Hirahara Kiyoshi 平原潔

… Alternative Names

KIYOSHI Hirahara 平原潔

Less

Researcher Number	00707193
Other IDs
Affiliation (Current)	2022: 千葉大学, 大学院医学研究院, 教授
Affiliation (based on the past Project Information) *help	2022: 千葉大学, 大学院医学研究院, 教授 2017 – 2022: 千葉大学, 大学院医学研究院, 准教授 2013 – 2014: 千葉大学, 医学(系)研究科(研究院), 客員准教授
Review Section/Research Field	Principal Investigator Immunology / Transformative Research Areas, Section (III) / Basic Section 53030:Respiratory medicine-related Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator 免疫学 / 遺伝子 / シグナル伝達 / サイトカイン / 真菌感染症 / アスペルギルス / 肺線維化 / CD4 / 組織局在性記憶 / CD103 … More / Foxp3 / RNA-Seq / CD4組織局在性記憶 / 肺繊維症 / 真菌感染 / 獲得免疫 / 組織局在記憶T細胞 / 線維化誘導-病原性CD4+ T細胞 / 肺の線維化 / single cell RNA-Seq / ATAC-Seq / 慢性炎症 / 炎症収束 / 炎症記憶 / 炎症性組織レンジエンス / 組織障害エントロピー / 炎症性組織レジリエンス / 炎症組織記憶 / 組織常在性記憶CD4+ T細胞 / 神経-炎症性組織レジリエンス連関 / iBALT / Proof of concept … More Except Principal Investigator IL-33 / ST2陽性Th2細胞 / ステロイド抵抗性喘息 / ステロイド血中濃度 / ST2 / 気管支喘息 / 好酸球 / ステロイド抵抗性 / Th2細胞 / CD4+T細胞 / ステロイド / 外因性ステロイド / 組織常在性T細胞 / 胸膜炎 / インターロイキン33 / リモデリング / 線維化 / 肺組織常在性T細胞 / 舌下免疫療法 / 花粉症 / アレルギー性鼻炎 / T細胞 / シングルセル / 免疫チェックポイント阻害剤 / 癌性胸膜炎 / 効果予測マーカー / IFNγ / 治療反応予測 / IrAE Less

シングルセル解析からつなげる舌下免疫療法の作用機序の解明
- Principal Investigator
  
  飯沼智久
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Chiba University
Integrated elucidation of inflammatory tissue-resilience and tissue damage-entropy;Creation of innovative science for resolution of inflammationArea Organizer
- Area Organizer
  
  平原潔
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
炎症性組織レジリエンスと組織障害エントロピーの統合的理解と炎症収束学の創成Principal Investigator
- Principal Investigator
  
  平原潔
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Chiba University
炎症性組織レジリエンスの高次機能としての炎症記憶の制御機構の解明Principal Investigator
- Principal Investigator
  
  平原潔
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Chiba University
癌性胸膜炎における免疫チェックポイント阻害剤の治療予測系の確立と効果増強戦略
- Principal Investigator
  
  間藤尚子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jichi Medical University
線維化誘導-病原性CD4+T細胞の制御機構の解明 -肺線維化疾患の病態の理解へ-Principal Investigator
- Principal Investigator
  
  平原潔
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Chiba University
Contribution of ST2+CD4+ T cells in the mechanism of steroid-resistant asthma
- Principal Investigator
  
  Mato Naoko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jichi Medical University
Elucidation of pathological regulation of tissue-resident memory CD4 T cells in lung fibosisPrincipal Investigator
- Principal Investigator
  
  Hirahara Kiyoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
Asymmetric action of STATs drive transcriptional outputs and cytokine specificity.Principal Investigator
- Principal Investigator
  
  KIYOSHI Hirahara
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  Chiba University

All 2022 2021 2020 2019 2018 2017 2015 2014 2013

All Journal Article Presentation Book Patent

[Book] Induction and regulation of mucosal memory T cell response2020
- Author(s)
  Hirahara, K, Nakayama, T
- Total Pages
  940
- Publisher
  MUCOSAL VACCINES Second Edition ELSEVIER
- ISBN
  9780128119242
- Data Source
  KAKENHI-PROJECT-17K08876
[Book] 免疫・アレルギー疾患イラストレイテッド2013
- Author(s)
  平原潔、中山俊憲
- Total Pages
  8
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-25893032
[Journal Article] Nematode ascarosides attenuate mammalian type 2 inflammatory responses2022
- Author(s)
  Shinoda Kenta、Choe Andrea、Hirahara Kiyoshi、Kiuchi Masahiro、Kokubo Kota、Ichikawa Tomomi、Hoki Jason S.、Suzuki Akane S.、Bose Neelanjan、Appleton Judith A.、Aroian Raffi V.、Schroeder Frank C.、Sternberg Paul W.、Nakayama Toshinori
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119(9)
- DOI
  10.1073/pnas.2108686119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-19K16683, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-21K20754
[Journal Article] Eosinophils: Cells known for over 140 years with broad and new functions2021
- Author(s)
  Kiuchi Masahiro、Onodera Atsushi、Kokubo Kota、Ichikawa Tomomi、Morimoto Yuki、Kawakami Eiryo、Takayama Naoya、Eto Koji、Koseki Haruhiko、Hirahara Kiyoshi、Nakayama Toshinori
- Journal Title
  
  J Exp Med.
  
  Volume: 218 Pages: 3-8
- DOI
  10.1084/jem.20201690
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-18K07164, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-21K20754
[Journal Article] The role of CD4+ resident memory T cells in local immunity in the mucosal tissue - Protection versus Pathology -2021
- Author(s)
  Kiyoshi Hirahara、Kota Kokubo、Ami Aoki、Masahiro Kiuchi、Toshinori Nakayama
- Journal Title
  
  Frontiers in Immunology
  
  Volume: - Pages: 616309-616309
- DOI
  10.3389/fimmu.2021.616309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-20K20383, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-21K20754
[Journal Article] Trithorax複合体を構成するCxxc1はCD4+T細胞分化におけるepigenetic licensingをつかさどる2021
- Author(s)
  木内政宏、平原潔、中山俊憲
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 76(６) Pages: 688-693
- NAID
  40022755458
- Data Source
  KAKENHI-PROJECT-20H03685
[Journal Article] CD4+ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69?Myl9 system2021
- Author(s)
  Nakayama Toshinori、Hirahara Kiyoshi、Kimura Motoko Y、Iwamura Chiaki、Kiuchi Masahiro、Kokubo Kota、Onodera Atsushi、Hashimoto Kahoko、Motohashi Shinichiro
- Journal Title
  
  International Immunology
  
  Volume: 33(12) Pages: 699-704
- DOI
  10.1093/intimm/dxab053
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-20K21537, KAKENHI-PROJECT-19K16683, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03464, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-20K08769, KAKENHI-PROJECT-21K20754, KAKENHI-PROJECT-20KK0351
[Journal Article] The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation2021
- Author(s)
  Takasato Y, Kurashima Y, Kiuchi M, Hirahara K, Murasaki S, Arai F, Izawa K, Kaitani A, Shimada k, Saito Y, Toyoshima S, Nakamura M, Fujisawa K, Okayama Y, Kunisawa J, Kubo M, Takemura N, Uematsu S, Akira S, Kitaura J, Takahashi T, Nakayama T, Kiyono H
- Journal Title
  
  Mucosal Immunol.
  
  Volume: 14 Pages: 640-651
- DOI
  10.1038/s41385-020-00358-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08782, KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-19K17818, KAKENHI-PROJECT-18H02571, KAKENHI-PROJECT-19H03450, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-20H03721, KAKENHI-PROJECT-19K22634, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-18H05280, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-21K19083, KAKENHI-PROJECT-21K19495
[Journal Article] Pathogenic helper T cells2021
- Author(s)
  Hirahara Kiyoshi、Aoki Ami、Nakayama Toshinori
- Journal Title
  
  Allergology International
  
  Volume: 70 Issue: 2 Pages: 036-173
- DOI
  10.1016/j.alit.2021.02.001
- NAID
  130008024337
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-20K17175, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685
[Journal Article] Trithorax複合体を構成するCxxc1はCD4+T細胞分化におけるepigenetic licensingをつかさどる2021
- Author(s)
  木内政宏、平原潔、中山俊憲
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 76(6) Pages: 688-693
- NAID
  40022755458
- Data Source
  KAKENHI-PLANNED-21H05121
[Journal Article] Eosinophils: Cells known for over 140 years with broad and new functions2021
- Author(s)
  Aoki Ami、Hirahara Kiyoshi、Kiuchi Masahiro、Nakayama Toshinori
- Journal Title
  
  Allergology International
  
  Volume: 70 Issue: 1 Pages: 2223-2233
- DOI
  10.1016/j.alit.2020.09.002
- NAID
  130007966778
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-20K17175, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685
[Journal Article] Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy2021
- Author(s)
  Hirahara Kiyoshi、Aoki Ami、Kiuchi Masahiro、Nakayama Toshinori
- Journal Title
  
  J. Allergy Clin. Immunol.
  
  Volume: -
- DOI
  10.1016/j.jaci.2021.02.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-20K17175, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685
[Journal Article] Trithorax複合体を構成するCxxc1はCD4+T細胞分化におけるepigenetic licensingをつかさどる2021
- Author(s)
  木内政宏、平原潔、中山俊憲
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 76(6) Pages: 688-693
- NAID
  40022755458
- Data Source
  KAKENHI-ORGANIZER-21H05120
[Journal Article] 病原性Th2細胞2021
- Author(s)
  青木亜美、平原潔、中山俊憲
- Journal Title
  
  アレルギ－
  
  Volume: 70(2) Pages: 134-135
- NAID
  130007996948
- Data Source
  KAKENHI-PROJECT-20H03685
[Journal Article] CD103highTreg細胞による肺繊維化抑制2020
- Author(s)
  小久保幸太、平原潔、中山俊憲
- Journal Title
  
  臨床免疫・アレルギ－科
  
  Volume: 74(2) Pages: 180-184
- Data Source
  KAKENHI-PROJECT-20H03685
[Journal Article] Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis2020
- Author(s)
  Goschl,L, Preglej,T, Boucheron,N, Saferding,V, Muller,L, Platzer,A, Hirahara,K, Han-Yu,S, Backlund,J, Matthias,P, Niederreiter,B, Hladik,A, Kugler,M, Gualdoni,G, Scheinecker,C, Knapp,S, Seiser,C, Holmdahl,R, Tillmann,K, Plasenzotti,R, Podesser,B, Aletaha,D, Smolen, Karonitsch,TJ, Steiner,G, Ellmeier,W, Bonelli,M
- Journal Title
  
  Journal of Autoimmunity
  
  Volume: 108 Pages: 102379-102379
- DOI
  10.1016/j.jaut.2019.102379
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08876
[Journal Article] Rapid remodeling of poised chromatin landscapes and transcription factor repurposing facilitate gene induction in natural killer cells.2020
- Author(s)
  Sciume G, Mikami Y, Jankovic D, Nagashima H, Villarino AV, Morrison T, Signorella S, Yao C, Sun HW, Brooks SR, Fang D, Sartorelli V, Nakayamada S, Hirahara K, Zitti B, Davis FP, Kanno Y, O’Shea JJ, Shih HY
- Journal Title
  
  Immunity
  
  Volume: 53(4) Pages: 745-758
- DOI
  10.1016/j.immuni.2020.09.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03685
[Journal Article] 肺における組織常在性病原性記憶T細胞と制御性T細胞2020
- Author(s)
  平原潔、中山俊憲
- Journal Title
  
  炎症と免疫　感染・炎症・免疫
  
  Volume: 50(1) Pages: 24-34
- Data Source
  KAKENHI-PROJECT-20H03685
[Journal Article] Essential role for CD30-Transglutaminase 2 axis in memory Th1 and Th17 cell generation.2020
- Author(s)
  Suzuki Akane S.、Yagi Ryoji、Kimura Motoko Y.、Iwamura Chiaki、Shinoda Kenta、Onodera Atsushi、Hirahara Kiyoshi、Tumes Damon J.、Koyama-Nasu Ryo、Iismaa Siiri E.、Graham Robert M.、Motohashi Shinichiro、Nakayama Toshinori
- Journal Title
  
  Front. Immunol.
  
  Volume: 11 Pages: 1536-1536
- DOI
  10.3389/fimmu.2020.01536
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08769, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-20K21537, KAKENHI-PUBLICLY-19H04800, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-18H02892, KAKENHI-PROJECT-20H03464, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-18K07164, KAKENHI-PROJECT-18K07257, KAKENHI-PROJECT-19K23838
[Journal Article] Activated invariant natural killer T cells directly recognize leukemia cells in a CD1d-independent manner.2020
- Author(s)
  Aoki Takahiro、Takami Mariko、Takatani Tomozumi、Motoyoshi Kiwamu、Ishii Ayana、Hara Ayaka、Toyoda Takahide、Okada Reona、Hino Moeko、Koyama‐Nasu Ryo、Kiuchi Masahiro、Hirahara Kiyoshi、Kimura Motoko Y.、Nakayama Toshinori、Shimojo Naoki、Motohashi Shinichiro
- Journal Title
  
  Cancer Sci.
  
  Volume: 111 Pages: 2223-2233
- DOI
  10.1111/cas.14428
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07652, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-20K21537, KAKENHI-PUBLICLY-19H04800, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-18H02892, KAKENHI-PROJECT-20H03464, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-18K07257, KAKENHI-PROJECT-19K18379
[Journal Article] 肺の組織線維化をひき起こす新たな細胞集団の同定2020
- Author(s)
  青木亜美、平原潔、中山俊憲
- Journal Title
  
  臨床免疫・アレルギ－科
  
  Volume: 73(6) Pages: 652-657
- NAID
  40022265221
- Data Source
  KAKENHI-PROJECT-20H03685
[Journal Article] 記憶型病原性Th2細胞とアレルギー -好酸球浸潤から線維化反応まで-2020
- Author(s)
  平原潔、中山俊憲
- Journal Title
  
  あたらしい眼科
  
  Volume: 37(4) Pages: 435-442
- Data Source
  KAKENHI-PROJECT-20H03685
[Journal Article] 繊維化を誘導するCD4+組織常在性記憶T細胞のエピジェネティクス2020
- Author(s)
  平原潔、木内政宏、中山俊憲
- Journal Title
  
  医学のあゆみ
  
  Volume: 275(1) Pages: 133-137
- Data Source
  KAKENHI-PROJECT-20H03685
[Journal Article] Pathogenicity of Acquired Immunity in Human Diseases2019
- Author(s)
  Hirahara, K.
- Journal Title
  
  Semin. Immunopathol.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08876
[Journal Article] Immune cell-epithelial/mesenchymal interaction contributing to allergic airway inflammation associated pathology2019
- Author(s)
  Hirahara, K., Shinoda, K., Morimoto, Y., Kiuchi, M., Aoki, A., Kumagai, J., Kokubo, K., and Nakayama, T.
- Journal Title
  
  Front. Immunol
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08876
[Journal Article] An optimized protocol for the analysis of house dust mite (Dermatophagoides farinae)-induced neutrophil-dominant airway inflammation2019
- Author(s)
  Wada, T., Hirahara, K., Aoki, A., Morimoto, Y., Kiuchi, M., Kumagai, J., Okano, M., Kokubo, K., Kato, M., Fukano, C., Ohashi-Doi, K., and Nakayama, T.
- Journal Title
  
  Journal of Immunological Methods
  
  Volume: 465 Pages: 53-60
- DOI
  10.1016/j.jim.2018.12.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08876, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-20K20383
[Journal Article] Pathogenicity of acquired immunity in human diseases2019
- Author(s)
  Hirahara, K
- Journal Title
  
  Seminars in Immunopathology
  
  Volume: 41 Pages: 279-281
- DOI
  10.1007/s00281-019-00739-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08876
[Journal Article] The immunopathology of lung fibrosis: Amphiregulin-producing pathogenic memory T helper-2 cells control the airway fibrotic responses by inducing eosinophils to secrete osteopntin2019
- Author(s)
  Hirahara, K., Aoki, A., Morimoto, Y., Kiuchi, M., Okano, M., and Nakayama, T.
- Journal Title
  
  Semin. Immunopathol.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08876
[Journal Article] アレルギ－性気道炎症の病態形成におけるPathogenic Th2細胞の多様な役割2019
- Author(s)
  青木亜美, 平原潔, 中山俊憲
- Journal Title
  
  実験医学増刊
  
  Volume: 37(10) Pages: 49-54
- Data Source
  KAKENHI-PROJECT-17K08876
[Journal Article] CD103hi Treg cells constrain lung fibrosis induced by CD103low tissue-resident pathogenic CD4 T cells.2019
- Author(s)
  Ichikawa, T.*, Hirahara, K.*, Kokubo, K.*, Kiuchi, M., Aoki, A., Morimoto, Y., Kumagai, J., Onodera, A., Mato, N., Tumes, D., Goto, Y., Hagiwara, K., Inagaki, Y., Sparwasser, T., Tobe, K., and Nakayama, T.
- Journal Title
  
  Nat Immunol
  
  Volume: 20 Pages: 1469-1480
- DOI
  10.1038/s41590-019-0494-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07164, KAKENHI-PROJECT-19K22627, KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-17H04166, KAKENHI-PROJECT-19H03465, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-17K08876
[Journal Article] Induction and regulation of mucosal memory T cell response.2019
- Author(s)
  Hirahara, K, Aoki, A, Morimoto, Y, Kiuchi, M, Okano, M, Nakayama, T
- Journal Title
  
  Semin Immunopathol.
  
  Volume: 41(3) Pages: 339-348
- DOI
  10.1007/s00281-019-00735-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-17K08876
[Journal Article] 【新時代が始まった-アレルギー疾患研究疾患多様性を理解し病態の層別化に基づく治療を実現する】(第1章)アレルギーのメカニズム研究免疫細胞とサイトカインなどアレルギー性気道炎症の病態形成におけるPathogenic Th2細胞の多様な役割2019
- Author(s)
  青木亜美, 平原潔, 中山俊憲
- Journal Title
  
  実験医学
  
  Volume: 37(10) Pages: 1561-1566
- Data Source
  KAKENHI-PROJECT-17K08876
[Journal Article] Ezh2 controls development of natural killer T cells that cause spontaneous asthma-like pathology2019
- Author(s)
  Tumes, D., Hirahara, K., Papadopoulos, M., Shinoda, K., Onodera, A., Kumagai, J., Yip, KH., Pant, H., Kokubo, K., Masahiro, K., Aoki, A., Obata-Ninomiya, K., Yokoyoda, K., Endo, Y., Kimura, MY., Nakayama, T.
- Journal Title
  
  J. Allergy Clin. Immunol.
  
  Volume: 0091-6749(19) Pages: 549-560
- DOI
  10.1016/j.jaci.2019.02.024
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08876, KAKENHI-PROJECT-18K07164, KAKENHI-PROJECT-18K19466, KAKENHI-PUBLICLY-17H05787, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-20K20383, KAKENHI-PUBLICLY-18H04665, KAKENHI-PUBLICLY-19H04800, KAKENHI-PROJECT-19H05650
[Journal Article] 専門医のためのアレルギー学講座免疫学における基礎と新たな展開病原性Th細胞2019
- Author(s)
  森本侑樹, 平原潔, 中山俊憲
- Journal Title
  
  アレルギー
  
  Volume: 68(3) Pages: 138-143
- Data Source
  KAKENHI-PROJECT-17K08876
[Journal Article] 各種サイトカインで誘導される2型免疫応答による組織線維化のしくみ2019
- Author(s)
  平原潔, 中山俊憲
- Journal Title
  
  医学のあゆみ
  
  Volume: 271(5) Pages: 486-490
- Data Source
  KAKENHI-PROJECT-17K08876
[Journal Article] DUSP10 constrains innate IL-33-mediated cytokine production in ST2(hi) memory-type pathogenic Th2 cells.2018
- Author(s)
  Yamamoto, T., Endo, Y., Onodera, A., Hirahara, K., Asou, H., Nakajima, T., Kanno, T., Ouchi, Y., Uematsu, S., Nishimasu, H., Nureki, O., Tumes, D. J., Shimojo, N., and Nakayama, T.
- Journal Title
  
  Nat Commun
  
  Volume: 9 Pages: 4231-4231
- DOI
  10.1038/s41467-018-06468-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08876, KAKENHI-PROJECT-18K07164, KAKENHI-PUBLICLY-18H04665, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-17H04257, KAKENHI-PROJECT-18H02571, KAKENHI-PROJECT-16H06224, KAKENHI-PROJECT-17K19543, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-17K07212, KAKENHI-PROJECT-17KK0189
[Journal Article] Amphiregulin-Producing Pathogenic Memory T Helper 2 Cells Instruct Eosinophils to Secrete Osteopontin and Facilitate Airway Fibrosis2018
- Author(s)
  Morimoto, Y., Hirahara, K., Kiuchi, M., Wada, T., Ichikawa, T., Kanno, T., Okano, M., Kokubo, K., Onodera, A., Sakurai, D., Okamoto, Y., Nakayama, T.
- Journal Title
  
  Immunity
  
  Volume: 49 Pages: 134-150
- DOI
  10.1016/j.immuni.2018.04.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08876, KAKENHI-PROJECT-18K07164, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-18K16830, KAKENHI-PROJECT-20K20383
[Journal Article] CXCR6+ST2+ memory Th2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth2018
- Author(s)
  Obata-Ninomiya, K., Ishiwata, K., Nakano, H., Endo, Y., Ichikawa, T., Onodera, A., Hirahara, K., Okamoto, Y., Kanuka, H., Nakayama, T.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 115
- DOI
  10.1073/pnas.1714731115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08876, KAKENHI-PROJECT-18K07164, KAKENHI-PUBLICLY-18H04665, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-16H06224, KAKENHI-PROJECT-20K20383
[Journal Article] Pathogenicity of memory Th2 cells is linked to stage of allergic rhinitis2018
- Author(s)
  Iinuma T.、Okamoto Y.、Morimoto Y.、Arai T.、Sakurai T.、Yonekura S.、Sakurai D.、Hirahara K.、Nakayama T.
- Journal Title
  
  Allergy
  
  Volume: 73 Pages: 479-489
- DOI
  10.1111/all.13295
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08876, KAKENHI-PROJECT-16H05483
[Journal Article] The pathogenicity of IL-33 on steroid-resistant eosinophilic inflammation via the activation of memory-type ST2+CD4+ T cells2018
- Author(s)
  Hirahara K, Mato N, Hagiwara K, Nakayama T.
- Journal Title
  
  J Leukoc Biol.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08876
[Journal Article] The pathogenicity of IL-33 on steroid-resistant eosinophilic inflammation via the activation of memory-type ST2+CD4+ T cells2018
- Author(s)
  Hirahara K*, Mato N*, Hagiwara K, Nakayama T. (*: These authors are equally contributed.)
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: 104 Pages: 895-901
- DOI
  10.1002/jlb.mr1117-456r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08152, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-20K20383
[Journal Article] A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis2018
- Author(s)
  Goschl L, Preglej T, Hamminger P, Bonelli M, Andersen L, Boucherron N, Gulich A, Muller L, Saferding V, Mufazolov AI, Hirahara K, Seiser C, Matthias P, Penz T, Schuster M, Bock C, Waisman A, Steiner G, Ellmeier W.
- Journal Title
  
  J Autoimmun
  
  Volume: 86 Pages: 51-61
- DOI
  10.1016/j.jaut.2017.09.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08876
[Journal Article] Maintenance of memory-type pathogenic Th2 cells in the pathophysiology of chronic airway inflammation2018
- Author(s)
  Hirahara K, Shinoda K, Endo Y, Ichikawa T, Nakayama T.
- Journal Title
  
  Inflammation and Regeneration 2018
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08876
[Journal Article] Anti-tumor immunity via the superoxide-eosinophil axis induced by a lipophilic component of Mycobacterium lipomannan2017
- Author(s)
  Ito Toshihiro、Hirahara Kiyoshi、Onodera Atsushi、Koyama-Nasu Ryo、Yano Ikuya、Nakayama Toshinori
- Journal Title
  
  Int Immunol.
  
  Volume: 29 Pages: 411-421
- DOI
  10.1093/intimm/dxx051
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08876, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-15K06838, KAKENHI-PROJECT-15K08522
[Journal Article] Menin Controls the Memory Th2 Cell Function by Maintaining the Epigenetic Integrity of Th2 Cells2017
- Author(s)
  Onodera Atsushi、Kiuchi Masahiro、Kokubo Kota、Kato Miki、Ogino Tomohiro、Horiuchi Shu、Kanai Urara、Hirahara Kiyoshi、Nakayama Toshinori
- Journal Title
  
  J. Immunol.
  
  Volume: 199 Pages: 1153-1162
- DOI
  10.4049/jimmunol.1602129
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08876, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-15K08522
[Journal Article] Maintenance of pathogenic Th2 cells in allergic disorders2017
- Author(s)
  Shinoda K, Hirahara K, Nakayama T.
- Journal Title
  
  Allergology International
  
  Volume: 66 Issue: 3 Pages: 369-376
- DOI
  10.1016/j.alit.2017.03.005
- NAID
  130005858825
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08876, KAKENHI-PROJECT-26221305
[Journal Article] Th2 Cells in Health and Disease2017
- Author(s)
  Nakayama T, Hirahara K, Onodera A, Endo Y, Hosokawa H, Shinoda K, Tumes DJ, Okamoto Y.
- Journal Title
  
  Annu. Rev. Immunol.
  
  Volume: 35 Pages: 53-84
- DOI
  10.1146/annurev-immunol-051116-052350
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05483, KAKENHI-PROJECT-17K08876, KAKENHI-PUBLICLY-16H01352, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-16H06224, KAKENHI-PROJECT-15K08522
[Journal Article] Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma2017
- Author(s)
  Tumes Damon J.、Papadopoulos Magdalene、Endo Yusuke、Onodera Atsushi、Hirahara Kiyoshi、Nakayama Toshinori
- Journal Title
  
  Immunol.Rev.
  
  Volume: 278 Pages: 8-19
- DOI
  10.1111/imr.12560
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08876, KAKENHI-PUBLICLY-16H01352, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-16H06224, KAKENHI-PROJECT-15K08522
[Journal Article] The Transcription Factor T-bet Limits Amplification of Type I IFN Transcriptome and Circuitry in T Helper 1 Cells2017
- Author(s)
  Iwata Shigeru、Mikami Yohei、Sun Hong-Wei、Brooks Stephen R.、Jankovic Dragana、Hirahara Kiyoshi、Onodera Atsushi、Shih Han-Yu、Kawabe Takeshi、Jiang Kan、Nakayama Toshinori、Sher Alan、O’Shea John J.、Davis Fred P.、Kanno Yuka
- Journal Title
  
  Immunity
  
  Volume: 46
- DOI
  10.1016/j.immuni.2017.05.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08876, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-15K08522
[Journal Article] Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia2017
- Author(s)
  Mato Naoko、Hirahara Kiyoshi、Ichikawa Tomomi、Kumagai Jin、Nakayama Masayuki、Yamasawa Hideaki、Bando Masashi、Hagiwara Koichi、Sugiyama Yukihiko、Nakayama Toshinori
- Journal Title
  
  Sci. Rep.
  
  Volume: 7 Pages: 6805-6805
- DOI
  10.1038/s41598-017-06962-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08876, KAKENHI-PROJECT-26221305
[Journal Article] The Interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway.2015
- Author(s)
  Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K, Nakae, S., Saito, H., Okamoto, Y., and Nakayama, T.
- Journal Title
  
  Immunity
  
  Volume: 42(2) Pages: 294-308
- DOI
  10.1016/j.immuni.2015.01.016
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-24591475, KAKENHI-PROJECT-25893032, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-26870172
[Journal Article] Interleukin-25 and mucosal T cells in noneosinophilic and eosinophilic chronic rhinosinusitis.2015
- Author(s)
  Iinuma T, Okamoto Y, Yamamoto H, Inamine-Sasaki A, Ohki Y, Sakurai T, Funakoshi U, Yonekura S, Sakurai D, Hirahara K, Nakayama T
- Journal Title
  
  Ann. Allergy Asthma Immunol.
  
  Volume: 114 Pages: 289-298
- DOI
  10.1016/j.anai.2015.01.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25893032, KAKENHI-PROJECT-26221305
[Journal Article] A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.2014
- Author(s)
  Steward-Tharp SM, Laurence A, Kanno Y, Kotlyar A, Villarino AV, Sciume G, Kuchen S, Resch W, Wohlfert E, Jiang K, Hirahara K, Vahedi G, Sun HW, Feigenbaum L, Milner JD, Holland SM, Casellas R, Powrie F, and O'Shea JJ
- Journal Title
  
  Blood
  
  Volume: 印刷中 Pages: 2978-2987
- DOI
  10.1182/blood-2013-09-523167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25893032
[Journal Article] Pathogenic memory type Th2 cells in allergic inflammation.2014
- Author(s)
  Endo, Y., Hirahara, K., Yagi, R., Tumes, D. J., and Nakayama, T.
- Journal Title
  
  Trends Immunol.
  
  Volume: 35(2) Pages: 69-78
- DOI
  10.1016/j.it.2013.11.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790461, KAKENHI-PROJECT-25893032, KAKENHI-PROJECT-25893033
[Journal Article] Th2細胞分化制御の新知見とアレルギー発症の新概念2014
- Author(s)
  平原潔、中山俊憲
- Journal Title
  
  実験医学増刊
  
  Volume: 32 Pages: 70-74
- Data Source
  KAKENHI-PROJECT-25893032
[Journal Article] Helper T Cell Plasticity: Impact of Extrinsic and Intrinsic Signals on Transcriptomes and Epigenomes.2014
- Author(s)
  Mizuno S, Mikami Y, Kamada N, Handa T, Hayashi A, Sato T, Matsuoka K, Matano M, Ohta Y, Sugita A, Koganei K, Sahara R, Takazoe M, Hisamatsu T, Kanai T
- Journal Title
  
  Curr Top Microbiol Immunol.
  
  Volume: 20 Pages: 1426-1434
- DOI
  10.1007/82_2014_371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J05920, KAKENHI-PROJECT-25893032
[Journal Article] エピジェネティクス(Epigenetics)と呼吸器疾患2014
- Author(s)
  平原潔、中山俊憲
- Journal Title
  
  Respiratory Medical Research
  
  Volume: 2 Pages: 63-65
- Data Source
  KAKENHI-PROJECT-25893032
[Journal Article] Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells.2014
- Author(s)
  Watanabe, Y., Onodera, A., Kanai, U., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kiuchi, M., Iwamura, C., Tumes, DJ., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K. and Nakayama, T.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 111(35) Pages: 12829-12834
- DOI
  10.1073/pnas.1321245111
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-25860351, KAKENHI-PROJECT-25860352, KAKENHI-PROJECT-25893032, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-26870172
[Journal Article] Type I IFN Induces Binding of STAT1 to Bcl6: Divergent Roles of STAT Family Transcription Factors in the T Follicular Helper Cell Genetic Program.2014
- Author(s)
  Nakayamada S, Poholek AC, Lu KT, Takahashi H, Kato M, Iwata S, Hirahara K, Cannons JL, Schwartzberg PL, Vahedi G, Sun HW, Kanno Y, O'Shea JJ.
- Journal Title
  
  J Immunol.
  
  Volume: 192 Pages: 2156-2166
- DOI
  10.4049/jimmunol.1300675
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25893032
[Journal Article] Transcriptional and epigenetic networks of helper T and innate lymphoid cells.2014
- Author(s)
  Shih HY, Sciumè G, Poholek A, Vahedi G, Hirahara K, Villarino AV, Bonelli M, Bosselut R, Kanno Y, Muljo SA, O'Shea JJ
- Journal Title
  
  Immunol Rev.
  
  Volume: 261 Pages: 23-49
- DOI
  10.1111/imr.12208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25893032
[Journal Article] Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.2013
- Author(s)
  Hosokawa H, Tanaka T, Kato M, Tohyama H, Hanazawa A, Tamaki Y, Hirahara K, Sakikawa I, Morita A, Nagira M, Suzuki Y, Nakayama T.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 110(46) Pages: 18626-18631
- DOI
  10.1073/pnas.1311100110
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24116506, KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-24390239, KAKENHI-PROJECT-24592083, KAKENHI-PROJECT-25670438, KAKENHI-PROJECT-25860352, KAKENHI-PROJECT-25893032, KAKENHI-PROJECT-25893033
[Patent] IL-33関連疾患の予防又は治療剤2019
- Inventor(s)
  中山俊憲, 熊谷仁, 平原潔, 木内政宏
- Industrial Property Rights Holder
  国立大学法人千葉大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-057333
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17K08876
[Patent] 細胞外基質の産生抑制剤及びその使用2018
- Inventor(s)
  森本侑樹、中山俊憲、岡本美孝、平原潔
- Industrial Property Rights Holder
  国立大学法人　千葉大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K08876
[Patent] 細胞外基質の産生抑制剤及びその使用2017
- Inventor(s)
  森本侑樹、中山俊憲、岡本美孝、平原潔
- Industrial Property Rights Holder
  千葉大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-176017
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] 慢性アレルギー性結膜炎におけるIL-33-ST2-CGRP経路を介した記憶型Th2細胞の役割2021
- Author(s)
  横山美樹子、尾上美樹、木内政宏、平原潔、池原譲、海老原伸行、中山俊憲
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-20H03685
[Presentation] 病原性ヘルパー細胞によるアレルギー性炎症の難治性病態形成機構について2021
- Author(s)
  平原潔、中山俊憲
- Organizer
  第70回日本アレルギー学会学術大会
- Invited
- Data Source
  KAKENHI-PLANNED-21H05121
[Presentation] 病原性Th2細胞による難治性アレルギー性気道炎症の病態制御2021
- Author(s)
  中山俊憲、市川智巳、小久保幸太、木内政宏、青木亜美、平原潔
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-20H03685
[Presentation] 病原性Th2細胞による難治性アレルギー性気道炎症の病態制御2021
- Author(s)
  中山俊憲、市川智巳、小久保幸太、木内政宏、青木亜美、平原潔
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-ORGANIZER-21H05120
[Presentation] ベンラリズマブによる好酸球性炎症組織局所での抗体依存性細胞傷害活性についての検討2021
- Author(s)
  青木亜美、辻香織、小久保幸太、木内政宏、平原潔、中山俊憲
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-20H03685
[Presentation] 慢性アレルギー性結膜炎におけるIL-33-ST2-CGRP経路を介した記憶型Th2細胞の役割2021
- Author(s)
  横山美樹子、尾上美樹、木内政宏、平原潔、池原譲、海老原伸行、中山俊憲
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PLANNED-21H05121
[Presentation] 病原性Th2細胞による難治性アレルギー性気道炎症の病態制御2021
- Author(s)
  中山俊憲、市川智巳、小久保幸太、木内政宏、青木亜美、平原潔
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PLANNED-21H05121
[Presentation] ベンラリズマブによる好酸球性炎症組織局所での抗体依存性細胞傷害活性についての検討2021
- Author(s)
  青木亜美、辻香織、小久保幸太、木内政宏、平原潔、中山俊憲
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PLANNED-21H05121
[Presentation] ベンラリズマブによる好酸球性炎症組織局所での抗体依存性細胞傷害活性についての検討2021
- Author(s)
  青木亜美、辻香織、小久保幸太、木内政宏、平原潔、中山俊憲
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-ORGANIZER-21H05120
[Presentation] 病原性ヘルパー細胞によるアレルギー性炎症の難治性病態形成機構について2021
- Author(s)
  平原潔、中山俊憲
- Organizer
  第70回日本アレルギー学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03685
[Presentation] 慢性アレルギー性結膜炎におけるIL-33-ST2-CGRP経路を介した記憶型Th2細胞の役割2021
- Author(s)
  横山美樹子、尾上美樹、木内政宏、平原潔、池原譲、海老原伸行、中山俊憲
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-ORGANIZER-21H05120
[Presentation] ー性炎症の難治性病態形成機構について2021
- Author(s)
  平原潔、中山俊憲
- Organizer
  第70回日本アレルギー学会学術大会
- Invited
- Data Source
  KAKENHI-ORGANIZER-21H05120
[Presentation] アレルギー炎症に伴う線維化に対する新規治療法開発2020
- Author(s)
  平原潔、小野寺淳、飯沼智久、間藤尚子
- Organizer
  難治性疾患実用化研究事業免疫アレルギー疾患実用化研究事業 2019年度合同成果報告会
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] 線維化誘導-病原性ヘルパーT細胞が誘導する組織線維化の形成機構について2020
- Author(s)
  平原潔
- Organizer
  第60回日本呼吸器学会学術講演会,若手シンポジウム：呼吸器疾患の克服に向けて -肺線維化研究の新展開-
- Invited
- Data Source
  KAKENHI-PROJECT-20H03685
[Presentation] 線維化誘導-病原性ヘルパーT細胞による肺線維化の病態形成機構2020
- Author(s)
  平原潔
- Organizer
  第64回日本リウマチ学会総会・学術講演会,シンポジウム16「Advances in research on autoimmune diseases」ウェブ開催
- Invited
- Data Source
  KAKENHI-PROJECT-20H03685
[Presentation] 重症喘息におけるリモデリングを科学する～アンフィレグリン、オステオポンチン～2020
- Author(s)
  平原潔
- Organizer
  Scientific Exchange Meeting in Mie, Zoomによるオンライン講演会,
- Data Source
  KAKENHI-PROJECT-20H03685
[Presentation] 肺線維化の病態形成におけるCD4陽性T細胞を起点とした新たな「細胞-分子機構」2020
- Author(s)
  平原潔
- Organizer
  第7回T-cell seminar, 山の上ホテル（東京）
- Data Source
  KAKENHI-PROJECT-20H03685
[Presentation] 重症喘息における線維化病態を反映する新たなバイオマーカーの可能性～アンフィレグリン、オステオポンチン～2020
- Author(s)
  平原潔
- Organizer
  Biomarker Scientific Exchange Meeting 2021, Zoomによるオンライン講演会
- Data Source
  KAKENHI-PROJECT-20H03685
[Presentation] 病原性CD4 T細胞による肺線維化の分子・細胞機構 -好酸球から真菌まで-2020
- Author(s)
  平原潔
- Organizer
  第9回神奈川気道炎症病態研究会 TKPガーデンシティ横浜（神奈川）
- Data Source
  KAKENHI-PROJECT-20H03685
[Presentation] 好酸球性気道炎症において線維化誘導-病原性ヘルパーT細胞が誘導する組織線維化の形成機構について2019
- Author(s)
  平原潔
- Organizer
  第12回次世代アジュバント研究会
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] 病原性Th2細胞による喘息の発症と炎症遷延化の最新知見2019
- Author(s)
  平原潔
- Organizer
  Scientific Exchange Meeting in 栃木　～アレルギー週間 2019～
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] Tissue remodeling fibrosis in mucosal sites of the airway2019
- Author(s)
  Hirahara, K.
- Organizer
  The 3nd Chiba University-UC San Diego Symposium “Mucosal Immunology, Allergy and Vaccine”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] CD103hi Treg cells regulate lung fibrotic response induced by CD103lo tissue-resident pathogenic CD4 T cells.2019
- Author(s)
  Hirahara, K
- Organizer
  2019 NIH-Japan-JSPS symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] Cellular and molecular mechanisms underlying the induction of fibrotic responses in the lung.2019
- Author(s)
  Hirahara, K
- Organizer
  The 1st Chiba University-University Toronto Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] CD103hi Treg cells regulate lung fibrotic response induced by CD103lo tissue-resident pathogenic CD4 T cells.2019
- Author(s)
  Hirahara, K, Ichikawa, T, Kokubo, K, Kiuchi, M, Aoki, A, Morimoto, Y, Kumagai, J, Nakayama, T
- Organizer
  The 7th Annual Meeting of the International Cytokine and Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] 好酸球性アレルギー炎症において組織線維化を引き起こす線維化誘導-病原性ヘルパーT細胞を標的とした新規線維化治療法開発2019
- Author(s)
  平原潔、小野寺淳、森本侑樹、間藤尚子
- Organizer
  東京国際フォーラム, 東京（ポスター発表）
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] Amphiregulin-producing pathogenic memory T helper-2 cells drive airway fibrosis via activation of eosinophils.2019
- Author(s)
  Hirahara, K, Morimoto, Y, Kiuchi, M, Okano, M, Kokubo, K, Nakayama, T
- Organizer
  Tissue Repair and Regeneration (Gordon Research Conference)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] 病原性ヘルパー細胞による慢性アレルギー性気道炎症の病態形成機構2019
- Author(s)
  平原潔
- Organizer
  第3回アレルギー治療updateフォーラム
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] 肺の線維化を誘導する新たな「細胞-分子機構」2019
- Author(s)
  平原潔
- Organizer
  Scientific Exchange Meeting in Osaka
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] Amphiregulin-producing pathogenic memory T helper-2 cells drive airway fibrosis via activation of eosinophils2018
- Author(s)
  Hirahara, K., Morimoto, Y., Kiuchi, M., Okano, M., Kokubo, K., Onodera, A., Sakurai, D., Okamoto, Y., Nakayama, T.
- Organizer
  The 6th Annual Meeting of the International Cytokine and Interferon Society (ICIS 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] Pathogenic Th population disease induction model: From the recruitment of eosinophils to the induction of fibrosis2018
- Author(s)
  Hirahara K
- Organizer
  The 2nd Chiba University-UC San Diego Symposium “Mucosal Immunology, Allergy and Vaccine”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] 好酸球性気道炎症において線維化誘導-病原性ヘルパーT細胞が誘導する組織線維化の形成機構について2018
- Author(s)
  平原潔、森本侑樹、木内政宏、和田朋子、市川智巳、岡野美樹子、小野寺淳、櫻井大樹、岡本美孝、中山俊憲
- Organizer
  第67回日本アレルギー学会,シンポジウム 16
- Invited
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] 線維化誘導-病原性ヘルパーT細胞によるイムノエイジング病態形成機構の解析と病態制御2018
- Author(s)
  平原潔
- Organizer
  老化メカニズムの解明・制御プロジェクト、AMED-CREST/PRIME「機能低下」合同リトリート会議
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] Orally-desensitized mast cells acquired regulatory characteristics for the control of food allergy2018
- Author(s)
  Kurashima, Y., Takasato, Y., Kiuchi, M., Hirahara, K., Murasaki, S., Kunisawa, J., Kubo, M., Uematsu, S., Nakayama, T., and Kiyono, H.
- Organizer
  第47回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] 気道粘膜免疫とアレルギー2018
- Author(s)
  平原潔
- Organizer
  第5回総合アレルギ－講習会～Total Allergistをめざして～
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] Pathogenic Th population disease induction model: From the recruitment of eosinophils to the induction of fibrosis2018
- Author(s)
  Hirahara, K., Morimoto, Y., Kiuchi, M., Okano, M., Kokubo, K., Ogino, T., and Nakayama, T.
- Organizer
  第47回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] Memory-type CD62LlowCD44hi ST2+CD4+ T cells contribute to the steroid-resistant pathology of eosinophilic pneumonia2018
- Author(s)
  Hirahara K, Mato N, Ichikawa T, Kumagai J, Nakayama M, Yamasawa H, Bando M, Hagiwara K, Sugiyama Y, Nakayama T
- Organizer
  Keystone Symposia Immunological Memory (X1)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] 線維化誘導-病原性ヘルパーT細胞が誘導する組織線維化の形成機構について2018
- Author(s)
  平原潔、森本侑樹、木内政宏、和田朋子、市川智巳、岡野美樹子、小野寺淳、櫻井大樹、岡本美孝、中山俊憲
- Organizer
  第46回日本臨床免疫学会,ワークショップ 6
- Invited
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] 病原性ヘルパーT細胞による慢性アレルギー性炎症の病態形成機構2018
- Author(s)
  平原潔
- Organizer
  第17回　お茶の水眼アレルギー研究会
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] 記憶型ヘルパーT細胞の多様性・可塑性: -慢性気道炎症における記憶型病原性Th2(Tpath2)細胞の役割-2017
- Author(s)
  平原潔, 小野寺淳, 森本侑樹, 間藤尚子
- Organizer
  Legend Seminar 2017
- Invited
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] 免疫記憶の最新知見: -記憶型T細胞の研究最前線2017
- Author(s)
  平原潔, 小野寺淳, 森本侑樹, 間藤尚子
- Organizer
  Legend Seminar 2017
- Invited
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia2017
- Author(s)
  Hirahara K, Mato N, Ichikawa T, Kumagai J, Nakayama M, Yamasawa H, Bando M, Hagiwara K, Sugiyama Y, Nakayama T.
- Organizer
  The 5th Annual Meeting of the International Cytokine and Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] 肺バリア障害における記憶型病原性Th2(Tpath2)細胞の役割2017
- Author(s)
  平原潔、中山俊憲
- Organizer
  第66回日本アレルギー学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08876
[Presentation] CD4 T細胞を介した免疫恒常性の制御およびその破綻による慢性真菌感染症について2014
- Author(s)
  平原　潔
- Organizer
  真菌医学研究センターMonthlyセミナー
- Place of Presentation
  千葉大学真菌医学研究センター(千葉県、千葉市）
- Year and Date
  2014-10-07
- Invited
- Data Source
  KAKENHI-PROJECT-25893032
[Presentation] Crucial roles for CD4+ helper T cells at the host defense mucosal barriers of the lung.2014
- Author(s)
  Hirahara K and Nakayama T
- Organizer
  第87回日本生化学大会
- Place of Presentation
  京都国際会館（京都府、京都市）
- Year and Date
  2014-10-15
- Invited
- Data Source
  KAKENHI-PROJECT-25893032
[Presentation] Asymmetry of STAT action to define specificity and redundancy of IL-27 and IL-6 signals.2014
- Author(s)
  Hirahara K, Wada T, Nakayama T, O’Shea JJ
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都国際会館（京都府、京都市）
- Year and Date
  2014-12-11
- Data Source
  KAKENHI-PROJECT-25893032
[Presentation] Asymmetry of STAT Action to Define Specificity and Redundancy of IL-27 and IL-6 Signals.2014
- Author(s)
  Hirahara K, Kanno Y , Nakayama T and O’Shea JJ
- Organizer
  The 2nd Symposium of International Immunological Memory and Vaccine Forum
- Place of Presentation
  La Jolla (USA)
- Year and Date
  2014-08-26
- Invited
- Data Source
  KAKENHI-PROJECT-25893032
[Presentation] アレルギー性炎症の病態形成における多様なヘルパーT細胞サブセットの役割2014
- Author(s)
  平原　潔
- Organizer
  第10回千葉小児感染・アレルギー懇話会
- Place of Presentation
  京成ホテルミラマーレ（千葉県、千葉市）
- Year and Date
  2014-11-20
- Invited
- Data Source
  KAKENHI-PROJECT-25893032
[Presentation] Asymmetry of STAT action to define specificity and redundancy of IL-27 and IL-6 signals.2014
- Author(s)
  Hirahara K, Nakayama T, Hunter C, Hollnad S, Kanno Y, O’Shea JJ
- Organizer
  Keystone Symposia Emerging Cytokine Networks(J3)
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-25893032
[Presentation] Bach2 represses effector Programmes to stabilize Treg-mediated immune homeostasis.2013
- Author(s)
  Hirahara K
- Organizer
  The 3rd CSI/JSI/KAI Joint Symposium on Immunology
- Place of Presentation
  Korea
- Invited
- Data Source
  KAKENHI-PROJECT-25893032
[Presentation] Anti-tumor effect of BCG-LM via the activation of eosinophils.2013
- Author(s)
  Ito T, Hirahara K, Yano I, Nakayama T
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25893032
[Presentation] Bach2 represses effector programs to stabilize Treg-mediated immune homeostasis.2013
- Author(s)
  Hirahara K
- Organizer
  第42回日本免疫学会総会学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-25893032

1. Mato Naoko (80406149)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 飯沼智久 (00748361)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 栗田惇也 (80867268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 新井郷子 (60422276)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 三上洋平 (80528662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ONODERA atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 24 results
7. NASU Ryo

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. ENDO yusuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 12 results
9. NAKAYAMA TOSHINORI

# of Collaborated Projects: 0 results

# of Collaborated Products: 32 results
10. KIUCHI masahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 14 results
11. MORIMOTO Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. IWAMURA Chiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. MOTOHASHI Shinichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
14. SHINODA Kenta

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
15. HOSOKAWA hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. INAGAKI Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. KIMURA motoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
18. 八木良二

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. 古関明彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 植松智

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. 大内靖夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 岡本美孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
23. 田中知明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 伊沢久未

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 倉島洋介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 北浦次郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 清野宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 武村直紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 青木亜美

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
30. 大保木啓介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 二宮一茂

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
32. 高見真理子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 原彩佳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 後藤義幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirahara Kiyoshi 平原 潔

KIYOSHI Hirahara 平原 潔

Research Projects

Research Products

Co-Researchers

シングルセル解析からつなげる舌下免疫療法の作用機序の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrated elucidation of inflammatory tissue-resilience and tissue damage-entropy;Creation of innovative science for resolution of inflammationArea Organizer

Area Organizer

Project Period (FY)

Research Category

炎症性組織レジリエンスと組織障害エントロピーの統合的理解と炎症収束学の創成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

炎症性組織レジリエンスの高次機能としての炎症記憶の制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

癌性胸膜炎における免疫チェックポイント阻害剤の治療予測系の確立と効果増強戦略

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

線維化誘導-病原性CD4+T細胞の制御機構の解明 -肺線維化疾患の病態の理解へ-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Contribution of ST2+CD4+ T cells in the mechanism of steroid-resistant asthma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of pathological regulation of tissue-resident memory CD4 T cells in lung fibosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Asymmetric action of STATs drive transcriptional outputs and cytokine specificity.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Induction and regulation of mucosal memory T cell response2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 免疫・アレルギー疾患イラストレイテッド2013

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Nematode ascarosides attenuate mammalian type 2 inflammatory responses2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Eosinophils: Cells known for over 140 years with broad and new functions2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The role of CD4+ resident memory T cells in local immunity in the mucosal tissue - Protection versus Pathology -2021

Author(s)

Hirahara Kiyoshi 平原潔

KIYOSHI Hirahara 平原潔