Kohjima Motoyuki 国府島庸之

Researcher Number	00650748
Other IDs
Affiliation (Current)	2025: 独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, 消化器内科医師 2025: 九州大学, 医学研究院, 共同研究員
Affiliation (based on the past Project Information) *help	2023: 九州大学, 医学研究院, 共同研究員 2020 – 2022: 九州大学, 医学研究院, 准教授 2017 – 2019: 九州大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator 非実質細胞 / hCLS / 一細胞遺伝子発現解析 / 肝星細胞 / マクロファージ / クッパー細胞 / crown-like structure / 線維化 / NASH / 非アルコール性脂肪肝炎 … More / 糖代謝 / Warburg effect / 脂質代謝 / 糖質代謝 / 肝細胞癌 … More Except Principal Investigator 肝実質細胞 / 一細胞遺伝子発現解析 / C型レクチン受容体 / hCLS / シングルセルトランスクリプトーム解析 / マクロファージ / 細胞間相互作用 / ミトコンドリア / NASH Less

The role of non-parenchymal cells on the pathogenesis for NASHPrincipal Investigator
- Principal Investigator
  
  国府島庸之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyushu University
Development and progression mechanism of NASH from the viewpoint of cell-cell interaction and medical application
- Principal Investigator
  
  Ogawa Yoshihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kyushu University
The change of glucose and lipid metabolism in hepatocellular carcinoma and the involvement to tumor dedifferntiationPrincipal Investigator
- Principal Investigator
  
  Kohjima Motoyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyushu University

All 2023 2022 2021 2019

All Journal Article Presentation

[Journal Article] Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR842023
- Author(s)
  Ohue-Kitano Ryuji、Nonaka Hazuki、Nishida Akari、Masujima Yuki、Takahashi Daisuke、Ikeda Takako、Uwamizu Akiharu、Tanaka Miyako、Kohjima Motoyuki、Igarashi Miki、Katoh Hironori、Tanaka Tomohiro、Inoue Asuka、Suganami Takayoshi、Hase Koji、Ogawa Yoshihiro、Aoki Junken、Kimura Ikuo
- Journal Title
  
  JCI Insight
  
  Volume: 8 Issue: 2 Pages: 165469-165469
- DOI
  10.1172/jci.insight.165469
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08526, KAKENHI-PROJECT-22K07987, KAKENHI-PROJECT-22K19524, KAKENHI-PROJECT-20H00509, KAKENHI-PROJECT-21H04862, KAKENHI-PROJECT-20H03447, KAKENHI-PROJECT-22KJ1973, KAKENHI-PROJECT-20K11600, KAKENHI-PUBLICLY-22H04806, KAKENHI-PROJECT-22K08660
[Journal Article] Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation2022
- Author(s)
  Tashiro Shigeki、Tanaka Masatake、Goya Takeshi、Aoyagi Tomomi、Kurokawa Miho、Imoto Koji、Kuwano Akifumi、Takahashi Motoi、Suzuki Hideo、Kohjima Motoyuki、Kato Masaki、Ogawa Yoshihiro
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 434 Pages: 115817-115817
- DOI
  10.1016/j.taap.2021.115817
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17496, KAKENHI-PROJECT-20K22877, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-20H04949, KAKENHI-PROJECT-19H01054, KAKENHI-PROJECT-21K15976
[Journal Article] The Efficacy of Tofogliflozin onMetabolic Dysfunction-Associated Fatty Liver Disease2022
- Author(s)
  Takeshi Goya, Koji Imoto, Shigeki Tashiro, Tomomi Aoyagi, Motoi Takahashi, Miho Kurokawa, Hideo Suzuki, Masatake Tanaka, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa
- Journal Title
  
  Gastroenterology Insights
  
  Volume: 13 Issue: 1 Pages: 20-26
- DOI
  10.3390/gastroent13010003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22877, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-20H04949, KAKENHI-PROJECT-19H01054
[Journal Article] Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma2021
- Author(s)
  Suzuki Hideo、Kohjima Motoyuki、Tanaka Masatake、Goya Takeshi、Itoh Shinji、Yoshizumi Tomoharu、Mori Masaki、Tsuda Mariko、Takahashi Motoi、Kurokawa Miho、Imoto Koji、Tashiro Shigeki、Kuwano Akifumi、Kato Masaki、Okada Seiji、Nakamuta Makoto、Ogawa Yoshihiro
- Journal Title
  
  Canadian Journal of Gastroenterology and Hepatology
  
  Volume: 2021 Pages: 1-13
- DOI
  10.1155/2021/8813410
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17496, KAKENHI-PUBLICLY-20H04949, KAKENHI-PROJECT-19H01054, KAKENHI-PROJECT-19H03771
[Journal Article] Bilirubin reduces visceral obesity and insulin resistance by suppression of inflammatory cytokines.2019
- Author(s)
  Takei R, Inoue T, Sonoda N, Kohjima M, Okamoto M, Sakamoto R, Inoguchi T, Ogawa Y.
- Journal Title
  
  PLoS One.
  
  Volume: 14 Issue: 10 Pages: e0223302-e0223302
- DOI
  10.1371/journal.pone.0223302
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09430
[Journal Article] Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients2019
- Author(s)
  Imoto Koji、Kohjima Motoyuki、Hioki Tomonobu、Kurashige Tomoyuki、Kurokawa Miho、Tashiro Shigeki、Suzuki Hideo、Kuwano Akifumi、Tanaka Masatake、Okada Seiji、Kato Masaki、Ogawa Yoshihiro
- Journal Title
  
  Canadian Journal of Gastroenterology and Hepatology
  
  Volume: 2019 Pages: 1-12
- DOI
  10.1155/2019/6391712
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17496, KAKENHI-PUBLICLY-18H05039, KAKENHI-PROJECT-19H01054, KAKENHI-PROJECT-19H03771, KAKENHI-PROJECT-17K09430
[Journal Article] AFLD/NASH～診断・治療の最新動向～2019
- Author(s)
  国府島庸之、伊藤美智子、小川佳宏
- Journal Title
  
  日本臨床
  
  Volume: 77 Pages: 799-805
- Data Source
  KAKENHI-PROJECT-19H01054
[Journal Article] Recombinant human soluble thrombomodulin ameliorates acetaminophen-induced liver toxicity in mice2019
- Author(s)
  A. Kuwano, M. Kohjima, H. Suzuki, A. Yamasaki, T. Ohashi, K. Imoto, M. Kurokawa, Y. Morita, M. Kato, and Y. Ogawa
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: 18 Pages: 1323-1330
- DOI
  10.3892/etm.2019.7665
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H05039, KAKENHI-PROJECT-19H01054, KAKENHI-PROJECT-17K09430
[Presentation] NASHモデルマウスにおける肝線維化機序の解明2023
- Author(s)
  井本効志, 東夕喜, 大野あかり, 青柳知美, 高橋基, 黒川美穂, 合谷孟, 田中正剛, 国府島庸之, 小川佳宏
- Organizer
  第59回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K07987
[Presentation] 肝非実質細胞を介した閉経後NASHの発症増悪メカニズムの解析2023
- Author(s)
  合谷孟, 青柳知美, 鈴木秀生, 東夕喜, 日置智惟, 高橋基, 井本効志, 黒川美穂, 田代茂樹, 田中正剛, 国府島庸之, 小川佳宏
- Organizer
  第59回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K07987
[Presentation] 肝非実質細胞に注目した閉経後NASHの発症・増悪メカニズムの検討2022
- Author(s)
  青柳知美、鈴木秀生、高橋基、井本効志、東夕喜、大野あかり、黒川美穂、田代茂樹、合谷孟、田中正剛、国府島庸之、小川佳宏
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K07987
[Presentation] 非アルコール性脂肪性肝疾患の組織学的特徴に関連した臨床病態および遺伝子発現変化の検討2021
- Author(s)
  井本効志、田代茂樹、日置智惟、川元美緒、高橋　基、黒川美穂、鈴木秀生、合谷　孟、田中正剛、加藤正樹、国府島庸之、小川佳宏
- Organizer
  第57回日本肝臓学会総会（札幌）（WEB開催）
- Data Source
  KAKENHI-PROJECT-19H01054
[Presentation] 肝細胞癌における糖・脂質代謝関連遺伝子発現の変化：高分化型肝細胞癌における脂肪蓄積のメカニズム2021
- Author(s)
  鈴木秀生、高橋　基、井本効志、黒川美穂、田代茂樹、合谷　孟、田中正剛、加藤正樹、伊藤心二、吉住朋晴、森　正樹、中牟田誠、国府島庸之、小川佳宏
- Organizer
  第57回日本肝臓学会総会（札幌）（WEB開催）
- Data Source
  KAKENHI-PROJECT-19H01054
[Presentation] 当院におけるFib-4 index上昇患者の臨床的特徴についての検討2019
- Author(s)
  倉重智之、正月泰士、井本効志、田代茂樹、鈴木秀生、桒野哲史、田中正剛、国府島庸之、加藤正樹、小川佳宏
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09430
[Presentation] 閉経後女性における脂肪肝発症のメカニズムの解析とその臨床的特徴の検討2019
- Author(s)
  鈴木秀生、倉重智之、正月泰士、井本効志、黒川美穂、田代茂樹、桒野哲史、田中正剛、国府島庸之、加藤正樹、小川佳宏
- Organizer
  第55回日本肝臓学会総会（京王プラザホテル 2019.5.30-31）
- Data Source
  KAKENHI-PROJECT-19H01054
[Presentation] 肝細胞癌に対する放射線治療についての検討2019
- Author(s)
  森田祐輔、大江真里、大穂有恒、田中正剛、国府島庸之、加藤正樹、小川佳宏
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09430
[Presentation] New biochemical parameter using serum alanine aminotransferase and lactate dehydrogenase level of hepatic hyper-coagulation and hypoxia in acute liver injury2019
- Author(s)
  A. Kuwano, M. Kohjima, S. Tashiro, H. Suzuki, M. Tanaka, M. Kato, and Y. Ogawa
- Organizer
  AASLD liver meeting 2019 (Boston 2019.11.8-11.12)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01054
[Presentation] The effects of menopause and fructose intake on NAFLD/NASH development.2019
- Author(s)
  Hideo Suzuki, Motoyuki Kohjima, Koji Imoto, Miho Kurokawa, Shigeki Tashiro, Akifumi Kuwano, Masatake Tanaka, Masaki Kato, Yoshihiro Ogawa
- Organizer
  AASLD liver meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09430
[Presentation] Glecaprevir + Pibrentasvir併用療法の治療効果・安全性と代謝への影響2019
- Author(s)
  大角真央、国府島庸之、本村健太、中牟田誠、佐藤丈顕、多田靖哉、杉本理恵、大穂有恒、古藤和浩、徳松誠、横田昌樹、小柳年正、鶴田悟、國吉政美、森園周祐、内村浩太郎、本多正直、田畑伸司、加藤正樹、小川佳宏
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09430
[Presentation] 急性肝障害の病型分類とステロイド動注療法の治療効果2019
- Author(s)
  国府島庸之、倉重智之、正月泰士、黒川美穂、井本効志、田代茂樹、鈴木英生、桒野哲史、田中正剛、加藤正樹、小川佳宏
- Organizer
  日本急性肝不全研究会
- Data Source
  KAKENHI-PROJECT-17K09430
[Presentation] Microcirculatory disturbance in acute liver injury.2019
- Author(s)
  Motoyuki Kohjima, Hideo Suzuki, Akifumi Kuwano, Miho Kurokawa, Koji Imoto, Shigeki Tashiro, Masatake Tanaka, Masaki Kato, Yoshihiro Ogawa
- Organizer
  International symposium on inflammation cellular sociology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09430
[Presentation] The effects of menopause and fructose intake on NAFLD/NASH development2019
- Author(s)
  H. Suzuki, M. Kohjima, K. Imoto, M. Kurokawa, S. Tashiro, A. Kuwano, M. Tanaka, M. Kato, and Y. Ogawa
- Organizer
  AASLD liver meeting 2019 (Boston 2019.11.8-11.12)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01054
[Presentation] 肝癌に対するレンバチニブ治療における早期治療効果、奏効に寄与する因子の解析2019
- Author(s)
  宮崎将之　杉本理恵、上田哲弘、大穂有恒、国府島庸之、多田靖哉、佐藤丈顕、吉本剛士、田中紘介、矢田雅佳、荒武良総、千住猛士、田中正剛、山下晋作、田中ゆき、本村健太、加藤正樹
- Organizer
  JDDW
- Data Source
  KAKENHI-PROJECT-17K09430
[Presentation] NAFLDにおけるSteatosis, Inflammation, Ballooning, Mallory-Denk body, Fibrosisの各因子と関連する臨床的特徴と遺伝子発現変化2019
- Author(s)
  国府島庸之、田代茂樹、鈴木秀生、桒野哲史、倉重智之、井本効志、正月泰士、田中正剛、加藤正樹、小川佳宏
- Organizer
  第55回日本肝臓学会総会（京王プラザホテル 2019.5.30-31）
- Data Source
  KAKENHI-PROJECT-19H01054
[Presentation] New biochemical parameter using serum alanine aminotransferase and lactate dehydrogenase level of hepatic hyper-coagulation and hypoxia in acute liver injury2019
- Author(s)
  Akifumi Kuwano, Motoyuki Kohjima, Shigeki Tashiro, Hideo Suzuki, Masatake Tanaka, Masaki Kato, Yoshihiro Ogawa
- Organizer
  AASLD liver meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09430
[Presentation] 高度進行肝癌(stage4)に対するレンバチニブの有効性と安全性の検討～多施設共同研究～2019
- Author(s)
  杉本理恵、上田哲弘、大穂有恒、国府島庸之、多田靖哉、佐藤丈顕、吉本剛士、田中紘介、宮崎将之、矢田雅佳、荒武良総、千住猛士、田中正剛、山下晋作、田中ゆき、本村健太、加藤正樹
- Organizer
  JDDW
- Data Source
  KAKENHI-PROJECT-17K09430
[Presentation] 進行肝癌に対するレンバチニブ治療における早期奏効と副作用の関係2019
- Author(s)
  荒武良総、本村健太、中牟田誠、佐藤丈顕、多田靖哉、杉本理恵、大穂有恒、古藤和浩、徳松誠、横田昌樹、小柳年正、鶴田悟、國吉政美、森園周祐、内村浩太郎、本多正直、田畑伸司、国府島庸之、加藤正樹、小川佳宏
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09430
[Presentation] 閉経後女性における脂肪肝発症のメカニズムの解析とその臨床的特徴の検討2019
- Author(s)
  鈴木英生、倉重智之、正月泰士、井本効志、黒川美穂、田代茂樹、桒野哲史、田中正剛、国府島庸之、加藤正樹、小川佳宏
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09430
[Presentation] 当院における免疫チェックポイント阻害剤での肝障害の臨床的特徴2019
- Author(s)
  井本効志、国府島庸之、加藤正樹
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09430
[Presentation] NAFLDにおけるSteatosis, Inflammation, Ballooning, Mallory-Denk body, Fibrosisの各因子と関連する臨床的特徴と遺伝子発現変化2019
- Author(s)
  国府島庸之、田代茂樹、鈴木秀生、桒野哲史、倉重智之、井本効志、正月泰士、田中正剛、加藤正樹、小川佳宏
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09430

1. Ogawa Yoshihiro (70291424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. 加藤正樹 (60444808)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
3. 宮澤崇 (30443500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 合谷孟 (30884754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 田中正剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
6. 田中都

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kohjima Motoyuki 国府島 庸之

Research Projects

Research Products

Co-Researchers

The role of non-parenchymal cells on the pathogenesis for NASHPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development and progression mechanism of NASH from the viewpoint of cell-cell interaction and medical application

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The change of glucose and lipid metabolism in hepatocellular carcinoma and the involvement to tumor dedifferntiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR842023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Efficacy of Tofogliflozin onMetabolic Dysfunction-Associated Fatty Liver Disease2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bilirubin reduces visceral obesity and insulin resistance by suppression of inflammatory cytokines.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AFLD/NASH～診断・治療の最新動向～2019

Author(s)

Journal Title

Data Source

[Journal Article] Recombinant human soluble thrombomodulin ameliorates acetaminophen-induced liver toxicity in mice2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] NASHモデルマウスにおける肝線維化機序の解明2023

Author(s)

Organizer

Data Source

[Presentation] 肝非実質細胞を介した閉経後NASHの発症増悪メカニズムの解析2023

Author(s)

Organizer

Data Source

[Presentation] 肝非実質細胞に注目した閉経後NASHの発症・増悪メカニズムの検討2022

Author(s)

Organizer

Data Source

[Presentation] 非アルコール性脂肪性肝疾患の組織学的特徴に関連した臨床病態および遺伝子発現変化の検討2021

Author(s)

Organizer

Data Source

[Presentation] 肝細胞癌における糖・脂質代謝関連遺伝子発現の変化：高分化型肝細胞癌における脂肪蓄積のメカニズム2021

Author(s)

Organizer

Kohjima Motoyuki 国府島庸之