Horikoshi Yasunori 堀越保則

Researcher Number	00719429
Other IDs
Affiliation (Current)	2025: 広島大学, 原爆放射線医科学研究所, 助教
Affiliation (based on the past Project Information) *help	2015 – 2024: 広島大学, 原爆放射線医科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 63020:Radiation influence-related Except Principal Investigator Medium-sized Section 63:Environmental analyses and evaluation and related fields / Basic Section 63020:Radiation influence-related / Risk sciences of radiation and chemicals
Keywords	Principal Investigator 核構造 / DNA損傷修復 / 放射線応答 / DNA二本鎖切断 / 放射線被ばく / 核骨格タンパク質 / 細胞核構造 / DNA修復 / 放射線 Except Principal Investigator 放射線被ばく … More / ハイスループット解析技術 / バイオマーカー / 医療放射線 / ゲノムダメージ / 放射線誘発核内ドメイン / 医療放射線被ばく / 放射線核内誘発ドメイン / 染色体構造異常 / 染色体転座 / 放射線 / 染色体異常 / ゲノム修復 / 細胞核構造 / 損傷ゲノム Less

Natural history of genome damage
- Principal Investigator
  
  田代聡
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  Hiroshima University
Functional analyses of nucleoskeleton proteins on formation of radiation-induced nuclear foci of DNA repair factorsPrincipal Investigator
- Principal Investigator
  
  Horikoshi Yasunori
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Hiroshima University
Mechanisms of radiation-induced chromosome abnormalities
- Principal Investigator
  
  Tashiro Satoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Hiroshima University
Study of the mechanisms of radiation-induced chromosome abnormalities
- Principal Investigator
  
  Tashiro Satoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Hiroshima University

All 2023 2022 2021 2020 2019 2018 2017 2015

All Journal Article Presentation

[Journal Article] Klotho protects chromosomal DNA from radiation-induced damage2023
- Author(s)
  Nakayama Shinya、Sun Jiying、Horikoshi Yasunori、Kamimura Yoshitaka、Ike Takeshi、Fujino Shu、Kinugasa Yasuha、Sasaki Kensuke、Nakashima Ayumu、Masaki Takao、Tashiro Satoshi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: online Issue: 5 Pages: 375-382
- DOI
  10.1093/jb/mvad001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15017, KAKENHI-PROJECT-21H04927, KAKENHI-PROJECT-22K07212
[Journal Article] Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis2023
- Author(s)
  Ueda Keitaro、Sakai Chiemi、Ishida Takafumi、Morita Kosuke、Kobayashi Yusuke、Horikoshi Yasunori、Baba Akiko、Okazaki Yuma、Yoshizumi Masao、Tashiro Satoshi、Ishida Mari
- Journal Title
  
  Clinical Science
  
  Volume: 137 Issue: 2 Pages: 163-180
- DOI
  10.1042/cs20220525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08029, KAKENHI-PROJECT-21H04927, KAKENHI-PROJECT-20K08494, KAKENHI-PROJECT-22K16076
[Journal Article] A Combination of Iohexol Treatment and Ionizing Radiation Exposure Enhances Kidney Injury in Contrast-Induced Nephropathy by Increasing DNA Damage2022
- Author(s)
  Fujino Shu、Sun Jying、Nakayama Shinya、Horikoshi Yasunori、Kinugasa Yasuha、Ishida Mari、Sakai Chiemi、Ike Takeshi、Doi Shigehiro、Masaki Takao、Tashiro Satoshi
- Journal Title
  
  Radiation Research
  
  Volume: 197 Issue: 4 Pages: 384-395
- DOI
  10.1667/rade-21-00178.1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15017, KAKENHI-PROJECT-22K07212, KAKENHI-PROJECT-21H04927
[Journal Article] Piwi-piRNA complexes induce stepwise changes in nuclear architecture at target loci2021
- Author(s)
  Iwasaki Yuka W、Sriswasdi Sira、Kinugasa Yasuha、Adachi Jun、Horikoshi Yasunori、Shibuya Aoi、Iwasaki Wataru、Tashiro Satoshi、Tomonaga Takeshi、Siomi Haruhiko
- Journal Title
  
  The EMBO Journal
  
  Volume: 40 Issue: 18
- DOI
  10.15252/embj.2021108345
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-19H05749, KAKENHI-PLANNED-19H05753, KAKENHI-PUBLICLY-21H00259, KAKENHI-PROJECT-21H04927, KAKENHI-PROJECT-21K15017, KAKENHI-PROJECT-16H06279
[Journal Article] Replication-stress-associated DSBs induced by ionizing radiation risk genomic destabilization and associated clonal evolution.2021
- Author(s)
  Matsuno Y, Hyodo M, Suzuki M, Tanaka Y, Horikoshi Y, Murakami Y, Torigoe H, Mano H, Tashiro S, Yoshioka KI.
- Journal Title
  
  iScience.
  
  Volume: 24 Issue: 4 Pages: 102313-102313
- DOI
  10.1016/j.isci.2021.102313
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04927, KAKENHI-PROJECT-21J12419, KAKENHI-PROJECT-21K12252
[Journal Article] Evaluating Individual Radiosensitivity for the Prediction of Acute Toxicities of Chemoradiotherapy in Esophageal Cancer Patients2020
- Author(s)
  Imano Nobuki、Nishibuchi Ikuno、Kawabata Emi、Kinugasa Yasuha、Shi Lin、Sakai Chiemi、Ishida Mari、Sakane Hiroaki、Akita Tomoyuki、Ishida Takafumi、Kimura Tomoki、Murakami Yuji、Tanaka Kimio、Horikoshi Yasunori、Sun Jiying、Nagata Yasushi、Tashiro Satoshi
- Journal Title
  
  Radiation Research
  
  Volume: 195 Issue: 3 Pages: 244-252
- DOI
  10.1667/rade-20-00234.1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15551, KAKENHI-PROJECT-18H03373, KAKENHI-PROJECT-17K16447, KAKENHI-PROJECT-19K23725, KAKENHI-PROJECT-21H04927, KAKENHI-PROJECT-20K08494, KAKENHI-PROJECT-19K07641
[Journal Article] Matrin3 promotes homologous recombinational repair by regulation of RAD51.2019
- Author(s)
  Shi L, Sun J, Kinomura A, Fukuto A, Horikoshi Y, Tashiro S.
- Journal Title
  
  J Biochem.
  
  Volume: 166 Issue: 4 Pages: 343-351
- DOI
  10.1093/jb/mvz041
- NAID
  40022023652
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07641, KAKENHI-PROJECT-18H03373, KAKENHI-PROJECT-18K18195
[Journal Article] Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations2018
- Author(s)
  Sun, J., Shi, L., Kinomura, A., Fukuto, A., Horikoshi, Y., Oma, Y., Harata, M., Ikura, M., Ikura, T., Kanaar, R., Tashiro, S
- Journal Title
  
  elife
  
  Volume: 7
- DOI
  10.7554/elife.32222
- NAID
  120006539566
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01875, KAKENHI-PROJECT-18H03373, KAKENHI-PROJECT-18J40044, KAKENHI-PROJECT-16K00544, KAKENHI-PROJECT-25850242, KAKENHI-PROJECT-15H04625, KAKENHI-PROJECT-18H02164
[Journal Article] SUMO modification system facilitates the exchange of histone variant H2A.Z-2 at DNA damage sites2017
- Author(s)
  Fukuto Atsuhiko、Ikura Masae、Ikura Tsuyoshi、Sun Jiying、Horikoshi Yasunori、Shima Hiroki、Igarashi Kazuhiko、Kusakabe Masayuki、Harata Masahiko、Horikoshi Naoki、Kurumizaka Hitoshi、Kiuchi Yoshiaki、Tashiro Satoshi
- Journal Title
  
  Nucleus
  
  Volume: 9 Issue: 1 Pages: 87-94
- DOI
  10.1080/19491034.2017.1395543
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00544, KAKENHI-PUBLICLY-16H01307, KAKENHI-PUBLICLY-16H01312, KAKENHI-PLANNED-25116009, KAKENHI-PROJECT-15H02821, KAKENHI-PROJECT-17H01875, KAKENHI-PROJECT-15K14706, KAKENHI-PROJECT-15H04625, KAKENHI-PROJECT-18H02164
[Journal Article] Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage.2015
- Author(s)
  Liu NA, Sun J, Kono K, Horikoshi Y, Ikura T, Tong X, Haraguchi T, Tashiro S.
- Journal Title
  
  FASEB J.
  
  Volume: in press Issue: 6 Pages: 2514-25
- DOI
  10.1096/fj.14-265546
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23221006, KAKENHI-PROJECT-26430114, KAKENHI-PLANNED-25116006, KAKENHI-PROJECT-15H02821
[Journal Article] hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair2015
- Author(s)
  1.Okimoto S, Sun J, Fukuto A, Horikoshi Y, Matsuda S, Matsuda T, Ikura M, Ikura T, Machida S, Kurumizaka H, Miyamoto Y, Oka M, Yoneda Y, Kiuchi Y, Tashiro S.
- Journal Title
  
  Genes Cells.
  
  Volume: 20 Issue: 9 Pages: 681-94
- DOI
  10.1111/gtc.12262
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430114, KAKENHI-PROJECT-15K12203, KAKENHI-PUBLICLY-26116514, KAKENHI-PROJECT-23221006, KAKENHI-PROJECT-15H02821, KAKENHI-PROJECT-26550028, KAKENHI-PROJECT-26281020, KAKENHI-PLANNED-25116008
[Presentation] ゲノム損傷依存的RAD51核内フォーカス形成の制御機構2019
- Author(s)
  堀越保則，孫継英，田代聡
- Organizer
  第十一回「光塾」
- Data Source
  KAKENHI-PROJECT-18K18195
[Presentation] Homologous pairing during recombinational DNA repair take place within distinctive nuclear compartment.2019
- Author(s)
  Yasunori Horikoshi, Hiroki Shima, Wataru Kobayashi, Hiroshi Ochiai, Jiying Sun, Hitoshi Kurumizaka, Tsuyoshi Ikura, Shin-ichi Tate, Kazuhiko Igarashi, Thomas Cremer, Satoshi Tashiro
- Organizer
  EMBO Workshop Chromatin and Epigenetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18195
[Presentation] Homologous pairing during recombinational DNA repair take place within distinctive nuclear compartment2019
- Author(s)
  Yasunori Horikoshi
- Organizer
  EMBO Workshop Chromatin and Epigenetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18195
[Presentation] ゲノム損傷依存的RAD51核内フォーカス形成の制御機構2018
- Author(s)
  堀越保則
- Organizer
  第59回原子爆弾後障害研究会
- Data Source
  KAKENHI-PROJECT-18K18195
[Presentation] 相同組換え修復時の相同的対合は特徴的な核内区画で起こる2018
- Author(s)
  堀越保則
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K18195

1. Tashiro Satoshi (20243610)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. 孫継英 (80397926)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 粟井和夫 (30294573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 西淵いくの (70595834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 太田邦史 (90211789)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 衣笠泰葉 (60852118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. ISHIDA Takafumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 井倉毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 今野伸樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 井倉正枝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 石田万里

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Horikoshi Yasunori 堀越 保則

Research Projects

Research Products

Co-Researchers

Natural history of genome damage

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analyses of nucleoskeleton proteins on formation of radiation-induced nuclear foci of DNA repair factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of radiation-induced chromosome abnormalities

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the mechanisms of radiation-induced chromosome abnormalities

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Klotho protects chromosomal DNA from radiation-induced damage2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Combination of Iohexol Treatment and Ionizing Radiation Exposure Enhances Kidney Injury in Contrast-Induced Nephropathy by Increasing DNA Damage2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Piwi-piRNA complexes induce stepwise changes in nuclear architecture at target loci2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Replication-stress-associated DSBs induced by ionizing radiation risk genomic destabilization and associated clonal evolution.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluating Individual Radiosensitivity for the Prediction of Acute Toxicities of Chemoradiotherapy in Esophageal Cancer Patients2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Matrin3 promotes homologous recombinational repair by regulation of RAD51.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] SUMO modification system facilitates the exchange of histone variant H2A.Z-2 at DNA damage sites2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage.2015

Author(s)

Journal Title

DOI

Data Source

Horikoshi Yasunori 堀越保則