HIROSUE AKIYUKI 廣末晃之

… Alternative Names

HIROSUE Akiyuki 廣末晃之

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Researcher Number	00638182
Other IDs
Affiliation (Current)	2025: 熊本大学, 病院, 講師
Affiliation (based on the past Project Information) *help	2025: 熊本大学, 病院, 講師 2022 – 2023: 熊本大学, 大学院生命科学研究部(医), 特定研究員 2019 – 2021: 熊本大学, 病院, 助教 2014 – 2018: 熊本大学, 医学部附属病院, 助教 2012 – 2013: 熊本大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Surgical dentistry
Keywords	Principal Investigator エピゲノム / 口腔癌 / 治療抵抗性 / ヒストン修飾 / DNAメチル化 / 高次エピゲノム / 放射線耐性 / マイクロバイオーム / 短鎖脂肪酸 / 代謝 … More / 酪酸 / 口腔細菌叢 / 難治性口腔癌 / スーパーエンハンサー / BRD4 / 高転移 / 高悪性 / エピゲノム治療 / エピジェネティクス治療薬 / 抗癌剤耐性 / INK4/ARF 遺伝子座 / クロマチン高次構造 / エピジェネティクス / 薬剤耐性 / 口腔扁平上皮癌 / INK4/ARF遺伝子座 Less

口腔癌の治療抵抗性における口腔細菌と細胞老化の役割の解明と制御法の創出Principal Investigator
- Principal Investigator
  
  廣末晃之
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kumamoto University
Elucidation of the mechanism of treatment resistance in oral cancer via crosstalk between metabolism and epigenome by oral microbiome.Principal Investigator
- Principal Investigator
  
  Hirosue Akiyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kumamoto University
Development of novel therapeutic strategies for refractory oral cancer targeting higher-order epigenomic regulationPrincipal Investigator
- Principal Investigator
  
  Hirosue Akiyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kumamoto University
Creation of novel diagnostic methods and epigenome therapy based on higher-order epigenome analysis in treatment-resistant oral cancerPrincipal Investigator
- Principal Investigator
  
  Hirosue Akiyuki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kumamoto University
Analysis of epigenomic alterations in chemoresistance and radioresistance of oral squamous cell carcinoma to provide the personalized medicine.Principal Investigator
- Principal Investigator
  
  Hirosue Akiyuki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kumamoto University
Higher-order epigenetic analysis of the INK4/ARF locus in oral cancer and development of novel diagnostic methodsPrincipal Investigator
- Principal Investigator
  
  HIROSUE Akiyuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Surgical dentistry
- Research Institution
  Kumamoto University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Involvement of ferroptosis-defensive xCT/GPX4 axis in radioresistance and its impacts on prognosis in oral squamous cell carcinoma2024
- Author(s)
  Ishikawa K, Matsuoka Y, Shinohara K, Inoue J, Yano H, Eto T, Yamamoto T, Yamana K, Gohara S, Takeshita H, Hirayama M, Kawahara K, Hirosue A, Fukugawa F, Yoshida R, Komohara Y, Nakayama H
- Journal Title
  
  Oral Science International
  
  Volume: - Issue: 3 Pages: 359-372
- DOI
  10.1002/osi2.1227
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-19K23736
[Journal Article] Programmed death-ligand 1-expressing extracellular vesicles are a prognostic factor in patients with oral squamous cell carcinoma treated with immune checkpoint inhibitors2023
- Author(s)
  Seki Yuki、Yamana Keisuke、Yoshida Ryoji、Inoue Junki、Shinohara Kosuke、Oyama Toru、Kubo Ryuta、Nagata Masashi、Kawahara Kenta、Hirayama Masatoshi、Takahashi Nozomu、Nakamoto Masafumi、Hirosue Akiyuki、Kariya Ryusho、Okada Seiji、Nakayama Hideki
- Journal Title
  
  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
  
  Volume: in press Issue: 4 Pages: 518-525
- DOI
  10.1016/j.ajoms.2023.12.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K09400, KAKENHI-PROJECT-21K10048, KAKENHI-PROJECT-21K10099, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-21K10142
[Journal Article] FOXM1-Mediated Regulation of Reactive Oxygen Species and Radioresistance in Oral Squamous Cell Carcinoma Cells2023
- Author(s)
  Takeshita Hisashi、Yoshida Ryoji、Inoue Junki、Ishikawa Kohei、Shinohara K、Hirayama M、Oyama T、Kubo R、Yamana K、Nagao Y、Gohara S、Sakata J、Nakashima H、Matsuoka Y、Nakamoto M、Hirayama M、Kawahara K、Takahashi N、Hirosue A、Kuwahara Y、Fukumoto M、Toya R、Murakami R、Nakayama H
- Journal Title
  
  Laboratory Investigation
  
  Volume: 103 Issue: 5 Pages: 100060-100060
- DOI
  10.1016/j.labinv.2022.100060
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K12173, KAKENHI-PROJECT-21K10048, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-22K12379, KAKENHI-PROJECT-21K17145, KAKENHI-PROJECT-23K09400, KAKENHI-PROJECT-21K10099
[Journal Article] Factors Affecting Human Damage in Heavy Rains and Typhoon Disasters2022
- Author(s)
  Naito Hisaki、Sueta Daisuke、Hanatani Satoko、Ikeda Hatsuo、Hirosue Akiyuki、Senokuchi Takafumi、Araki Eiichi、Tsujita Kenichi、Nakayama Hideki、Kasaoka Shunji
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 256 Issue: 2 Pages: 175-185
- DOI
  10.1620/tjem.256.175
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08533, KAKENHI-PROJECT-21K10118
[Journal Article] The antioxidative stress regulator Nrf2 potentiates radioresistance of oral squamous cell carcinoma accompanied with metabolic modulation2022
- Author(s)
  Matsuoka Yuichiro、Yoshida Ryoji、Kawahara Kenta、Sakata Junki、Arita Hidetaka、Nkashima Hikaru、Takahashi Nozomu、Hirayama Masatoshi、Nagata Masashi、Hirosue Akiyuki、Kuwahara Yoshikazu、Fukumoto Manabu、Toya Ryo、Murakami Ryuji、Nakayama Hideki
- Journal Title
  
  Laboratory Investigation
  
  Volume: 102 Issue: 8 Pages: 896-907
- DOI
  10.1038/s41374-022-00776-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12173, KAKENHI-PROJECT-21K10048, KAKENHI-PROJECT-21K10099, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-21K17145
[Journal Article] Three-dimensional volumetric analysis of the efficiency of marsupialization in patients with mandibular dentigerous cysts involving impacted third molars2022
- Author(s)
  Masatoshi Hirayama,Kazushige Inoue,Hidetaka Arita,Nozomu Takahashi,Hikaru Nakashima,Junki Sakata,Manabu Maeshiro,Yuka Nagao,Shunsuke Gohara,Keisuke Yamana,Yuichiro Matsuoka,Akira Yuno,Masafumi Nakamoto,Kenta Kawahara,Masashi Nagata,Akiyuki Hirosue,Daiki Fukuma,Ryoji Yoshida,Hideki Nakayama
- Journal Title
  
  JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
  
  Volume: 34 Issue: 6 Pages: 690-697
- DOI
  10.1016/j.ajoms.2022.03.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K10099, KAKENHI-PROJECT-21K10118
[Journal Article] Naringenin potentiates anti-tumor immunity against oral cancer by inducing lymph node CD169-positive macrophage activation and cytotoxic T cell infiltration2022
- Author(s)
  Kawaguchi S、Kawahara a、Fujiwara Y、Ohnishi K、Pan C、Yano H、Hirosue A、Nagata M、Hirayama M、Sakata J、Nakashima H、Arita H、Yamana K、Gohara S、Nagao Y、Maeshiro M、Iwamoto A、Hirayama M、Yoshida R、Komohara Y、Nakayama H
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: - Issue: 9 Pages: 2127-2139
- DOI
  10.1007/s00262-022-03149-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07370, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-20K18699
[Journal Article] Laterality on FDG-PET/CT in clinically node-negative early-stage oral squamous cell carcinoma: a retrospective analysis of patients with late neck metastasis2022
- Author(s)
  Minamitake A, Murakami R, Shiraishi S, Yoshida R, Sakata J, Hirosue A, Kawahara K, Yamana K, Nakayama H, Kitajima M, Sakamoto F.
- Journal Title
  
  Oral Radiology
  
  Volume: 38 Issue: 3 Pages: 438-442
- DOI
  10.1007/s11282-021-00581-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K10118
[Journal Article] An oncolytic virus as a promising candidate for the treatment of radioresistant oral squamous cell carcinoma.2022
- Author(s)
  Gohara S, Shinohara K, Yoshida R, Kariya R, Tazawa H, Hashimoto M, Inoue J, Kubo R, Nakashima H, Arita H, Kawaguchi S, Yamana K, Nagao Y, Iwamoto A, Sakata J, Matsuoka Y, Takeshita H, Hirayama M, Kawahara K, Nagata M, Hirosue A, Kuwahara Y, Fukumoto M, Okada S, Urata Y, Fujiwara T, and Nakayama H.
- Journal Title
  
  Molecular Therapy Oncolytics
  
  Volume: 27 Pages: 141-156
- DOI
  10.1016/j.omto.2022.10.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K10048, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-22K12379, KAKENHI-PROJECT-21K17145, KAKENHI-PROJECT-22K21067
[Journal Article] Can MRI-derived depth of invasion predict nodal recurrence in oral tongue cancer?2021
- Author(s)
  Minamitake Anri、Murakami Ryuji、Sakamoto Fumi、Yoshida Ryoji、Sakata Junki、Hirosue Akiyuki、Kawahara Kenta、Yamana Keisuke、Nakayama Hideki、Toya Ryo、Shiraishi Shinya
- Journal Title
  
  Oral Radiology
  
  Volume: - Issue: 4 Pages: 641-646
- DOI
  10.1007/s11282-020-00505-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-18K07757, KAKENHI-PROJECT-21K10118
[Journal Article] miR-30a attenuates drug sensitivity to 5-FU by modulating cell proliferation possibly by downregulating cyclin E2 in oral squamous cell carcinoma.2021
- Author(s)
  Kenta Kawahara, Masashi Nagata, Ryoji Yoshida, Akiyuki Hirosue, Takuya Tanaka, Yuichiro Matsuoka, Hidetaka Arita, Hikaru Nakashima, Junki Sakata, Keisuke Yamana, Sho Kawaguchi, Shunsuke Gohara, Yuka Nagao, Masatoshi Hirayama, Nozomu Takahashi, Mayumi Hirayama, Hideki Nakayama
- Journal Title
  
  Biochemistry Biophysics Reports
  
  Volume: 21 Pages: 28-28
- DOI
  10.1016/j.bbrep.2021.101114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10099, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-20K18699, KAKENHI-PROJECT-21K17145
[Journal Article] Re-evaluating the clinical significance of serum p53 antibody levels in patients with oral cancer in Japanese clinical practice.2021
- Author(s)
  Shunsuke Gohara, Ryoji Yoshida, Kenta Kawahara, Junki Sakata, Hidetaka Arita, Hikaru Nakashima, Sho Kawaguchi, Yuka Nagao, Keisuke Yamana, Masashi Nagata, Akiyuki Hirosue, Akimitsu Hiraki, Hideki Nakayama
- Journal Title
  
  Molecular and clinical oncology
  
  Volume: 15 Issue: 4 Pages: 209-209
- DOI
  10.3892/mco.2021.2372
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10118
[Journal Article] Extracellular vesicles derived from radioresistant oral squamous cell carcinoma cells contribute to the acquisition of radioresistance via the miR‐503‐3p‐BAK axis2021
- Author(s)
  K Yamana,J Inoue,R Yoshida,J Sakata,H Nakashima,H Arita,S Kawaguchi,S Gohara,Y Nagao,H Takeshita,M Maeshiro,R Liu,Y Matsuoka,M Hirayama,K Kawahara,M Nagata,A Hirosue,R Toya,R Murakami,Y Kuwahara,M Fukumoto,H Nakayama
- Journal Title
  
  Journal of Extracellular Vesicles
  
  Volume: 10 Issue: 14
- DOI
  10.1002/jev2.12169
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12326, KAKENHI-PROJECT-20K12173, KAKENHI-PROJECT-21K10048, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-21K17145, KAKENHI-PROJECT-21K21019
[Journal Article] Compositional Shift of Oral Microbiota Following Surgical Resection of Tongue Cancer2020
- Author(s)
  Kageyama Shinya、Nagao Yuka、Ma Jiale、Asakawa Mikari、Yoshida Ryoji、Takeshita Toru、Hirosue Akiyuki、Yamashita Yoshihisa、Nakayama Hideki
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 10 Pages: 60084-60084
- DOI
  10.3389/fcimb.2020.600884
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18808, KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-18K09727, KAKENHI-PROJECT-19K22722, KAKENHI-PROJECT-19H03863
[Journal Article] FOXP3 lymphocyte status may predict the risk of malignant transformation in oral leukoplakia2020
- Author(s)
  Sakata Junki、Yoshida Ryoji、Matsuoka Yuichiro、Kawahara Kenta、Arita Hidetaka、Nakashima Hikaru、Hirosue Akiyuki、Naito Hisaki、Takeshita Hisashi、Kawaguchi Sho、Gohara Shunsuke、Nagao Yuka、Yamana Keisuke、Hiraki Akimitsu、Shinohara Masanori、Ito Takaaki、Nakayama Hideki
- Journal Title
  
  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
  
  Volume: 32 Issue: 1 Pages: 33-39
- DOI
  10.1016/j.ajoms.2019.06.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21413, KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-18K09727
[Journal Article] BRD4 promotes metastatic potential in oral squamous cell carcinoma through the epigenetic regulation of the MMP2 gene2020
- Author(s)
  Yamamoto Tatsuro、Hirosue Akiyuki、Nakamoto Masafumi、Yoshida Ryoji、Sakata Junki、Matsuoka Yuichiro、Kawahara Kenta、Nagao Yuka、Nagata Masashi、Takahashi Nozomu、Hiraki Akimitsu、Shinohara Masanori、Nakao Mitsuyoshi、Saitoh Noriko、Nakayama Hideki
- Journal Title
  
  British Journal of Cancer
  
  Volume: 123 Issue: 4 Pages: 580-590
- DOI
  10.1038/s41416-020-0907-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18700, KAKENHI-PROJECT-20KK0185, KAKENHI-PROJECT-18H02618, KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-20H03520, KAKENHI-PROJECT-18K09727, KAKENHI-PROJECT-18K19310, KAKENHI-PROJECT-19K19237, KAKENHI-PLANNED-18H05531
[Journal Article] Efficacy of adjuvant chemotherapy with S-1 in stage II oral squamous cell carcinoma patients: A comparative study using the propensity score matching method2020
- Author(s)
  Ryoji Yoshida, Masashi Nagata, Akiyuki Hirosue, Kenta Kawahara, Masafumi Nakamoto, Masatoshi Hirayama, Nozomu Takahashi, Yuichiro Matsuoka, Junki Sakata, Hikaru Nakashima, Hidetaka Arita, Akimitsu Hiraki, Masanori Shinohara, Ken Kikuchi, Hideki Nakayama
- Journal Title
  
  PLoS One
  
  Volume: 15 Issue: 4 Pages: e0231656-e0231656
- DOI
  10.1371/journal.pone.0231656
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18730, KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-18K09727, KAKENHI-PROJECT-19K19237
[Journal Article] Enhanced Expression of IGFBP-3 Reduces Radiosensitivity and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma2020
- Author(s)
  Sakata J, Hirosue A, Yoshida R, Matsuoka Y, Kawahara K, Arita H, Nakashima H, Yamamoto T, Nagata M, Kawaguchi S, Gohara S, Nagao Y, Yamana K, Toya R, Murakami R, Kuwahara Y, Fukumoto M, Nakayama H
- Journal Title
  
  Cancers (Basel)
  
  Volume: 12(2) Issue: 2 Pages: 494-494
- DOI
  10.3390/cancers12020494
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07757, KAKENHI-PROJECT-18K09727, KAKENHI-PROJECT-19K12326, KAKENHI-PROJECT-19K21413, KAKENHI-PROJECT-19K23736, KAKENHI-PROJECT-20K18700, KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-19K19237
[Journal Article] Hypofractionated palliative volumetric modulated arc radiotherapy with the Radiation Oncology Study Group 8502 “QUAD shot” regimen for incurable head and neck cancer2020
- Author(s)
  Toya Ryo、Saito Tetsuo、Yamaguchi Kohsei、Matsuyama Tomohiko、Watakabe Takahiro、Matsumoto Tadashi、Yoshida Ryoji、Hirosue Akiyuki、Murakami Daizo、Orita Yorihisa、Nakayama Hideki、Oya Natsuo
- Journal Title
  
  Radiation Oncology
  
  Volume: 15 Issue: 1 Pages: 123-123
- DOI
  10.1186/s13014-020-01548-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-18K09727
[Journal Article] Onodera's prognostic nutritional index correlates with tumor immune environment and survival in patients with oral squamous cell carcinoma undergoing chemoradiotherapy2020
- Author(s)
  Yoshida Ryoji、Gohara Shunsuke、Sakata Junki、Matsuoka Yuichiro、Hirosue Akiyuki、Kawahara Kenta、Kawaguchi Sho、Nagao Yuka、Yamana Keisuke、Nagata Masashi、Fukuma Daiki、Toya Ryo、Murakami Ryuji、Hiraki Akimitsu、Shinohara Masanori、Nakayama Hideki
- Journal Title
  
  Translational Oncology
  
  Volume: 13 Issue: 12 Pages: 100850-100850
- DOI
  10.1016/j.tranon.2020.100850
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18700, KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-18K09727, KAKENHI-PROJECT-19K19237
[Journal Article] Role of serum amylase and salivary cytokines in oral complications during chemoradiotherapy2020
- Author(s)
  Kawahara Kenta、Hiraki Akimitsu、Arita Hidetaka、Takeshita Hisashi、Hirosue Akiyuki、Matsuoka Yuichiro、Sakata Junki、Obayashi Yuko、Nakashima Hikaru、Hirayama Mayumi、Nagata Masashi、Yoshida Ryoji、Shinohara Masanori、Nakayama Hideki
- Journal Title
  
  Oral Diseases
  
  Volume: Online ahead of print Issue: 6 Pages: 1564-1571
- DOI
  10.1111/odi.13686
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10129, KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-19K19237, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-21K17145
[Journal Article] Reliability of MRI-Derived Depth of Invasion of Oral Tongue Cancer2019
- Author(s)
  Murakami Ryuji、Shiraishi Shinya、Yoshida Ryoji、Sakata Junki、Yamana Keisuke、Hirosue Akiyuki、Uchiyama Yoshikazu、Nakayama Hideki、Yamashita Yasuyuki
- Journal Title
  
  Academic Radiology
  
  Volume: 印刷中 Issue: 7 Pages: 30423-9
- DOI
  10.1016/j.acra.2018.08.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07757, KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-18K09727, KAKENHI-PROJECT-19K21413
[Journal Article] Circulating miRNA-1290 as a potential biomarker for response to chemoradiotherapy and prognosis of patients with advanced oral squamous cell carcinoma: A single-center retrospective study2019
- Author(s)
  Nakashima H, Yoshida R, Hirosue A, Kawahara K, Sakata J, Arita H, Yamamoto T, Toya R, Murakami R, Hiraki A, Shinohara M, Ito T, Kuwahara Y, Nakayama H
- Journal Title
  
  Tumour Biol
  
  Volume: 41(3) Issue: 3 Pages: 1-10
- DOI
  10.1177/1010428319826853
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07757, KAKENHI-PROJECT-18K09727, KAKENHI-PROJECT-18K09771, KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-17H06974, KAKENHI-PROJECT-19K21413
[Journal Article] HMGA2 Contributes to Distant Metastasis and Poor Prognosis by Promoting Angiogenesis in Oral Squamous Cell Carcinoma.2019
- Author(s)
  Sakata J,Hirosue A,Yoshida R,Kawahara K,Matsuoka Y,Yamamoto T,Nakamoto M,Hirayama M,Takahashi N,Nakamura T,Arita H,Nakashima H,Nagata M,Hiraki A,Shinohara M,Nakayama H
- Journal Title
  
  International journal of molecular sciences
  
  Volume: 20 Issue: 10 Pages: 2473-2473
- DOI
  10.3390/ijms20102473
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09727, KAKENHI-PROJECT-19K19204, KAKENHI-PROJECT-19K19237, KAKENHI-PROJECT-18K17202, KAKENHI-PROJECT-19K21413
[Journal Article] Tumor budding as a novel predictor of occult metastasis in cT2N0 tongue squamous cell carcinoma2018
- Author(s)
  Sakata Junki、Yamana Keisuke、Yoshida Ryoji、Matsuoka Yuichiro、Kawahara Kenta、Arita Hidetaka、Nakashima Hikaru、Nagata Masashi、Hirosue Akiyuki、Kawaguchi Sho、Gohara Shunsuke、Nagao Yuka、Hiraki Akimitsu、Shinohara Masanori、Toya Ryo、Murakami Ryuji、Nakayama Hideki
- Journal Title
  
  Human Pathology
  
  Volume: 76 Pages: 1-8
- DOI
  10.1016/j.humpath.2017.12.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11296, KAKENHI-PROJECT-16K20595, KAKENHI-PROJECT-18K07757, KAKENHI-PROJECT-18K09727, KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-17H06974
[Journal Article] Severe interstitial pneumonia associated with anti-PD-1 immune checkpoint antibody after talc slurry pleurodesis2018
- Author(s)
  Sakata Shinya、Matsuoka Yuichiro、Kawahara Kenta、Kakiuchi Yosuke、Takaki Akira、Hirosue Akiyuki、Yoshida Ryoji、Saeki Sho、Fujii Kazuhiko、Nakayama Hideki
- Journal Title
  
  Respiratory Investigation
  
  Volume: 56 Issue: 2 Pages: 195-198
- DOI
  10.1016/j.resinv.2017.11.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11296, KAKENHI-PROJECT-16K20595, KAKENHI-PROJECT-18K09727, KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-17H06974
[Journal Article] FBXW7 expression affects the response to chemoradiotherapy and overall survival among patients with oral squamous cell carcinoma: A single-center retrospective study.2017
- Author(s)
  Hidetaka Arita, Masashi Nagata, Ryoji Yoshida, Yuichiro Matsuoka1, Akiyuki Hirosue, Kenta Kawahara, Junki Sakata, Hikaru Nakashima, Taku Kojima, Ryo Toya, Ryuji Murakami, Akimitsu Hiraki, Masanori Shinohara and Hideki Nakayama.
- Journal Title
  
  Tumour Biology
  
  Volume: 39 Issue: 10 Pages: 1-9
- DOI
  10.1177/1010428317731771
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06974, KAKENHI-PROJECT-15K11296, KAKENHI-PROJECT-16K20592, KAKENHI-PROJECT-16K20595
[Journal Article] Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia.2017
- Author(s)
  Sakata J, Yoshida R, Matsuoka Y, Nagata M, Hirosue A, Kawahara K, Nakamura T, Nakamoto M, Hirayama M, Takahashi N, Nakashima H, Arita H, Ogi H, Hiraki A, Shinohara M, Nakayama H
- Journal Title
  
  Cancer medicine
  
  Volume: 6 Issue: 4 Pages: 730-738
- DOI
  10.1002/cam4.1005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K20592, KAKENHI-PROJECT-16K20595, KAKENHI-PROJECT-16H07082, KAKENHI-PROJECT-17H06974, KAKENHI-PROJECT-15K11296
[Journal Article] Salivary duct carcinoma treated with cetuximab-based targeted therapy: A case report.2017
- Author(s)
  Kawahara K, Hiraki A, Yoshida R, Arita H, Matsuoka Y, Yamashita T, Koga K, Nagata M, Hirosue A, Fukuma D, Nakayama H.
- Journal Title
  
  Molecular and clinical oncology
  
  Volume: 6 Issue: 6 Pages: 886-892
- DOI
  10.3892/mco.2017.1226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11714, KAKENHI-PROJECT-15K11296, KAKENHI-PROJECT-16K20592, KAKENHI-PROJECT-16K20595
[Journal Article] The glucocorticoid receptor regulates the ANGPTL4 gene in a CTCF-mediated chromatin context in human hepatic cells.2017
- Author(s)
  Nakamoto M, Ishihara K, Watanabe T, Hirosue A, Hino S, Shinohara M, Nakayama H, and Nakao M
- Journal Title
  
  PLOS ONE
  
  Volume: 12
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K20595
[Journal Article] Pre-treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell carcinoma2016
- Author(s)
  Hikaru Nakashima, Yuichiro Matsuoka, Ryoji Yoshida, Masashi Nagata, Akiyuki Hirosue, Kenta Kawahara, Jyunki Sakata, Hidetaka Arita, Akimitsu Hiraki and Hideki Nakayama
- Journal Title
  
  BMC Cancer
  
  Volume: 26 Issue: 1 Pages: 41-41
- DOI
  10.1186/s12885-016-2079-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26861737, KAKENHI-PROJECT-26861738, KAKENHI-PROJECT-15K20546, KAKENHI-PROJECT-15K11296, KAKENHI-PROJECT-16K20592
[Journal Article] Factors affecting volume change of myocutaneous flaps in oral cancer.2016
- Author(s)
  Hiraki Akimitsu
- Journal Title
  
  Int J Oral Maxillofac Surg
  
  Volume: 45 Issue: 11 Pages: 1395-1399
- DOI
  10.1016/j.ijom.2016.04.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K20546, KAKENHI-PROJECT-15K11296, KAKENHI-PROJECT-16K20592, KAKENHI-PROJECT-16K20595
[Journal Article] IL-6 controls resistance to radiation by suppressing oxidative stress via the Nrf2-antioxidant pathway in oral squamous cell carcinoma.2016
- Author(s)
  Matsuoka Yuichiro
- Journal Title
  
  Br J Cancer
  
  Volume: 115 Issue: 10 Pages: 1234-1244
- DOI
  10.1038/bjc.2016.327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K20546, KAKENHI-PROJECT-15K11296, KAKENHI-PROJECT-16K11726, KAKENHI-PROJECT-16K20592, KAKENHI-PROJECT-16K20595
[Journal Article] Phase II clinical trial of multiple peptide vaccination for advanced head and neck cancer patients revealed induction of immune responses and improved OS2015
- Author(s)
  Yoshitake, Y., Fukuma, D., Yuno, A., Hirayama, M., Nakayama, H., Tanaka. T., Nagata, M., Takamune, Y., Kawahara, K., Nakagawa, Y., Yoshida, R., Hirosue, A., Ogi, H., Hiraki, A. , Jono, H., Hamada, A., Yoshida, K., Nishimura, Y., Nakamura, Y., Shinohara, M.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 21 Issue: 2 Pages: 312-321
- DOI
  10.1158/1078-0432.ccr-14-0202
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22133005, KAKENHI-PROJECT-24300334, KAKENHI-PROJECT-25463114, KAKENHI-PROJECT-26861736, KAKENHI-PROJECT-15K11296, KAKENHI-PROJECT-25461918, KAKENHI-PROJECT-25463113, KAKENHI-PROJECT-26861737, KAKENHI-PROJECT-26861738
[Journal Article] A case of adenomatoid odontogenic tumor-like tumor, unusual benign odontogenic tumor in the maxilla.2015
- Author(s)
  Kawahara K., Nakayama H., Fukuma D., Nagata M., Yoshida R., Tanaka T., Nakagawa Y., Hirosue A., Hiraki A., Takeda Y & Shinohara M.
- Journal Title
  
  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
  
  Volume: 27 Issue: 2 Pages: 299-302
- DOI
  10.1016/j.ajoms.2014.05.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26861738
[Journal Article] The tumour stromal features are associated with resistance to 5-FU-based chemoradiotherapy and a poor prognosis in patients with oral squamous cell carcinoma.2015
- Author(s)
  Matsuoka Y, Yoshida R, Nakayama H, Nagata M, Hirosue A, Tanaka T, Kawahara K, Nakagawa Y, Sakata J, Arita H, Hiraki A, Shinohara M.
- Journal Title
  
  APMIS
  
  Volume: 3 Issue: 3 Pages: 205-14
- DOI
  10.1111/apm.12344
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26861736, KAKENHI-PROJECT-15K11296, KAKENHI-PROJECT-25461918, KAKENHI-PROJECT-26861737, KAKENHI-PROJECT-26861738
[Journal Article] Overexpression of fibronectin confers cell adhesion-mediated drug resistance (CAM-DR) against 5-FU in oral squamous cell carcinoma cells2014
- Author(s)
  Nakagawa Y, Nakayama H, Nagata M, Yoshida R, Hirosue A, Tanaka T, Kawahara K, Matsuoka Y, Kojima Taku, Takamune Y, Yoshitake Y, Hiraki A, Shinohara M
- Journal Title
  
  Int J Oncol
  
  Volume: 44 Pages: 1376-1384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890176
[Journal Article] A low dicer expression is associated with resistance to 5-FU-based chemoradiotherapy and a shorter overall survival in patients with oral squamous cell carcinoma2014
- Author(s)
  Kawahara K, Nakayama H, Nagata M, Yoshida R, Hirosue A, Tanaka T, Nakagawa Y, Matsuoka Y, Kojima Taku, Takamune Y, Yoshitake Y, Hiraki A, Shinohara M
- Journal Title
  
  J Oral Pathol Med
  
  Volume: 43 Pages: 350-356
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890176
[Presentation] 高齢口腔癌患者における治療前の大腰筋体積と予後との関連性の検討2024
- Author(s)
  廣末晃之、林信、新山宗、山隈優、上田倫弘
- Organizer
  第42回日本口腔腫瘍学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] 当科における口腔癌に対する術前PCE 療法の臨床的検討2024
- Author(s)
  山隈優、新山宗、廣末晃之、林信、上田倫弘
- Organizer
  第42回日本口腔腫瘍学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] 高齢口腔がん診療における治療前栄養評価2024
- Author(s)
  林信、高野昌士、浅香雄一郎、田村優志、瀬田祥平、廣末晃之、山田有佳
- Organizer
  第42回日本口腔腫瘍学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] 再発・転移口腔がんに対する免疫チェックポイント阻害剤(ICI)の効果予測因子の検討2023
- Author(s)
  新山宗、林信、廣末晃之、山隈優、上田倫弘
- Organizer
  第68回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] 病理組織標本を用いた包括的HPV検出法確率と口腔扁平上皮癌における真のHPV陽性率の検討2023
- Author(s)
  諸富静香、廣末晃之、松尾美沙希、中元雅史、吉田遼司、佐藤賢文、中山秀樹
- Organizer
  第47回日本頭頸部癌学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] 高齢口腔癌治療における治療前栄養評価2023
- Author(s)
  林信、高野昌士、浅香雄一郎、田村優志、瀬田祥平、廣末晃之
- Organizer
  第41回日本腫瘍学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] New reconstruction methods after mandibulectomy.2023
- Author(s)
  Takashi Niyama, Shin Rin, Akiyuki Hirosue, Yu Yamaguma, Michihiro Ueda
- Organizer
  The 3rd International Congress of Asian Oncology Society
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] 口腔癌患者における周術期栄養管理と体組成変化に関する検討2023
- Author(s)
  岡村美帆、廣末晃之、前中あおい、長瀬博美、川原健太、中元雅史、諸富静香、吉田遼司、三島裕子、荒木栄一
- Organizer
  第26回日本病態栄養学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] Establishment of HPV-16 detection methods using histopathology specimens and HPV positive rates in oral cancer.2023
- Author(s)
  Shizuka Morodomi, Akiyuki Hirosue, Misaki Matuo, Akihnur Rahman, Masafumi Nakamoto, Ryoji Yoshida, Yorifumi Sato, Hideki Nakayama
- Organizer
  第82回　日本癌学会総会学術総会
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] 高齢口腔癌患者における治療前サルコペニアと予後との関連性の検討2023
- Author(s)
  廣末晃之、林信、新山宗、上田倫弘
- Organizer
  第41回日本腫瘍学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] 高齢口腔癌患者における治療前の栄養指標と予後との関連性の検討2023
- Author(s)
  廣末晃之、林信、山隈優、新山宗、上田倫弘
- Organizer
  第68回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] 放射線耐性口腔扁平上皮細胞によるエクソソームを介したフェロトーシス制御機構の解明2022
- Author(s)
  井上淳貴、吉田遼司、山名啓介、坂田純基、松岡祐一郎、大山徹、石川紘平、久保隆太、高橋望、平山真敏、竹下尚志、川原健太、廣末晃之、桑原義和、福本学、中山秀樹
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] 口腔癌におけるシスプラチンによるカルシウム動体への影響2022
- Author(s)
  篠原光佑、川原健太、平山真弓、鈴木真奈美、高橋望、平山真敏、廣末晃之、吉田遼司、鈴木良弘、中山秀樹
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] 放射線耐性口腔癌細胞由来細胞外小胞はmiR-503-3p/BAK軸を介し放射線耐性を賦与する2021
- Author(s)
  山名啓介、吉田遼司、井上淳貴、中嶋光、川口翔、郷原俊輔、永尾優果、竹下尚志、廣末晃之、中山秀樹
- Organizer
  第66回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] 口腔扁平上皮癌におけるIL-6阻害薬による放射線感受性効果の検討2021
- Author(s)
  有田英生、吉田遼司、松岡祐一郎、山名啓介、廣末晃之、永田将士、川原健太、中嶋光、坂田純基、中山秀樹
- Organizer
  第66回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] 口腔癌患者における周術期栄養管理と手術前後の体組成変化に関する検討2021
- Author(s)
  廣末晃之、吹原　美帆、川原　健太、松岡　祐一郎、高橋　望、平山　真敏、永田　将士、吉田　遼司、三島　裕子、中山　秀樹
- Organizer
  第34回日本口腔診断学会・第31回日本口腔内科学会合同学術大会
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] CD169の高発現は口腔扁平上皮癌において抗腫瘍免疫を活性化させる2021
- Author(s)
  川口翔、川原健太、廣末晃之、吉田遼司、坂田純基、前城学、郷原俊輔、永尾優果、山名啓介、中山秀樹
- Organizer
  第66回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] 酪酸によるエピゲノム変化を介した口腔癌の細胞制御機序の解明2021
- Author(s)
  永尾　優果、廣末　晃之、山本　達郎、平山　真弓、中元　雅史、川原　健太、永田　将士、吉田　遼司、中山秀樹
- Organizer
  第66回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10118
[Presentation] Development of a prediction system for delayed neck metastases of tongue cancer2020
- Author(s)
  Junki Inoue, Ryoji Yoshida, Junki Sakata, Kenta Kawahara, Masatoshi Hirayama, Akiyuki Hirosue, Masashi Nagata, Hideki Nakayama
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K09727
[Presentation] Interactions of calcium with mitochondria contribute to cisplatin resistance in oral cancer2020
- Author(s)
  Mayumi Hirayama, Kenta Kawahara, Akiyuki Hirosue, Satoru Shinriki, Ryoji Yoshida, Hirotaka Matsui, Hideki Nakayama
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K09727
[Presentation] 2 型糖尿病を有する口腔扁平上皮癌患者の臨床統計学的，免疫組織学的検討2019
- Author(s)
  永尾優果、廣末晃之、中元雅史、中嶋光、川口翔、郷原俊輔、山名啓介、川原健太、福間大喜、尾木秀直、吉田遼司、平木昭光、篠原正徳、中山秀樹
- Organizer
  第43回日本頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-18K09727
[Presentation] ANGPTL4 is involved in high malignant potential in oral squamous cell carcinoma through the epigenetic regulation.2019
- Author(s)
  Yuka Nagao, Akiyuki Hirosue, Masafumi Nakamoto,Tatsuro Yamamoto, Junki Sakata, Hidetaka Arita, Hikaru Nakashima, Kenta Kawahara, Ryoji Yoshida, Hideki Nakayama
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K09727
[Presentation] BRD4はエピジェネティックな調節を介して口腔扁平上皮癌の転移に関与する2018
- Author(s)
  山本達郎、廣末晃之、中元雅史、川原健太、高橋望、吉田遼司、坂田純基、中山秀樹
- Organizer
  日本口腔外科学会
- Data Source
  KAKENHI-PROJECT-18K09727
[Presentation] BRD4 is involved in high malignant potential in oral squamous cell carcinoma through the epigenetic regulation2018
- Author(s)
  Yuka Nagao, Akiyuki Hirosue, Tatsuro Yamamoto, Junki Sakata, Masafumi Nakamoto, Yuichiro Matsuoka, Hidetaka Arita, Hikaru Nakashima, Kenta Kawahara, Ryoji Yoshida, Noriko Saitoh, Hideki Nakayama
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-18K09727
[Presentation] BRD4はMMP2遺伝子座にエピジェネティックな調節を介して口腔扁平上皮癌の転移に関与する2018
- Author(s)
  山本　達郎、廣末　晃之、中元　雅史、川原　健太、高橋　望、吉田　遼司、平木　昭光、篠原　正徳斉藤　典子、中尾　光善、中山　秀樹
- Organizer
  第36回　日本口腔腫瘍学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-16K20595
[Presentation] Overexpression of IGFBP3 contributes to radioresistance and a poor prognosis in oral squamous cell carcinoma2017
- Author(s)
  Junki Sakata, Akiyuki Hirosue, Ryoji Yoshida, Yuichiro Matsuoka, Kenta Kawahara, Tatsuro Yamamoto, Hidetaka Arita, Hikaru Nakashima, Shunsuke Gohara, Sho Kawaguchi, Yuka Nagao, Keisuke Yamana, Hideki Nakayama
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K20595
[Presentation] IGFBP3 は DNA 修復の促進を介して口腔扁平上皮癌に放射線抵抗性を附与する2017
- Author(s)
  坂田純基、廣末晃之、吉田遼司、松岡祐一郎、永田将士、川原健太、有田英生、中嶋光、田中拓也、福間大喜、尾木秀直、中山秀樹
- Organizer
  第71回NPO法人日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-16K20595
[Presentation] IGFBP3 は DNA 修復の促進を介して口腔扁平上皮癌に放射線抵抗性を附与する2017
- Author(s)
  坂田純基、廣末晃之、吉田遼司、松岡祐一郎、永田将士、川原健太、高橋望、有田英生、中嶋光、田中拓也、福間大喜、尾木秀直、中山秀樹
- Organizer
  第41回日本頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-16K20595
[Presentation] 口腔扁平上皮癌におけるHMGA2の臨床的意義2016
- Author(s)
  坂田純基, 廣末晃之, 吉田遼司, 永田将士, 松岡祐一郎, 有田英生, 中嶋光, 福間大喜, 尾木秀直, 篠原正徳, 中山秀樹
- Organizer
  第40回日本頭頸部癌学会
- Place of Presentation
  大宮ソニックシティ、埼玉
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-16K20595
[Presentation] BRD4 contributes to metastasis in oral squamous cell carcinoma through the epigenetic regulation of MMP2.2016
- Author(s)
  山本達郎、廣末晃之、中元雅史、吉田遼司、川原健太、永田将士、田中拓也、斉藤典子、中尾光善、中山秀樹
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜、神奈川
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K20595
[Presentation] The clinicopathological analysis of IGFBP3 in oral squamous cell carcinoma.2016
- Author(s)
  坂田　純基、廣末　晃之、吉田　遼司、永田　将士、松岡　祐一郎、有田　英生、中嶋　光、川原　健太、福間　大喜、尾木　秀直、篠原　正徳、中山　秀樹
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜、神奈川
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K20595
[Presentation] Epigenetic alterations in chemoresistance and radioresistance of oral squamous cell carcinoma.2015
- Author(s)
  A. Hirosue, M. Nakamoto, T. Yamamoto, Y. Matsuoka, C. Nakamura, K. Kawahara, R. Yoshida, A. Hiraki, H. Nakayama, M. Shinohara
- Organizer
  22nd International conference on oral & maxillofacial surgery
- Place of Presentation
  メルボルン、オーストラリア
- Year and Date
  2015-10-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861738
[Presentation] Epigenetic analysis of the drug resistance in oral squamous cell carcinoma2013
- Author(s)
  Masafumi Nakamoto, Akiyuki Hirosue, Chiho Nakamura, Kenta Kawahara, Nakagawa Yoshihiro, Ryoji Yoshida, Masashi Nagata, Hideki Nakayama, Akimitsu Hiraki, Masanori Shinohara
- Organizer
  21ST INTERNATIONAL CONFERENCE ON ORAL AND MAXILLOFACIAL SURGERY
- Place of Presentation
  Palau de Congressos, Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-24890176
[Presentation] Epigenetic alterations in the drug resistance of oral squamous cell carcinoma2013
- Author(s)
  Hirosue A,Nakamoto M,Nakamura C,Kawahara K,Nakagawa Y,Yoshida R,Nagata M,Nakayama H,Hiraki A,Shinohara M
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフイコ横浜神奈川
- Data Source
  KAKENHI-PROJECT-24890176
[Presentation] 口腔扁平上皮癌の抗癌剤耐性に関与するエピケノム異常2013
- Author(s)
  廣末晃之、中山秀樹、中元雅史、中村智穂、川原健太、中川純泰、吉田遼司、永田将士、平木昭光、牧正啓、篠原正徳
- Organizer
  第58回日本口腔外科学会総会学術大会
- Place of Presentation
  福岡国際会議場福岡
- Data Source
  KAKENHI-PROJECT-24890176
[Presentation] 口腔扁平上皮癌の抗癌剤耐性に関与するエピゲノム異常2013
- Author(s)
  廣末　晃之、中山　秀樹、中元　雅史、中村　智穂、川原　健太、中川　純泰、吉田　遼司、永田　将士、平木　昭光、牧　正啓、篠原　正徳
- Organizer
  第58回日本口腔外科学会総会・学術大会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24890176
[Presentation] Epigenetic alterations in the drug resistance of oral squamous cell carcinoma.2013
- Author(s)
  Akiyuki Hirosue, Masafumi Nakamoto, Chiho Nakamura, Kenta Kawahara, Nakagawa Yoshihiro, Ryoji Yoshida, Masashi Nagata, Hideki Nakayama, Akimitsu Hiraki, Masanori Shinohara
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24890176
[Presentation] Epigenetic analysis of the drug resistance in oral squamous cell carcinoma2013
- Author(s)
  Nakamoto M,Hirosue A,Nakamura C,Kawahara K,Nakagawa Y,Yoshida R,Nagata M,Nakayama H,Hiraki A,Shinohara
- Organizer
  21ST INTERNATIONAL CONFERENCE ON ORAL AND MAXILLOFACIAL SURGERY
- Place of Presentation
  Palaude Congressos, Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-24890176
[Presentation] Quantitative assessment of higher-order chiromatin structure of the INK4/ARF locus in reprogrammed human cells2012
- Author(s)
  Hirosue A, Nakayama H, Ishihara K, Nakamoto M, Nagata M, Kawahara K, Yoshida R, Nakao M, Shinohara M
- Organizer
  17th World Congress on Advances in Oncology and 15th International Symposium on Molecular Medicine
- Place of Presentation
  Hotel Creta Maris Resort, Creta, Greece
- Data Source
  KAKENHI-PROJECT-24890176
[Presentation] Quantitative assessment of higher-order chiromatin structure of the INK4/ARF locus in human senescent cells2012
- Author(s)
  Hirosue A, Nakamoto M, shihara K, Takehisa T, Narita M, Nakao M, Shinohara M
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌北海道
- Data Source
  KAKENHI-PROJECT-24890176
[Presentation] Quantitative assessment of higher-order chiromatin structure of the INK4/ARF locus in reprogrammed human cells2012
- Author(s)
  Akiyuki HIrosue
- Organizer
  17th World Congress on Advances in Oncology and15th International Symposium on Molecular Medicine
- Place of Presentation
  Hotel Creta Maris Resort, Creta-Greece
- Data Source
  KAKENHI-PROJECT-24890176
[Presentation] Quantitative assessment of higher-order chiromatin structure of the INK4/ARF locus in human senescent cells2012
- Author(s)
  Akiyuki HIrosue
- Organizer
  第71回　日本癌学会学術総会
- Place of Presentation
  ロイトン札幌、　北海道　札幌
- Data Source
  KAKENHI-PROJECT-24890176
[Presentation] Epigenetic alterations in the drug resistance of oral squamous cell carcinoma.
- Author(s)
  Akiyuki Hirosue
- Organizer
  96th Annual Meeting, Scientific Sessions & Exhibition in conjunction with the Japanese Society and Korean Association of Oral and Maxilllofacial Surgeons
- Place of Presentation
  Hawaii Convention Center
- Year and Date
  2014-09-08 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26861738

1. NAKAYAMA Hideki

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
2. NAGATA MASASHI

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. MURAKAMI Ryuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
4. Arita Hidetaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. HIRAKI Akimitsu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. YOSHIDA Ryoji

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 影山伸哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 西村康治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 坂田純基

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
10. 川原健太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 福本学

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 大野剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 平山真敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 松岡祐一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 高橋望

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 大西紘二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 桑原義和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIROSUE AKIYUKI 廣末 晃之

HIROSUE Akiyuki 廣末 晃之

Research Projects

Research Products

Co-Researchers

口腔癌の治療抵抗性における口腔細菌と細胞老化の役割の解明と制御法の創出Principal Investigator

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Elucidation of the mechanism of treatment resistance in oral cancer via crosstalk between metabolism and epigenome by oral microbiome.Principal Investigator

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Development of novel therapeutic strategies for refractory oral cancer targeting higher-order epigenomic regulationPrincipal Investigator

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Creation of novel diagnostic methods and epigenome therapy based on higher-order epigenome analysis in treatment-resistant oral cancerPrincipal Investigator

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Analysis of epigenomic alterations in chemoresistance and radioresistance of oral squamous cell carcinoma to provide the personalized medicine.Principal Investigator

Principal Investigator

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Higher-order epigenetic analysis of the INK4/ARF locus in oral cancer and development of novel diagnostic methodsPrincipal Investigator

Principal Investigator

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[Journal Article] Involvement of ferroptosis-defensive xCT/GPX4 axis in radioresistance and its impacts on prognosis in oral squamous cell carcinoma2024

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[Journal Article] Programmed death-ligand 1-expressing extracellular vesicles are a prognostic factor in patients with oral squamous cell carcinoma treated with immune checkpoint inhibitors2023

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[Journal Article] FOXM1-Mediated Regulation of Reactive Oxygen Species and Radioresistance in Oral Squamous Cell Carcinoma Cells2023

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[Journal Article] Factors Affecting Human Damage in Heavy Rains and Typhoon Disasters2022

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[Journal Article] The antioxidative stress regulator Nrf2 potentiates radioresistance of oral squamous cell carcinoma accompanied with metabolic modulation2022

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[Journal Article] Three-dimensional volumetric analysis of the efficiency of marsupialization in patients with mandibular dentigerous cysts involving impacted third molars2022

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[Journal Article] Naringenin potentiates anti-tumor immunity against oral cancer by inducing lymph node CD169-positive macrophage activation and cytotoxic T cell infiltration2022

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[Journal Article] Laterality on FDG-PET/CT in clinically node-negative early-stage oral squamous cell carcinoma: a retrospective analysis of patients with late neck metastasis2022

Author(s)

HIROSUE AKIYUKI 廣末晃之

HIROSUE Akiyuki 廣末晃之