Ota Chiharu 大田千晴

Researcher Number	00733106
Other IDs
Affiliation (Current)	2025: 東北大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 東北大学, 医学系研究科, 教授 2018 – 2021: 東北大学, 大学病院, 助教 2017: 東北大学, 東北大学病院小児科, 助教 2016: 東北大学, 医学系研究科, 非常勤講師
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics Except Principal Investigator Basic Section 58030:Hygiene and public health-related: excluding laboratory approach / Basic Section 53020:Cardiology-related / Basic Section 38050:Food sciences-related
Keywords	Principal Investigator 肺胞上皮幹細胞 / サーファクタント / 肺胞傷害 / 肺胞上皮細胞 / 肺血管内皮細胞 / 抗線維化薬 / 肺血管拡張薬 / 間質性肺炎 / 早産低出生体重児 / 慢性肺疾患 … More / 肺発達 / 線維化 / 気腫 / 肺ボリュメトリ / 肺高血圧 / 肺volumetry / 肺発生 / 肺高血圧症 / 未熟児慢性肺疾患 / 小児間質性肺炎 / 2型肺胞上皮細胞 / サーファクタント蛋白 / FACS / 薬剤スクリーニング / 薬物スクリーニング / 小児 / 分化誘導法 / 肺線維化 / 肺胞修復 / 肺胞上皮前駆細胞 / ABCA3 / 遺伝性間質性肺炎 … More Except Principal Investigator ADHD / IQ / 子どもの発達 / 不飽和脂肪酸 / 脳MRI / フレイル / エピジェネティック時計 / 加齢リスク / 成人先天性心疾患 / 出生コホート / オメガ３系脂肪酸 / オメガ３ / 母乳 / 疫学研究 / 縦断的コホート研究 / コホート調査 / 自閉スペクトラル症 / 注意欠如・多動性障害 / 注意欠陥・多動症 / 発達障害 / テストステロン / 行動観察 / 自閉スペクトラム症 / 注意欠如・多動症 Less

成人先天性心疾患患者の長期予後改善に向けた包括的加齢リスク評価法の確立
- Principal Investigator
  
  建部俊介
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Tohoku University
Do omega-3 fatty acids during pregnancy affect IQ at 10 years old?
- Principal Investigator
  
  龍田希
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
- Research Institution
  National Institute for Environmental Studies
胎児期及び乳児期のオメガ３系脂肪酸は８歳のADHD様行動を改善するか
- Principal Investigator
  
  安里要
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Tohto University
  Tohoku University
Analysis of predictors of attention deficit / hyperactivity disorder by longitudinal analysis
- Principal Investigator
  
  Nakai Kunihiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
- Research Institution
  Tokai Gakuen University
Investigation of the pathophysiology and the treatment for pulmonary fibrosis associated with bronchopulmonary dysplasiaPrincipal Investigator
- Principal Investigator
  
  Ota Chiharu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tohoku University
Investigating the drugs to repair injured alveolar epithelial cells using type 2 alveolar epithelial progenitor cells with ABCA3 mutationsPrincipal Investigator
- Principal Investigator
  
  Ota Chiharu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Male infant with Noonan syndrome with RAF-1 gene mutation who survived hypertrophic cardiomyopathy-induced fatal heart failure and uncontrollable arrhythmias2022
- Author(s)
  Hagino Mao、Ota Chiharu、Onoki Takehiko、Iwasawa Shinya
- Journal Title
  
  BMJ Case Reports
  
  Volume: 15 Issue: 9 Pages: e250342-e250342
- DOI
  10.1136/bcr-2022-250342
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08315
[Journal Article] Two Distinct Cases of Adult-onset Kawasaki Disease2022
- Author(s)
  Onoki Takehiko、Metoki Takaya、Iwasawa Shinya、Kawano Kengo、Kimura Masato、Kure Shigeo、Ota Chiharu
- Journal Title
  
  Intern. Med.
  
  Volume: 61 Issue: 23 Pages: 3525-3529
- DOI
  10.2169/internalmedicine.9044-21
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2022-12-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08315
[Journal Article] Thoracic Empyema Secondary to Congenital Chylothorax in a 14-Month-Old Boy with Noonan syndrome2021
- Author(s)
  Takeru Oikawa, Chiharu Ota, Shinya Iwasawa, Takehiko Onoki, Hideyuki Ikeda, and Takushi Hanita
- Journal Title
  
  Casae report in Pediatrics
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08315
[Journal Article] Thoracic Empyema Secondary to Congenital Chylothorax in a 14-Month-Old Boy with Noonan Syndrome.2021
- Author(s)
  Takeru Oikawa, Chiharu Ota, Shinya Iwasawa, Takehiko Onoki, Hideyuki Ikeda, Takushi Hanita
- Journal Title
  
  Case Rep Pediatr
  
  Volume: 6620353 Pages: 1-5
- DOI
  10.1155/2021/6620353
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08315
[Journal Article] Bilateral lung transplantation in a 9-year-old girl with bronchopulmonary dysplasia with pulmonary hypertension.2021
- Author(s)
  Chiharu Ota, Ryoko Saito, Junya Tominaga, Shinya Iwasawa, Takashi Hirama, Yasushi Matsuda, Katsunori Ono, Takehiko Onoki, Masato Kimura, Yoshinori Kawabata, Yoshinori Okada
- Journal Title
  
  Pediatric Pulmonology
  
  Volume: 56 Issue: 10 Pages: 3417-3421
- DOI
  10.1002/ppul.25597
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08315
[Journal Article] Wnt/β-catenin signaling is critical for regenerative potential of distal lung epithelial progenitor cells in homeostasis and emphysema2020
- Author(s)
  Hu Yan、Ng-Blichfeldt John-Poul、Ota Chiharu、Ciminieri Chiara、Ren Wenhua、Hiemstra Pieter S.、Stolk Jan、Gosens Reinoud、K?nigshoff Melanie
- Journal Title
  
  STEM CELLS
  
  Volume: 38 Issue: 11 Pages: 1467-1478
- DOI
  10.1002/stem.3241
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08315
[Journal Article] Extracellular‐Matrix‐Reinforced Bioinks for 3D Bioprinting Human Tissue2020
- Author(s)
  De Santis Martina M, Alsafadi Hani N, Tas Sinem, Ota Chiharu, Wagner Darcy E, et al..
- Journal Title
  
  Advanced Materials
  
  Volume: 33 Issue: 3 Pages: 2005476-2005476
- DOI
  10.1002/adma.202005476
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08315
[Journal Article] Preoperative administration of propranolol reduced the surgical risks of PHACES syndrome in a 14-month-old girl2019
- Author(s)
  Rokugo Yuka、Ota Chiharu、Kimura Masato、Sasahara Yoji
- Journal Title
  
  BMJ Case Reports
  
  Volume: 12 Issue: 4 Pages: e228117-e228117
- DOI
  10.1136/bcr-2018-228117
- Data Source
  KAKENHI-PROJECT-19K08315, KAKENHI-PROJECT-16K10056
[Journal Article] Improving the viability of tissue‐resident stem cells using an organ‐preservation solution2019
- Author(s)
  Suzuki Takaya、Ota Chiharu、Fujino Naoya、Tando Yukiko、Suzuki Satoshi、Yamada Mitsuhiro、Kondo Takashi、Okada Yoshinori、Kubo Hiroshi
- Journal Title
  
  FEBS Open Bio
  
  Volume: 9 Issue: 12 Pages: 2093-2104
- DOI
  10.1002/2211-5463.12748
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08134, KAKENHI-PROJECT-19K08315, KAKENHI-PROJECT-16K10056
[Journal Article] Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis2018
- Author(s)
  Ota Chiharu、Ng-Blichfeldt John-Poul、Korfei Martina、Alsafadi Hani N.、Lehmann Mareike、Skronska-Wasek Wioletta、M. De Santis Martina、Guenther Andreas、Wagner Darcy E.、K?nigshoff Melanie
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41598-018-31214-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10056
[Journal Article] Expression of cytochrome P450 mRNAs in Type II alveolar cells from subjects with chronic obstructive pulmonary disease.2018
- Author(s)
  Kamata S, Fujino N, Yamada M, Grime K, Suzuki S, Ota C, Tando Y, Okada Y, Sakurada A, Noda M, Matsuda Y, Sugiura H, Ichinose M.
- Journal Title
  
  Pharmacol Res Perspect.
  
  Volume: 6 Pages: 1-7
- Data Source
  KAKENHI-PROJECT-16K10056
[Journal Article] Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis2018
- Author(s)
  Lehmann Mareike、Buhl Lara、Alsafadi Hani N.、Klee Stephan、Hermann Sarah、Mutze Kathrin、Ota Chiharu、Lindner Michael、Behr J?rgen、Hilgendorff Anne、Wagner Darcy E.、K?nigshoff Melanie
- Journal Title
  
  Respiratory Research
  
  Volume: 19 Issue: 1 Pages: 1-12
- DOI
  10.1186/s12931-018-0876-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10056
[Journal Article] Asymptomatic left atrial appendage aneurysm (LAAA) with pericardial defect in a 1-year-old girl2018
- Author(s)
  Ota Chiharu、Kimura Masato、Kitami Masahiro、Kure Shigeo
- Journal Title
  
  BMJ Case Reports
  
  Volume: bcr～2018-224573 Pages: 1-2
- DOI
  10.1136/bcr-2018-224573
- Data Source
  KAKENHI-PROJECT-16K10056
[Journal Article] Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo2017
- Author(s)
  Lehmann M, Korfei M, Mutze K, Klee S, Skronska-Wasek W, Alsafadi HN, Ota C, Costa R, Schiller HB, Lindner M, Wagner DE, Guenther A, Koenigshoff M
- Journal Title
  
  European Respiratory Journal
  
  Volume: 50 Issue: 2 Pages: 1-7
- DOI
  10.1183/13993003.02367-2016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10056
[Presentation] 当院小児科および循環器内科でフォロー中の異なる年齢層の成人期Eisenmenger症候群症例の検討2020
- Author(s)
  大田千晴，岩澤伸哉，大軒健彦，木村正人，六郷由佳，建部俊介
- Organizer
  小児循環器学会
- Data Source
  KAKENHI-PROJECT-19K08315
[Presentation] Bilateral lung transplantation (BLTx) in a 9-year-old girl with pulmonary hypertension associated with severe bronchopulmonary dysplasia (BPD)2019
- Author(s)
  Chiharu Ota, Masato Kimura, Yasushi Matsuda, Shinya Iwasawa, Ryoko Saito, Yoshinori Kawabata, Shigeo Kure, Yoshinori Okada
- Organizer
  American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08315
[Presentation] ABCA3変異に伴う遺伝性間質性肺炎に対し脳死肺移植を行った女児例2019
- Author(s)
  大田千晴，木村正人，岩澤伸哉，松田安史，岡田克典，齊藤涼子，呉繁夫
- Organizer
  第52回日本小児呼吸器学会
- Data Source
  KAKENHI-PROJECT-16K10056
[Presentation] 間質性肺炎に対し，脳死肺移植を施行した1歳女児例2019
- Author(s)
  大田千晴
- Organizer
  第19回東北びまん性肺疾患研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16K10056
[Presentation] 慢性肺疾患に合併した肺高血圧に対し　肺血管拡張薬投与が有効であった2例2018
- Author(s)
  大田千晴，木村正人，荒川貴弘呉　繁夫
- Organizer
  日本小児呼吸器学会
- Data Source
  KAKENHI-PROJECT-16K10056
[Presentation] Wnt activity marks lung progenitors capable of forming spheres in vitro2017
- Author(s)
  John-Poul Ng-Blichfeldt, Chiharu Ota, Jan Stolk, Pieter Hiemstra, Reinoud Gosens, Melanie Koenigshoff
- Organizer
  American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10056
[Presentation] HOPX-WNT pathway regulates alveolar homeostasis2017
- Author(s)
  Chiharu Ota, John-Poul Ng-Blichfeldt, Kathrin Mutze, Wioletta Skronska, Hoeke Baasma, Darcy Wagner, Melanie Koenigshoff
- Organizer
  American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10056

1. Nakai Kunihiko (00291336)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 龍田希 (40547709)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 菊池敦生 (30447156)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 木村正人 (80646894)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 川端輝江 (80190932)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 丹藤由希子 (70596212)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 山田充啓 (00396483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 埴田卓志 (30400360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 小山涼子 (30733349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 大田英揮 (40586905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
11. 和田陽一 (60843670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 竹澤祐介 (10837793)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 穴井茜 (30825724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 安里要 (40848149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 鈴木吉也 (30422116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 建部俊介 (90456062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 安田聡 (00431578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 矢尾板信裕 (00735368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 竹内雅史 (00973819)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 鈴木秀明 (20705462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 岩澤伸哉 (30843627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 舘脇康子 (40722202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 齊藤涼子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Ota Chiharu 大田 千晴

Research Projects

Research Products

Co-Researchers

成人先天性心疾患患者の長期予後改善に向けた包括的加齢リスク評価法の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Do omega-3 fatty acids during pregnancy affect IQ at 10 years old?

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

胎児期及び乳児期のオメガ３系脂肪酸は８歳のADHD様行動を改善するか

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of predictors of attention deficit / hyperactivity disorder by longitudinal analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the pathophysiology and the treatment for pulmonary fibrosis associated with bronchopulmonary dysplasiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigating the drugs to repair injured alveolar epithelial cells using type 2 alveolar epithelial progenitor cells with ABCA3 mutationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Male infant with Noonan syndrome with RAF-1 gene mutation who survived hypertrophic cardiomyopathy-induced fatal heart failure and uncontrollable arrhythmias2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two Distinct Cases of Adult-onset Kawasaki Disease2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Thoracic Empyema Secondary to Congenital Chylothorax in a 14-Month-Old Boy with Noonan syndrome2021

Author(s)

Journal Title

Data Source

[Journal Article] Thoracic Empyema Secondary to Congenital Chylothorax in a 14-Month-Old Boy with Noonan Syndrome.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bilateral lung transplantation in a 9-year-old girl with bronchopulmonary dysplasia with pulmonary hypertension.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Wnt/β-catenin signaling is critical for regenerative potential of distal lung epithelial progenitor cells in homeostasis and emphysema2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular‐Matrix‐Reinforced Bioinks for 3D Bioprinting Human Tissue2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preoperative administration of propranolol reduced the surgical risks of PHACES syndrome in a 14-month-old girl2019

Author(s)

Journal Title

Ota Chiharu 大田千晴

[Presentation] ABCA3変異に伴う遺伝性間質性肺炎に対し脳死肺移植を行った女児例2019

[Presentation] 慢性肺疾患に合併した肺高血圧に対し　肺血管拡張薬投与が有効であった2例2018