MOTOMURA Kenitiro 本村健一郎

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Motomura Kenichiro 本村健一郎

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Researcher Number	00724329
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立成育医療研究センター, 免疫アレルギー・感染研究部, 研究員
Affiliation (based on the past Project Information) *help	2023: 国立研究開発法人国立成育医療研究センター, 免疫アレルギー・感染研究部, 上級研究員 2022 – 2023: 国立研究開発法人国立成育医療研究センター, 免疫アレルギー・感染研究部, 研究員 2016 – 2018: 国立研究開発法人国立成育医療研究センター, 免疫アレルギー・感染研究部, 共同研究員 2017: 国立研究開発法人国立成育医療研究センター, 免疫アレルギー・感染研究部, リサーチアソシエイト 2015: 国立研究開発法人国立成育医療研究センター, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Embryonic/Neonatal medicine / Basic Section 56040:Obstetrics and gynecology-related / 0906:Surgery related to the biological and sensory functions and related fields Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology
Keywords	Principal Investigator 妊娠合併症 / 胎盤 / 合胞体栄養膜細胞 / 細胞性栄養膜細胞 / 妊娠 / Single cell解析 / 先天性ウイルス感染症 / 初代培養 / 自然免疫 / ウイルス感染症 … More / 栄養膜細胞 / 自然免疫系受容体 / Apoptosis / 合胞体栄養栄養膜細胞 / 二本鎖RNA / パターン認識受容体 / toll like receptor / Syncytiotrophoblast / toll like receptors / Toll like receptors … More Except Principal Investigator 産科学 / 妊娠高血圧腎症 / 病態解析 / 全国患者検体収集 / 薬物動態解析 / 胎内治療全国調査 / ハプロ解析 / 原因蛋白 / 発症頻度 / 全国調査 / エクソーム解析 / 原因遺伝子 / 同種免疫性疾患 / 新生児ヘモクロマトーシス Less

Novel phenotyping and functional analysis of the human cytotrophoblasts in single cell resolutionPrincipal Investigator
- Principal Investigator
  
  本村健一郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  National Center for Child Health and Development
Elucidating the anti-viral responses and host defense mechanisms in the placenta using primary human villous trophoblastsPrincipal Investigator
- Principal Investigator
  
  Motomura Kenichiro
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0906:Surgery related to the biological and sensory functions and related fields
- Research Institution
  National Center for Child Health and Development
妊娠高血圧腎症の母児合併症を改善する抗炎症治療の開発
- Principal Investigator
  
  成瀬勝彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Dokkyo Medical University
Novel mechanisms of pregnancy complications resulting in the innate immune response in the syncytiotrophoblast induced by double-stranded RNAPrincipal Investigator
- Principal Investigator
  
  Motomura Kenichiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  National Center for Child Health and Development
The molecular pathogenesis of immune tolerance and host defense in primary human placenta-derived trophoblastsPrincipal Investigator
- Principal Investigator
  
  Motomura Kenichiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  National Center for Child Health and Development
Identification of fetal hepatic antigen of neonatl hemochromatosis and development of maternal IgG assay for NH
- Principal Investigator
  
  Sasaki Aiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  National Center for Child Health and Development

All 2024 2023 2017 2016 2015

All Journal Article Presentation

[Journal Article] Implication of viruses in the etiology of preeclampsia2024
- Author(s)
  Motomura Kenichiro、Morita Hideaki、Naruse Katsuhiko、Saito Hirohisa、Matsumoto Kenji
- Journal Title
  
  American Journal of Reproductive Immunology
  
  Volume: 91 Issue: 4
- DOI
  10.1111/aji.13844
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09577, KAKENHI-PROJECT-23K08813, KAKENHI-PROJECT-22K20982
[Journal Article] Comprehensive Analysis of the Expression and Functions of Pattern Recognition Receptors in Differentiated Cytotrophoblasts Derived from Term Human Placentas2023
- Author(s)
  Motomura Kenichiro、Morita Hideaki、Okada Naoko、Matsuda Akio、Nakae Susumu、Fujieda Mikiya、Sago Haruhiko、Saito Hirohisa、Matsumoto Kenji
- Journal Title
  
  The Journal of Immunology
  
  Volume: 210 Issue: 10 Pages: 1552-1563
- DOI
  10.4049/jimmunol.2300008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08570, KAKENHI-PROJECT-23K08813, KAKENHI-PROJECT-22K20982, KAKENHI-PROJECT-21H02963
[Journal Article] Roles of human trophoblasts’ pattern recognition receptors in host defense and pregnancy complications2023
- Author(s)
  Motomura Kenichiro、Hara Mariko、Ito Ikuyo、Morita Hideaki、Matsumoto Kenji
- Journal Title
  
  Journal of Reproductive Immunology
  
  Volume: 156 Pages: 103811-103811
- DOI
  10.1016/j.jri.2023.103811
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K20982
[Journal Article] サイトカインネットワーク2017
- Author(s)
  本村健一郎　松本健治
- Journal Title
  
  周産期医学
  
  Volume: 47 Pages: 1521-1526
- Data Source
  KAKENHI-PROJECT-17K18404
[Journal Article] A Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro2017
- Author(s)
  Kenichiro Motomura, Naoko Okada, Hideaki Morita, Mariko Hara, Masato Tamari, Keisuke Orimo, Go Matsuda, Ken-Ichi Imadome, Akio Matsuda, Takeshi Nagamatsu, Mikiya Fujieda, Haruhiko Sago, Hirohisa Saito, and Kenji Matsumoto
- Journal Title
  
  PLOS ONE
  
  Volume: in press Issue: 5 Pages: e0177994-e0177994
- DOI
  10.1371/journal.pone.0177994
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K21655, KAKENHI-PROJECT-17K10116, KAKENHI-PROJECT-17K11500, KAKENHI-PROJECT-17K18404, KAKENHI-PROJECT-15H04979, KAKENHI-PROJECT-15K09468, KAKENHI-PROJECT-17K10166
[Journal Article] 初代培養合胞体栄養膜細胞の母児免疫寛容・生体防御機構と妊娠合併症発症機序の解明2016
- Author(s)
  本村　健一郎
- Journal Title
  
  産科と婦人科
  
  Volume: 84 Pages: 210-212
- Data Source
  KAKENHI-PROJECT-15K21655
[Journal Article] Fetal Magnetic Resonance Imaging Detection of Liver Iron Deposition in Neonatal Hemochromatosis During Prenatal Therapy2016
- Author(s)
  Sasaki A1, Motomura K, Suyama F, Nagasawa J, Hisano M, Ito R, Miyazaki O, Nakazawa A, Ito Y, Kasahara M, Asai A, Matsumoto K, Sago H, Yamaguchi K.
- Journal Title
  
  J Pediatr Gastroenterol Nutr
  
  Volume: 63 Issue: 5
- DOI
  10.1097/mpg.0000000000001265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10696
[Presentation] . Viral Infection Impairs Placenta Function by Inhibiting Human Cytotrophoblasts’ Differentiation and Fusion into the Syncytiotrophoblast2024
- Author(s)
  Kenichiro Motomura, Hideaki Morita, Keiko Matsubara, Seiji Wada, Haruhiko Sago, Hirohisa Saito, Kenji Matsumoto
- Organizer
  The 71st meeting of the Society for Reproductive Investigation
- Data Source
  KAKENHI-PROJECT-22K20982
[Presentation] Viral infection impairs placenta function by inhibiting differentiation of human cytotrophoblasts2024
- Author(s)
  Kenichiro Motomura, Keiko Matsubara, Seiji Wada, Haruhiko Sago
- Organizer
  第76回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-22K20982
[Presentation] ヒト合胞体栄養膜細胞に発現する自然免疫系受容体の網羅的発現・機能解析2023
- Author(s)
  本村　健一郎, 森田　英明, 左合　治彦, 斎藤　博久, 松本　健治
- Organizer
  第38回日本生殖免疫学会
- Data Source
  KAKENHI-PROJECT-22K20982
[Presentation] Comprehensive analysis of expression of functional pattern recognition receptors in differentiated cytotrophoblasts derived from human term placentas2023
- Author(s)
  Kenichiro Motomura
- Organizer
  The 70th Annual Meeting of the Society for Reproductive Investigation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20982
[Presentation] Comprehensive analysis of expression of functional pattern recognition receptors in differentiated cytotrophoblasts derived from human term placentas2023
- Author(s)
  Kenichiro Motomura, Hideaki Morita, Haruhiko Sago, Hirohisa Saito, Kenji Matsumoto
- Organizer
  The 70st meeting of the Society for Reproductive Investigation
- Data Source
  KAKENHI-PROJECT-22K20982
[Presentation] Differentiated cytotrophoblasts induce anti-viral responses through receptors for double-stranded RNA2017
- Author(s)
  Kenichiro Motomura, Naoko Okada, Hideaki Morita, Akio Matsuda, Haruhiko Sago, Hirohisa Saito and Kenji Matsumoto
- Organizer
  AMERICAN SOCIETY FOR REPRODUCTIVE IMMUNOLOGY ANNUAL MEETING
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18404
[Presentation] Double-stranded RNA regulates BCL2 family molecules and induces apoptosis in human cultured syncytiotrophoblasts via toll-like receptor 3. A possible mechanism for pregnancy complications?2017
- Author(s)
  Kenichiro Motomura, Haruhiko Sago
- Organizer
  日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K18404
[Presentation] Double-stranded RNA regulates BCL2 family molecules and induces apoptosis in human cultured syncytiotrophoblasts via toll-like receptor 3. A possible mechanism for pregnancy complications?2017
- Author(s)
  Kenichiro Motomura, Haruhiko Sago
- Organizer
  第69回日本産科婦人科学会学術講演会
- Place of Presentation
  広島
- Year and Date
  2017-04-13
- Data Source
  KAKENHI-PROJECT-15K21655
[Presentation] Double-stranded RNA induces apoptosis in human term Syncytiotrophoblasts and mouse placentas via Toll-like receptor 32016
- Author(s)
  Kenichiro Motomura, Naoko Okada, Akio Matsuda, Susumu Nakae, Haruhiko Sago, Hirohisa Saito and Kenji Matsumoto
- Organizer
  International Society for Immunology of Reproduction
- Place of Presentation
  Germany
- Year and Date
  2016-06-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21655
[Presentation] ウイルス由来二本鎖RNAはtoll-like receptor３を介して満期胎盤由来合胞体栄養膜細胞にアポトーシスを誘導する2016
- Author(s)
  本村　健一郎
- Organizer
  日本産婦人科学会
- Place of Presentation
  東京
- Year and Date
  2016-04-23
- Data Source
  KAKENHI-PROJECT-15K21655
[Presentation] Double-stranded RNA regulates BCL2 family molecules and induces apoptosis in human cultured syncytiotrophoblasts via toll-like receptor 3. A possible mechanism for pregnancy complications?2016
- Author(s)
  Kenichiro Motomura, Naoko Okada, Akio Matsuda, Susumu Nakae, Haruhiko Sago, Hirohisa Saito, Kenji Matsumoto
- Organizer
  Gordon Research Conference
- Place of Presentation
  USA
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21655
[Presentation] Double stranded RNA induces apoptosis in human term syncytiotrophoblast by stimulation via TLR32016
- Author(s)
  Kenichiro Motomura
- Organizer
  世界生殖免疫学会
- Place of Presentation
  Erfurt
- Year and Date
  2016-06-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21655
[Presentation] Induction of apoptosis in human term Syncytiotrophoblast by stimulation via TLR32015
- Author(s)
  Kenichiro Motomura
- Organizer
  国際胎盤学会
- Place of Presentation
  Brisbane
- Year and Date
  2015-09-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21655

1. Sasaki Aiko (60560711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 成瀬勝彦 (70453165)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 三宅龍太 (20866008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 市川麻祐子 (30833678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 竹田善紀 (50825239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 赤坂珠理晃 (90526724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 柴田英治 (90419838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 岡田直子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MOTOMURA Kenitiro 本村 健一郎

Motomura Kenichiro 本村 健一郎

Research Projects

Research Products

Co-Researchers

Novel phenotyping and functional analysis of the human cytotrophoblasts in single cell resolutionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the anti-viral responses and host defense mechanisms in the placenta using primary human villous trophoblastsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

妊娠高血圧腎症の母児合併症を改善する抗炎症治療の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel mechanisms of pregnancy complications resulting in the innate immune response in the syncytiotrophoblast induced by double-stranded RNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The molecular pathogenesis of immune tolerance and host defense in primary human placenta-derived trophoblastsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of fetal hepatic antigen of neonatl hemochromatosis and development of maternal IgG assay for NH

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Implication of viruses in the etiology of preeclampsia2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive Analysis of the Expression and Functions of Pattern Recognition Receptors in Differentiated Cytotrophoblasts Derived from Term Human Placentas2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Roles of human trophoblasts’ pattern recognition receptors in host defense and pregnancy complications2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] サイトカインネットワーク2017

Author(s)

Journal Title

Data Source

[Journal Article] A Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 初代培養合胞体栄養膜細胞の母児免疫寛容・生体防御機構と妊娠合併症発症機序の解明2016

Author(s)

Journal Title

Data Source

[Journal Article] Fetal Magnetic Resonance Imaging Detection of Liver Iron Deposition in Neonatal Hemochromatosis During Prenatal Therapy2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] . Viral Infection Impairs Placenta Function by Inhibiting Human Cytotrophoblasts’ Differentiation and Fusion into the Syncytiotrophoblast2024

Author(s)

Organizer

Data Source

[Presentation] Viral infection impairs placenta function by inhibiting differentiation of human cytotrophoblasts2024

Author(s)

MOTOMURA Kenitiro 本村健一郎

Motomura Kenichiro 本村健一郎