Tsuda Masataka 津田雅貴

Researcher Number	00734104
Other IDs	https://orcid.org/0000-0002-4736-1212
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, ゲノム安全科学部, 室長
Affiliation (based on the past Project Information) *help	2022 – 2023: 国立医薬品食品衛生研究所, 変異遺伝部, 室長 2019 – 2021: 広島大学, 統合生命科学研究科(理), 助教 2020: 京都大学, 医学研究科, 特定助教 2018: 広島大学, 理学研究科, 助教 2016 – 2017: 京都大学, 医学研究科, 特定助教
Review Section/Research Field	Principal Investigator Basic Section 63030:Chemical substance influence on environment-related / Basic Section 63020:Radiation influence-related Except Principal Investigator Risk sciences of radiation and chemicals / Medium-sized Section 50:Oncology and related fields
Keywords	Principal Investigator DNA二本鎖切断 / DNA double-strand break / 放射線 / 二本鎖切断 / チロシル-DNAホスホジエステラーゼ / チロシルDNAホスホジエステラーゼ / 放射線類似作用物質 / DNA修復 / プロテアソーム / エトポシド / トポイソメラーゼ2 … More Except Principal Investigator … More QSAR / トキシコロジー / 治療 / 腫瘍 / ゲノム維持 / DNA複製 / ガン治療 / 分子標的 / 損傷 / 相同組換え / スクリーニング / 化学物質 / 合成致死 / がん治療 / ゲノム不安定化 / ガン / 癌治療 / ゲノム編集細胞コレクション / 遺伝子シナジー / チェックポイント / ヌクレオシドアナログ / DNA修復 / DNA損傷 / 抗がん治療薬 / ケモインフォマティクス / TK6細胞 / 変異原 / 発がん物質 / 遺伝毒物学 / 人体有害物質 / 発がん化学物質 / エームテスト / 化審法 Less

Repair pathway for DNA double-strand break induced by radiomimetic drugPrincipal Investigator
- Principal Investigator
  
  津田雅貴
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  National Institute of Health Sciences
Novel pathway for DNA double-strand break repair associated with tyrosyl-DNA phosphodiesterasePrincipal Investigator
- Principal Investigator
  
  Tsuda Masataka
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Hiroshima University
International collaborations for revealing the synergistic genetic relationship in genome maintenance systems
- Principal Investigator
  
  Hirota Kouji
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Tokyo Metropolitan University
Analysis of a novel DNA repair pathway associated with Mre11/BRCA1 and non-homologous recombination end joiningPrincipal Investigator
- Principal Investigator
  
  Tsuda Masataka
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Hiroshima University
ヒトゲノム編集細胞を使った、化学物質の薬理作用・有害性を解析するシステムの構築
- Principal Investigator
  
  Takeda Shunichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Kyoto University
Establishment of Novel Bioassays for in vivo Genotoxicity Prediction and Mechanism Characterization
- Principal Investigator
  
  Takeda Shunichi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] 新規DNA修復機構に着目した新たながん治療法2024
- Author(s)
  清水直登, 津田雅貴
- Journal Title
  
  月刊細胞
  
  Volume: 56 Pages: 36-38
- Data Source
  KAKENHI-PROJECT-22K12374
[Journal Article] The proofreading exonuclease of leading-strand DNA polymerase epsilon prevents replication fork collapse at broken template strands2023
- Author(s)
  Ahmad Tasnim、Kawasumi Ryotaro、Taniguchi Tomoya、Abe Takuya、Terada Kazuhiro、Tsuda Masataka、Shimizu Naoto、Tsurimoto Toshiki、Takeda Shunichi、Hirota Kouji
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 51 Issue: 22 Pages: 12288-12302
- DOI
  10.1093/nar/gkad999
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15040, KAKENHI-PROJECT-19KK0210, KAKENHI-PLANNED-22H05072, KAKENHI-ORGANIZER-22H05069
[Journal Article] Repair of topoisomerase 1?induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding2023
- Author(s)
  Shimizu Naoto、Hamada Yusaku、Morozumi Ryosuke、Yamamoto Junpei、Iwai Shigenori、Sugiyama Kei-ichi、Ide Hiroshi、Tsuda Masataka
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 8 Pages: 104988-104988
- DOI
  10.1016/j.jbc.2023.104988
- Open Access
- Data Source
  KAKENHI-PROJECT-22K12374
[Journal Article] XRCC1 counteracts poly(ADP ribose)polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal of trapped PARP1 from broken DNA.2022
- Author(s)
  Hirota Kouji、Ooka Masato、Shimizu Naoto、Yamada Kousei、Tsuda Masataka、Ibrahim Mahmoud Abdelghany、Yamada Shintaro、Sasanuma Hiroyuki、Masutani Mitsuko、Takeda Shunichi
- Journal Title
  
  Genes to Cells
  
  Volume: in press Issue: 5 Pages: 331-344
- DOI
  10.1111/gtc.12929
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-20H04337, KAKENHI-PROJECT-21K19235, KAKENHI-PROJECT-19KK0210, KAKENHI-PROJECT-16H06279
[Journal Article] SPRTN and TDP1/TDP2 Independently Suppress 5-Aza-2′-deoxycytidine-Induced Genomic Instability in Human TK6 Cell Line2022
- Author(s)
  Nakano Toshiaki，Moriwaki Takahito，Tsuda Masataka，Miyakawa Misa，Hanaichi Yuto，Sasanuma Hiroyuki，Hirota Kouji，Kawanishi Masanobu，Ide Hiroshi，Tano Keizo，Bessho Tadayoshi
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 35 Issue: 11 Pages: 2059-2067
- DOI
  10.1021/acs.chemrestox.2c00213
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11640, KAKENHI-PROJECT-21K12248, KAKENHI-PROJECT-19KK0210, KAKENHI-PROJECT-20H04337, KAKENHI-PROJECT-21K19235, KAKENHI-PROJECT-20K17055
[Journal Article] Division of labor of Y-family polymerases in translesion-DNA synthesis for distinct types of DNA damage2021
- Author(s)
  Y. Inomata, T. Abe, M. Tsuda, S. Takeda, K. Hirota
- Journal Title
  
  PLoS One
  
  Volume: 16
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0210
[Journal Article] Repair pathways for radiation DNA damage under normoxic and hypoxic conditions: Assessment with a panel of repair-deficient human TK6 cells2021
- Author(s)
  Tsuda Masataka、Shimizu Naoto、Tomikawa Hinako、Morozumi Ryosuke、Ide Hiroshi
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 62 Pages: 999-1004
- DOI
  10.1093/jrr/rrab084
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K19974
[Journal Article] XRCC1 Prevents Toxic PARP1 Trapping During DNA Base Excision Repair.2021
- Author(s)
  Demin AA, Hirota K, Tsuda M, Adamowicz M, Hailstone R, Brazina J, Gittens W, Kalasova I, Shao Z, Zha S, Sasanuma H, Hanzlikova H, Takeda S, Caldecott KW
- Journal Title
  
  Mol Cell
  
  Volume: in press
- NAID
  120007052730
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] ポイソメラーゼ阻害剤が引き起こすDNA損傷の修復機構2021
- Author(s)
  津田雅貴, 清水直登
- Journal Title
  
  月刊細胞
  
  Volume: 53 Pages: 792-794
- Data Source
  KAKENHI-PROJECT-20K19974
[Journal Article] XRCC1 prevents toxic PARP1 trapping during DNA base excision repair2021
- Author(s)
  Demin Annie A.、Hirota Kouji、Tsuda Masataka、Adamowicz Marek、Hailstone Richard、Brazina Jan、Gittens William、Kalasova Ilona、Shao Zhengping、Zha Shan、Sasanuma Hiroyuki、Hanzlikova Hana、Takeda Shunichi、Caldecott Keith W.
- Journal Title
  
  Molecular Cell
  
  Volume: 81 Issue: 14 Pages: 3018-3030
- DOI
  10.1016/j.molcel.2021.05.009
- NAID
  120007052730
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-20H04337, KAKENHI-PROJECT-21K19235, KAKENHI-PROJECT-19KK0210, KAKENHI-PROJECT-16H06279
[Journal Article] Restoration of ligatable "clean" double-strand break ends is the rate-limiting step in the rejoining of ionizing-radiation-induced DNA breakage.2020
- Author(s)
  Sasanuma H, Yamada S, Tsuda M, Takeda S.
- Journal Title
  
  DNA Repair (Amst)
  
  Volume: 93 Pages: 102913-102913
- DOI
  10.1016/j.dnarep.2020.102913
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-19K20449
[Journal Article] Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3′-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1)2020
- Author(s)
  Tsuda Masataka、Kitamasu Kaito、Kumagai Chiho、Sugiyama Kazuya、Nakano Toshiaki、Ide Hiroshi
- Journal Title
  
  DNA Repair
  
  Volume: - Pages: 102849-102849
- DOI
  10.1016/j.dnarep.2020.102849
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K18200, KAKENHI-PROJECT-20K19974, KAKENHI-PROJECT-18H03374
[Journal Article] UBC13-mediated ubiquitin signaling promotes removal of blocking adducts from DNA double-strand breaks.2020
- Author(s)
  Akagawa R, Trinh TH, Saha LK, Tsuda M, Hirota K, Yamada S, Shibata A, Kanemaki MT, Nakada S, Takeda S, Sasanuma H
- Journal Title
  
  iScience
  
  Volume: 23 Pages: 101027-101027
- NAID
  120006956714
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells2020
- Author(s)
  Toshiaki Nakano, Mahmoud I. Shoulkamy, Masataka Tsuda, Hiroyuki Sasanuma, Kouji Hirota, Minoru Takata, Shin-ichiro Masunaga, Shunichi Takeda, Hiroshi Ide, Tadayoshi Bessho, Keizo Tano
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 6 Pages: 0234859-0234859
- DOI
  10.1371/journal.pone.0234859
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11640, KAKENHI-PROJECT-19K08171, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-18H03374, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-19K22561
[Journal Article] Genetic evidence for the involvement of mismatch repair proteins, PMS2 and MLH3, in a late step of homologous recombination.2020
- Author(s)
  Rahman MM, Mohiuddin M, Shamima Keka I, Yamada K, Tsuda M, Sasanuma H, Andreani J, Guerois R, Borde V, Charbonnier JB, Takeda S.
- Journal Title
  
  J Biol Chem.
  
  Volume: 295 Issue: 51 Pages: 17460-17475
- DOI
  10.1074/jbc.ra120.013521
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-19K22561
[Journal Article] DNA にトラップされたトポイソメラーゼの除去機構2020
- Author(s)
  津田雅貴、井出博
- Journal Title
  
  月刊「細胞」
  
  Volume: 52 Pages: 515-518
- Data Source
  KAKENHI-PROJECT-20K19974
[Journal Article] Estrogen Induces Mammary Ductal Dysplasia via the Upregulation of Myc Expression in a DNA-Repair-Deficient Condition2020
- Author(s)
  Itou Junji、Takahashi Rei、Sasanuma Hiroyuki、Tsuda Masataka、Morimoto Suguru、Matsumoto Yoshiaki、Ishii Tomoko、Sato Fumiaki、Takeda Shunichi、Toi Masakazu
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 2 Pages: 100821-100821
- DOI
  10.1016/j.isci.2020.100821
- NAID
  120006779803
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07665, KAKENHI-PROJECT-19K09063, KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-18K18200
[Journal Article] UBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA Double-Strand Breaks2020
- Author(s)
  Akagawa Remi、Trinh Hai Thanh、Saha Liton Kumar、Tsuda Masataka、Hirota Kouji、Yamada Shintaro、Shibata Atsushi、Kanemaki Masato T.、Nakada Shinichiro、Takeda Shunichi、Sasanuma Hiroyuki
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 4 Pages: 101027-101027
- DOI
  10.1016/j.isci.2020.101027
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04719, KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-18H02170, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-20K21536, KAKENHI-PROJECT-19KK0210, KAKENHI-PROJECT-17H04713, KAKENHI-PUBLICLY-20H04879, KAKENHI-PROJECT-20H04337
[Journal Article] Direct observation of damage clustering in irradiated DNA with atomic force microscopy2020
- Author(s)
  Xu Xu, Toshiaki Nakano, Masataka Tsuda, Ryota Kanamoto,Ryoichi Hirayama, Akiko Uzawa and Hiroshi Ide
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 48(3) Issue: 3 Pages: e18-e18
- DOI
  10.1093/nar/gkz1159
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03374, KAKENHI-PROJECT-18K18200, KAKENHI-PROJECT-20H03620
[Journal Article] PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching.2019
- Author(s)
  Tsuda M, Ogawa S, Ooka M, Kobayashi K, Hirota K, Wakasugi M, Matsunaga T, Sakuma T, Yamamoto T, Chikuma S, Sasanuma H, Debatisse M, Doherty AJ, Fuchs RP, Takeda S
- Journal Title
  
  PLoS One
  
  Volume: 14 Issue: 3 Pages: e0213383-e0213383
- DOI
  10.1371/journal.pone.0213383
- NAID
  120006822506
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05801, KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02952, KAKENHI-PROJECT-16H02953, KAKENHI-PROJECT-16H02957, KAKENHI-PROJECT-19K12319, KAKENHI-PROJECT-19H04265
[Journal Article] Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms2019
- Author(s)
  Masataka Tsuda, Kaito Kitamasu, Seiji Hosokawa, Toshiaki Nakano, Hiroshi Ide
- Journal Title
  
  Nucleosides, Nucleotides & Nucleic Acids
  
  Volume: - Issue: 1-3 Pages: 1-15
- DOI
  10.1080/15257770.2019.1674332
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03374, KAKENHI-PROJECT-18K18200
[Journal Article] Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA2019
- Author(s)
  Morimoto S, Tsuda M, Bunch H, Sasanuma H, Austin C, Takeda S
- Journal Title
  
  Genes (Basel)
  
  Volume: 10 Issue: 11 Pages: 868-868
- DOI
  10.3390/genes10110868
- NAID
  120006898175
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H04267
[Journal Article] SUMOylation of PCNA by PIAS1 and PIAS4 promotes template switch in the chicken and human B cell lines2018
- Author(s)
  Mohiuddin Mohiuddin、Evans Terry John、Rahman Md Maminur、Keka Islam Shamima、Tsuda Masataka、Sasanuma Hiroyuki、Takeda Shunichi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 50 Pages: 12793-12798
- DOI
  10.1073/pnas.1716349115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18200, KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes2018
- Author(s)
  Sasanuma Hiroyuki、Tsuda Masataka、Morimoto Suguru、Saha Liton Kumar、Rahman Md Maminur、Kiyooka Yusuke、Fujiike Haruna、Cherniack Andrew D.、Itou Junji、Callen Moreu Elsa、Toi Masakazu、Nakada Shinichiro、Tanaka Hisashi、Tsutsui Ken、Yamada Shintaro、Nussenzweig Andre、Takeda Shunichi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 45
- DOI
  10.1073/pnas.1803177115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18200, KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953, KAKENHI-PROJECT-26241014
[Journal Article] The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C).2017
- Author(s)
  Tsuda M, Terada K, Ooka M, Kobayashi K, Sasanuma H, Fujisawa R, Tsurimoto T, Yamamoto J, Iwai S, Kadoda K, Akagawa R, Huang SN, Pommier Y, Sale JE, Takeda S, Hirota K.
- Journal Title
  
  Oncotarget
  
  Volume: in press Issue: 20 Pages: 33457-33474
- DOI
  10.18632/oncotarget.16508
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440011, KAKENHI-PUBLICLY-16H01314, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02957, KAKENHI-PROJECT-16H04743, KAKENHI-PROJECT-16K12595, KAKENHI-PROJECT-16K12598, KAKENHI-PROJECT-16H02953
[Journal Article] Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts2017
- Author(s)
  Caglayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC and Wilson SH
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 45 Issue: 17 Pages: 10079-10088
- DOI
  10.1093/nar/gkx654
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00537, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair.2017
- Author(s)
  Tsuda M, Cho K, Ooka M, Shimizu N, Watanabe R, Yasui A, Nakazawa Y, Ogi T, Harada H, Agama K, Nakamura J, Asada R, Fujiike H, Sakuma T, Yamamoto T, Murai J, Hiraoka M, Koike K, Pommier Y, Takeda S, Hirota K.
- Journal Title
  
  PLos One
  
  Volume: 12 Issue: 11 Pages: e0188320-e0188320
- DOI
  10.1371/journal.pone.0188320
- NAID
  120006800808
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05333, KAKENHI-PUBLICLY-16H01314, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-15H01737, KAKENHI-PROJECT-17H00783, KAKENHI-PROJECT-16H02957, KAKENHI-PROJECT-16J02252, KAKENHI-PROJECT-16K12598, KAKENHI-PROJECT-16K18478, KAKENHI-PROJECT-17H01877
[Journal Article] Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells2017
- Author(s)
  Kadoda K, Moriwaki T, Tsuda M, Sasanuma H, Ishiai M, Takata M, Ide H, Masunaga S, Takeda S and Tano K
- Journal Title
  
  PLOS ONE
  
  Volume: 12 Issue: 9 Pages: e0185141-e0185141
- DOI
  10.1371/journal.pone.0185141
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00537, KAKENHI-PROJECT-15H04295, KAKENHI-PUBLICLY-16H01642, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides.2016
- Author(s)
  Kobayashi K, Guilliam TA, Tsuda M, Yamamoto J, Bailey LJ, Iwai S, Takeda S, Doherty AJ, Hirota K.
- Journal Title
  
  Cell Cycle
  
  Volume: 15(15) Issue: 15 Pages: 1997-2008
- DOI
  10.1080/15384101.2016.1191711
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01314, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02957, KAKENHI-PROJECT-16K12598
[Journal Article] Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.2016
- Author(s)
  Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsusui K, Takeda S, Sasanuma H
- Journal Title
  
  Mol Cell
  
  Volume: 64 Issue: 3 Pages: 580-592
- DOI
  10.1016/j.molcel.2016.10.011
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] In vivo evidence for translesion synthesis by the replicative DNA polymerase δ.2016
- Author(s)
  Hirota K, Tsuda M, Mohiuddin, Tsurimoto T, Cohen IS, Livneh Z, Kobayashi K, Narita T, Nishihara K, Murai J, Iwai S, Guilbaud G, Sale JE, Takeda S.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 44(15) Pages: 7242-50
- DOI
  10.1093/nar/gkw439
- NAID
  120006338056
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01314, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02957, KAKENHI-PROJECT-16H04743, KAKENHI-PROJECT-25440011, KAKENHI-PROJECT-16K12598
[Presentation] Role of proofreading exonuclease activity of polymerase ε in the maintenance of genome integrity2024
- Author(s)
  3.Tasnim Ahmad, Ryotaro Kawasumi, Tomoya Taniguchi, Takuya Abe, Kazuhiro Terada, Masataka Tsuda, (他4名), Kouji Hirota,
- Organizer
  染色体ワークショップ
- Data Source
  KAKENHI-PROJECT-19KK0210
[Presentation] DNAにトラップされたタンパク質が引き起こすゲノム毒性とその関連疾患2023
- Author(s)
  津田雅貴, 清水直登, 笹沼博之, 武田俊一, 井出博
- Organizer
  第50回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K12374
[Presentation] 相同組換え中間体解消における動的変化の可視化2023
- Author(s)
  津田雅貴, 濵田優作, 清水直登
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K12374
[Presentation] 相同組換え中間体解消における動的変化を可視化する技術の開発2023
- Author(s)
  津田雅貴, 濱田優作, 清水直登
- Organizer
  日本放射線影響学会第66回大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K12374
[Presentation] 相同組換え中間体解消における動的変化を可視化する技術の開発2023
- Author(s)
  津田雅貴, 清水直登
- Organizer
  日本環境変異原ゲノム学会第52回大会
- Data Source
  KAKENHI-PROJECT-22K12374
[Presentation] DNA にトラップされたトポイソメラーぜ 1 の除去機構2023
- Author(s)
  津田雅貴, 井出博
- Organizer
  第82回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K12374
[Presentation] Repair pathways of trapped topoisomerases covalent cleavage complexes.2022
- Author(s)
  Tsuda Masataka
- Organizer
  Nucleic Acids 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K19974
[Presentation] チロシル ‐ DNA ホスホジエステラーゼが関与する新規な DNA 二本鎖切断修復経路2022
- Author(s)
  津田雅貴
- Organizer
  放射線影響学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K12374
[Presentation] Effects of tritiated water on the early development of sea urchin and Xenopus.2021
- Author(s)
  Tsuda M, Shimizu N, Shoulkamy M, Salem A, Ide H.
- Organizer
  IER International Symposium Fukushima
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K19974
[Presentation] Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3’-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1).2021
- Author(s)
  Tsuda Masataka, Shimizu Naoto, Nakano Toshiaki, Ide Hiroshi
- Organizer
  Nucleic Acids 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K19974
[Presentation] チロシル-DNAホスホジエステラーゼが関与する新規なDNA二本鎖切断修復経路2020
- Author(s)
  津田雅貴, 諸角涼介, 北舛海斗, 山本あかね, 中野敏彰, 井出博
- Organizer
  第63回日本放射線影響学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K19974
[Presentation] チロシル-DNA ホスホジエステラーゼ 2(TDP2) は DNA にトラップされたトポイソメラーゼ 1 を修復する2020
- Author(s)
  津田雅貴, 北舛海斗, 中野敏彰, 井出博
- Organizer
  第49回日本環境変異原学会
- Data Source
  KAKENHI-PROJECT-20K19974
[Presentation] DNA にトラップされたトポイソメラーゼ 1 の除去機構2020
- Author(s)
  津田雅貴, 北舛海斗, 山本あかね, 諸角涼介, 井出博
- Organizer
  第45回中国地区放射線影響研究会
- Data Source
  KAKENHI-PROJECT-20K19974
[Presentation] 複製ポリメラーゼεの校正活性はカンプトテシンによるDNA損傷における安全な複製停止に寄与する2019
- Author(s)
  阿部拓也, 津田雅貴, 釣本俊樹, 柴田武彦, 武田俊一, 廣田耕志
- Organizer
  染色体ワークショップ
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Alternate processing pathways of a single ribonucleotide incorporated into DNA and its consequences in human cells.2019
- Author(s)
  Akira SASSA, Haruto TADA, Ayuna TAKEISHI, Kaho HARADA, Kazuma NAKATANI, Masataka TSUDA, Hiroyuki SASANUMA, Shunichi TAKEDA, Kaoru SUGASAWA, Manabu YASUI, Masamitsu HONMA, Kiyoe URA
- Organizer
  The Joint Meeting of The 6th Asian Congress on Environmental Mutagens and The 48th Japanese Environmental Mutagen Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Repair of topoisomerase2 covalent cleavage complexes by tyrosyl-DNA phosphodiesterase 2(TDP2)2019
- Author(s)
  Masataka Tsuda, Kaito Kitamasu, Toshiaki Nakano, Hiroshi Ide
- Organizer
  The Joint Meeting of The 6th Asian Congress on Environmental Mutagenes (ACEM) and The 48th Annual Meeting of the Japanese Environmental Mutagen Society (JEMS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18200
[Presentation] BRCA1 and BRCA2 protect transcriptional response to estrogens from abortive catalysis by Topoisomerase II2019
- Author(s)
  Rahman MM, Sasanuma H, Tsuda M, Morimoto S, Yamada S, Nussenzweig A, Tanaka H, Takeda S
- Organizer
  FASEB Science Research Conference “The Genetic Recombination and Genome Rearrangements Conference”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Role of proofreading exonuclease activity of replicative polymerase ε in replication fork slowing at DNA damage2019
- Author(s)
  Tsuda M, Abe T, Tsurimoto T, Shibata T, Takeda S, Hirota K
- Organizer
  分子生物学会
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] チロシルDNAホスホジエステラーゼ2(TDP2)によるDNA切断端に共有結合したトポイソメラーゼ2の修復機構2019
- Author(s)
  津田雅貴, 北舛海斗, 中野敏彰, 笹沼博之, 武田俊一, 井出博
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19KK0210
[Presentation] Repair of topoisomerase2 covalent cleavage complexes by tyrosyl-DNA phosphodiesterase 2(TDP2).2019
- Author(s)
  Tsuda M, Kitamasu K, Nakano T, Ide H.
- Organizer
  ACEM/JEMS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0210
[Presentation] チロシルDNAホスホジエステラーゼ2(TDP2)によるDNA切断端に共有結合したトポイソメラーゼ2の修復機構2019
- Author(s)
  津田雅貴, 北舛海斗, 中野敏彰, 笹沼博之, 武田俊一, 井出博
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K18200
[Presentation] 複製ポリメラーゼεの校正活性はDNA損傷における安全なフォーク停止に寄与する2019
- Author(s)
  津田雅貴、阿部拓也、釣本俊樹、柴田武彦、武田俊一、廣田耕志
- Organizer
  第37 回染色体ワークショップ/第18 回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Role of proofreading exonuclease activity of replicative polymerase ε in replication fork slowing at DNA damage2019
- Author(s)
  Masataka Tsuda, Takuya Abe, Toshiki Tsurimoto, Takehiko Shibata, Shunichi Takeda, and Kouji Hirota
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19KK0210
[Presentation] 複製ポリメラーゼεの校正活性はカンプトテシンによるDNA損傷における安全な複製停止に寄与する2019
- Author(s)
  阿部拓也, 津田雅貴, 釣本俊樹, 柴田武彦, 武田俊一, 廣田耕志
- Organizer
  第37 回染色体ワークショップ/第18 回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-19KK0210
[Presentation] PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching2018
- Author(s)
  Masataka Tsuda, Hiroshi Ide, Robert P. Fuchs, Shunichi Takeda
- Organizer
  環境変異原学会
- Data Source
  KAKENHI-PROJECT-18K18200
[Presentation] SUMO化蛋白質を認識するRING型ユビキチンリガーゼRNF4による、スピンドルアセンブリチェックポイント(SAC)活性維持と染色体ロスの防止2017
- Author(s)
  廣田耕志、高木季代、津田雅貴、村井純子、Keka Islam, 成田岳雄、藤田真梨、笹沼博之、小林純也、武田俊一
- Organizer
  SUMO研究会
- Place of Presentation
  関西学院大学（大阪府・大阪市）
- Year and Date
  2017-01-22
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] In vivo evidence for translation synthesis by the replicative DNA polymerase delta2016
- Author(s)
  Hirota K, Tsuda M, Sale J, Takeda S
- Organizer
  DNA Polymerases Meeting
- Place of Presentation
  ビアリッツ（フランス）
- Year and Date
  2016-10-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] In vivo evidence for translesion synthesis by the replicative DNA polymeraseδ2016
- Author(s)
  Hirota K, Tsuda M, Sale J, Takeda S
- Organizer
  The 10th 3R Symposium
- Place of Presentation
  ホテル一畑（島根県・松江市）
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] The proofreading exonuclease activity of replicative polymerase ε　contributes to cellular tolerance of cytarabine(Ara-C)2016
- Author(s)
  Tsuda M, Takeda S, Hirota K
- Organizer
  The 10th 3R Symposium
- Place of Presentation
  ホテル一畑（島根県・松江市）
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] The Proofreading Exonuclease Activity of Replicative Polymerasee significantly Contributes to Elimination of Cytarabine (Ara-C)2016
- Author(s)
  Tsuda M, Takeda S, Hirota K
- Organizer
  DNA Polymerases Meeting
- Place of Presentation
  ビアリッツ（フランス）
- Year and Date
  2016-10-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306

1. Takeda Shunichi (60188191)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
2. Hirota Kouji (00342840)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
3. 笹沼博之 (00531691)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
4. 安井学 (50435707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Brown John (90583188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 阿部拓也 (50779999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. HIRAYAMA Ryoichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. NAKAZAWA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 釣本敏樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 竹馬俊介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 増永慎一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 田野恵三

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
13. 伊東潤二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 鐘巻将人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 井出博

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 川澄遼太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 川西優喜

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsuda Masataka 津田 雅貴

Research Projects

Research Products

Co-Researchers

Repair pathway for DNA double-strand break induced by radiomimetic drugPrincipal Investigator

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Novel pathway for DNA double-strand break repair associated with tyrosyl-DNA phosphodiesterasePrincipal Investigator

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International collaborations for revealing the synergistic genetic relationship in genome maintenance systems

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Analysis of a novel DNA repair pathway associated with Mre11/BRCA1 and non-homologous recombination end joiningPrincipal Investigator

Principal Investigator

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ヒトゲノム編集細胞を使った、化学物質の薬理作用・有害性を解析するシステムの構築

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Establishment of Novel Bioassays for in vivo Genotoxicity Prediction and Mechanism Characterization

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[Journal Article] 新規DNA修復機構に着目した新たながん治療法2024

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[Journal Article] The proofreading exonuclease of leading-strand DNA polymerase epsilon prevents replication fork collapse at broken template strands2023

Author(s)

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DOI

Data Source

[Journal Article] Repair of topoisomerase 1?induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding2023

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DOI

Data Source

[Journal Article] XRCC1 counteracts poly(ADP ribose)polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal of trapped PARP1 from broken DNA.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SPRTN and TDP1/TDP2 Independently Suppress 5-Aza-2′-deoxycytidine-Induced Genomic Instability in Human TK6 Cell Line2022

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DOI

Data Source

[Journal Article] Division of labor of Y-family polymerases in translesion-DNA synthesis for distinct types of DNA damage2021

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[Journal Article] Repair pathways for radiation DNA damage under normoxic and hypoxic conditions: Assessment with a panel of repair-deficient human TK6 cells2021

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DOI

Data Source

[Journal Article] XRCC1 Prevents Toxic PARP1 Trapping During DNA Base Excision Repair.2021

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NAID

Data Source

[Journal Article] ポイソメラーゼ阻害剤が引き起こすDNA損傷の修復機構2021

Author(s)

Tsuda Masataka 津田雅貴