HIRANO IKUO 平野育生

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HIRANO Ikuo 平野育生

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Researcher Number	00708117
Other IDs
Affiliation (Current)	2025: 東北大学, 医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2021 – 2023: 東北大学, 医学系研究科, 講師 2016 – 2020: 東北大学, 医学系研究科, 助教 2019: 東北大学, 医学(系)研究科(研究院), 助教 2015: 東北大学, 大学院医学系研究科, 助教 2014 – 2015: 東北大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Drug development chemistry / Kidney internal medicine Except Principal Investigator Basic Section 52010:General internal medicine-related / Hematology / Laboratory medicine
Keywords	Principal Investigator GATA1 / Erythropoietin / erythropoiesis / GATA / Down syndrome / Leukemia / GATA1s / eosinophil / hematopoiesis / leukemia … More / EPO / differentiation / Erythropoiesis / Doping / GATA inhibitor / GATA2 / Anemia / 化合物スクリーニング / ハイスループットスクリーニング / erythropoietin / drug screening / ESA / Mitoxantrone / hypoxia / transgenic mouse / Kidney / 遺伝子発現制御 / 慢性腎臓病 / 慢性貧血モデル / 転写制御機構 / 腎性貧血 / 転写調節機構 / 低酸素ストレス / エリスロポエチン … More Except Principal Investigator 転写因子 / 白血病 / 純赤白血病 / 純席白血病 / ドライバー変異 / Ras変異 / GATA1 / 純赤白血病発 / 遺伝的素因 / 神経堤細胞 / 転写調節 / 赤血球 / 血液内科学 / 低酸素応答性 / 腎性貧血 / 赤血球造血 / エリスロポエチン / 遺伝子発現制御 / E2F / 癌 / 遺伝子 / がん / Rasシグナル / 遺伝子改変マウス / GATA転写因子 Less

Physiological function of GATA1 lacking the N-terminal trans-activating domain in ML-DS pathogenesisPrincipal Investigator
- Principal Investigator
  
  平野育生
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tohoku University
The effects of a candidate compound for hematopoiesis of that induces ectopic EPO gene expression via GATA inhibition.Principal Investigator
- Principal Investigator
  
  HIRANO IKUO
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Research Field
  
  Drug development chemistry
- Research Institution
  Tohoku University
Analysis of the regulation of early erythropoiesis by transcription factor GATA1 and erythropoietin signalPrincipal Investigator
- Principal Investigator
  
  Hirano Ikuo
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tohoku University
Modifiers for the Gata1.05 leukemogenesis.
- Principal Investigator
  
  Shimizu Ritsuko
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tohoku University
Development of novel erythropoiesis-stimulating agents that enhance erythropoietin gene expressionPrincipal Investigator
- Principal Investigator
  
  Hirano Ikuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tohoku University
Multistep leukemogenesis caused by imbalanced GATA1 function
- Principal Investigator
  
  Shimizu Ritsuko
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Tohoku University
Analysis of kidney-specific transcriptional regulation of Epo gene and establishment of mouse model of renal anemiaPrincipal Investigator
- Principal Investigator
  
  Hirano Ikuo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tohoku University
Regulation of Erythropoietin production and its roles on adult hematopoiesis
- Principal Investigator
  
  MINEGISHI Naoko
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tohoku University

All 2024 2022 2021 2019 2018 2017 2016 2015 2014 2013 2012

All Journal Article Presentation Book

[Book] 実験医学別冊『マウス表現型解析パーフェクトガイド』2016
- Author(s)
  平野育生、清水律子（分担執筆）
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-15H04759
[Journal Article] The abundance of the short GATA1 isoform affects megakaryocyte differentiation and leukemic predisposition in mice2024
- Author(s)
  Ishihara Daishi、Hasegawa Atsushi、Hirano Ikuo、Engel James Douglas、Yamamoto Masayuki、Shimizu Ritsuko
- Journal Title
  
  Experimental Hematology & Oncology
  
  Volume: 13 Issue: 1
- DOI
  10.1186/s40164-024-00492-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07826, KAKENHI-PROJECT-19KK0398
[Journal Article] Strain-dependent modifiers exacerbate familial leukemia caused by GATA1-deficiency2024
- Author(s)
  Hirano Ikuo、Abe Kanako、Engel James Douglas、Yamamoto Masayuki、Shimizu Ritsuko
- Journal Title
  
  Experimental Hematology & Oncology
  
  Volume: 13 Issue: 1
- DOI
  10.1186/s40164-024-00491-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07826, KAKENHI-PROJECT-19KK0398
[Journal Article] Heterozygous variants in GATA2 contribute to DCML deficiency in mice by disrupting tandem protein binding.2022
- Author(s)
  Hasegawa A, Hayasaka Y, Morita M, Takenaka Y, Hosaka Y, Hirano I, Yamamoto M, Shimizu R.
- Journal Title
  
  Commun Biol.
  
  Volume: - Issue: 1 Pages: 376-376
- DOI
  10.1038/s42003-022-03316-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03555, KAKENHI-PROJECT-21K08364, KAKENHI-PROJECT-19K07341
[Journal Article] Blockade of the interaction between BMP9 and endoglin on erythroid progenitors promotes erythropoiesis in mice.2021
- Author(s)
  Yamaguchi A, Hirano I, Narusawa S, Shimizu K, Ariyama H, Yamawaki K, Nagao K, Yamamoto M, Shimizu R
- Journal Title
  
  Gene Cell.
  
  Volume: 26 Pages: 782-797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03555
[Journal Article] GATA2 hypomorphism induces chronic myelomonocytic leukemia in mice2019
- Author(s)
  Harada Nobuhiko、Hasegawa Atsushi、Hirano Ikuo、Yamamoto Masayuki、Shimizu Ritsuko
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 4 Pages: 1183-1193
- DOI
  10.1111/cas.13959
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H02507, KAKENHI-PROJECT-19H03555
[Journal Article] Induction of erythropoietin gene expressing in epithelial cells by chemicals identified in GATA-inhibitor screening.2017
- Author(s)
  Kaneko H, Katoh T, Hirano I, Hasegawa A, Tsujita T, Yamamoto M, Shimizu R.
- Journal Title
  
  Gene Cells
  
  Volume: 22 Pages: 939-952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04759
[Journal Article] Renal Anemia Model Mouse Established by Transgenic Rescue with an Erythropoietin Gene Lacking Kidney-Specific Regulatory Elements2017
- Author(s)
  Hirano I, Suzuki N, Yamazaki S, Sekine H, Minegishi N, Shimizu R, Yamamoto M.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 37 Issue: 4
- DOI
  10.1128/mcb.00451-16
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-26860625, KAKENHI-PROJECT-15K09464, KAKENHI-PROJECT-17K19680
[Journal Article] Renal Anemia Model Mouse Established by Transgenic Rescue with Erythropoietin Gene Lacking Kidney-specific Regulatory Elements.2017
- Author(s)
  Hirano I, Suzuki N, Yamazaki S, Sekine H, Minegishi N, Shimizu R and Yamamoto M
- Journal Title
  
  Mol Cell Biol
  
  Volume: 37
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04759
[Journal Article] Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling2016
- Author(s)
  Tomokazu Souma, Masahiro Nezu, Daisuke Nakano, Shun Yamazaki, Ikuo Hirano, Hiroki Sekine, Takashi Dan, Kotaro Takeda, Guo-Hua Fong, Akira Nishiyama, Sadayoshi Ito, Toshio Miyata, Masayuki Yamamoto, Norio Suzuki
- Journal Title
  
  Journal of the american society of nephlorogy
  
  Volume: 27 Issue: 2 Pages: 428-438
- DOI
  10.1681/asn.2014121184
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860625, KAKENHI-PLANNED-26111002, KAKENHI-PUBLICLY-26116702, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-25670157, KAKENHI-PROJECT-26860623
[Journal Article] Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.2015
- Author(s)
  Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, Kawaguchi S, Takeda N, Takeda K, Fong GH, Dan T, Ichinose M, Miyata T, Yamamoto M, Suzuki N.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 35 Issue: 15 Pages: 2658-2672
- DOI
  10.1128/mcb.00161-15
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860623, KAKENHI-PROJECT-26860625, KAKENHI-PLANNED-26111002, KAKENHI-PLANNED-26111003, KAKENHI-PUBLICLY-26116702, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-25461113, KAKENHI-PROJECT-25670157
[Journal Article] Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis2013
- Author(s)
  Suzuki N, Hirano I, Pan X, Minegishi N, Yamamoto M
- Journal Title
  
  Nature Commun
  
  Volume: 4 Issue: 1 Pages: 2902-2902
- DOI
  10.1038/ncomms3902
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24116502, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24591404, KAKENHI-PROJECT-25670157
[Journal Article] Plasticity of renal erythropoietin-producing cells governs fibrosis2013
- Author(s)
  Souma T, Yamazaki S, Moriguchi T, Suzuki N, Hirano I, Pan X, Minegishi N, Abe M, Kiyomoto H, Ito S, Yamamoto M
- Journal Title
  
  J Am Soc Nephrol
  
  Volume: 24 Issue: 10 Pages: 1599-1616
- DOI
  10.1681/asn.2013010030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-24116502, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24591187, KAKENHI-PROJECT-24591404, KAKENHI-PROJECT-25462533, KAKENHI-PROJECT-25670157
[Journal Article] A mouse model of adult-onset anaemia due to erythropoietin deficiency2013
- Author(s)
  Yamazaki S, Souma T, Hirano I, Pan X, Minegishi N, Suzuki N, Yamamoto M
- Journal Title
  
  Nature Communications
  
  Volume: 4 Issue: 1 Pages: 1950-1950
- DOI
  10.1038/ncomms2950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J07924, KAKENHI-PUBLICLY-24116502, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24591404, KAKENHI-PROJECT-25670157
[Presentation] 転写因子GATA1による初期赤血球分化制御機構の解析2022
- Author(s)
  平野育生、Lin Zhang、西羽美、木下賢吾、山本雅之、清水律子.
- Organizer
  日本生化学会東北支部第88回例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-19H03555
[Presentation] ATA1発現異常によるAML発症マウスモデルの白血病発症機序の解析2022
- Author(s)
  平野育生、Jia Yao、成澤志保、清水律子
- Organizer
  第26回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-20K17392
[Presentation] A Novel murine model for study on GATA1 functions in multi-step megakaryopoiesis.2022
- Author(s)
  姚佳、平野育生、成澤志保、葉祉其、鈴木未来子、清水律子
- Organizer
  日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03555
[Presentation] GATA1発現AML発症マウスモデルの白血病発症機序の解析2022
- Author(s)
  平野育生、Jia Yao、成澤志保、清水律子
- Organizer
  第26回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-19H03555
[Presentation] The functional analysis of GATA1S in megakaryopoiesis.2022
- Author(s)
  葉祉其、平野育生、姚佳、成澤志保、芦澤あや、清水律子
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03555
[Presentation] 赤白血病における転写因子GATA1の機能解析2022
- Author(s)
  成澤志保、平野育生、Jia Yao、Tsz Ki Yip、芦澤あや、清水律子.
- Organizer
  日本生化学会東北支部第88回例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-19H03555
[Presentation] 赤白血病における転写因子GATA1の機能解析2022
- Author(s)
  成澤志保、平野育生、Jia Yao、Tsz Ki Yip、芦澤あや、清水律子.
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03555
[Presentation] 低酸素非依存性のエリスロポエチン産生を異所的に誘導する化合物の探索2019
- Author(s)
  平野育生、長谷川敦史、金子寛、加藤剛英、山本雅之、清水律子
- Organizer
  第７回低酸素研究会学術集会
- Data Source
  KAKENHI-PROJECT-17K08361
[Presentation] マウス白血病発症モデルを用いた赤白血病発症に影響を与える遺伝的素因の探索2019
- Author(s)
  平野育生、田宮元、佐々木瞳、田高周、鈴木美野里、後藤あや、元池育子、木下賢吾、山本雅之、清水律子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03555
[Presentation] nalysis of mechanism of erythroblastic leukemia by GATA1 knockdown2019
- Author(s)
  garashi T, Hirano I, Sasaki H, Shimizu R
- Organizer
  2019th Tohoku University Thematic Forum for Creativity: Cancer -from Biology to Acceptance-: International symposium 2
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03555
[Presentation] 赤芽球性白血病発症機序における転写因子GATA1の役割2019
- Author(s)
  五十嵐友哉、平野育生、佐々木瞳、清水律子
- Organizer
  第85回日本生化学会東北支部例会
- Data Source
  KAKENHI-PROJECT-19H03555
[Presentation] DCML欠損症発症に関与する変異GATA2の分子機能解析2018
- Author(s)
  藤田優城、長谷川敦史、平野育生、清水律子
- Organizer
  第91回生化学会大会
- Data Source
  KAKENHI-PROJECT-15H04759
[Presentation] GATA2 hypomorph triggers chronic myelomonocytic leukemia in mice.2018
- Author(s)
  Shimizu R. Harada N, Hasegawa A, Hirano I, Yamamoto M.
- Organizer
  IUBMB Focused Meeting on GATA Transcription Factors.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04759
[Presentation] B細胞分化におけるGATA1転写因子の必要性2017
- Author(s)
  平野育生、櫻井悠香子、南良悟、及川圭、五十嵐友哉、山本雅之、清水律子.
- Organizer
  第90回日本生化学会大会第40回日本分子生物学会年会（同時開催）
- Data Source
  KAKENHI-PROJECT-15H04759
[Presentation] 腎性貧血の新規治療薬となる化合物の創出2017
- Author(s)
  加藤剛英、金子寛、平野育生、長谷川敦史、可野邦行、大澤宏祐、青木淳賢、土井隆行、山本雅之、清水律子
- Organizer
  日本生化学会東北支部第83回例会
- Data Source
  KAKENHI-PROJECT-17K08361
[Presentation] エリスロポエチン遺伝子制御領域の同定および同領域を利用した腎性貧血モデルマウスの樹立2016
- Author(s)
  平野育生、鈴木教郎、山崎瞬、清水律子、山本雅之
- Organizer
  酸素生物学・ダイイングコード合同若手会議
- Place of Presentation
  千葉県　長生郡　一宮シーサイドオーツカ
- Year and Date
  2016-01-26
- Data Source
  KAKENHI-PROJECT-26860625
[Presentation] 転写因子GATA1のB細胞分化における機能解析2016
- Author(s)
  櫻井悠香子, 平野育生, 山本雅之, 清水律子
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター、仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15H04759
[Presentation] Genetic modifiers in the GATA1-related leukemogenesis2016
- Author(s)
  Hirano I, Goto A, Engel J.D, Yamamo to M, Shimizu R
- Organizer
  20th Hemoglobin Switching Conference
- Place of Presentation
  Asiloma Conference Grounds, CA, USA
- Year and Date
  2016-09-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04759
[Presentation] 腎臓におけるエリスロポエチン遺伝子発現制御機構の解明2016
- Author(s)
  平野育生, 鈴木教郎, 清水律子, 山本雅之
- Organizer
  腎とエリスロポエチン研究会
- Place of Presentation
  品川プリンスホテル、東京
- Data Source
  KAKENHI-PROJECT-15H04759
[Presentation] 腎臓におけるエリスロポエチン遺伝子発現制御機構の解明2016
- Author(s)
  平野育生、鈴木教郎、清水律子、山本雅之
- Organizer
  第25回　腎とエリスロポエチン研究会
- Place of Presentation
  品川プリンスホテル（東京都港区）
- Data Source
  KAKENHI-PROJECT-26860625
[Presentation] マウスモデルを用いた白血病発症に関わる遺伝的素因の探索2016
- Author(s)
  平野育生, 鈴木美野里, 櫻井悠香子, 後藤あや, 山本雅之, 清水律子
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター、仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15H04759
[Presentation] エリスロポエチン遺伝子の腎特異的転写制御領域の解析と腎性貧血モデルマウスの樹立2015
- Author(s)
  平野育生、鈴木教郎、祢津昌広、関根弘樹、相馬友和、峯岸直子、清水律子、山本雅之
- Organizer
  日本分子生物学会・日本生化学会合同大会 2015 （BMB2015）
- Place of Presentation
  兵庫県　神戸市　神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26860625
[Presentation] エリスロポエチン遺伝子の腎特異的転写制御領域の解析と腎性貧血モデルマウスの樹立2015
- Author(s)
  平野育生, 鈴木教郎, 祢津昌広, 関根弘樹, 相馬友和, 峯岸直子, 清水律子, 山本雅之
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04759
[Presentation] エリスロポエチン産生制御機構の解析2014
- Author(s)
  平野育生、鈴木教郎、潘小青、小原直、峯岸直子、山本雅之、清水律子
- Organizer
  第２回低酸素研究会
- Place of Presentation
  東京都、新宿区、早稲田大学
- Year and Date
  2014-07-26
- Data Source
  KAKENHI-PROJECT-26860625
[Presentation] 胎仔期エリスロポエチン先生機構の解析2014
- Author(s)
  平野育生
- Organizer
  生化学会東北支部代８０回例会
- Place of Presentation
  秋田県、秋田市、アキタパークホテル
- Year and Date
  2014-05-10
- Invited
- Data Source
  KAKENHI-PROJECT-26860625
[Presentation] トランスジェニックマウスを利用したエリスロポエチン遺伝子エンハンサーの探索.2013
- Author(s)
  平野育生、鈴木教郎、山㟢瞬、峯岸直子、山本雅之、清水律子.
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド、兵庫
- Data Source
  KAKENHI-PROJECT-24591404
[Presentation] 神経堤細胞におけるエリスロポエチン遺伝子発現．2012
- Author(s)
  平野育生，鈴木教郎，潘小青，峯岸直子，山本雅之
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24591404

1. Shimizu Ritsuko (40226262)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
2. MINEGISHI Naoko (40271895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. SUZUKI Mikiko (80508309)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. SUZUKI Norio (20447254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. 長谷川敦史 (80747460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. SOUMA Tomokazu

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. YAMAZAKI Shun

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SEKINE Hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 山本雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

HIRANO IKUO 平野 育生

HIRANO Ikuo 平野 育生

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Physiological function of GATA1 lacking the N-terminal trans-activating domain in ML-DS pathogenesisPrincipal Investigator

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The effects of a candidate compound for hematopoiesis of that induces ectopic EPO gene expression via GATA inhibition.Principal Investigator

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Analysis of the regulation of early erythropoiesis by transcription factor GATA1 and erythropoietin signalPrincipal Investigator

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Modifiers for the Gata1.05 leukemogenesis.

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Development of novel erythropoiesis-stimulating agents that enhance erythropoietin gene expressionPrincipal Investigator

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Multistep leukemogenesis caused by imbalanced GATA1 function

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Analysis of kidney-specific transcriptional regulation of Epo gene and establishment of mouse model of renal anemiaPrincipal Investigator

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Regulation of Erythropoietin production and its roles on adult hematopoiesis

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[Book] 実験医学別冊『マウス表現型解析パーフェクトガイド』2016

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[Journal Article] The abundance of the short GATA1 isoform affects megakaryocyte differentiation and leukemic predisposition in mice2024

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[Journal Article] Strain-dependent modifiers exacerbate familial leukemia caused by GATA1-deficiency2024

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[Journal Article] Heterozygous variants in GATA2 contribute to DCML deficiency in mice by disrupting tandem protein binding.2022

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[Journal Article] Blockade of the interaction between BMP9 and endoglin on erythroid progenitors promotes erythropoiesis in mice.2021

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[Journal Article] GATA2 hypomorphism induces chronic myelomonocytic leukemia in mice2019

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HIRANO IKUO 平野育生

HIRANO Ikuo 平野育生