Saito Tsunenori 齋藤恒徳

Researcher Number	00716631
Other IDs	https://orcid.org/0000-0002-8214-2736
Affiliation (Current)	2025: 日本医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2016 – 2024: 日本医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Cardiovascular surgery
Keywords	Principal Investigator オートファジー / 拡張型心筋症 / ミトコンドリア / マイトファジー / プレセニリン2 / 心筋細胞 / 循環器内科学 / 原因遺伝子 / 次世代シーケンサー / 全エクソーム解析 … More / 電子顕微鏡 / PARL / PINK1 / パーキン / 心筋生検 / エキソーム解析 / 心不全 / ゲノミクス … More Except Principal Investigator microRNA / 循環器・高血圧 / 左心耳 / 心房細動 / マイクロRNA Less

Development of a new treatment for dilated cardiomyopathy targeting mitophagy activation in cardiomyocytesPrincipal Investigator
- Principal Investigator
  
  齋藤恒徳
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Nippon Medical School
Elucidation of the role and interaction of presenilin 1 and 2 in myocardial mitophagyPrincipal Investigator
- Principal Investigator
  
  齋藤恒徳
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Nippon Medical School
Clarification for clinical significance of autophagy-related gene variants in dilated cardiomyopathyPrincipal Investigator
- Principal Investigator
  
  Saito Tsunenori
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Nippon Medical School
Evaluation of autophagy for patients with dilated cardiomyopathyPrincipal Investigator
- Principal Investigator
  
  Saito Tsunenori
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Nippon Medical School
Elucidation of microRNA as a biomarker related to structural remodeling on atrial fibrillation
- Principal Investigator
  
  FUJII MASAHIRO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Nippon Medical School

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] 拡張型心筋症の遺伝子変異と電子顕微鏡2022
- Author(s)
  齋藤恒徳
- Journal Title
  
  国際抗老化再生医療学会雑誌
  
  Volume: 4 Pages: 1-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21KK0298
[Journal Article] Myocardial ultrastructure can augment genetic testing for sporadic dilated cardiomyopathy with initial heart failure2021
- Author(s)
  Saito Tsunenori、Sato Naoko Saito、Mozawa Kosuke、Adachi Akiko、Sasaki Yoshihiro、Nakamura Kotoka、Oka Eiichiro、Otsuka Toshiaki、Kodani Eitaro、Asai Kuniya、Mizuno Kyoichi、Shimizu Wataru、Gottlieb Roberta A.
- Journal Title
  
  ESC Heart Failure
  
  Volume: 8 Issue: 6 Pages: 5178-5191
- DOI
  10.1002/ehf2.13596
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08460
[Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)12021
- Author(s)
  Daniel J Klionsky、Shu Aizawa、Amal Kamal Abdel-Aziz、Sara Abdelfatah、Mahmoud Abdellatif、Asghar Abdoli、Steffen Abel、Hagai Abeliovich、Marie H Abildgaard、Yakubu Princely Abudu、Abraham Acevedo-Arozena、Iannis E Adamopoulos、Khosrow Adeli、Timon E Adolph、Annagrazia Adornetto、Elma Aflaki、Galila Agam et al.
- Journal Title
  
  Autophagy
  
  Volume: 17 Issue: 1 Pages: 1-382
- DOI
  10.1080/15548627.2020.1797280
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06375, KAKENHI-PROJECT-19K07568, KAKENHI-PROJECT-20K06501, KAKENHI-PROJECT-20K06636, KAKENHI-PROJECT-20K07896, KAKENHI-PROJECT-20K21769, KAKENHI-PLANNED-20H05772, KAKENHI-PROJECT-19H01042, KAKENHI-PROJECT-18H02439, KAKENHI-PROJECT-18H02656, KAKENHI-PROJECT-18H02807, KAKENHI-PROJECT-20J00363, KAKENHI-PROJECT-18K06210, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-18K09427, KAKENHI-PROJECT-19K08851, KAKENHI-PROJECT-18KK0193, KAKENHI-PLANNED-19H05710, KAKENHI-PROJECT-18H02901, KAKENHI-PROJECT-20H02990, KAKENHI-PUBLICLY-20H05504, KAKENHI-PROJECT-19H03471, KAKENHI-PROJECT-19H03791, KAKENHI-PROJECT-20H03249, KAKENHI-PROJECT-19K09677, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-20K08460, KAKENHI-PROJECT-20K08662, KAKENHI-PROJECT-21K07926, KAKENHI-PROJECT-20K21531, KAKENHI-PROJECT-19K24690, KAKENHI-PROJECT-23K21397
[Journal Article] Phospholipidosis in cardiomyocytes suffering flecainide intoxication.2020
- Author(s)
  Saito T, Hayashi M, Shimizu W.
- Journal Title
  
  Eur Heart J.
  
  Volume: 41 Issue: 10 Pages: 1141-1141
- DOI
  10.1093/eurheartj/ehz833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16026
[Journal Article] Long-term prognostic value of ultrastructural features in dilated cardiomyopathy: comparison with cardiac magnetic resonance.2020
- Author(s)
  Saito T, Asai K, Tachi M, Sato S, Mozawa K, Adachi A, Sasaki Y, Amano Y, Mizuno K, Kumita SI, Shimizu W.
- Journal Title
  
  ESC Heart Fail.
  
  Volume: 7 Issue: 2 Pages: 682-691
- DOI
  10.1002/ehf2.12662
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16026
[Journal Article] Is steroid therapy really banned for lymphocytic myocarditis before excluding viral infection?2019
- Author(s)
  Saito T, Katayama H, Kodani E.
- Journal Title
  
  Eur Heart J
  
  Volume: 40 Issue: 12 Pages: 2014-2015
- DOI
  10.1093/eurheartj/ehy738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16026
[Journal Article] Eosinophilic myocarditis associated with anti-mitochondrial M2 antibodies: a mechanism underlying the onset of myocarditis2018
- Author(s)
  Saito Tsunenori、Kodani Eitaro、Katayama Hironori、Kusama Yoshiki
- Journal Title
  
  European Heart Journal
  
  Volume: 印刷中 Issue: 37 Pages: 3480-3481
- DOI
  10.1093/eurheartj/ehy246
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16026
[Journal Article] Myocardial alterations in a patient with mucopolysaccharidosis type IS2018
- Author(s)
  Izumi Yuki、Saito Tsunenori、Sato Shigeru、Shimizu Wataru
- Journal Title
  
  European Heart Journal
  
  Volume: 印刷中 Issue: 20 Pages: 1863-1863
- DOI
  10.1093/eurheartj/ehy149
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16026
[Presentation] Mitochondria-selective autophagy as a therapeutic target for heart failure2024
- Author(s)
  Tsunenori Saito, Eitaro Kodani, Kuniya Asai
- Organizer
  第88回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0298
[Presentation] Electron microscopy assists genomic medicine for early phase dilated cardiomyopathy2024
- Author(s)
  Masaki Morooka, Tsunenori Saito, Eitaro Kodani, Kuniya Asai
- Organizer
  第88回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08460
[Presentation] 心房細動手術時に切除された左心耳の組織学的特徴と左心耳内血栓の形成機序：そもそもの始まり2023
- Author(s)
  齋藤恒徳
- Organizer
  第45回心筋生検研究会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08460
[Presentation] 心筋細胞におけるPSEN2とミトコンドリア選択的オートファジー2023
- Author(s)
  齋藤恒徳
- Organizer
  第14回国際抗老化再生医療学会定期学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21KK0298
[Presentation] Electron microscopy shows a role of presenilin-2 in mitochondria-selective autophagy.2023
- Author(s)
  Watanabe M, Saito T, Kodani E.
- Organizer
  第87回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0298
[Presentation] Dilated cardiomyopathy but not mitochondrial cardiomyopathy with mitochondria- and mitophagy-related gene variants by whole-exome analysis.2023
- Author(s)
  Morooka M, Saito T, Kodani E.
- Organizer
  第87回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08460
[Presentation] Presenilin-2 regulates mitophagy via promoting SirT1-PGC1α-PINK1 pathway and intracellular translocation of Parkin to mitochondria.2023
- Author(s)
  Saito T, Gottlieb RA, Kodani E.
- Organizer
  第87回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0298
[Presentation] Electron microscopy shows a role of presenilin-2 in mitochondria-selective autophagy.2023
- Author(s)
  Watanabe M, Saito T, Kodani E.
- Organizer
  第87回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08460
[Presentation] Genome and Pathology of Dilated Cardiomyopathy.2022
- Author(s)
  齋藤恒徳.
- Organizer
  第26回日本心不全学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21KK0298
[Presentation] 血球貪食症候群を契機に診断された急性心不全および急性腎障害の原因としてのHTLV-1感染.2022
- Author(s)
  岡田泰司、齋藤恒徳、中野博之、小谷英太郎.
- Organizer
  第44回心筋生検研究会学術集会
- Data Source
  KAKENHI-PROJECT-20K08460
[Presentation] アベルマブによる心筋障害が疑われた一例.2022
- Author(s)
  中島悠希, 齋藤恒徳, 小谷英太郎.
- Organizer
  第8回日本心筋症研究会.
- Data Source
  KAKENHI-PROJECT-20K08460
[Presentation] Presenilin-2 regulates mitophagy via promoting intracellular translocation of Parkin to mitochondria.2022
- Author(s)
  Saito T, Gottlieb RA, Kodani E.
- Organizer
  American Heart Association Scientific Sessions 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0298
[Presentation] COVID-19 vaccine-related myocarditis diagnosed with cerebral infarction.2022
- Author(s)
  Watanabe M, Saito T, Kodani E.
- Organizer
  第86回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08460
[Presentation] アベルマブによる心筋障害が疑われた一例.2022
- Author(s)
  中島悠希、齋藤恒徳、上杉智香、諸岡雅城、大塚悠介、渡辺允、石原翔、鈴木啓士、中野博之、小谷英太郎、清水渉.
- Organizer
  第264回日本循環器学会関東甲信越地方会.
- Data Source
  KAKENHI-PROJECT-20K08460
[Presentation] Comparison of ultrastructural features of cardiomyocytes with variants in known causal genes of dilated cardiomyopathy.2022
- Author(s)
  Watanabe M, Saito T, Kodani E.
- Organizer
  第86回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08460
[Presentation] 竹村元三先生追悼シンポジウム. 拡張型心筋症における電子顕微鏡利用の今までとこれから.2021
- Author(s)
  齋藤恒徳.
- Organizer
  第43回心筋生検研究会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08460
[Presentation] 脳塞栓を契機に診断されたCOVID-19ワクチン関連心筋炎.2021
- Author(s)
  渡辺允, 齋藤恒徳, 小谷英太郎.
- Organizer
  第43回心筋生検研究会学術集会
- Data Source
  KAKENHI-PROJECT-20K08460
[Presentation] Presenilin 1 and Presenilin 2 contribute to mitophagy including alternative pathway.2020
- Author(s)
  齋藤恒徳
- Organizer
  American Heart Association Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08460
[Presentation] Dilated cardiomyopathy includes arrhythmogenic cardiomyopathy as a type with severe myocardial degeneration.2019
- Author(s)
  Mozawa K, Saito T, Oka E, Sato-Saito N, Kodani E, Iwasaki YK, Asai K, Shimizu W.
- Organizer
  American Heart Association Scientific Sessions 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16026
[Presentation] Comparison Between Ultrastructural Features and Causative Genes of Dilated Cardiomyopathy Detected by Whole Exome Sequencing.2019
- Author(s)
  Saito T, Asai K, Sato-saito N, Mozawa K, Oka E, Sato S, Mizuno K, Shimizu W, Gottlieb RA.
- Organizer
  American Heart Association Scientific Sessions 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16026
[Presentation] Eosinophilic myocarditis associated with anti-mitochondrial M2 antibodies: a new evidence of the onset of myocarditis2018
- Author(s)
  Tsunenori Saito
- Organizer
  The American College of Physicians Internal Medicine Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16026
[Presentation] 拡張型心筋症の電子顕微鏡所見の臨床的意義とオートファジー発現に関与する因子の探索2018
- Author(s)
  齋藤恒徳
- Organizer
  第86回日本医科大学医学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K16026
[Presentation] 好酸球性心筋炎における炎症細胞の種類と量についての検討2018
- Author(s)
  齋藤恒徳、小谷英太郎、片山博徳、清水渉
- Organizer
  第4回日本心筋症研究会
- Data Source
  KAKENHI-PROJECT-17K16026
[Presentation] Ultrastructural assist for searching causative genes of dilated cardiomyopathy using next generation sequencer.2018
- Author(s)
  Saito T, Asai K, Sato-Saito N, Mozawa K, Oka E, Sato S, Kodani E, Wataru Shimizu.
- Organizer
  日本人類遺伝学会第63回大会
- Data Source
  KAKENHI-PROJECT-17K16026
[Presentation] 心筋生検の役立て方と電子顕微鏡の活用2018
- Author(s)
  齋藤恒徳
- Organizer
  第27回日本小児心筋疾患学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K16026
[Presentation] Clinical utility of myocardial autophagy in patients with dilated cardiomyopathy to predict prognosis and recovery of cardiac function.2017
- Author(s)
  Tsunenori Saito
- Organizer
  第81回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16026
[Presentation] 心内膜心筋生検による病理診断の役割と重要性; 拡張型心筋症の心内膜心筋生体標本における電子顕微鏡所見の臨床的有用性2017
- Author(s)
  齋藤恒徳
- Organizer
  第106回日本病理学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K16026
[Presentation] Comparison between cardiac magnetic resonance and myocardial ultrastructural features in patients with dilated cardiomyopathy to predict recovery of cardiac function.2017
- Author(s)
  Tsunenori Saito
- Organizer
  第21回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16026
[Presentation] 好酸球性心筋炎の治療中に抗ミトコンドリアM2抗体陽性筋炎を発症した一例2017
- Author(s)
  齋藤恒徳
- Organizer
  第39回心筋生検研究会
- Data Source
  KAKENHI-PROJECT-17K16026

1. FUJII MASAHIRO (60297926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 軸薗智雄 (10465312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 坂本俊一郎 (50398872)

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4. 相澤修

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# of Collaborated Products: 1 results

Saito Tsunenori 齋藤 恒徳

Research Projects

Research Products

Co-Researchers

Development of a new treatment for dilated cardiomyopathy targeting mitophagy activation in cardiomyocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the role and interaction of presenilin 1 and 2 in myocardial mitophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification for clinical significance of autophagy-related gene variants in dilated cardiomyopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of autophagy for patients with dilated cardiomyopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of microRNA as a biomarker related to structural remodeling on atrial fibrillation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 拡張型心筋症の遺伝子変異と電子顕微鏡2022

Author(s)

Journal Title

Data Source

[Journal Article] Myocardial ultrastructure can augment genetic testing for sporadic dilated cardiomyopathy with initial heart failure2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)12021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phospholipidosis in cardiomyocytes suffering flecainide intoxication.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long-term prognostic value of ultrastructural features in dilated cardiomyopathy: comparison with cardiac magnetic resonance.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Is steroid therapy really banned for lymphocytic myocarditis before excluding viral infection?2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Eosinophilic myocarditis associated with anti-mitochondrial M2 antibodies: a mechanism underlying the onset of myocarditis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Myocardial alterations in a patient with mucopolysaccharidosis type IS2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] Mitochondria-selective autophagy as a therapeutic target for heart failure2024

Author(s)

Organizer

Data Source

[Presentation] Electron microscopy assists genomic medicine for early phase dilated cardiomyopathy2024

Author(s)

Organizer

Saito Tsunenori 齋藤恒徳