Kawaguchi Shin-ichi 川口真一

Researcher Number	00722894
Other IDs
Affiliation (Current)	2025: 佐賀大学, 生物資源教育研究センター, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 佐賀大学, 農学部附属アグリ創生教育研究センター, 准教授 2019 – 2023: 佐賀大学, 農学部, 准教授 2015 – 2016: 佐賀大学, 農学部, 特任助教 2014: 東北大学, 医学(系)研究科(研究院), 特別研究員(PD)
Review Section/Research Field	Principal Investigator Basic Section 64030:Environmental materials and recycle technology-related / Basic Section 53040:Nephrology-related / General pharmacology Except Principal Investigator Basic Section 39030:Horticultural science-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Keywords	Principal Investigator 持続可能性 / リサイクル / リン / リンのリサイクル / フィチン酸 / リン酸 / 縮合反応 / リン酸エステル / Hypoxia Inducible Factor / HIFアナログ … More / PHD阻害薬 / HIF活性化剤 / PHD阻害 / HIF活性化 / 虚血性疾患治療薬 / ドッキングシミュレーション / 低分子化合物 / 構造活性相関 / 低分子阻害剤 / FIH / 低酸素誘導因子 / HIF … More Except Principal Investigator 新規活性物質 / GWAS解析 / QTL解析 / 健康機能性 / ミカン亜科植物 / PHD-HIF系 / 低酸素応答 / HIF / PHD / PHD/HIF / 低分子化合物 / 低酸素 Less

Elucidation of the biosynthetic factors of Aurantioideae-derived natural products by QTL/GWAS and its bioactivities
- Principal Investigator
  
  古藤田信博
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 39030:Horticultural science-related
- Research Institution
  Saga University
リン資源循環の鍵となるリン酸とアルコールによるリン酸エステル合成反応の開発Principal Investigator
- Principal Investigator
  
  川口真一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 64030:Environmental materials and recycle technology-related
- Research Institution
  Saga University
New strategic approach for ameliorate hypoxic injury using the PHD1 specific inhibitor and definition of the molecular mechanism.
- Principal Investigator
  
  辻田忠志
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Saga University
Selective HIF activation by allosteric PHD inhibition: a novel therapeutic compound for chronic kidney diseasePrincipal Investigator
- Principal Investigator
  
  Kawaguchi Shin-ichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Saga University
Activation of HIF by inhibiting FIH: the development of novel organic molecules inhibiting FIH selectivelyPrincipal Investigator
- Principal Investigator
  
  Kawaguchi Shin-ichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Saga University
  Tohoku University

All 2024 2023 2022 2021 2020 2019 2017 2016 2015

All Journal Article Presentation Patent

[Journal Article] 含リン廃液を利用したリン製品の製造～リンの循環を指向した工業用リン酸エステルの製造法の開発2024
- Author(s)
  川口真一、浅尾和弥、佐々木猛、平田直也
- Journal Title
  
  環境浄化技術
  
  Volume: 23 Pages: 24-28
- Data Source
  KAKENHI-PROJECT-22K12445
[Journal Article] リン資源循環のためのリン酸をリン源としたリン酸エステル類の合成2023
- Author(s)
  浅尾和弥、川口真一
- Journal Title
  
  触媒
  
  Volume: 65 Pages: 360-365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K12445
[Journal Article] Identification and mechanistic investigation of ellagitannins from <i>Osbeckia octandra</i> that attenuate liver fibrosis via the TGF-<i>β</i>/SMAD signaling pathway2023
- Author(s)
  Bogahawaththa Sudarma、Kawamura Tomoaki、Bandaranayake Udari、Hirakawa Tomoaki、Yamada Goki、Ishino Hana、Hirohashi Tsuzumi、Kawaguchi Shin-ichi、Wijesundera Kavindra K、Wijayagunawardane Missaka P B、Ishimaru Kanji、Kodithuwakku Suranga P、Tsujita Tadayuki
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 87 Issue: 11 Pages: 1295-1309
- DOI
  10.1093/bbb/zbad114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19755, KAKENHI-PROJECT-23K24772
[Journal Article] Synthesis of diaryl phosphates using orthophosphoric acid as a phosphorus source2022
- Author(s)
  Tran Cong Chi、Asao Kazuya、Sasaki Takeshi、Hayakawa Yasuyuki、Kawaguchi Shin-ichi
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 96 Pages: 153726-153726
- DOI
  10.1016/j.tetlet.2022.153726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K12445
[Journal Article] Improving lipophilicity of 5-(1-acetyl-5-phenylpyrazolidin-3-ylidene)-1,3-dimethylbarbituric acid increases its efficacy to activate hypoxia-inducible factors2022
- Author(s)
  Sonoda Kento、Ujike Saki、Katayama Akito、Suzuki Norio、Kawaguchi Shin-ichi、Tsujita Tadayuki
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume: 73 Pages: 117039-117039
- DOI
  10.1016/j.bmc.2022.117039
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19396, KAKENHI-PROJECT-22K19755, KAKENHI-PROJECT-23K21372
[Journal Article] リン資源循環の鍵となるか　リン酸とアルコールによるリン酸エステル合成反応2022
- Author(s)
  浅尾　和弥、川口　真一
- Journal Title
  
  月刊アグリバイオ
  
  Volume: 6 Pages: 43-46
- Data Source
  KAKENHI-PROJECT-22K12445
[Journal Article] Prolyl Hydroxylase Domain Protein Inhibitor Not Harboring a 2-Oxoglutarate Scaffold Protects against Hypoxic Stress2022
- Author(s)
  Kento Sonoda , Sudarma Bogahawatta, Akito Katayama, Saki Ujike, Sae Kuroki, Naho Kitagawa, Kohichi Hirotsuru, Norio Suzuki, Toshio Miyata, Shin-ichi Kawaguchi, and Tadayuki Tsujita*
- Journal Title
  
  ACS Pharmacol. Transl. Sci.
  
  Volume: 5 Issue: 5 Pages: 362-372
- DOI
  10.1021/acsptsci.2c00002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17746, KAKENHI-PROJECT-22K19396, KAKENHI-PROJECT-22K19755, KAKENHI-PROJECT-23K21372
[Journal Article] Photoinduced Cyclizations of o-Diisocyanoarenes with Organic Diselenides and Thiols that Afford Chalcogenated Quinoxalines2020
- Author(s)
  Tran Cong Chi、Kawaguchi Shin-ichi、Sato Fumiya、Nomoto Akihiro、Ogawa Akiya
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 85 Issue: 11 Pages: 7258-7266
- DOI
  10.1021/acs.joc.0c00647
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02756, KAKENHI-PROJECT-19H02791, KAKENHI-PROJECT-19K17746
[Journal Article] Phosphorus-Recycling Wittig Reaction: Design and Facile Synthesis of a Fluorous Phosphine and Its Reusable Process in the Wittig Reaction2020
- Author(s)
  Yamamoto Yuki、Kawaguchi Shin-ichi、Nishimura Misaki、Sato Yuki、Shimada Yoshihisa、Tabuchi Akihiro、Nomoto Akihiro、Ogawa Akiya
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 85 Issue: 22 Pages: 14684-14696
- DOI
  10.1021/acs.joc.0c01926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02756, KAKENHI-PROJECT-19K17746
[Journal Article] Photoinduced Syntheses and Reactivities of Phosphorus-Containing Interelement Compounds2020
- Author(s)
  Yamamoto Yuki、Tanaka Ryo、Ota Miyuto、Nishimura Misaki、Tran Cong Chi、Kawaguchi Shin-ichi、Kodama Shintaro、Nomoto Akihiro、Ogawa Akiya
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 85 Issue: 22 Pages: 14708-14719
- DOI
  10.1021/acs.joc.0c02014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02756, KAKENHI-PROJECT-19K17746
[Journal Article] Palladium-Catalyzed Diarylation of Isocyanides with Tetraarylleads for the Selective Synthesis of Imines and α-Diimines2019
- Author(s)
  Tran Cong Chi、Kawaguchi Shin-ichi、Kobiki Yohsuke、Matsubara Hitomi、Tran Dat Phuc、Kodama Shintaro、Nomoto Akihiro、Ogawa Akiya
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 84 Issue: 18 Pages: 11741-11751
- DOI
  10.1021/acs.joc.9b01639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17746, KAKENHI-PROJECT-19H02756
[Journal Article] P-Fluorous Phosphines as Electron-Poor/Fluorous Hybrid Functional Ligands for Precious Metal Catalysts: Synthesis of Rh(I), Ir(I), Pt(II), and Au(I) Complexes Bearing P-Fluorous Phosphine Ligands2017
- Author(s)
  Kawaguchi, S-i.; Saga, Y.; Sato, Y.; Minamida, Y.; Nomoto, A.; Ogawa, A.
- Journal Title
  
  Inorganics
  
  Volume: 5 Issue: 1 Pages: 5-5
- DOI
  10.3390/inorganics5010005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860168, KAKENHI-PROJECT-16K14049
[Journal Article] Highly Selective Phosphinylphosphination of Alkenes with Tetraphenyldiphosphine Monoxide2016
- Author(s)
  Sato, Y.; Kawaguchi, S-i.; Nomoto, A.; Ogawa, A.
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 55 Issue: 33 Pages: 9700-9703
- DOI
  10.1002/anie.201603860
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860168, KAKENHI-PROJECT-16K14049
[Journal Article] Discovery of an NRF1-specific inducer from a large-scale chemical library using a direct NRF1-protein monitoring system.2015
- Author(s)
  Tsujita T, Baird L, Furusawa Y, Katsuoka F, Hou Y, Gotoh S, Kawaguchi S-i, and Yamamoto M.
- Journal Title
  
  Genes Cells
  
  Volume: 7 Issue: 7 Pages: 563-577
- DOI
  10.1111/gtc.12248
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25750357, KAKENHI-PROJECT-26860168
[Journal Article] Hypoxia-Sensitive Reporter System for High-Throughput Screening2015
- Author(s)
  Tsujita, T.; Kawaguchi, S-i.; Dan, T.; Baird, L.; Miyata, T.; Yamamoto, M.
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 235 Issue: 2 Pages: 151-159
- DOI
  10.1620/tjem.235.151
- NAID
  130004822440
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J05784, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-25750357, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26860168
[Patent] フィチン酸を利用したリン酸エステルの製造方法2023
- Inventor(s)
  川口真一、浅尾和弥、佐々木猛、早川康之
- Industrial Property Rights Holder
  佐賀大学、日本コンクリート工業株式会社
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Acquisition Date
  2023
- Data Source
  KAKENHI-PROJECT-22K12445
[Patent] リン酸エステルの製造方法2023
- Inventor(s)
  川口真一、浅尾和弥、佐々木猛、早川康之
- Industrial Property Rights Holder
  川口真一、浅尾和弥、佐々木猛、早川康之
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K12445
[Patent] 新規な含窒素環状化合物及びその用途2020
- Inventor(s)
  川口真一、辻田忠志
- Industrial Property Rights Holder
  佐賀大学
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K17746
[Patent] 新規な含窒素環状化合物及びその用途2020
- Inventor(s)
  川口真一、辻田忠志
- Industrial Property Rights Holder
  佐賀大学
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Acquisition Date
  2021
- Data Source
  KAKENHI-PROJECT-19K17746
[Presentation] 資源循環を目指した塩化リンフリーなリン酸エステルの製造とリン含有バイオマスの活用2024
- Author(s)
  浅尾和弥・森康貴・松本星奏・早川康之・佐々木猛・平田直也・川口真一
- Organizer
  日本化学会第104春季年会
- Data Source
  KAKENHI-PROJECT-22K12445
[Presentation] リン酸トリエステルのエステル交換と加水分解における条件の精査2023
- Author(s)
  森康貴・川口真一
- Organizer
  第60回化学関連支部合同九州大会
- Data Source
  KAKENHI-PROJECT-22K12445
[Presentation] 2-OG骨格を持たない新規HIF-PH阻害薬PyrzA2023
- Author(s)
  川口真一, 濱田悠菜, 氏家沙綺, 園田健登, 辻田忠志.
- Organizer
  第45回蛋白質と酵素の構造と機能に関する九州シンポジウム
- Data Source
  KAKENHI-PROJECT-22K19755
[Presentation] 植物の3大栄養素の一つリン資源の循環利用・有効活用2023
- Author(s)
  川口真一
- Organizer
  第13回CSJ化学フェスタ2023
- Invited
- Data Source
  KAKENHI-PROJECT-22K12445
[Presentation] リンの循環に向けて～リン酸とアルコールの縮合反応によるリン酸エステル合成についての再検討2023
- Author(s)
  川口真一
- Organizer
  2023年度第3回リン循環産業振興機構セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22K12445
[Presentation] リン酸のエステル化反応はリン循環のブレイクスルーとなるか？2023
- Author(s)
  川口真一
- Organizer
  PAdeCS研究会
- Invited
- Data Source
  KAKENHI-PROJECT-22K12445
[Presentation] 新たな骨格を持つPHD活性阻害剤PyrzAの創出と構造活性相関研究2022
- Author(s)
  辻田忠志, 園田健登, 氏家沙綺, 片山彰人, 鈴木教郎川口真一
- Organizer
  第18回がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-22K19755
[Presentation] 低酸素ストレスから防御する新奇HIF活性化剤PyrzAの発見2022
- Author(s)
  園田健登, 片山彰人, 氏家沙綺, 黒木紗英, 北川尚穂, 廣津留倖一, 川口真一, 辻田忠志
- Organizer
  第95回日本生化学会大会.
- Data Source
  KAKENHI-PROJECT-22K19755
[Presentation] 低酸素誘導因子HIF活性化分子PyrzAとその誘導体の合成と活性評価2021
- Author(s)
  氏家沙綺、片山彰人、黒木紗英、川口真一、辻田忠志
- Organizer
  第58回化学関連支部合同九州大会
- Data Source
  KAKENHI-PROJECT-19K17746
[Presentation] 2-カルボニルフラン誘導体によるHIFの活性化およびその活性化経路の検討2016
- Author(s)
  川口真一・辻田忠志・小川昭弥・宮田敏男
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26860168
[Presentation] HIF(低酸素誘導因子)活性化剤の設計と合成およびその活性評価2016
- Author(s)
  川口真一・辻田忠志・宮田敏男・小川昭弥
- Organizer
  第40回蛋白質と酵素の構造と機能に関する九州シンポジウム
- Place of Presentation
  指宿ベイテラス
- Year and Date
  2016-08-26
- Data Source
  KAKENHI-PROJECT-26860168
[Presentation] フランおよびチオフェン-2-カルボニルアミノ酸誘導体によるfactor of inhibiting HIF(FIH)阻害2015
- Author(s)
  川口真一・辻田忠志・宮田敏男・小川昭弥
- Organizer
  第13回がんとハイポキシア研究会
- Place of Presentation
  国立遺伝学研究所
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-26860168

1. 辻田忠志 (20622046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. 伴匡人 (00579667)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 古藤田信博 (50355426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 渡邊啓史 (40425541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SUZUKI Norio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 小川昭弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Kawaguchi Shin-ichi 川口 真一

Research Projects

Research Products

Co-Researchers

Elucidation of the biosynthetic factors of Aurantioideae-derived natural products by QTL/GWAS and its bioactivities

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

リン資源循環の鍵となるリン酸とアルコールによるリン酸エステル合成反応の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New strategic approach for ameliorate hypoxic injury using the PHD1 specific inhibitor and definition of the molecular mechanism.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Selective HIF activation by allosteric PHD inhibition: a novel therapeutic compound for chronic kidney diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Activation of HIF by inhibiting FIH: the development of novel organic molecules inhibiting FIH selectivelyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 含リン廃液を利用したリン製品の製造～リンの循環を指向した工業用リン酸エステルの製造法の開発2024

Author(s)

Journal Title

Data Source

[Journal Article] リン資源循環のためのリン酸をリン源としたリン酸エステル類の合成2023

Author(s)

Journal Title

Data Source

[Journal Article] Identification and mechanistic investigation of ellagitannins from <i>Osbeckia octandra</i> that attenuate liver fibrosis via the TGF-<i>β</i>/SMAD signaling pathway2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of diaryl phosphates using orthophosphoric acid as a phosphorus source2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Improving lipophilicity of 5-(1-acetyl-5-phenylpyrazolidin-3-ylidene)-1,3-dimethylbarbituric acid increases its efficacy to activate hypoxia-inducible factors2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] リン資源循環の鍵となるか リン酸とアルコールによるリン酸エステル合成反応2022

Author(s)

Journal Title

Data Source

[Journal Article] Prolyl Hydroxylase Domain Protein Inhibitor Not Harboring a 2-Oxoglutarate Scaffold Protects against Hypoxic Stress2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Photoinduced Cyclizations of o-Diisocyanoarenes with Organic Diselenides and Thiols that Afford Chalcogenated Quinoxalines2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorus-Recycling Wittig Reaction: Design and Facile Synthesis of a Fluorous Phosphine and Its Reusable Process in the Wittig Reaction2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Photoinduced Syntheses and Reactivities of Phosphorus-Containing Interelement Compounds2020

Author(s)

Journal Title

DOI

Kawaguchi Shin-ichi 川口真一

[Journal Article] リン資源循環の鍵となるか　リン酸とアルコールによるリン酸エステル合成反応2022