Yahiro Takuya 八代拓也

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Yashiro Takuya 八代拓也

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Researcher Number	00726482
Other IDs	https://orcid.org/0000-0002-9319-3467
Affiliation (Current)	2024: 大阪大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2022: 東京理科大学, 基礎工学部生物工学科, 講師 2021 – 2022: 大阪大学, 医学系研究科, 助教 2020: 東京理科大学, 基礎工学部生物工学科, 講師 2017 – 2019: 東京理科大学, 基礎工学部生物工学科, 助教
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Food science / Basic Section 38050:Food sciences-related Except Principal Investigator Basic Section 38050:Food sciences-related
Keywords	Principal Investigator アレルギー / ストレス / 2型自然リンパ球 / 発現制御 / 食品 / 経口免疫寛容 / レチノイン酸 / Aldh1a2 / Kaempferol / RALDH2 … More / AhR / ケンフェロール / γ-オキソ脂肪酸 / T細胞 / 樹状細胞 / 自己免疫疾患 / 免疫抑制 / 不飽和脂肪酸 / 乳酸菌 … More Except Principal Investigator IgE抗体 / シクロオキシゲナーゼ（COX） / 短鎖脂肪酸(SCFA) / Gタンパク質共役型受容体（GPCR） / 免疫 / アレルギー / 多価不飽和脂肪酸（PUFA） / 短鎖脂肪酸（SCFA） / アナフィラキシー / IgE / GPR109A / Gタンパク質共役型受容体 / PGE2 / 多価不飽和脂肪酸 / マスト細胞 / 短鎖脂肪酸 Less

Effect of psychological stress on group2 innate lymphoid cell-dependent allergic diseasesPrincipal Investigator
- Principal Investigator
  
  八代拓也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Osaka University
Molecular mechanisms and physiological significance of short chain fatty acid- and polyunsaturated fatty acid-mediated regulation of mast cell function
- Principal Investigator
  
  Nishiyama Chiharu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Tokyo University of Science
Immunosuppressive function of unsaturated fatty acid produced by lactic acid bacteria.Principal Investigator
- Principal Investigator
  
  Yashiro Takuya
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Osaka University
  Tokyo University of Science
Effects of polyphenol intake on RALDH2 expression and intestinal immunityPrincipal Investigator
- Principal Investigator
  
  Yashiro Takuya
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Food science
- Research Institution
  Tokyo University of Science

All 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] PU.1 and IRF8 Modulate Activation of NLRP3 Inflammasome via Regulating Its Expression in Human Macrophages2021
- Author(s)
  Yashiro Takuya、Yamamoto Machiko、Araumi Sanae、Hara Mutsuko、Yogo Kyoko、Uchida Koichiro、Kasakura Kazumi、Nishiyama Chiharu
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 649572-649572
- DOI
  10.3389/fimmu.2021.649572
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H02939
[Journal Article] Cooperative Regulation of the Mucosal Mast Cell-Specific Protease Genes Mcpt1 and Mcpt2 by GATA and Smad Transcription Factors.2020
- Author(s)
  Kasakura K, Nagata K, Miura R, Iida M, Nakaya H, Okada H, Arai T, Arai T, Kawakami Y, Kawakami T, Yashiro T, Nishiyama C.
- Journal Title
  
  The Journal of Immunology
  
  Volume: 204 Issue: 6 Pages: 1641-1649
- DOI
  10.4049/jimmunol.1900094
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08920, KAKENHI-PROJECT-20H02939
[Journal Article] The anti-inflammatory effect of the gut lactic acid bacteria-generated metabolite 10-oxo-cis-6,trans-11-octadecadienoic acid on monocytes2020
- Author(s)
  Hagiwara Shuhei、Nagata Kazuki、Kasakura Kazumi、Sakata Fumiya、Kishino Shigenobu、Ogawa Jun、Yashiro Takuya、Nishiyama Chiharu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 530 Issue: 1 Pages: 342-347
- DOI
  10.1016/j.bbrc.2020.07.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02939
[Journal Article] PU.1 regulates Ccr7 gene expression by binding to its promoter in na?ve CD4 + T cells2020
- Author(s)
  Yashiro Takuya、Takeuchi Hiromi、Kasakura Kazumi、Nishiyama Chiharu
- Journal Title
  
  FEBS Open Bio
  
  Volume: 10 Issue: 6 Pages: 1115-1121
- DOI
  10.1002/2211-5463.12861
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H02939
[Journal Article] Pterostilbene reduces colonic inflammation by suppressing dendritic cell activation and promoting regulatory T cell development2020
- Author(s)
  Yashiro Takuya、Yura Shiori、Tobita Akari、Toyoda Yuki、Kasakura Kazumi、Nishiyama Chiharu
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 11 Pages: 14810-14819
- DOI
  10.1096/fj.202001502r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02939
[Journal Article] Dual Roles of PU.1 in the Expression of PD-L2: Direct Transactivation with IRF4 and Indirect Epigenetic Regulation2020
- Author(s)
  Inaba Keito、Yashiro Takuya、Hiroki Ikumi、Watanabe Ryosuke、Kasakura Kazumi、Nishiyama Chiharu
- Journal Title
  
  The Journal of Immunology
  
  Volume: 205 Issue: 3 Pages: 822-829
- DOI
  10.4049/jimmunol.1901008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02939
[Journal Article] The transcription factors PU.1 and IRF4 determine cell-specific expression of RALDH2.2018
- Author(s)
  Yashiro T, Yamaguchi M, Watanuki Y, Kasakura K, Nishiyama C
- Journal Title
  
  Journal of Immunology
  
  Volume: 201 Issue: 12 Pages: 3677-3682
- DOI
  10.4049/jimmunol.1800492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J03241, KAKENHI-PROJECT-17K15276, KAKENHI-PROJECT-17K15275
[Presentation] The effects of butyrate on immune checkpoint signaling and improvement of psoriasis2021
- Author(s)
  Hinako Ikeda, Shodai Suzuki, Takuya Yashiro, Chiharu Nishiyama
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-20H02939
[Presentation] GATA2とPU.1による粘膜型マスト細胞特異的遺伝子の発現制御機構2021
- Author(s)
  井上真理子、秋元悠太、長田和樹、笠倉和巳、八代拓也、西山千春
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-20H02939
[Presentation] シソ葉香気成分ペリルアルデヒドは樹状細胞における炎症性サイトカインの発現を抑制し、皮膚炎を改善する2021
- Author(s)
  岡田光、八代拓也、西山千春
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-20H02939
[Presentation] NotchシグナルとTGF-βシグナルの相互依存的な作用が粘膜型マスト細胞の分化を促進させる2021
- Author(s)
  中野信浩、才田一樹、北浦次郎、八代拓也、西山千春、奥村康、小川秀興
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-20H02939
[Presentation] γ-リノレン酸の乳酸菌代謝産物であるγKetoCはNRF2活性化を介して免疫抑制作用を発揮する2021
- Author(s)
  八代拓也、山本愛日、飯田真由、大村さくら、市原学、岸野重信、小川順、西山千春
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-20H02939
[Presentation] The nature of delta opioid receptor as an immunomodulator in the colitis2021
- Author(s)
  Kazuki Nagata, Hiroshi Nagase, Takuya Yashiro, Chiharu Nishiyama
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-20H02939
[Presentation] 新規免疫抑制化合物の探索とその作用機序の解析2020
- Author(s)
  横山友香、八代拓也、坂田文弥、平野弘之、長田裕之、西山千春
- Organizer
  日本農芸化学会関東支部2020年度大会
- Data Source
  KAKENHI-PROJECT-20H02939
[Presentation] シンナムアルデヒドによる免疫調節2020
- Author(s)
  伊藤直人、八代拓也、西山千春
- Organizer
  日本農芸化学会関東支部2020年度大会
- Data Source
  KAKENHI-PROJECT-20H02939
[Presentation] Formation of pH-responsive associations targeting macrophages & dendritic cells2020
- Author(s)
  Shotaro Matsuda, Ken Gotoh, Syuuhei Komatsu, Takuya Yashiro, Chiharu Nishiyama, Akihiko Kikuchi
- Organizer
  3rd G'L'owing Polymer Symposium in KANTO
- Data Source
  KAKENHI-PROJECT-20H02939
[Presentation] マスト細胞機能を調節するポリフェノールの作用機構2020
- Author(s)
  廣木郁美、長田和樹、八代拓也、西山千春
- Organizer
  日本農芸化学会関東支部2020年度大会
- Data Source
  KAKENHI-PROJECT-20H02939
[Presentation] 粘膜型マスト細胞の特異的遺伝子発現制御機構2020
- Author(s)
  井上真理子、長田和樹、笠倉和巳、八代拓也、西山千春
- Organizer
  日本農芸化学会関東支部2020年度大会
- Data Source
  KAKENHI-PROJECT-20H02939
[Presentation] フラボノイドkaempferolによるマスト細胞の活性化抑制2020
- Author(s)
  荒海咲苗、長田和樹、八代拓也、西山千春
- Organizer
  日本農芸化学会関東支部2020年度大会
- Data Source
  KAKENHI-PROJECT-20H02939
[Presentation] レチノイン酸合成酵素RALDH2を介したフラボノールによる腸管免疫の恒常性維持2019
- Author(s)
  八代拓也、綿貫優実、山口昌樹、西山千春
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-17K15275
[Presentation] KaempferolによるRALDH2発現誘導メカニズム2018
- Author(s)
  綿貫優実、八代拓也、山口昌樹、笠倉和巳、西山千春
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-17K15275

1. Nishiyama Chiharu (20327836)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
2. WATANUKI Yumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. YAMAGUCHI Masaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. KASAKURA Kazumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Yahiro Takuya 八代 拓也

Yashiro Takuya 八代 拓也

Research Projects

Research Products

Co-Researchers

Effect of psychological stress on group2 innate lymphoid cell-dependent allergic diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms and physiological significance of short chain fatty acid- and polyunsaturated fatty acid-mediated regulation of mast cell function

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Immunosuppressive function of unsaturated fatty acid produced by lactic acid bacteria.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of polyphenol intake on RALDH2 expression and intestinal immunityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] PU.1 and IRF8 Modulate Activation of NLRP3 Inflammasome via Regulating Its Expression in Human Macrophages2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cooperative Regulation of the Mucosal Mast Cell-Specific Protease Genes Mcpt1 and Mcpt2 by GATA and Smad Transcription Factors.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The anti-inflammatory effect of the gut lactic acid bacteria-generated metabolite 10-oxo-cis-6,trans-11-octadecadienoic acid on monocytes2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PU.1 regulates Ccr7 gene expression by binding to its promoter in na?ve CD4 + T cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pterostilbene reduces colonic inflammation by suppressing dendritic cell activation and promoting regulatory T cell development2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dual Roles of PU.1 in the Expression of PD-L2: Direct Transactivation with IRF4 and Indirect Epigenetic Regulation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The transcription factors PU.1 and IRF4 determine cell-specific expression of RALDH2.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] The effects of butyrate on immune checkpoint signaling and improvement of psoriasis2021

Author(s)

Organizer

Data Source

[Presentation] GATA2とPU.1による粘膜型マスト細胞特異的遺伝子の発現制御機構2021

Author(s)

Organizer

Data Source

[Presentation] シソ葉香気成分ペリルアルデヒドは樹状細胞における炎症性サイトカインの発現を抑制し、皮膚炎を改善する2021

Author(s)

Organizer

Data Source

[Presentation] NotchシグナルとTGF-βシグナルの相互依存的な作用が粘膜型マスト細胞の分化を促進させる2021

Author(s)

Organizer

Data Source

Yahiro Takuya 八代拓也

Yashiro Takuya 八代拓也