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FUJIMOTO Takashi  藤本 隆史

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… Alternative Names

藤本 隆史  フジモト タカシ

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Researcher Number 00712085
Other IDs
Affiliation (Current) 2025: 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員
Affiliation (based on the past Project Information) *help 2021 – 2023: 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員
2019 – 2020: 長崎大学, 医歯薬学総合研究科(医学系), 研究協力員
2017 – 2018: 長崎大学, 病院(医学系), 医員
Review Section/Research Field
Principal Investigator
Basic Section 56010:Neurosurgery-related
Except Principal Investigator
Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 56010:Neurosurgery-related / Neurosurgery
Keywords
Principal Investigator
スタチン / ペリサイト / in vitro model / アルツハイマー / 脳転移 / 血液脳関門
Except Principal Investigator
ドラッグリポジショニング / 血液脳関門 / drug repositioning / 初代培養細胞 … More / ぺリサイト / 脳虚血 / 血液脳関門モデル / 3次元モデル / 脳卒中 / がん / 中枢神経薬剤開発 / in vitro model / 治療薬 / 中枢神経疾患 / tight junction protein / brain / metastasis / pericyte / metastatic brain tumor / fasudil hydorochloride / blood brain barrier / 転移性脳腫瘍 / 脳梗塞 / アストロサイト / ペリサイト / サイトカイン / 脳血管内皮細胞 Less
  • Research Projects

    (4 results)
  • Research Products

    (34 results)
  • Co-Researchers

    (7 People)
  •  Development of a Perfusion-Based 3D Blood-Brain Barrier Model for Analysis of Cancer Brain Metastasis and PharmacokineticsPrincipal Investigator

    • Principal Investigator
      藤本 隆史
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Nagasaki University
  •  Drug development of central nervous system diseases using dynamic three-dimensional in vitro blood-brain barrier model

    • Principal Investigator
      諸藤 陽一
    • Project Period (FY)
      2020 – 2025
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 90:Biomedical engineering and related fields
    • Research Institution
      Nagasaki University
  •  Targeting Blood-Brain Barrier Protection to Develop Therapeutic Agents for Central Nervous System Diseases

    • Principal Investigator
      Izumo Tsuyoshi
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Nagasaki University
  •  Three dimensional blood-brain barrier model

    • Principal Investigator
      Morofuji Yoichi
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Nagasaki University

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book

  • [Book] Stem Cell Biology and Regenerative Medicine. Biology of Pericytes; Recent Advances: Role of Pericytes in Brain Metastasis2021

    • Author(s)
      Yoichi Morofuji (Corresponding author), Shinsuke Nakagawa, Takashi Fujimoto, Susumu Yamaguchi, Kenta Ujifuku, Takayuki Matsuo
    • Total Pages
      278
    • Publisher
      Springer Nature
    • Data Source
      KAKENHI-PROJECT-17K10840
  • [Book] Biology of Pericytes -Recent Advances2021

    • Author(s)
      Morofuji Y, Nakagawa S, Fujimoto T, Yamaguchi S, Ujifuku K, Matsuo T
    • Total Pages
      278
    • Publisher
      Springer Nature
    • Data Source
      KAKENHI-PROJECT-20KK0254
  • [Book] Biology of Pericytes; Recent Advances2021

    • Author(s)
      Morofuji Y, Nakagawa S, Fujimoto T, Yamaguchi S, Ujifuku K, Matsuo T
    • Total Pages
      278
    • Publisher
      Springer Nature
    • Data Source
      KAKENHI-PROJECT-17K10840
  • [Journal Article] Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer’s brain milieu2022

    • Author(s)
      Williams Lindsey M.、Fujimoto Takashi、Weaver Riley R.、Logsdon Aric F.、Evitts Kira M.、Young Jessica E.、Banks William A.、Erickson Michelle A.
    • Journal Title

      Fluids and Barriers of the CNS

      Volume: 19 Issue: 1

    • DOI

      10.1186/s12987-022-00307-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K16635
  • [Journal Article] Effects of fasudil on blood?brain barrier integrity2022

    • Author(s)
      Sato Kei、Nakagawa Shinsuke、Morofuji Yoichi、Matsunaga Yuki、Fujimoto Takashi、Watanabe Daisuke、Izumo Tsuyoshi、Niwa Masami、Walter Fruzsina R.、Vigh Judit P.、Santa-Maria Ana Raquel、Deli Maria A.、Matsuo Takayuki
    • Journal Title

      Fluids and Barriers of the CNS

      Volume: 19 Issue: 1 Pages: 43-43

    • DOI

      10.1186/s12987-022-00336-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09351, KAKENHI-PROJECT-21K09180, KAKENHI-PROJECT-22K09287, KAKENHI-PROJECT-20KK0254, KAKENHI-PROJECT-18K08973, KAKENHI-PROJECT-19K09531
  • [Journal Article] Transport of the Proinflammatory Chemokines C-C Motif Chemokine Ligand 2 (MCP-1) and C-C Motif Chemokine Ligand 5 (RANTES) across the Intact Mouse Blood-Brain Barrier Is Inhibited by Heparin and Eprodisate and Increased with Systemic Inflammation2022

    • Author(s)
      Quaranta Daniel V.、Weaver Riley R.、Baumann Kristen K.、Fujimoto Takashi、Williams Lindsey M.、Kim Hyung Chan、Logsdon Aric F.、Omer Mohamed、Reed May J.、Banks William A.、Erickson Michelle A.
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics

      Volume: 384 Issue: 1 Pages: 205-223

    • DOI

      10.1124/jpet.122.001380

    • Data Source
      KAKENHI-PROJECT-21K16635
  • [Journal Article] Beyond Lipid-Lowering: Effects of Statins on Cardiovascular and Cerebrovascular Diseases and Cancer2022

    • Author(s)
      Morofuji Yoichi、Nakagawa Shinsuke、Ujifuku Kenta、Fujimoto Takashi、Otsuka Kaishi、Niwa Masami、Tsutsumi Keisuke
    • Journal Title

      Pharmaceuticals

      Volume: 15 Issue: 2 Pages: 151-151

    • DOI

      10.3390/ph15020151

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10840, KAKENHI-PROJECT-20K09351, KAKENHI-PROJECT-20K09394, KAKENHI-PROJECT-21K16635, KAKENHI-PROJECT-20KK0254, KAKENHI-PROJECT-21K09154
  • [Journal Article] Neurotropism and blood-brain barrier involvement in COVID-192022

    • Author(s)
      Fujimoto Takashi、Erickson Michelle A.、Banks William A.
    • Journal Title

      Frontiers in Drug Delivery

      Volume: 2

    • DOI

      10.3389/fddev.2022.1073815

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K16635
  • [Journal Article] Partial Clipping Occlusion Including Rupture Point Is an Effective Strategy for Ruptured Giant Fusiform Basilar Artery Aneurysm: A Technical Case Report2021

    • Author(s)
      Izumo Tsuyoshi、Fujimoto Takashi、Morofuji Yoichi、Tateishi Yohei、Matsuo Takayuki
    • Journal Title

      Frontiers in Neurology

      Volume: 12 Pages: 743654-743654

    • DOI

      10.3389/fneur.2021.743654

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09351, KAKENHI-PROJECT-21K16635, KAKENHI-PROJECT-20KK0254
  • [Journal Article] Ischemic Stroke as a Warning Sign of Impending Aneurysmal Rupture: A Report of Two Cases2021

    • Author(s)
      OKAMURA Kazuaki、MOROFUJI Yoichi、IZUMO Tsuyoshi、SATO Kei、FUJIMOTO Takashi、HORIE Nobutaka、MATSUO Takayuki
    • Journal Title

      NMC Case Report Journal

      Volume: 8 Issue: 1 Pages: 85-88

    • DOI

      10.2176/nmccrj.cr.2020-0040

    • NAID

      130007995210

    • ISSN
      2188-4226
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10840, KAKENHI-PROJECT-20K09351, KAKENHI-PROJECT-20KK0254
  • [Journal Article] Pitavastatin Ameliorates Lipopolysaccharide-Induced Blood-Brain Barrier Dysfunction2021

    • Author(s)
      Fujimoto Takashi、Morofuji Yoichi、Kovac Andrej、Erickson Michelle A.、Deli Maria A.、Niwa Masami、Banks William A.
    • Journal Title

      Biomedicines

      Volume: 9 Issue: 7 Pages: 837-837

    • DOI

      10.3390/biomedicines9070837

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10840, KAKENHI-PROJECT-20K09351, KAKENHI-PROJECT-21K16635, KAKENHI-PROJECT-20KK0254
  • [Journal Article] A Case of Invasive Sphenoid Sinus Aspergillosis Presenting as Oculomotor Nerve Palsy in a Healthy Patient2021

    • Author(s)
      FUJIMOTO Takashi、MOROFUJI Yoichi、HIU Takeshi、YOSHIDA Koichi、IZUMIKAWA Koichi、WATANABE Takeshi、MATSUO Takayuki
    • Journal Title

      NMC Case Report Journal

      Volume: 8 Issue: 1 Pages: 343-347

    • DOI

      10.2176/nmccrj.cr.2020-0189

    • NAID

      130008055891

    • ISSN
      2188-4226
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10840, KAKENHI-PROJECT-20K09328, KAKENHI-PROJECT-20K09351, KAKENHI-PROJECT-21K16635, KAKENHI-PROJECT-20KK0254
  • [Journal Article] Increased In Vitro Intercellular Barrier Function of Lung Epithelial Cells Using Adipose-Derived Mesenchymal Stem/Stromal Cells2021

    • Author(s)
      Ishii Mitsutoshi、Tsuchiya Tomoshi、Doi Ryoichiro、Morofuji Yoichi、Fujimoto Takashi、Muto Hideki、Suematsu Takashi、Mori Ryoichi、Matsumoto Keitaro、Miyazaki Takuro、Tomoshige Koichi、Watanabe Hironosuke、Iwatake Mayumi、Nagayasu Takeshi
    • Journal Title

      Pharmaceutics

      Volume: 13 Issue: 8 Pages: 1264-1264

    • DOI

      10.3390/pharmaceutics13081264

    • NAID

      120007172252

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10840, KAKENHI-PROJECT-18K16424, KAKENHI-PROJECT-21H04838, KAKENHI-PROJECT-19H03747, KAKENHI-PROJECT-20K09351, KAKENHI-PROJECT-21K08907, KAKENHI-PROJECT-20K20479, KAKENHI-PROJECT-21K16635, KAKENHI-PROJECT-20KK0254, KAKENHI-PROJECT-20KK0255
  • [Journal Article] Hematoma expansion unrelated to rebleeding in ruptured anterior cerebral artery aneurysms treated by early endovascular embolization2021

    • Author(s)
      Okamura Kazuaki、Morofuji Yoichi、Horie Nobutaka、Izumo Tsuyoshi、Sato Kei、Fujimoto Takashi、Matsuo Takayuki
    • Journal Title

      Surgical Neurology International

      Volume: 12 Pages: 571-571

    • DOI

      10.25259/sni_816_2021

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10840, KAKENHI-PROJECT-20K09351, KAKENHI-PROJECT-21K16635, KAKENHI-PROJECT-20KK0254
  • [Journal Article] Hybrid Neurosurgery for Complex Cerebral Aneurysms2020

    • Author(s)
      高平 良太郎、日宇 健、諸藤 陽一、堀江 信貴、案田 岳夫、永田 泉、松尾 孝之、出雲 剛、塩崎 絵里、近松 元気、伊木 勇輔、佐藤 慧、松永 祐希、藤本 隆史、定方 英作
    • Journal Title

      NEUROSURGICAL EMERGENCY

      Volume: 25 Issue: 2 Pages: 224-230

    • DOI

      10.24723/jsne.25.2_224

    • NAID

      130007959147

    • ISSN
      1342-6214
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10840
  • [Journal Article] Exploration of Pericyte-Derived Factors Implicated in Lung Cancer Brain Metastasis Protection: A Pilot Messenger RNA Sequencing Using the Blood?Brain Barrier In Vitro Model2020

    • Author(s)
      Ujifuku Kenta、Fujimoto Takashi、Sato Kei、Morofuji Yoichi、Muto Hideki、Masumoto Hiroshi、Nakagawa Shinsuke、Niwa Masami、Matsuo Takayuki
    • Journal Title

      Cellular and Molecular Neurobiology

      Volume: - Issue: 4 Pages: 997-1004

    • DOI

      10.1007/s10571-020-00988-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10840, KAKENHI-PROJECT-20K09351, KAKENHI-PROJECT-20KK0254, KAKENHI-PROJECT-17K10839, KAKENHI-PROJECT-17K10869, KAKENHI-PROJECT-21K16635
  • [Journal Article] Comparison of the rate of dedifferentiation with increasing passages among cell sources for an in vitro model of the blood?brain barrier2020

    • Author(s)
      Fujimoto Takashi、Morofuji Yoichi、Nakagawa Shinsuke、Kovac Andrej、Horie Nobutaka、Izumo Tsuyoshi、Niwa Masami、Matsuo Takayuki、Banks William A.
    • Journal Title

      Journal of Neural Transmission

      Volume: 127 Issue: 8 Pages: 1117-1124

    • DOI

      10.1007/s00702-020-02202-1

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10840, KAKENHI-PROJECT-18K08973, KAKENHI-PROJECT-20K09351, KAKENHI-PROJECT-20KK0254, KAKENHI-PROJECT-18K08972
  • [Journal Article] Pericytes Suppress Brain Metastasis from Lung Cancer In Vitro.2019

    • Author(s)
      Fujimoto, T., Nakagawa, S., Morofuji, Y., Watanabe, D., Ujifuku, K., Horie, N., Izumo, T., Niwa, M., Banks, W. A., Deli, M. A., Matsuo, T.
    • Journal Title

      Cell Mol Neurobiol

      Volume: 40(1) Issue: 1 Pages: 113-121

    • DOI

      10.1007/s10571-019-00725-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10839, KAKENHI-PROJECT-17K10840, KAKENHI-PROJECT-18K08973, KAKENHI-PROJECT-20K09351, KAKENHI-PROJECT-20KK0254
  • [Journal Article] Early Diagnosis of Infective Endocarditis by Brain T2*-Weighted Magnetic Resonance Imaging2018

    • Author(s)
      Fujimoto Takashi、Morofuji Yoichi、Matsunaga Yuki、Horie Nobutaka、Izumo Tsuyoshi、Tateishi Yohei、Morikawa Minoru、Miura Takashi、Eishi Kiyoyuki、Matsuo Takayuki
    • Journal Title

      Circ J

      Volume: 82 Issue: 2 Pages: 464-468

    • DOI

      10.1253/circj.CJ-17-0212

    • NAID

      130006321865

    • ISSN
      1346-9843, 1347-4820
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15KK0349, KAKENHI-PROJECT-17K10840
  • [Presentation] Intraarterial therapy of Rho-kinase inhibitor for acute ischemic stroke2021

    • Author(s)
      Morofuji Y, Nakagawa S, Sato K, Matsunaga Y, Fujimoto T, Izumo T, Niwa M, Matsuo T
    • Organizer
      The 13th World Stroke Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10840
  • [Presentation] Intraarterial therapy of Rho-kinase inhibitor for acute ischemic stroke2021

    • Author(s)
      Morofuji Y, Nakagawa S, Sato K, Matsunaga Y, Fujimoto T, Izumo T, Niwa M, Matsuo T
    • Organizer
      The 13th World Stroke Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20KK0254
  • [Presentation] Interaction between Pericytes and brain metastasis2021

    • Author(s)
      Takashi Fujimoto
    • Organizer
      3rd Mini symposium on the blood brain barrier From basic to clinical research
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08973
  • [Presentation] 血液脳関門をターゲットとした脳梗塞治療薬の開発2021

    • Author(s)
      諸藤陽一、中川慎介、佐藤慧、松永裕希、藤本隆史、堀江信貴、出雲剛、松尾孝之
    • Organizer
      日本脳神経外科学会 第80回学術総会
    • Data Source
      KAKENHI-PROJECT-20KK0254
  • [Presentation] 急性期脳梗塞治療としてのファスジル動注療法の可能性2020

    • Author(s)
      諸藤陽一、中川慎介、藤本隆史、佐藤慧、松永裕希
    • Organizer
      第36回日本脳神経血管内治療学会
    • Data Source
      KAKENHI-PROJECT-20KK0254
  • [Presentation] 急性期脳梗塞治療としてのファスジル動注療法の可能性2020

    • Author(s)
      諸藤陽一、中川慎介、藤本隆史、佐藤慧、松永裕希
    • Organizer
      Stroke2021
    • Data Source
      KAKENHI-PROJECT-20KK0254
  • [Presentation] 急性期脳梗塞治療としてのファスジル動注療法の可能性2020

    • Author(s)
      諸藤陽一、中川慎介、藤本隆史、佐藤慧、松永裕希、堀江信貴、出雲剛、松尾孝之
    • Organizer
      Stroke2021
    • Data Source
      KAKENHI-PROJECT-17K10840
  • [Presentation] Interaction between Pericytes and brain metastasis2020

    • Author(s)
      Takashi Fujimoto, Yoichi Morofuji
    • Organizer
      3rd Minisymposium on the blood-brain barrier: from basic to clinical research
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10840
  • [Presentation] 急性期脳梗塞治療としてのファスジル動注療法の可能性2020

    • Author(s)
      諸藤陽一、中川慎介、藤本隆史、佐藤慧、松永裕希、堀江信貴、出雲剛、松尾孝之
    • Organizer
      第36回日本脳神経血管内治療学会
    • Data Source
      KAKENHI-PROJECT-17K10840
  • [Presentation] Role of pericytes in brain metastasis formation2019

    • Author(s)
      Takashi Fujimoto, Yoichi Morofuji, Shinsuke Nakagawa, Nobutaka Horie, Tsuyoshi Izumo, Takeo Anda, Takayuki Matsuo
    • Organizer
      1st Mini-symposium on the Blood Brain Barrier from Basic to Research
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08973
  • [Presentation] Rho-kinase inhibitor fasudil protcts blood brain barrier from ischemia/prefusion injury2019

    • Author(s)
      Yuki Matsunaga, Yoichi Morofuji, Shinsuke Nakagawa, Takashi Fujimoto, Nobutaka Horie, Tsuyoshi Izumo, Takeo Anda, Takayuki Matsuo
    • Organizer
      1st Mini-symposium on the Blood Brain Barrier from Basic to Research
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08973
  • [Presentation] Role of Pericytes in brain metastasis formation2019

    • Author(s)
      Takashi Fujimoto
    • Organizer
      22th International Symposium on Signal Transduction at the Blood-Brain Barriers
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10840
  • [Presentation] The current trends in the treatment for brain metastasis2019

    • Author(s)
      Kei Sato, Yoichi Morofuji, Shinsuke Nakagawa, Takashi Fujimoto, Nobutaka Horie, Tsuyoshi Izumo, Takeo Anda, Takayuki Matsuo
    • Organizer
      1st Mini-symposium on the Blood Brain Barrier from Basic to Research
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08973
  • [Presentation] Role of Pericytes in brain metastasis formation2018

    • Author(s)
      Takashi Fujimoto, Yoichi Morofuji
    • Organizer
      21st Symposium on Signal Transduction at the Blood-Brain Barriers
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10840
  • [Presentation] In vitro analysis to evaluate brain metastatic potential of cancer cells from human surgical specimens -Preliminary report-2017

    • Author(s)
      Yoichi Morofuji1, Takashi Fujimoto1, Daisuke Watanabe2, Shinsuke Nakagawa2, Kenta Ujifuku1, Nobutaka Horie1, Tsuyoshi Izumo1, Takeo Anda1, Takayuki Matsuo1
    • Organizer
      the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10840
  • 1.  Morofuji Yoichi (40437869)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 25 results
  • 2.  Izumo Tsuyoshi (40343347)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 9 results
  • 3.  中川 慎介 (10404211)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 4.  佐藤 慧 (40849486)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 5.  松永 裕希 (80772136)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 6.  氏福 健太
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  松尾 孝之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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