Higuchi Takashi 樋口貴史

… Alternative Names

樋口貴史ヒグチタカシ

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Researcher Number	00728719
Other IDs	https://orcid.org/0000-0002-7489-1657
Affiliation (Current)	2025: 金沢大学, 医学系, 協力研究員
Affiliation (based on the past Project Information) *help	2024: 金沢大学, 医学系, 協力研究員 2020 – 2022: 金沢大学, 医学系, 協力研究員 2017: 金沢大学, 附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / 0901:Oncology and related fields / Orthopaedic surgery
Keywords	Principal Investigator 化学療法 / 骨肉腫 / 薬剤耐性 / RAGE / 動物実験 / マルチキナーゼ阻害剤 / 患者由来組織移植モデル / マルチキナーゼ阻害薬 / 細胞・組織 / 癌 … More / 臨床 / 非ステロイド性抗炎症薬 / 軟骨肉腫 / PPARγ Less

骨肉腫における後期糖化産物受容体（RAGE）を標的とした病態解析と新規治療の開発Principal Investigator
- Principal Investigator
  
  樋口貴史
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kanazawa University
Development of a novel treatment for osteosarcoma with multi-kinase inhibitorsPrincipal Investigator
- Principal Investigator
  
  Higuchi Takashi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Kanazawa University
軟骨肉腫に対するPPARγを標的にした抗腫瘍効果の解析Principal Investigator
- Principal Investigator
  
  樋口貴史
- Project Period (FY)
  2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kanazawa University

All 2022 2021 2017

All Journal Article Presentation

[Journal Article] A nonsteroidal anti-inflammatory drug, zaltoprofen, inhibits the growth of extraskeletal chondrosarcoma cells by inducing PPARγ, p21, p27, and p532022
- Author(s)
  Higuchi T, Takeuchi A, Munesue S, Yamamoto N, Hayashi K, Harashima A, Yamamoto Y, Tsuchiya H
- Journal Title
  
  Cell Cycle
  
  Volume: 22 Issue: 8 Pages: 939-950
- DOI
  10.1080/15384101.2023.2166195
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22802, KAKENHI-PROJECT-22K09396, KAKENHI-PROJECT-23K06376, KAKENHI-PROJECT-21K09317, KAKENHI-PROJECT-21H02695
[Journal Article] Multikinase-Inhibitor Screening in Drug-resistant Osteosarcoma Patient-derived Orthotopic Xenograft Mouse Models Identifies the Clinical Potential of Regorafenib2021
- Author(s)
  HIGUCHI TAKASHI、IGARASHI KENTARO、YAMAMOTO NORIO、HAYASHI KATSUHIRO、KIMURA HIROAKI、MIWA SHINJI、BOUVET MICHAEL、TSUCHIYA HIROYUKI、HOFFMAN ROBERT M.
- Journal Title
  
  Cancer Genomics - Proteomics
  
  Volume: 18 Issue: 5 Pages: 637-643
- DOI
  10.21873/cgp.20286
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09571, KAKENHI-PROJECT-21K09198, KAKENHI-PROJECT-20K22802
[Journal Article] ザルトプロフェンはPPARγを介して軟骨肉腫における浸潤能および遊走能の抑制効果を発揮する2017
- Author(s)
  樋口貴史、武内章彦、土屋弘行、山本靖彦、棟居聖一
- Journal Title
  
  整形外科
  
  Volume: 68 Pages: 1082-1082
- Data Source
  KAKENHI-PROJECT-17K16682
[Presentation] Efficacy of multi-kinase inhibitors in osteosarcoma treatment: A patient-derived orthotopic xenograft study2022
- Author(s)
  Higuchi T, Yamamoto N, Hayashi K, Takeuchi A, Miwa S, Igarashi K, Taniguchi Y, Morinaga S, Asano Y, Hoffman RM, Tsuchiya H
- Organizer
  21st International Society Of Limb Salvage (ISOLS) General Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22802
[Presentation] マルチキナーゼ阻害薬による骨肉腫治療の可能性：患者由来組織同所移植モデルを用いた解析2022
- Author(s)
  樋口貴史, 山本憲男, 林克洋, 武内章彦, 三輪真嗣, 五十嵐健太郎, Robert, M.Hoffman, 土屋弘行
- Organizer
  第37回日本整形外科学会基礎学術集会第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-20K22802
[Presentation] 軟骨肉腫に対する非ステロイド性抗炎症薬による抗腫瘍効果の解析と新たな治療戦略の可能性2017
- Author(s)
  樋口貴史、山本憲男、武内章彦、林　克洋、棟居聖一、山本靖彦、土屋弘行
- Organizer
  第129回中部日本整形外科災害外科学会・学術集会
- Place of Presentation
  富山
- Year and Date
  2017-10-06
- Data Source
  KAKENHI-PROJECT-17K16682
[Presentation] Non-steroidal anti-inflammatory drug zaltoprofen demonstrates antitumor potency via the activation of peroxisome proliferator-activated receptor gamma in chondrosarcoma2017
- Author(s)
  Higuchi T, Yamamoto N, Hayashi K, Takeuchi A, Abe K, Taniguchi Y, Aiba H, Karem Zekry, Xu Gang, Tsuchiya H
- Organizer
  19th ISOLS/MSTS
- Place of Presentation
  Kanazawa, Japan
- Year and Date
  2017-05-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16682
[Presentation] Zaltoprofenはin vitro とin vivoにおいてPPARγを介して軟骨肉腫の増殖を抑制する2017
- Author(s)
  樋口貴史、山本憲男、武内章彦、林　克洋、阿部健作、谷口裕太、相羽久輝、村上英樹、棟居聖一、山本靖彦、土屋弘行
- Organizer
  第32回日本整形外科基礎学術集会
- Place of Presentation
  沖縄
- Year and Date
  2017-10-26
- Data Source
  KAKENHI-PROJECT-17K16682
[Presentation] ZaltoprofenはPPARγを介して軟骨肉腫の増殖を抑制する2017
- Author(s)
  樋口貴史、山本憲男、武内章彦、林　克洋、阿部健作、谷口裕太、相羽久輝、荒木麗博、棟居聖一、山本靖彦、土屋弘行
- Organizer
  第55回日本癌治療学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2017-10-20
- Data Source
  KAKENHI-PROJECT-17K16682
[Presentation] 軟骨肉腫に対するzaltoprofen のPPARγ (Peroxisome Proliferator-Activated Receptor γ)を介した抗腫瘍効果の解析2017
- Author(s)
  樋口貴史、山本憲男、武内章彦、林　克洋、阿部健作、谷口裕太、相羽久輝、村上英樹、棟居聖一、山本靖彦、土屋弘行
- Organizer
  第50回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  仙台
- Year and Date
  2017-05-18
- Data Source
  KAKENHI-PROJECT-17K16682

1. HAYASHI Katsuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 土屋弘行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 山本憲男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 三輪真嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 五十嵐健太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Higuchi Takashi 樋口 貴史

樋口 貴史 ヒグチ タカシ

Research Projects

Research Products

Co-Researchers

骨肉腫における後期糖化産物受容体（RAGE）を標的とした病態解析と新規治療の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel treatment for osteosarcoma with multi-kinase inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

軟骨肉腫に対するPPARγを標的にした抗腫瘍効果の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A nonsteroidal anti-inflammatory drug, zaltoprofen, inhibits the growth of extraskeletal chondrosarcoma cells by inducing PPARγ, p21, p27, and p532022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multikinase-Inhibitor Screening in Drug-resistant Osteosarcoma Patient-derived Orthotopic Xenograft Mouse Models Identifies the Clinical Potential of Regorafenib2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ザルトプロフェンはPPARγを介して軟骨肉腫における浸潤能および遊走能の抑制効果を発揮する2017

Author(s)

Journal Title

Data Source

[Presentation] Efficacy of multi-kinase inhibitors in osteosarcoma treatment: A patient-derived orthotopic xenograft study2022

Author(s)

Organizer

Data Source

[Presentation] マルチキナーゼ阻害薬による骨肉腫治療の可能性：患者由来組織同所移植モデルを用いた解析2022

Author(s)

Organizer

Data Source

[Presentation] 軟骨肉腫に対する非ステロイド性抗炎症薬による抗腫瘍効果の解析と新たな治療戦略の可能性2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Non-steroidal anti-inflammatory drug zaltoprofen demonstrates antitumor potency via the activation of peroxisome proliferator-activated receptor gamma in chondrosarcoma2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Zaltoprofenはin vitro とin vivoにおいてPPARγを介して軟骨肉腫の増殖を抑制する2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] ZaltoprofenはPPARγを介して軟骨肉腫の増殖を抑制する2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 軟骨肉腫に対するzaltoprofen のPPARγ (Peroxisome Proliferator-Activated Receptor γ)を介した抗腫瘍効果の解析2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

Higuchi Takashi 樋口貴史

樋口貴史ヒグチタカシ