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Seki Akihiro  関 晃裕

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… Alternative Names

Akihiro Seki  関 晃裕

関 晃裕  セキ アキヒロ

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Researcher Number 00733859
Other IDs
Affiliation (Current) 2025: 金沢大学, 附属病院, 助教
Affiliation (based on the past Project Information) *help 2022 – 2025: 金沢大学, 附属病院, 助教
2019 – 2021: 金沢大学, 医学系, 特任助教
2016: 金沢大学, 附属病院, 特任助教
Review Section/Research Field
Principal Investigator
Basic Section 53010:Gastroenterology-related / 0903:Organ-based internal medicine and related fields / Gastroenterology
Except Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 53010:Gastroenterology-related
Keywords
Principal Investigator
間葉系幹細胞 / 非アルコール性脂肪肝炎 / 再生療法 / 消化管免疫 / 腸管免疫 / 大腸癌 / NASH / iPS細胞 / 炎症性腸疾患
Except Principal Investigator
Combination therapy … More / Immune response / Pancreatic cancer / Immunotherapy / Proton radiation / adipose tissue (AT) / Immune therapy / SVF / uncultured ADSCs / ADSC / SS / NASH Less
  • Research Projects

    (7 results)
  • Research Products

    (34 results)
  • Co-Researchers

    (5 People)
  •  原発性硬化性胆管炎に対する間葉系幹細胞を用いた新規治療法開発に向けた基礎的検討Principal Investigator

    • Principal Investigator
      関 晃裕
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Kanazawa University
  •  Proton radiation therapy combined with immunotherapy for enhancing antitumor immune responses in pancreatic cancer murine models.

    • Principal Investigator
      Nasti Alessandro
    • Project Period (FY)
      2024 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Kanazawa University
  •  非アルコール性脂肪肝炎における局所環境動態に基づく間葉系幹細胞治療の機序解明Principal Investigator

    • Principal Investigator
      関 晃裕
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Kanazawa University
  •  The dynamics of Mucosal immunity and Cancer Microenvironmental on of Nonalcoholic Steatohepatitis Dynamics as the Effects on Colorectal CancerPrincipal Investigator

    • Principal Investigator
      Seki Akihiro
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Kanazawa University
  •  Study of liver restorative therapy for a murine nonalcoholic steatohepatitis model by the administration of immune-suppressive fractions of autologous adipose tissue-derived stromal cells

    • Principal Investigator
      Nasti Alessandro
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Kanazawa University
  •  Therapeutic effects and mechanisms of inflammatory bowel disease using immunomodulatory effects of iPS cell-derived mesenchymal stem cellsPrincipal Investigator

    • Principal Investigator
      Akihiro Seki
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0903:Organ-based internal medicine and related fields
    • Research Institution
      Kanazawa University
  •  間葉系幹細胞による非アルコール性脂肪性肝炎に対する治療効果機序解明Principal Investigator

    • Principal Investigator
      関 晃裕
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Kanazawa University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

  • [Journal Article] Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis2024

    • Author(s)
      Canales-Herrerias Pablo*、Uzzan Mathieu*、Seki Akihiro*、et.al. * equal contribution
    • Journal Title

      Science Immunology

      Volume: 9 Issue: 94

    • DOI

      10.1126/sciimmunol.adg7549

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K17017
  • [Journal Article] BMP9‐ID1 signaling promotes EpCAM‐positive cancer stem cell properties in hepatocellular carcinoma2021

    • Author(s)
      Chen Han、Nio Kouki、Yamashita Taro、Okada Hikari、Li Ru、Suda Tsuyoshi、Li Yingyi、Doan Phuong Thi Bich、Seki Akihiro et.al
    • Journal Title

      Molecular Oncology

      Volume: not available Issue: 8 Pages: 2203-2218

    • DOI

      10.1002/1878-0261.12963

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K17017, KAKENHI-PROJECT-18K15807, KAKENHI-PROJECT-19K23983, KAKENHI-PROJECT-18K07966, KAKENHI-PROJECT-21H04823, KAKENHI-PROJECT-20K16984
  • [Journal Article] Restorative effect of adipose tissue-derived stem cells on impaired hepatocytes through Notch signaling in non-alcoholic steatohepatitis mice2021

    • Author(s)
      Ishida Kosuke、Seki Akihiro、Kawaguchi Kazunori、Nasti Alessandro、Yamato Masatoshi、Inui Hiiro、Komura Takuya、Yamashita Taro、Arai Kuniaki、Yamashita Tatsuya、Mizukoshi Eishiro、Honda Masao、Wada Takashi、Harada Kenichi、Kaneko Shuichi、Sakai Yoshio
    • Journal Title

      Stem Cell Research

      Volume: 54 Pages: 102425-102425

    • DOI

      10.1016/j.scr.2021.102425

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H04823, KAKENHI-PROJECT-20K08327, KAKENHI-PROJECT-21K07940, KAKENHI-PROJECT-20K17017
  • [Journal Article] Characterization of adipose tissue-derived stromal cells of mice with nonalcoholic fatty liver disease and their use for liver repair2021

    • Author(s)
      Yano M, Honda M, Wada T, Kaneko S, Sakai Y.(ほか17名、19番目)
    • Journal Title

      Regenerative Therapy

      Volume: 18 Pages: 497-507

    • DOI

      10.1016/j.reth.2021.11.005

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H04823, KAKENHI-PROJECT-19K08486, KAKENHI-PROJECT-20K08327, KAKENHI-PROJECT-21K07940, KAKENHI-PROJECT-20K17017
  • [Journal Article] LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH2021

    • Author(s)
      Takata Noboru、Ishii Kiyo-aki、Takayama Hiroaki、Nagashimada Mayumi、Kamoshita Kyoko、Tanaka Takeo、Kikuchi Akihiro、Takeshita Yumie、Matsumoto Yukako、Ota Tsuguhito、Yamamoto Yasuhiko、Yamagoe Satoshi、Seki Akihiro、Sakai Yoshio、Kaneko Shuichi、Takamura Toshinari
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 555-555

    • DOI

      10.1038/s41598-020-80689-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08507, KAKENHI-PROJECT-19K08975, KAKENHI-PROJECT-20K17017, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-18K06889, KAKENHI-PROJECT-18K19560, KAKENHI-PROJECT-19K23983
  • [Journal Article] Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice2020

    • Author(s)
      Torres Joana、Hu Jianzhong、Seki Akihiro, et. al
    • Journal Title

      Gut

      Volume: 69 Issue: 1 Pages: 42-51

    • DOI

      10.1136/gutjnl-2018-317855

    • Data Source
      KAKENHI-PROJECT-20K17017, KAKENHI-PROJECT-19K23983
  • [Journal Article] Combination of gemcitabine and anti-PD-1 antibody enhances the anticancer effect of M1 macrophages and the Th1 response in a murine model of pancreatic cancer liver metastasis2020

    • Author(s)
      Ho Tuyen Thuy Bich、Nasti Alessandro、Seki Akihiro、Komura Takuya、Inui Hiiro、Kozaka Takashi、Kitamura Yoji、Shiba Kazuhiro、Yamashita Taro、Yamashita Tatsuya、Mizukoshi Eishiro、Kawaguchi Kazunori、Wada Takashi、Honda Masao、Kaneko Shuichi、Sakai Yoshio
    • Journal Title

      Journal for ImmunoTherapy of Cancer

      Volume: 8 Issue: 2 Pages: e001367-e001367

    • DOI

      10.1136/jitc-2020-001367

    • NAID

      120007185659

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08102, KAKENHI-PROJECT-20K17017, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-18K07935, KAKENHI-PROJECT-19K23983
  • [Journal Article] Regenerative Therapy for Liver Cirrhosis Based on Intrahepatic Arterial Infusion of Autologous Subcutaneous Adipose Tissue-Derived Regenerative (Stem) Cells: Protocol for a Confirmatory Multicenter Uncontrolled Clinical Trial.2020

    • Author(s)
      Y Sakai, S Fukunishi, M Takamura, O Inoue, S Takashima, S Usui, A Seki, A Nasti, T Ho, K Kawaguchi, A Asai, Y Tsuchiimura, T Muraymoto, T Yamashita, T Yamashita, E Mizukoshi, M Honda, Y Imai, K Yoshama, T Wada, K Harada, K Higuchi, S Kaneko
    • Journal Title

      JMIR Res Protoc

      Volume: 9 Issue: 3 Pages: e17904-e17904

    • DOI

      10.2196/17904

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-20K17017, KAKENHI-PROJECT-19K23983, KAKENHI-PROJECT-20K08327
  • [Presentation] Mesenchymal stromal cells improves liver function in NASH by reducing the ER stress induced by hepatic stellate cells in hepatocytes.2024

    • Author(s)
      Akihiro Seki, Norihiko Ogawa, Alessandro Nasti, Tuyen Thuy Bich Ho, Yoshio Sakai, Taro Yamashita.
    • Organizer
      The 33rd Annual Meeting of the Asian Pacific Association for the Study of the Liver (APASL)
    • Data Source
      KAKENHI-PROJECT-20K08327
  • [Presentation] Mesenchymal stem cells restore NASH by ameliorating ER stress in the local environment of the liver.2024

    • Author(s)
      Akihiro Seki , Norihiko Ogawa, Alessandro Nasti, Tuyen Thuy Bich Ho, Yoshio Sakai, Taro Yamashita
    • Organizer
      APASL 2024
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K15991
  • [Presentation] Mesenchymal stem cells restore NASH by ameliorating ER stress in the local environment of the liver.2024

    • Author(s)
      Akihiro Seki , Norihiko Ogawa, Alessandro Nasti, Tuyen Thuy Bich Ho, Yoshio Sakai, Taro Yamashita
    • Organizer
      APASL 2024
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K17017
  • [Presentation] 脂肪組織由来間葉系幹細胞によるNASHの肝局所環境における小胞体ストレス軽減を介した治療効果の検討2023

    • Author(s)
      小川 憲彦, 関 晃裕, 山下 太郎
    • Organizer
      日本消化器関連学会週間 (JDDW) 2023
    • Data Source
      KAKENHI-PROJECT-22K15991
  • [Presentation] 脂肪組織由来間葉系幹細胞によるNASHの肝局所環境における小胞体ストレス軽減を介した治療効果の検討2023

    • Author(s)
      小川 憲彦, 関 晃裕, 山下 太郎
    • Organizer
      日本消化器関連学会週間 (JDDW) 2023
    • Data Source
      KAKENHI-PROJECT-20K17017
  • [Presentation] MESENCHYMAL STROMAL CELLS RESTORE THE NASH BY AMELIORATING ER STRESS OF HEPATOCYTES DERIVED FROM HEPATIC STELLATE CELLS.2022

    • Author(s)
      Akihiro Seki, Yoshio Sakai,Eishiro Mizukoshi
    • Organizer
      AASLD2022
    • Data Source
      KAKENHI-PROJECT-20K17017
  • [Presentation] 間葉系幹細胞治療によるNASH肝細胞におけるJAG1・NOTCHシグナルを介した修復機構2022

    • Author(s)
      関 晃裕, 酒井 佳夫, 金子周一
    • Organizer
      第108回日本消化器病学会
    • Data Source
      KAKENHI-PROJECT-20K17017
  • [Presentation] 間葉系幹細胞治療によるNASH肝細胞におけるJAG1・NOTCHシグナルを介した修復機構2022

    • Author(s)
      関 晃裕, 酒井 佳夫, 金子 周一
    • Organizer
      第108回日本消化器病学会
    • Data Source
      KAKENHI-PROJECT-22K15991
  • [Presentation] MESENCHYMAL STROMAL CELLS RESTORE THE NASH BY AMELIORATING ER STRESS OF HEPATOCYTES DERIVED FROM HEPATIC STELLATE CELLS.2022

    • Author(s)
      Akihiro Seki, Yoshio Sakai,Eishiro Mizukoshi
    • Organizer
      AASLD2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K15991
  • [Presentation] The mesenchymal stromal cells ameliorated NASH cirrhosis by attenuating ER stress from hepatic stellate cells.2022

    • Author(s)
      Akihiro Seki, Yoshio Sakai, Shuichi Kaneko
    • Organizer
      JDDW2022
    • Data Source
      KAKENHI-PROJECT-22K15991
  • [Presentation] The mesenchymal stromal cells ameliorated NASH cirrhosis by attenuating ER stress from hepatic stellate cells.2022

    • Author(s)
      Akihiro Seki, Yoshio Sakai, Shuichi Kaneko
    • Organizer
      JDDW2022
    • Data Source
      KAKENHI-PROJECT-20K17017
  • [Presentation] 非アルコール性脂肪肝炎マウスの小胞体ストレスと脂肪組織由来間質細胞投与による治療効果機序の検討2021

    • Author(s)
      関 晃裕, 酒井 佳夫, 金子 周一
    • Organizer
      第107回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-20K17017
  • [Presentation] 非アルコール性脂肪肝炎マウスの小胞体ストレスと脂肪組織由来間質細胞投与による治療効果機序の検討2021

    • Author(s)
      関 晃裕, 酒井 佳夫, 金子 周一
    • Organizer
      第107回日本消化器病学会 総会
    • Data Source
      KAKENHI-PROJECT-19K23983
  • [Presentation] Restorative effect of adipose tissue-derived mesenchymal stem cells towards impaired hepatocytes via Notch signaling in a murine model of non-alcoholic steatohepatitis mice2021

    • Author(s)
      Kosuke Ishida, Yoshio Sakai, Akihiro Seki, Kazunori Kawaguchi, Alessandro Nasti, Hiiro Inui, Takashi Wada, Shuichi Kaneko
    • Organizer
      The 44th Annual Meeting of the Molecular Biology Society of Japan
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08327
  • [Presentation] 非アルコール性脂肪肝炎マウスの小胞体ストレスと脂肪組織由来間質細胞投与による治療効果機序の検討2021

    • Author(s)
      関 晃裕, 酒井 佳夫, 金子 周一
    • Organizer
      第107回消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-20K17017
  • [Presentation] 脂肪組織由来間葉系幹細胞によるNotchシグナルを介した非アルコール性脂肪肝炎に対する治療効果機序2021

    • Author(s)
      関 晃裕, 酒井 佳夫, 金子 周一
    • Organizer
      第21回JDDW
    • Data Source
      KAKENHI-PROJECT-20K17017
  • [Presentation] Jagged1 ON ADIPOSE TISSUE-DERIVED STROMAL / STEM CELLS IS INVOLVED IN THE RESTORATIVE EFFECT ON MURINE NON-ALCOHOLIC STEATOHEPATITIS.2021

    • Author(s)
      Kosuke Ishida, Yoshio Sakai, Akihiro Seki, Kazunori Kawaguchi, Alessandro Nasti, Takashi Wada and Shuichi Kaneko
    • Organizer
      AASLD, The Liver Meeting 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08327
  • [Presentation] 肝非実質細胞・液性因子を介する脂肪組織由来間葉系幹細胞の肝硬変修復治療機序2021

    • Author(s)
      関 晃裕, 酒井 佳夫, 金子 周一
    • Organizer
      第57回肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-20K17017
  • [Presentation] Therapy with adipose tissue-derived mesenchymal stromal/stem cells for NASH mice enhance the activation of Notch signaling and alleviate apoptosis in hepatocytes.2020

    • Author(s)
      Kosuke Ishida, Yoshio Sakai, Akihiro Seki, Kazunori Kawaguchi, Alessandro Nasti, Hiiro Inui, Takashi Wada, Shuichi Kaneko
    • Organizer
      AASLD, The Liver Meeting 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08327
  • [Presentation] Regenerative effect of adipose tissue-derived stromal cell administration in non-alcoholic steatohepatitis mice was mediated via Notch signaling system2020

    • Author(s)
      Akihiro Seki, Yoshio Sakai, Kazunori Kawaguchi, Kosuke Ishida, Masatoshi Yamato, Alessandro, Nasti, Takashi Wada, Shuichi Kaneko
    • Organizer
      2020 Keystone Symposia Conference Q5: Stromal Cells in Immunity and Disease
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23983
  • [Presentation] Investigator-initiated clinical trial of autologous adipose tissue-derived regenerative (stem) cells therapy for steatohepatitis-related cirrhosis.2020

    • Author(s)
      Yoshio Sakai, Shinya Fukunishi, Masayuki Takamura, Oto Inoue, Soichiro Usui, Shinichiro Takashima, Kazunori Kawaguchi, Akihiro Seki, Akira Asai, Yusuke Tsuchimoto, Alessandro Nasti, Tuyen Thuy Bich Ho, Kazuhide Higuchi, Shuichi Kaneko
    • Organizer
      AASLD, The Liver Meeting 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08327
  • [Presentation] Adipose tissue-derived stromal cells of steatohepatitis mice are useful for treatment of fibrosis-progressive NASH2020

    • Author(s)
      Akihiro Seki, Yoshio Sakai, Alessandro Nasti, Masatoshi Yamato, Kosuke Ishida, Hiiro Inui, Tuyen Thuy Bich Ho, Kazunori Kawaguchi, Takashi Wada, Shuichi Kaneko
    • Organizer
      AASLD, The Liver Meeting 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08327
  • [Presentation] Regenerative effect of adipose tissue-derived stromal cell administration in non-alcoholic steatohepatitis mice was mediated via Notch signaling system2020

    • Author(s)
      Akihiro Seki, Yoshio Sakai, Kazunori Kawaguchi, Kosuke Ishida, Masatoshi Yamato, Alessandro, Nasti, Takashi Wada, Shuichi Kaneko
    • Organizer
      keystone symposia 2020 Stromal Cells in Immunity and Disease
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23983
  • [Presentation] Adipose tissue derived stromal/stem cells suppress the hepatocyte apoptosis by restoring the Atf6 pathway activity in NASH mice.2020

    • Author(s)
      Masatoshi Yamato, Yoshio Sakai, Hiiro Inui, Akihiro Seki, Alessandro Nasti, Kosuke Ishida, Tuyen Thuy Bich Ho, Kazunori Kawaguchi, Takashi Wada, Shuichi Kaneko
    • Organizer
      AASLD, The Liver Meeting 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08327
  • [Presentation] Adipose tissue-derived stromal cells of steatohepatitis mice are useful for treatment of fibrosis-progressive NASH2020

    • Author(s)
      Akihiro Seki, Yoshio Sakai, Alessandro Nasti, Masatoshi Yamato, Kosuke Ishida, Hiiro Inui, Tuyen Thuy Bich Ho, Kazunori Kawaguchi, Takashi Wada, Shuichi Kaneko
    • Organizer
      AASLD The Liver Meeting Digital Experience 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K17017
  • [Presentation] ADIPOSE TISSUE-DERIVED STROMAL CELLS OF STEATOHEPATITIS MICE ARE USEFUL FOR TREATMENT OF FIBROSIS-PROGRESSIVE NASH2020

    • Author(s)
      Akihiro Seki , Yoshio Sakai , Alessandro Nasti , Dr. Masatoshi Yamato , Kosuke Ishida , Hiiro Inui , Tuyen Thuy Bich Ho , Kazunori Kawaguchi , Takashi Wada and Shuichi Kaneko
    • Organizer
      AASLD Liver meeting 2020
    • Data Source
      KAKENHI-PROJECT-19K23983
  • 1.  Nasti Alessandro (20830871)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 2.  酒井 佳夫 (80401925)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 3.  KITAMURA Yoji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  ISHII Kiyoaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  本多 政夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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