Terkawi Alaa 照川アラー

Researcher Number	00723074
Other IDs
Affiliation (Current)	2025: 北海道大学, 医学研究院, 助教
Affiliation (based on the past Project Information) *help	2017 – 2024: 北海道大学, 医学研究院, 助教 2018: 北海道大学, 医学研究院, 特任助教 2016: 北海道大学, 医学研究科, 助教 2015: 北海道大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery / Veterinary medical science Except Principal Investigator Basic Section 56020:Orthopedics-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 90110:Biomedical engineering-related / Surgery related to the biological and sensory functions and related fields / Plastic surgery
Keywords	Principal Investigator 骨リモデリング / 骨マクロファージ / インプラント / 炎症反応 / 骨融解 / Bone resorption / Osteoclastogenesis / Inflammation / Osteolysis / IL-27 … More / 破骨細胞 / 炎症性骨溶解 / 人工関節置換術後の無菌性緩み / ケモカイン / サイトカイン / マクロファージ / 人工股関節置換術後の無菌性緩み / CTSL / DEFB130 / DNA Microarray / effector molecules / neutrophils / Effector molecules / Phagocytes / Neutrophils / Macrophages … More Except Principal Investigator マクロファージ / 軟骨細胞 / 慢性炎症 / 変形性関節症 / 骨折 / 破骨細胞 / 骨粗鬆症 / 糖鎖 / 関節炎 / 細胞外小胞 / 偽関節 / 骨折治癒 / 便マイクロバイオーム / 腸管免疫 / 骨腸管連環 / 腸内細菌叢 / バイオマテリアル / 軟骨再生 / 組織再生 / 免疫異常 / 大腿骨頭軟骨下脆弱性骨折 / 急速破壊型股関節症 / 関節破壊 / 炎症収束性貪食細胞由来細胞外小胞 / 好中球由来細胞小胞 / 軟骨 / 好中球 / 抗炎症性マクロファージ / 遺伝子プロファイル / 制御性T細胞 / M2マクロファージ / 骨細胞 / インターフェロンシグナル / 糖鎖抗原 / 継代培養 / マウスBMSC / 統合グライコーム / マウス軟骨細胞 / 免疫原性 / 自家細胞移植 / 間葉系幹細胞 / スフィンゴ糖脂質 / 免疫応答 / RA / OA / エクソソーム / 関節リウマチ / 関節疾患 / パイロトーシス / 免疫学 / ダメージ関連分子パターン / 関節病学 / 移植・再生医療 / 線維芽細胞 / シュワン細胞 / 末梢神経損傷 / 細胞移植 / 軸索再生 / 末梢神経 Less

Exploring functional roles of osteal macrophages in bone metabolism for the development of osteoporosis therapeuticsPrincipal Investigator
- Principal Investigator
  
  照川アラー
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
Gut microbiome-Osteal macrophages axis as a new therapeutic target for prevention of osteoporosis
- Principal Investigator
  
  高畑雅彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Hokkaido University
Research on the effect of anti-inflammatory macrophage transplantation on fracture healing
- Principal Investigator
  
  高橋大介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
Elucidation of innate immune disorders that regulate joint destruction and joint degeneration after fracture
- Principal Investigator
  
  宮崎拓自
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
Development of Novel Cartilage Regeneration Materials with Functional Glycolipid Molecules
- Principal Investigator
  
  小野寺智洋
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Hokkaido University
Exploration of novel mechanism of osteoporosis focusing on resolving macrophage-derived factors.
- Principal Investigator
  
  Takahashi Daisuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
Resolving mechanism of arthritis induced by extracellular vesicles derived from resolving neutrophil
- Principal Investigator
  
  Asano Tsuyoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
Glycan antigen changes on cultured cells and the mechanism of immune response development in autologous cell transplantation
- Principal Investigator
  
  Norimasa Iwasaki
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Hokkaido University
Investigation of roles of the synovial macrophage-derived exosomes on the progression of osteoarthritis and rheumatoid arthritis
- Principal Investigator
  
  Hontani Kazutoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
Development of novel therapeutic intervention for controlling inflammatory osteolysis leading to total hip arthroplastyPrincipal Investigator
- Principal Investigator
  
  Terkawi Alaa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hokkaido University
Development of novel therapy for peripheral nerve regeneration by combinatorial cell therapy
- Principal Investigator
  
  Nagano Yusuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  Hokkaido University
Drug development using a novel immune network analysis method for osteoarthritis
- Principal Investigator
  
  Onodera Tomohiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Surgery related to the biological and sensory functions and related fields
- Research Institution
  Hokkaido University
Elucidation of mechanisms by which host immune cells kill protozoan parasites and development of antiparasitic peptidesPrincipal Investigator
- Principal Investigator
  
  Terkawi Alaa
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Hokkaido University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] 別冊BIO Clinica（バイオクリニカ）慢性炎症と疾患2018
- Author(s)
  小野寺智洋、濱崎雅成、Alaa Terkawi, 岩崎倫政
- Total Pages
  5
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-17K19707
[Journal Article] Noncanonical Pyroptosis Triggered by Macrophage‐Derived Extracellular Vesicles in Chondrocytes Leading to Cartilage Catabolism in Osteoarthritis2023
- Author(s)
  Ebata Taku、Terkawi Mohamad Alaa、Kitahara Keita、Yokota Shunichi、Shiota Junki、Nishida Yoshio、Matsumae Gen、Alhasan Hend、Hamasaki Masanari、Hontani Kazutoshi、Shimizu Tomohiro、Takahashi Daisuke、Endo Tsutomu、Onodera Tomohiro、Kadoya Ken、Iwasaki Norimasa
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: 75 Issue: 8 Pages: 1358-1369
- DOI
  10.1002/art.42505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22672
[Journal Article] Inflammasome Activation in the Hip Synovium of Rapidly Destructive Coxopathy Patients and Its Relationship with the Development of Synovitis and Bone Loss2022
- Author(s)
  Yokota Shunichi、Shimizu Tomohiro、Matsumae Gen、Ebata Taku、Alhasan Hend、Takahashi Daisuke、Terkawi Mohamad Alaa、Iwasaki Norimasa
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 192 Issue: 5 Pages: 794-804
- DOI
  10.1016/j.ajpath.2022.02.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09298, KAKENHI-PROJECT-20K17984
[Journal Article] Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis2021
- Author(s)
  Ebata Taku、Terkawi Mohamad Alaa、Hamasaki Masanari、Matsumae Gen、Onodera Tomohiro、Aly Mahmoud Khamis、Yokota Shunichi、Alhasan Hend、Shimizu Tomohiro、Takahashi Daisuke、Homan Kentaro、Kadoya Ken、Iwasaki Norimasa
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 6 Pages: 102643-102643
- DOI
  10.1016/j.isci.2021.102643
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18516, KAKENHI-PROJECT-20K09471
[Journal Article] Cardiotrophin Like Cytokine Factor 1 (CLCF1) alleviates excessive bone loss and osteoclast differentiation through activating interferon signaling and repressing the nuclear factor-κB signaling pathway.2021
- Author(s)
  Shunichi Yokota, Gen Matsumae, Tomohiro Shimizu, Tomoka Hasegawa, Taku Ebata, Daisuke Takahashi, Cai Heguo, Yuan Tian, Hend Alhasan, Masahiko Takahata, Ken Kadoya, Alaa Terkawi, Norimasa Iwasaki
- Journal Title
  
  Bone
  
  Volume: 153 Pages: 116140-116140
- DOI
  10.1016/j.bone.2021.116140
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09425, KAKENHI-PROJECT-21K19585
[Journal Article] Blockade of XCL1/Lymphotactin Ameliorates Severity of Periprosthetic Osteolysis Triggered by Polyethylene-Particles2020
- Author(s)
  Tian Yuan、Terkawi Mohamad Alaa、Onodera Tomohiro、Alhasan Hend、Matsumae Gen、Takahashi Daisuke、Hamasaki Masanari、Ebata Taku、Aly Mahmoud Khamis、Kida Hiroaki、Shimizu Tomohiro、Uetsuki Keita、Kadoya Ken、Iwasaki Norimasa
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 1720-1720
- DOI
  10.3389/fimmu.2020.01720
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09425, KAKENHI-PROJECT-20H03558
[Journal Article] Transcriptional profiling of murine macrophages stimulated with cartilage fragments revealed a strategy for treatment of progressive osteoarthritis2020
- Author(s)
  Hamasaki Masanari、Terkawi Mohamad Alaa、Onodera Tomohiro、Tian Yuan、Ebata Taku、Matsumae Gen、Alhasan Hend、Takahashi Daisuke、Iwasaki Norimasa
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1-9
- DOI
  10.1038/s41598-020-64515-1
- Data Source
  KAKENHI-PROJECT-19K22672
[Journal Article] A Novel Cartilage Fragments Stimulation Model Revealed that Macrophage Inflammatory Response Causes an Upregulation of Catabolic Factors of Chondrocytes In Vitro2019
- Author(s)
  Hamasaki Masanari、Terkawi Mohamad Alaa、Onodera Tomohiro、Homan Kentaro、Iwasaki Norimasa
- Journal Title
  
  CARTILAGE
  
  Volume: In press Issue: 3 Pages: 354-361
- DOI
  10.1177/1947603519828426
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10993, KAKENHI-PROJECT-17K19707
[Journal Article] Identification of IL-27 as potent regulator of inflammatory osteolysis associated with vitamin E-blended ultra-high molecular weight polyethylene debris of orthopedic implants2019
- Author(s)
  Terkawi Mohamad Alaa、Kadoya Ken、Takahashi Daisuke、Tian Yuan、Hamasaki Masanari、Matsumae Gen、Alhasan Hend、Elmorsy Sameh、Uetsuki Keita、Onodera Tomohiro、Takahata Masahiko、Iwasaki Norimasa
- Journal Title
  
  Acta Biomaterialia
  
  Volume: 89 Pages: 242-251
- DOI
  10.1016/j.actbio.2019.03.028
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10993
[Journal Article] Effects of Ultra-Purified Alginate Gel Implantation on Meniscal Defects in Rabbits2018
- Author(s)
  Kim WooYoung、Onodera Tomohiro、Kondo Eiji、Kawaguchi Yasuyuki、Terkawi Mohamad Alaa、Baba Rikiya、Hontani Kazutoshi、Joutoku Zenta、Matsubara Shinji、Homan Kentaro、Hishimura Ryosuke、Iwasaki Norimasa
- Journal Title
  
  The American Journal of Sports Medicine
  
  Volume: 47 Issue: 3 Pages: 640-650
- DOI
  10.1177/0363546518816690
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10993, KAKENHI-PROJECT-19K12746
[Journal Article] Is There an Association Between Borderline-to-mild Dysplasia and Hip Osteoarthritis? Analysis of CT Osteoabsorptiometry2018
- Author(s)
  Irie Tohru、Takahashi Daisuke、Asano Tsuyoshi、Arai Ryuta、Terkawi Muhammad Alaa、Ito Yoichi M.、Iwasaki Norimasa
- Journal Title
  
  Clinical Orthopaedics and Related Research
  
  Volume: 476 Issue: 7 Pages: 1455-1465
- DOI
  10.1097/01.blo.0000533619.50951.e3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10993
[Journal Article] Transcriptional profile of human macrophages stimulated by ultra-high molecular weight polyethylene particulate debris of orthopedic implants uncovers a common gene expression signature of rheumatoid arthritis2018
- Author(s)
  Terkawi Mohamad Alaa、Hamasaki Masanari、Takahashi Daisuke、Ota Masahiro、Kadoya Ken、Yutani Tomoyo、Uetsuki Keita、Asano Tsuyoshi、Irie Tohru、Arai Ryuta、Onodera Tomohiro、Takahata Masahiko、Iwasaki Norimasa
- Journal Title
  
  Acta Biomaterialia
  
  Volume: 65 Pages: 417-425
- DOI
  10.1016/j.actbio.2017.11.001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10993
[Journal Article] Differential Gene Expression Profile of Human Neutrophils Cultured with Plasmodium falciparum-Parasitized Erythrocytes2018
- Author(s)
  Terkawi Mohamad Alaa、Takano Ryo、Kato Kentaro
- Journal Title
  
  Journal of Immunology Research
  
  Volume: 2018 Pages: 1-8
- DOI
  10.1155/2018/6709424
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10993
[Journal Article] A mathematical model for predicting postoperative leg shortening after curved intertrochanteric varus osteotomy for osteonecrosis of the femoral head2018
- Author(s)
  Asano Tsuyoshi、Takahashi Daisuke、Shimizu Tomohiro、Irie Tohru、Arai Ryuta、Terkawi Mohamad Alaa、Iwasaki Norimasa
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 12 Pages: e0208818-e0208818
- DOI
  10.1371/journal.pone.0208818
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10993
[Journal Article] Chemotherapeutic efficacies of a clofazimine and diminazene aceturate combination against piroplasm parasites and their AT-rich DNA-binding activity on Babesia bovis2017
- Author(s)
  Tuvshintulga Bumduuren、AbouLaila Mahmoud、Sivakumar Thillaiampalam、Tayebwa Dickson Stuart、Gantuya Sambuu、Naranbaatar Khandsuren、Ishiyama Aki、Iwatsuki Masato、Otoguro Kazuhiko、?mura Satoshi、Terkawi Mohamad Alaa、Guswanto Azirwan、Rizk Mohamed Abdo、Yokoyama Naoaki、Igarashi Ikuo
- Journal Title
  
  Scientific Report
  
  Volume: 7 Issue: 1
- DOI
  10.1038/s41598-017-14304-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10993, KAKENHI-PROJECT-16H02768
[Journal Article] Human babesiosis: Indication of a molecular mimicry between thrombospondin domains from a novel Babesia microti BmP53 protein and host platelets molecules2017
- Author(s)
  Mousa Ahmed Abdelmoniem、Roche Daniel Barry、Terkawi Mohamad Alaa、Kameyama Kyohko、Kamyingkird Ketsarin、Vudriko Patrick、Salama Akram、Cao Shinuo、Orabi Sahar、Khalifa Hanem、Ahmed Mohamed、Attia Mabrouk、Elkirdasy Ahmed、Nishikawa Yoshifumi、Xuan Xuenan、Cornillot Emmanuel
- Journal Title
  
  Plos One
  
  Volume: 12 Issue: 10 Pages: e0185372-e0185372
- DOI
  10.1371/journal.pone.0185372
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10993
[Journal Article] Involvement of β-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum2017
- Author(s)
  Terkawi MA, Takano R, Furukawa A, Murakoshi F, Kato K.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 41772-41772
- DOI
  10.1038/srep41772
- NAID
  120006219999
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20840, KAKENHI-PROJECT-26870021
[Journal Article] Immunization with Toxoplasma gondii peroxiredoxin 1 induces protective immunity against toxoplasmosis in mice2017
- Author(s)
  Fereig Ragab M.、Kuroda Yasuhiro、Terkawi Mohamad Alaa、Mahmoud Motamed Elsayed、Nishikawa Yoshifumi
- Journal Title
  
  Plos One
  
  Volume: 12 Issue: 4 Pages: e0176324-e0176324
- DOI
  10.1371/journal.pone.0176324
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10993, KAKENHI-PROJECT-15H04589
[Journal Article] Dextran sulfate inhibits acute Toxoplama gondii infection in pigs2016
- Author(s)
  Kato K, Murata Y, Horiuchi N, Inomata A, Terkawi MA, Ishiwa A, Ogawa Y, Fukumoto S, Matsuhisa F, Koyama K.
- Journal Title
  
  Parasites & Vectors
  
  Volume: 9 Issue: 1 Pages: 134-134
- DOI
  10.1186/s13071-016-1421-9
- NAID
  120006390935
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20840, KAKENHI-PLANNED-23117007, KAKENHI-PROJECT-24688032, KAKENHI-PROJECT-16KT0141, KAKENHI-PUBLICLY-15H01306
[Journal Article] Depletion of phagocytic cells during nonlethal Plasmodium yoelii infection causes severe malaria characterized by acute renal failure in Mice2016
- Author(s)
  Terkawi MA, Nishimura M, Furuoka H, Nishikawa Y.
- Journal Title
  
  Infection & Immunty
  
  Volume: 84 Issue: 3 Pages: 845-855
- DOI
  10.1128/iai.01005-15
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20840
[Journal Article] Isolation and co-cultivation of human macrophages and neutrophils with Plasmodium falciparum-parasitized erythrocytes: An optimized system to study the phagocytic activity to malarial parasites2016
- Author(s)
  Terkawi MA, Takano, R, Kato K.
- Journal Title
  
  Parasitology International
  
  Volume: In press Issue: 5 Pages: 30025-3
- DOI
  10.1016/j.parint.2016.03.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20840, KAKENHI-PROJECT-26870021, KAKENHI-PROJECT-15J00136
[Journal Article] Optimization of a Fluorescence-Based Assay for Large-Scale Drug Screening against Babesia and Theileria Parasites.2015
- Author(s)
  Rizk, M.A., El-Sayed, S.A., Terkawi, M.A., Youssef, M.A., El Said el Sel, S., Elsayed, G., El-Khodery, S., El-Ashker, M., Elsify, A., Omar, M., Salama, A., Yokoyama, N., and Igarashi, I.
- Journal Title
  
  PLoS One.
  
  Volume: 10 Issue: 4 Pages: e0125276-e0125276
- DOI
  10.1371/journal.pone.0125276
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14862, KAKENHI-PROJECT-15K20840, KAKENHI-PROJECT-25292169, KAKENHI-PUBLICLY-15H00891
[Journal Article] Characterization of Toxoplasma gondii glyoxalase 1 and evaluation of inhibitory effects of curcumin on the enzyme and parasite cultures.2015
- Author(s)
  Youn-Kyoung Goo, Junya Yamagishi, Akio Ueno, Mohamad Alaa Terkawi, Gabriel Oluga Aboge, Dongmi Kwak, Yeonchul Hong, Dong-Il Chung, Makoto Igarashi, Yoshifumi Nishikawa and Xuenan Xuan.
- Journal Title
  
  Parasites & Vectors
  
  Volume: 8：654 Issue: 1 Pages: 1-8
- DOI
  10.1186/s13071-015-1268-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25450419, KAKENHI-PROJECT-15K20840
[Journal Article] Molecular detection and characterization of Babesia bovis, Babesia bigemina, Theileria species and Anaplasma marginale isolated from cattle in Kenya.2015
- Author(s)
  Adjou Moumouni PF, Aboge GO, Terkawi MA, Masatani T, Cao S, Kamyingkird K, Jirapattharasate C, Zhou M, Wang G, Liu M, Iguchi A, Vudriko P, Ybanez AP, Inokuma H, Shirafuji-Umemiya R, Suzuki H, Xuan X.
- Journal Title
  
  Parasites & Vectors
  
  Volume: 8 Issue: 1 Pages: 496-496
- DOI
  10.1186/s13071-015-1106-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20840, KAKENHI-PROJECT-26850183, KAKENHI-PROJECT-14J07525, KAKENHI-PROJECT-26304036
[Presentation] Extracellular Vesicles Derived From Neutrophils Suppress Catabolic Process Induced By Il-1β Stimulation In Chondrocytes.2023
- Author(s)
  北原圭太 ,江畑拓 ,照川アラー ,西田善郎, ヘンドアルハサン,横田隼一, 塩田惇喜, 徳廣泰貴, 遠藤努 ,清水智弘 ,髙橋大介 , 浅野毅, 岩崎倫政
- Organizer
  Orthopaedic Research Society 2023 ANNUAL MEETING
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09471
[Presentation] Immunological and glycan profiling of bone marrow stromal cells and chondrocytes after passaging for implantation in cartilage defects2023
- Author(s)
  Alaa Terkawi, Kentaro Homan, Taku Ebata, Tomohiro Onodera, Norimasa Iwasaki.
- Organizer
  The 17th World Congress of International Chemical Reference Substances (ICRS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22672
[Presentation] Passaging of bone marrow stromal cells and chondrocytes instigates significant modifications in their immunological behavior: Towards successful cellular implantation for cartilage defects.2022
- Author(s)
  Taku Ebata, Kentaro Homan, Alaa Terkawi, Tomohiro Onodera, Norimasa Iwasaki.
- Organizer
  Orthopaedic Research Society Annual Meeting ORS 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22672
[Presentation] Passaging Of Bone Marrow Stromal Cells And Chondrocytes Instigates Significant Modifications In Their Immunological Behavior: Towards Successful Cellular Implantation For Cartilage Defects2022
- Author(s)
  Taku Ebata, Kentaro Homan, Alaa Terkawi, Tomohiro Onodera, Norimasa Iwasaki
- Organizer
  The 68th Annual Meeting of Orthopaedic Research Society (ORS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22672
[Presentation] 炎症収束型好中球由来細胞外小胞による軟骨細胞抗異化作用の検討2022
- Author(s)
  北原圭太 ,江畑拓 ,照川アラー ,清水智弘 ,遠藤努 ,浅野毅,髙橋大介 ,角家健 ,岩崎倫政
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-20K09471
[Presentation] 骨リモデリング調節におけるアネキシンA1の機能解析2022
- Author(s)
  西田善郎, 松前元, 江畑拓, 横田隼一, 照川ヘンド, 塩田惇喜, 北原圭太, 清水智弘, 髙橋大介, 照川アラー, 岩崎倫政
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-20K09425
[Presentation] Cardiotrophin Like Cytokine Factor 1 (CLCF1) alleviates excessive bone loss and osteoclast differentiation through activating interferon signaling and repressing the nuclear factor-κB signaling pathway.2022
- Author(s)
  Shunichi Yokota, Gen Matsumae, Tomohiro Shimizu, Taku Ebata, Hend Alhasan, Daisuke Takahashi, Alaa Terkawi, Norimasa Iwasaki.
- Organizer
  Orthopaedic Research Society Annual Meeting ORS 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22672
[Presentation] Injectable thermosensitive hydrogel containing A2-26 peptide for local treatment of pathological bone resorption associated with inflammatory.2022
- Author(s)
  Hend Alhasan, Alaa Terkawi, Mahmoud M. Abd Elwakil, Gen Matsumae, Taku Ebata, Yoshio Nishida, Tomohiro Shimizu, Shunichi Yokota, Daisuke Takahashi, Hideyoshi Hideyoshi, Norimasa Iwasaki.
- Organizer
  Orthopaedic Research Society Annual Meeting ORS 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22672
[Presentation] CLCF1投与によるインターフェロンシグナルの活性化を介した骨粗鬆症モデルマウスの骨量減少抑制効果について2022
- Author(s)
  横田隼一, 松前元, 江畑拓, 照川ヘンド, 清水智弘, 髙橋大介, 照川アラー, 岩崎倫政
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-20K09425
[Presentation] Involvement of nephroblastoma overexpressed (NOV) in development of pathological bone resorption in rheumatoid arthritis.2022
- Author(s)
  Gen Matsumae, Mohamad Alaa Terkawi, Tomohiro Shimizu, Taku Ebata, Shunichi Yokota, Daisuke Takahashi, Norimasa Iwasaki.
- Organizer
  Orthopaedic Research Society Annual Meeting ORS 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22672
[Presentation] Cardiotrophin Like Cytokine Factor 1 (CLCF1) alleviates excessive bone loss and osteoclast differentiation through activating interferon signaling and repressing the nuclear factor-κB signaling pathway.2022
- Author(s)
  Shunichi Yokota, Gen Matsumae, Tomohiro Shimizu, Taku Ebata, Hend Alhasan, Daisuke Takahashi, M Alaa Terkawi, Norimasa Iwasaki
- Organizer
  ORS 2022 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09425
[Presentation] Inflammatory macrophage-derived extracellular vesicles promote chondrocyte catabolism and cartilage degeneration: An insight into the crosstalk between macrophage and chondrocytes in OA2021
- Author(s)
  Taku Ebata, M Alaa Terkawi, Gen Matsumae, Hiroaki Kida, Syunichi Yokota, Hend Alhasan, Tomohiro Shimizu, Daisuke Takahashi, Kazutoshi Hontani, Tomohiro Onodera, Ken Kadoya, Norimasa Iwasaki
- Organizer
  Orthopaedic Research Society 2021 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09014
[Presentation] Blockade of macrophage surface receptors suppresses inflammatory response triggered by cartilage fragments in vitro2020
- Author(s)
  Masanari Hamsasaki, Mohamad Alaa Terkawi, Tomohiro Onodera, Gen Matsumae, Yuan Tian, Hend Alhasan, Taku Ebata, Norimasa Iwasaki
- Organizer
  The 66th Annual Meeting of the Orthopaedic Research Society, Phoenix Convention Center（Phoenix, Arizona, USA）
- Data Source
  KAKENHI-PROJECT-17K19707
[Presentation] Blockade of macrophage surface receptors suppresses inflammatory response triggered by cartilage fragments in vitro.2020
- Author(s)
  Masanari Hamasaki, Mohamed Alaa Terkawi, Tomohiro Onodera, Gen Matsumae, Yuan Tian, Hend Alhasan, Taku Ebata, Norimasa Iwasaki.
- Organizer
  The 66th Annual Meeting of Orthopaedic Research Society (ORS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22672
[Presentation] Spatiotemporal investigation and transplantation analysis show an association of M2 macrophage with regenerating axons after peripheral nerve injury.2019
- Author(s)
  Matsui Y, Kadoya K, Endo T, Nagano Y, Terkawi A, Iwasaki N.
- Organizer
  The 74th Annual Meeting of the ASSH
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11527
[Presentation] Transcriptional profiling of murine macrophages stimulated with cartilage fragments a reveals novel mechanism for osteoarthritis2019
- Author(s)
  Masanari Hamasaki, Mohamad Alaa Terkawi, Tomohiro Onodera Kentaro Homan, Zenta Joutoku S. Matsubara R. Hishimura, Kim Woo Young, Liang Xu, Norimasa Iwasaki
- Organizer
  International Cartilage Repair Society world congress
- Data Source
  KAKENHI-PROJECT-17K19707
[Presentation] 末梢神経損傷後の再生軸索とマクロファージにおける時空間的検討2019
- Author(s)
  松居祐樹、角家健、鈴木智亮、福井隆史、山本康弘、袁儒非、鈴木裕貴、遠藤健、永野　裕介、Terkawii Alaa、岩崎倫政
- Organizer
  第136回北海道整形災害外科学会
- Data Source
  KAKENHI-PROJECT-17K11527
[Presentation] Inflamed macrophages by articular cartilage fragments elicits typical gene expression signature of endochondral ossification in chondrocytes in vitro.2019
- Author(s)
  Ebata T, Hamasaki M, Terkawi MA, Onodera T, Matsumae G,　Tian Y, Alhasan H, Takahashi D, Iwasaki N
- Organizer
  The 66th Annual Meeting of the Orthopaedic Research Society, Phoenix Convention Center（Phoenix, Arizona, USA）
- Data Source
  KAKENHI-PROJECT-17K19707
[Presentation] M2マクロファージの末梢神経損傷後の時空間的推移と軸索再生効果2019
- Author(s)
  松居祐樹、角家健、永野裕介、遠藤健、Alaa Terkawi、岩崎倫政
- Organizer
  第30回日本末梢神経学会
- Data Source
  KAKENHI-PROJECT-17K11527
[Presentation] M2マクロファージの末梢神経損傷後の時空間的推移と軸索再生効果2019
- Author(s)
  松居祐樹、角家健、永野裕介、遠藤健、Alaa Terkawi、岩崎倫政
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17K11527
[Presentation] Spatiotemporal investigation and transplantation analysis show an association of M2 macrophage with regenerating axons after peripheral nerve injury.2019
- Author(s)
  Matsui Y, Kadoya K, Endo T, Nagano Y, Terkawi A, Iwasaki N.
- Organizer
  The XIV European Meeting on Glial Cells in Health and Disease,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11527
[Presentation] Ｍ２マクロファージ移植の末梢神経軸索再生効果とその限界2019
- Author(s)
  永野裕介、角家健、遠藤健，松居祐樹、Alaa Terkawi、岩崎倫政
- Organizer
  第62回日本手外科学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11527
[Presentation] M2マクロファージの末梢神経損傷後の時空間的推移と軸索再生効果2019
- Author(s)
  松居祐樹、角家健、永野裕介、遠藤健、Alaa Terkawi、岩崎倫政
- Organizer
  第38回日本運動器移植・再生医学研究会
- Data Source
  KAKENHI-PROJECT-17K11527
[Presentation] A double-edged sword in aseptic loosening of total joint arthroplasty2019
- Author(s)
  Alaa Terkawi
- Organizer
  Asia Pacific Society for Biology and Medical Sciences (APSBMS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10993
[Presentation] 軟骨破片に対するマクロファージ炎症反応の網羅的遺伝子発現解析2019
- Author(s)
  濱崎　雅成 Mohamad Alaa Terkawi　小野寺　智洋　宝満　健太郎　徐　亮　宮崎　拓自　田　園　江畑　拓　松前　元　岩崎　倫政
- Organizer
  第34回　日本整形外科基礎学術集会
- Data Source
  KAKENHI-PROJECT-17K19707
[Presentation] Gene profiling of macrophages stimulated with vitamin E-blended polyethylene orthopedic implants debris identifies IL-27 as potent regulator of osteolysis2018
- Author(s)
  M Alaa Terkawi
- Organizer
  33rd Annual Research Meeting of the Japanese Orthopaedic Association
- Data Source
  KAKENHI-PROJECT-17K10993
[Presentation] Transcriptional profile of human macrophages stimulated by ultra-high molecular weight polyethylene particulate debris of orthopedic implants reveals a novel mechanism of osteolysis2018
- Author(s)
  Terkawi MA, Hamasaki M, Ota M, Takahashi D, Alhasan H, Iwasaki N.
- Organizer
  12th World Immune Regulation Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10993
[Presentation] マクロファージ共培養モデルにおいて軟骨破片が軟骨細胞に与える影響2018
- Author(s)
  濱崎雅成, TERKAWI Mohamad Alaa, 小野寺智洋ら
- Organizer
  第31回　日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-17K19707
[Presentation] Gene profiling of macrophages stimulated by vitamin E-blended ultra-high molecular weight polyethylene debris of orthopedic implants identifies IL-27 as potent regulator of osteolysis2018
- Author(s)
  M Alaa Terkawi
- Organizer
  47th Annual Meeting of the Japanese Society for Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10993
[Presentation] M2マクロファージが持つ末梢神経損傷後の軸索再生促進効果2018
- Author(s)
  永野裕介、角家健、遠藤健、Alaa Terkawi、岩崎倫政
- Organizer
  第61回日本手外科学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11527
[Presentation] マクロファージ共培養モデルにおいて軟骨破片が引き起こすマクロファージの炎症反応および軟骨細胞への影響2018
- Author(s)
  濱崎雅成, TERKAWI Mohamad Alaa, 小野寺智洋ら
- Organizer
  第33回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17K19707
[Presentation] The crucial role of neutrophils in resolution of inflammation elicited by polyethylene debris of orthopedic implants2018
- Author(s)
  M Alaa Terkawi
- Organizer
  40th Annual Meeting of the Japanese Society for Biomaterials
- Data Source
  KAKENHI-PROJECT-17K10993
[Presentation] An Up-Regulation Of Catabolic Factors Of Chondrocytes In Cartilage-Fragments Stimulation Model With Macrophages2018
- Author(s)
  Masanari Hamasaki, Alaa Terkawi, Tomohiro Onodera et al.
- Organizer
  2018 International Cartilage Repair Society World Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19707
[Presentation] The graft of M2 macrophage promotes axon regeneration after peripheral nerve injury2018
- Author(s)
  Yusuke Nagano, Ken Kadoya, Takeshi Endo, Matsui Yuki, Alaa Terkawi, Norimasa Iwasaki
- Organizer
  Orthopaedic Research Society 2018 annual meeting,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11527
[Presentation] Macrophage-secreted factors due to stimulation by implant wear debris promote osteoclast formation and function in bone loss2018
- Author(s)
  Terkawi MA, Hamasaki M, Ota M, Takahashi D, Alhasan H, Takahashi M, Asano T, Irie T, Kadoya K, Iwasaki N.
- Organizer
  2018 Orthopaedic Research Society meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10993
[Presentation] A novel cartilage-fragments stimulation model revealed that macrophage inflammatory response causes an upregulation of catabolic factors of chondrocytes in vitro2018
- Author(s)
  Masanari Hamasaki, Alaa Terkawi, Tomohiro Onodera et al.
- Organizer
  2018　Orthopaedic Research Society Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19707
[Presentation] Macrophage-secreted factors due to stimulation by implant wear debris promote osteoclast formation and function in bone loss2018
- Author(s)
  M Alaa Terkawi
- Organizer
  Orthopaedic Research Society Annual Meeting ORS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10993
[Presentation] Transcriptional profile of stimulated macrophages by ultra-high molecular weight polyethylene debris of orthopedic implants implies a novel mechanism of osteolysis2018
- Author(s)
  M Alaa Terkawi
- Organizer
  18th Japan-France Orthopedic Society Conference SOFJO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10993
[Presentation] Transcriptional profile of human macrophages exposed to ultra-high molecular weight polyethylene particles reveals a common gene expression signature of rheumatoid arthritis2017
- Author(s)
  Terkawi MA, Hamasaki M, Takahashi D, Kadoya K, Asano T, Irie T, Onodera T, Iwasaki N
- Organizer
  The 32nd Annual Research Meeting of the Japanese Orthopaedic Association
- Data Source
  KAKENHI-PROJECT-17K10993
[Presentation] Involvement of β-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum2017
- Author(s)
  Terkawi MA, Takano T, Kato K.
- Organizer
  Japan-Brazil Malaria Research Workshop
- Place of Presentation
  Brazil, Sao Paulo
- Year and Date
  2017-03-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20840
[Presentation] Transcriptional profile of human macrophages stimulated by ultra-high molecular weight polyethylene particulate debris of orthopaedic implants uncovers a common gene expression signature of rheumatoid arthritis2017
- Author(s)
  Terkawi MA, Hamasaki M, Takahashi D, Iwasaki N
- Organizer
  The 16th Awaji International Forum of Infection and Immunity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10993
[Presentation] Comparison of gene expression profiles of human macrophages stimulated by conventional and vitamin E-blended ultra-high molecular weight polyethylene particles of orthopedic implants2017
- Author(s)
  Terkawi MA, Hamasaki M, Takahashi D, Iwasaki N
- Organizer
  The 39th Annual Meeting of the Japanese Society for Biomaterials
- Data Source
  KAKENHI-PROJECT-17K10993
[Presentation] Differentiated gene profile of neutrophils induced by phagocytosis of Plasmodium falciparum-parasitized erythrocytes.2016
- Author(s)
  Terkawi MA
- Organizer
  The 85th Annual Meeting of the Japanese Society of Parasitology.
- Place of Presentation
  宮崎市民プラザ（宮崎市）
- Year and Date
  2016-03-19
- Data Source
  KAKENHI-PROJECT-15K20840
[Presentation] Involvement of a novel cysteine-rich cationic low molecular weight protein in the macrophage microbicidal mechanisms for killing Plasmodium falciparum2015
- Author(s)
  Terkawi MA
- Organizer
  The 14th Awaji international forum on infection and immunity
- Place of Presentation
  淡路夢舞台国際会議場（淡路市）
- Year and Date
  2015-09-08
- Data Source
  KAKENHI-PROJECT-15K20840

1. 清水智弘 (60784246)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
2. Takahashi Daisuke (90528845)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. Onodera Tomohiro (70547174)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
4. Nagano Yusuke (30600168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
5. Hontani Kazutoshi (10805279)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. Norimasa Iwasaki (30322803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
7. Asano Tsuyoshi (50722493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 角家健 (30374276)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
9. 古川潤一 (30374193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 宝満健太郎 (40823331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. 宮崎拓自 (70908194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 長濱宏治 (00551847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 花松久寿 (70734185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 松岡正剛 (70816066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 市川聡 (60333621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 高畑雅彦 (40374368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 堀千明 (50722948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 遠藤努 (90805293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. Kato Kentaro

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
20. Takano Ryo

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
21. 横山直明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 五十嵐慎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Terkawi Alaa 照川 アラー

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Exploring functional roles of osteal macrophages in bone metabolism for the development of osteoporosis therapeuticsPrincipal Investigator

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Development of novel therapeutic intervention for controlling inflammatory osteolysis leading to total hip arthroplastyPrincipal Investigator

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Elucidation of mechanisms by which host immune cells kill protozoan parasites and development of antiparasitic peptidesPrincipal Investigator

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[Book] 別冊BIO Clinica（バイオクリニカ）慢性炎症と疾患2018

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[Journal Article] Noncanonical Pyroptosis Triggered by Macrophage‐Derived Extracellular Vesicles in Chondrocytes Leading to Cartilage Catabolism in Osteoarthritis2023

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Terkawi Alaa 照川アラー