55050:Anesthesiology-related / General pharmacology Except Principal Investigator Anesthesiology / Basic Section 55050:Anesthesiology-related / Basic Section 48030:Pharmacology-related / General pharmacology
Keywords	Principal Investigator 肺高血圧 / モノクロタリン / GPR143 / L-DOPA / 肺高血圧症 / GPR１４３ / 肺血管 / アドレナリン受容体 / セロトニン / フェニレフリン / DOPA … More Except Principal Investigator … More 肺高血圧 / 血管平滑筋 / ROCK / protein kinase D / 血管収縮 / 平滑筋 / 肺高血圧症 / ドーパ / 核酸医薬 / protein kinase d / PKC / protain kinase D / 超音波ドプラー測定 / Windlessel 3要素model / インピーダンス測定 / 肺動脈コンプライアンス / Windkessel model / windkessel / モノクロタリン / 肺高血圧クライシス / Windkessel / 肺血管抵抗 / インピーダンス / 腎不全 / 腎結石 / GPR143 / 心不全 / 間質系幹細胞 / drug delivery / microRNA / 臍帯血由来間葉系幹細胞 / miRNA / exosome / 間葉系幹細胞 / アクチン / カルシウム / actin / MYPT1 / Protein kinase D / 一酸化窒素合成酵素 / 内皮由来一酸化窒素合成酵素 / 内皮細胞 / 一酸化窒素 / arginine / eNOS / arginase / 眼白子症原因遺伝子 / Gタンパク質連関型受容体 / α1アドレナリン受容体 / 日内変動 / 血圧 / 生理活性物質 Less

Protein kinase Dの肺高血圧症への関与解明と核酸医薬による制御
- Principal Investigator
  
  水野祐介
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Yokohama City University
重症肺高血圧モデルラットを用いた肺動脈コンプライアンスの検討および治療戦略の確立
- Principal Investigator
  
  菅原陽
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Yokohama City University
Cardio modulative function of L-DOPA receptors in prioperative pathophysiologyPrincipal Investigator
- Principal Investigator
  
  KOGA Motokazu
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Yokohama City University
Dopa as a neurotransmitter in heart failure and acute kidney injury
- Principal Investigator
  
  Hashimoto Tatsuo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kanagawa Dental College
  Yokohama City University
Role of protein kinase D in vasoconstriction
- Principal Investigator
  
  MIZUNO Yusuke
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Yokohama City University
Exosome of mesenchymal stem cells for the treatment of pulmonary hypertension with microRNA.
- Principal Investigator
  
  WATANABE Itaru
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Yokohama City University
Inhibitory effect of arginase on pulmonary hypertension
- Principal Investigator
  
  Shinbori Nobuhiro
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Yokohama City University
Functional Analysis of GPR143 in Pulmonary HypertensionPrincipal Investigator
- Principal Investigator
  
  KOGA Motokazu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Yokohama City University
Functional analysis of DOPAergic transmission in cardiovascular system
- Principal Investigator
  
  GOSHIMA Yoshio
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Yokohama City University

All 2022 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Right ventricular overloading is attenuated in monocrotaline-induced pulmonary hypertension model rats with a disrupted Gpr143 gene, the gene that encodes the 3,4-l-dihydroxyphenyalanine (l-DOPA) receptor.2022
- Author(s)
  Nakano M, Koga M, Hashimoto T, Matsushita N, Masukawa D, Mizuno Y, Uchimura H, Niikura R, Miyazaki T, Nakamura F, Zou S, Shimizu T, Saito M, Tamura K, Goto T, Goshima Y.
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 148 Issue: 2 Pages: 214-220
- DOI
  10.1016/j.jphs.2021.11.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02735, KAKENHI-PROJECT-21H02673, KAKENHI-PROJECT-20K07069, KAKENHI-PROJECT-20K21606, KAKENHI-PROJECT-18K16488, KAKENHI-PROJECT-22H04922
[Journal Article] L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor2017
- Author(s)
  Masukawa Daiki、Koga Motokazu、Sezaki Anna、Nakao Yuka、Kamikubo Yuji、Hashimoto Tatsuo、Okuyama-Oki Yuki、Aladeokin Aderemi Caleb、Nakamura Fumio、Yokoyama Utako、Wakui Hiromichi、Ichinose Hiroshi、Sakurai Takashi、Umemura Satoshi、Tamura Koichi、Ishikawa Yoshihiro、Goshima Yoshio
- Journal Title
  
  JCI Insight
  
  Volume: 2 Issue: 18 Pages: 1-16
- DOI
  10.1172/jci.insight.90903
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07062, KAKENHI-PROJECT-17K09040, KAKENHI-PROJECT-17K09313, KAKENHI-PROJECT-17K19403, KAKENHI-PROJECT-15H04687, KAKENHI-PROJECT-16H05358, KAKENHI-PROJECT-15K21273, KAKENHI-PROJECT-15H05761, KAKENHI-PUBLICLY-17H05555, KAKENHI-PROJECT-16H05300
[Journal Article] l-3,4-Dihydroxyphenylalanine induces ptosis through a GPR143-independent mechanism in mice.2016
- Author(s)
  Ueda S, Masukawa D, Koga M, Goshima Y
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 132 Issue: 1 Pages: 109-112
- DOI
  10.1016/j.jphs.2016.08.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] 肺高血圧症におけるドーパ性神経伝達機構の解析2020
- Author(s)
  中野雅友樹、橋本達夫、古賀資和、増川太輝、奥真哉、水野祐介、後藤隆久、田村功一、五嶋良郎
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06896
[Presentation] GPR143, an L-DOPA receptor, may help control inflammation in adenine-induced chronic kidney disease2019
- Author(s)
  Tatsuo Hashimoto, Masayuki Nakano, Shota Suzuki, Takayuki Yamada, Daiki Masukawa, Motokazu Koga, Ryuichi Ito, Kotaro Haruhara, Hiromichi Wakui, Koichi Tamura, Yoshio Goshima
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06896
[Presentation] L-DOPA CHE, an L-DOPA antagonist, protects neurostimulated contractile response in mice heart2018
- Author(s)
  Tatsuo Hashimoto, Shogo Hamaguchi, Daiki Masukawa, Motokazu Koga, Nakano Masayuki, Hikaru Tanaka, Koichi Tamura, Yoshio Goshima
- Organizer
  第18回国際薬理学・臨床薬理学会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06896
[Presentation] ドーパ受容体GPR143とアドレナリンα1受容体との機能的連関と複合体形成.2017
- Author(s)
  増川太輝, 古賀資和, 涌井広道, 上窪裕二, 横山詩子, 中村史雄, 櫻井隆, 田村功一, 石川義弘, 五嶋良郎
- Organizer
  第136回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] GPR143遺伝子欠損マウスにおけるメチルフェニデート, コカイン及びニコチンの行動に及ぼす効果.2017
- Author(s)
  金井香央里, 増川太輝, 古賀資和, 北村慧, 角田貴大, 五嶋良郎
- Organizer
  第137回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] L-DOPAの肺高血圧モデル肺血管におけるフェニレフリン応答の修飾作用2017
- Author(s)
  古賀資和, 増川太輝, 中村史雄, 菅原陽, 水野祐介, 後藤隆久, 五嶋良郎
- Organizer
  第136回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] GPR143 is involved in dopamine D2 receptor-mediated transmission in mice2017
- Author(s)
  Kitamura S, Masukawa D, Koga M, Nakamura F, Goshima Y
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] L-DOPAの肺高血圧モデル肺血管におけるフェニレフリン応答の修飾作用2017
- Author(s)
  古賀資和、増川太輝、中村史雄、菅原陽、水野祐介、後藤隆久、五嶋良郎
- Organizer
  第136回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-15K21271
[Presentation] L- DOPA sensitizes nervous system by modulating the vascular α1-adrenergic receptor.2017
- Author(s)
  Masukawa D, Koga M, Wakui H, Kamikubo Y, Yokoyama U, Nakamura F, Tamura K, Umemura S, Sakurai T, Ishikawa Y, Goshima Y
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] Immunoreactive signals of GPR 143 in ventral tegmental areas and its trajectory.2017
- Author(s)
  Koga M, Masukawa D, Nakamura F, Goshima Y
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] L-DOPA受容体候補分子GPR143のマウス腹側被蓋野及びその投射野における分布.2017
- Author(s)
  瀧澤光太郎, 古賀資和, 増川太輝, 中村史雄, 五嶋良郎
- Organizer
  第137回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] Screening for L-DOPA ligands by monitoring central cardiovascular regulation in the nucleus tractus solitarii.2017
- Author(s)
  Nakao Y, Masukawa D, Koga M, Goshima Y
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] DOPA-GPR143 signal augments α1-adrenergic receptor response2017
- Author(s)
  Masukawa D, Nakamura F, Yokoyama U, Koga M, Ishikawa Y, Goshima Y
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] 中枢神経系における抗ドーパ抗体を用いた免疫組織化学的検討.2016
- Author(s)
  増川太輝、ジョンソン実歌、古賀資和、中村史雄、五嶋良郎
- Organizer
  第135回日本薬理学会関東部会
- Place of Presentation
  アクトシティ浜松（静岡県浜松市）
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] ドーパ受容体GPR143はアドレナリンα1受容体応答を増強する.2016
- Author(s)
  増川太輝、古賀資和、横山詩子、上窪裕二、中村史雄、櫻井隆、石川義弘、五嶋良郎
- Organizer
  第135回日本薬理学会関東部会
- Place of Presentation
  アクトシティ浜松（静岡県浜松市）
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] Functional coupling between GPR143, a DOPA receptor, and alpha1-adrenergic receptor regulates peripheral sympathetic nerve transmission.2016
- Author(s)
  Daiki Masukawa, Anna Sezaki, Fumio Nakamura, Motokazu Koga, Yoshio Goshima
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] General behavioral test in the gpr143-/y mice.2016
- Author(s)
  Hiromi Okatsu, Junka Koyama, Haruko Nakamura, Daiki Masukawa, Motokazu Koga, Fumio Nakamura, Tohru Kimura, Yoshio Goshima
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] The effect of dopamine receptors agonists in gpr143-/y mice.2016
- Author(s)
  Satoshi Kitamura, Daiki Masukawa, Motokazu Koga, Fumio Nakamura, Yoshio Goshima
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] Distribution of GPR143-immunoreactive cells in the mouse ventral tegmental area.2016
- Author(s)
  Motokazu Koga, Daiki Masukawa, Fumio Nakamura, Yoshio Goshima
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] DOPA-GPR143 signal augments pressor response mediated by a1-adrenergic receptor.2016
- Author(s)
  Daiki Masukawa, Fumio Nakamura, Utako Yokoyama, Motokazu Koga, Yoshihiro Ishikawa, Yoshio Goshima
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] L-DOPAによって誘発される行動薬理学的変化の解析2015
- Author(s)
  上田傑、増川太輝、古賀資和、中村史雄、五嶋良郎
- Organizer
  第132回日本薬理学会関東部会
- Place of Presentation
  明海大学浦安キャンパス（千葉県浦安市）
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-15H04687
[Presentation] GPR143遺伝子欠損マウスにおけるドパミン受容体作動薬の効果2015
- Author(s)
  北村慧、増川太輝、古賀資和、中村史雄、五嶋良郎
- Organizer
  第133回日本薬理学会関東部会
- Place of Presentation
  柏の葉カンファレンスセンター（千葉県柏市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-15H04687

1. MIZUNO Yusuke (80433192)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. WATANABE Itaru (20534142)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 増川太輝 (10711898)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
4. 川上裕理 (90407958)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 菅原陽 (00596413)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. GOSHIMA Yoshio (00153750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
7. FUKAZAWA Yugo (60343745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ICHINOSE Hiroshi (90192492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Shinbori Nobuhiro (60404993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Hashimoto Tatsuo (20363806)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 中村史雄 (10262023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
12. 及川雅人 (70273571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 田村功一 (40285143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Koga Motokazu 古賀 資和

KOGA Motokazu 古賀 資和

Research Projects

Research Products

Co-Researchers

Protein kinase Dの肺高血圧症への関与解明と核酸医薬による制御

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

重症肺高血圧モデルラットを用いた肺動脈コンプライアンスの検討および治療戦略の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cardio modulative function of L-DOPA receptors in prioperative pathophysiologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Dopa as a neurotransmitter in heart failure and acute kidney injury

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of protein kinase D in vasoconstriction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exosome of mesenchymal stem cells for the treatment of pulmonary hypertension with microRNA.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inhibitory effect of arginase on pulmonary hypertension

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional Analysis of GPR143 in Pulmonary HypertensionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of DOPAergic transmission in cardiovascular system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Right ventricular overloading is attenuated in monocrotaline-induced pulmonary hypertension model rats with a disrupted Gpr143 gene, the gene that encodes the 3,4-l-dihydroxyphenyalanine (l-DOPA) receptor.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] l-3,4-Dihydroxyphenylalanine induces ptosis through a GPR143-independent mechanism in mice.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] 肺高血圧症におけるドーパ性神経伝達機構の解析2020

Author(s)

Organizer

Data Source

[Presentation] GPR143, an L-DOPA receptor, may help control inflammation in adenine-induced chronic kidney disease2019

Author(s)

Koga Motokazu 古賀資和

KOGA Motokazu 古賀資和