Unoki Takamitsu 鵜木隆光

… Alternative Names

UNOKI TAKAMITSU 鵜木隆光

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Researcher Number	00742868
Other IDs	https://orcid.org/0000-0002-2067-3734
Affiliation (Current)	2025: 昭和薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2019 – 2024: 国立水俣病総合研究センター, その他部局等, 主任研究員 2016 – 2017: 筑波大学, 医学医療系, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Environmental and hygienic pharmacy Except Principal Investigator Basic Section 64010:Environmental load and risk assessment-related
Keywords	Principal Investigator レドックスバイオロジー / メチル水銀 / 活性イオウ分子 / 超硫黄分子 / レドックスホメオスタシス / サルフェン硫黄 / 分析科学 / 環境 / 健康リスク / 親電子物質 / 環境中親電子物質 / 環境中新電子物質 … More Except Principal Investigator … More 水俣病 / miRNA / 神経機能障害 / エクソソーム / ポリチオール化 / バイオマーカー / メチル水銀 Less

超硫黄化を介したタンパク質機能制御のメチル水銀による撹乱と毒性機序の解明Principal Investigator
- Principal Investigator
  
  鵜木隆光
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  National Institute for Minamata Disease
Development of a biomarker that can objectively determine differences in individual susceptibility to methylmercury poisoning
- Principal Investigator
  
  藤村成剛
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 64010:Environmental load and risk assessment-related
- Research Institution
  National Institute for Minamata Disease
Neuronal cell function changes associated with methylmercury-induced variations in redox regulatory factorsPrincipal Investigator
- Principal Investigator
  
  Unoki Takamitsu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  National Institute for Minamata Disease
Research on methylmercury-induced selective cytotoxicity focusing on reactive sulfur speciesPrincipal Investigator
- Principal Investigator
  
  Unoki Takamitsu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  National Institute for Minamata Disease
Research on detoxification mechanism of environmental electrophiles mediated by reactive sulfur speciesPrincipal Investigator
- Principal Investigator
  
  UNOKI TAKAMITSU
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  University of Tsukuba

All 2023 2022 2021 2020 2019 2017 2016

All Journal Article Presentation

[Journal Article] Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress2022
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Aoki Hanako、Nishimura Akiyuki、Shinkai Yasuhiro、Warabi Eiji、Nishiyama Kazuhiro、Furumoto Yuka、Anzai Naohiko、Akaike Takaaki、Nishida Motohiro、Kumagai Yoshito
- Journal Title
  
  Redox Biology
  
  Volume: 57 Pages: 102514-102514
- DOI
  10.1016/j.redox.2022.102514
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06572, KAKENHI-PROJECT-22K19395, KAKENHI-PROJECT-22K19397, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05269, KAKENHI-PUBLICLY-22H05555, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340, KAKENHI-PROJECT-21H03065, KAKENHI-PUBLICLY-22H04799, KAKENHI-PLANNED-21H05263, KAKENHI-PROJECT-18H05277
[Journal Article] Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain2022
- Author(s)
  Unoki Takamitsu、Akiyama Masahiro、Shinkai Yasuhiro、Kumagai Yoshito、Fujimura Masatake
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 47 Issue: 1 Pages: 31-37
- DOI
  10.2131/jts.47.31
- NAID
  130008139752
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340, KAKENHI-PROJECT-21K06572, KAKENHI-PROJECT-19K16368
[Journal Article] Nrf2 Activation and Its Coordination with the Protective Defense Systems in Response to Electrophilic Stress2020
- Author(s)
  Unoki Takamitsu、Akiyama Masahiro、Kumagai Yoshito
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 2 Pages: 545-545
- DOI
  10.3390/ijms21020545
- NAID
  120007132700
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16368, KAKENHI-PROJECT-18H05293
[Journal Article] Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both2019
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Shinkai Yasuhiro、Ishii Isao、Ida Tomoaki、Akaike Takaaki、Yamamoto Masayuki、Kumagai Yoshito
- Journal Title
  
  Environmental Health Perspectives
  
  Volume: 127 Issue: 6 Pages: 067002-067002
- DOI
  10.1289/ehp4949
- NAID
  120007133174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16368, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-18K07099, KAKENHI-PROJECT-18H05277
[Journal Article] Adaptive Responses to Electrophilic Stress and Reactive Sulfur Species as their Regulator Molecules2019
- Author(s)
  Kumagai Yoshito、Akiyama Masahiro、Unoki Takamitsu
- Journal Title
  
  Toxicological Research
  
  Volume: 35 Issue: 4 Pages: 303-310
- DOI
  10.5487/tr.2019.35.4.303
- NAID
  120007127813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16368, KAKENHI-PROJECT-18H05293
[Journal Article] 1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides2017
- Author(s)
  Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC, Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y.
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 104 Pages: 118-128
- DOI
  10.1016/j.freeradbiomed.2016.12.047
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K18994, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-16K18920, KAKENHI-PROJECT-17K15489, KAKENHI-PROJECT-15K08042
[Journal Article] The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity2017
- Author(s)
  Akiyama Masahiro、Shinkai Yasuhiro、Unoki Takamitsu、Shim Ilseob、Ishii Isao、Kumagai Yoshito
- Journal Title
  
  Chem Res Toxicol
  
  Volume: 30 Issue: 12 Pages: 2209-2217
- DOI
  10.1021/acs.chemrestox.7b00278
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K08042, KAKENHI-PROJECT-16K15194, KAKENHI-PROJECT-16K18920, KAKENHI-PROJECT-16H05107
[Journal Article] Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts2017
- Author(s)
  Abiko Yumi、Shinkai Yasuhiro、Unoki Takamitsu、Hirose Reiko、Uehara Takashi、Kumagai Yoshito
- Journal Title
  
  Scientific Report
  
  Volume: 7 Issue: 1 Pages: 4814-4814
- DOI
  10.1038/s41598-017-04590-z
- NAID
  120007128910
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15489, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K08042, KAKENHI-PROJECT-16K18920, KAKENHI-PROJECT-15H04649
[Journal Article] Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells2016
- Author(s)
  Unoki T, Abiko Y, Toyama T, Uehara T, Tsuboi K, Nishida M, Kaji T, Kumagai Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 28944-28944
- DOI
  10.1038/srep28944
- NAID
  120007135346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-16H05092, KAKENHI-PROJECT-16H05387, KAKENHI-PROJECT-15K14952, KAKENHI-PROJECT-15K14959, KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-16K15573, KAKENHI-PROJECT-16K18920, KAKENHI-PROJECT-15H04649
[Presentation] Cystine-dependent antiporters prevent sulfur stress by excreting surplus supersulfide from cells2023
- Author(s)
  鵜木隆光, 秋山雅博, 青木はな子, 西村明幸, 新開泰弘, 西田基弘, 熊谷嘉人
- Organizer
  第50回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-21K06572
[Presentation] メチル水銀によるタンパク質超硫黄化変動の網羅的解析2023
- Author(s)
  鵜木隆光, 秋山雅博, 熊谷嘉人, 藤村成剛
- Organizer
  メタルバイオサイエンス研究会2023
- Data Source
  KAKENHI-PROJECT-21K06572
[Presentation] メチル水銀曝露による細胞内タンパク質超硫黄化の変動2023
- Author(s)
  鵜木隆光, 秋山雅博, 熊谷嘉人, 藤村成剛
- Organizer
  フォーラム2023：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-21K06572
[Presentation] メチル水銀毒性に対する耐性/脆弱性診断のための血中バイオマーカーの探索研究2023
- Author(s)
  藤村成剛, 鵜木隆光
- Organizer
  メタルバイオサイエンス研究会2023
- Data Source
  KAKENHI-PROJECT-23K25022
[Presentation] メチル水銀によるタンパク質結合性超硫黄分子の変動2022
- Author(s)
  鵜木隆光, 秋山雅博, 熊谷嘉人, 藤村成剛
- Organizer
  メタルバイオサイエンス研究会2022
- Data Source
  KAKENHI-PROJECT-21K06572
[Presentation] メチル水銀曝露における細胞内サルフェン硫黄の遷移2022
- Author(s)
  鵜木隆光, 秋山雅博, 熊谷嘉人, 藤村成剛
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-21K06572
[Presentation] メチル水銀曝露による細胞内サルフェン硫黄の遷移2022
- Author(s)
  鵜木隆光, 秋山雅博, 熊谷嘉人, 藤村成剛
- Organizer
  フォーラム2022：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-21K06572
[Presentation] RSS産生酵素CSEはマウスへのメチル水銀曝露による脳中水銀蓄積と中毒症状を抑制する2021
- Author(s)
  鵜木隆光, 秋山雅博, 新開泰弘, 石井功, 熊谷嘉人
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K16368
[Presentation] メチル水銀曝露による脳中水銀蓄積と中毒症状は活性イオウ分子産生酵素CSEにより抑制される2021
- Author(s)
  鵜木隆光, 秋山雅博, 新開泰弘, 石井功, 熊谷嘉人
- Organizer
  フォーラム2021 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-19K16368
[Presentation] RSS産生酵素CSEはマウスへのメチル水銀曝露による脳中水銀蓄積と中毒症状を抑制する2021
- Author(s)
  鵜木隆光, 秋山雅博, 新開泰弘, 石井功, 熊谷嘉人
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-21K06572
[Presentation] メチル水銀曝露による脳中水銀蓄積と中毒症状は活性イオウ分子産生酵素CSEにより抑制される2021
- Author(s)
  鵜木隆光, 秋山雅博, 新開泰弘, 石井功, 熊谷嘉人
- Organizer
  フォーラム2021 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-21K06572
[Presentation] 活性イオウ分子を介した親電子ストレス防御2020
- Author(s)
  鵜木隆光, 秋山雅博, 新開泰弘, 熊谷嘉人, 藤村成剛
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K16368
[Presentation] 活性イオウ分子の脳内分布とメチル水銀感受性の連関2020
- Author(s)
  鵜木隆光, 秋山雅博, 熊谷嘉人, 藤村成剛
- Organizer
  生命金属に関する合同年会2020 (メタルバイオサイエンス研究会2020)
- Data Source
  KAKENHI-PROJECT-19K16368
[Presentation] メチル水銀の細胞傷害特異性に対する活性イオウ分子の影響2019
- Author(s)
  鵜木隆光, 秋山雅博, 熊谷嘉人, 藤村成剛
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16368
[Presentation] メチル水銀の細胞傷害特異性に対する活性イオウ分子の影響2019
- Author(s)
  鵜木隆光
- Organizer
  環境省「重金属等による健康影響に関する総合的研究」メチル水銀研究ミーティング
- Data Source
  KAKENHI-PROJECT-19K16368
[Presentation] メチル水銀の細胞傷害特異性に対する含イオウ求核低分子の影響2019
- Author(s)
  鵜木隆光, 秋山雅博, 熊谷嘉人, 藤村成剛
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K16368
[Presentation] カドミウムによるHSP90の化学修飾を介する転写因子HSF1の活性化と活性イオウ分子によるその制御2017
- Author(s)
  鵜木隆光、新開泰弘、増田章、秋山雅博、Xian Ming、熊谷嘉人
- Organizer
  第70回日本酸化ストレス学会
- Data Source
  KAKENHI-PROJECT-16K18920
[Presentation] ポリスルフィドNa2S4はイオウ付加体形成を通じて1,4-NQによる PTEN/ Akt/CREB シグナルの活性化と細胞毒性を抑制する2017
- Author(s)
  鵜木隆光、安孫子ユミ、新開泰弘、広瀬玲子、上原孝、熊谷嘉人
- Organizer
  フォーラム2017：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-16K18920
[Presentation] カドミウムによるHSP90の化学修飾を介した転写因子HSF1の活性化と活性イオウ分子によるその制御2017
- Author(s)
  鵜木隆光、新開泰弘、増田章、秋山雅博、Ming XIAN、熊谷嘉人
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-16K18920
[Presentation] 1,4-Naphthoquinone-mediated activation of the HSP90/HSF1 signal transduction pathway and its negative regulation by reactive sulfur species in human A431 cells2016
- Author(s)
  Unoki T, Shinkai Y, Sha L, Hirose R, Kumagai Y
- Organizer
  IUTOX2016 XIV International Congress of Toxicology and X Mexican Congress of Toxicology
- Place of Presentation
  メリダ（メキシコ）
- Year and Date
  2016-10-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18920
[Presentation] 1,4-ナフトキノンによるHSF90/HSF1経路の活性化と活性イオウ分子によるその制御2016
- Author(s)
  鵜木隆光、新開泰弘、沙亮、広瀬玲子、熊谷嘉人
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  ウインクあいち（愛知県・名古屋市）
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-16K18920
[Presentation] 親電子物質による生体影響の二面性：SH-SY5Y 細胞におけるメチル水銀曝露により生じるAkt/CREB/Bcl-2 経路の活性化と破綻2016
- Author(s)
  鵜木隆光、安孫子ユミ、外山喬士、上原孝、坪井康次、西田基宏、鍜冶利幸、熊谷嘉人
- Organizer
  フォーラム2016 衛生薬学・環境トキシコロジー
- Place of Presentation
  昭和大学旗の台キャンパス（東京都・品川区）
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-16K18920
[Presentation] Sodium tetrasulfide, a reactive sulfur species, protects cells from 1,4-naphthoquinone induced cytotoxicity through sulfur adduct formation2016
- Author(s)
  Unoki T, Shinkai Y, Abiko Y, Hirose R, Kumagai Y
- Organizer
  The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2016-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18920

1. 藤村成剛 (20416564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 臼杵扶佐子 (50185013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 中村政明 (50399672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. WATANABE Yasuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. SHINKAI Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 赤池孝章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 石井功

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 熊谷嘉人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 安孫子ユミ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 西田基宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Unoki Takamitsu 鵜木 隆光

UNOKI TAKAMITSU 鵜木 隆光

Research Projects

Research Products

Co-Researchers

超硫黄化を介したタンパク質機能制御のメチル水銀による撹乱と毒性機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a biomarker that can objectively determine differences in individual susceptibility to methylmercury poisoning

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Neuronal cell function changes associated with methylmercury-induced variations in redox regulatory factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on methylmercury-induced selective cytotoxicity focusing on reactive sulfur speciesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on detoxification mechanism of environmental electrophiles mediated by reactive sulfur speciesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain2022

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Nrf2 Activation and Its Coordination with the Protective Defense Systems in Response to Electrophilic Stress2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Adaptive Responses to Electrophilic Stress and Reactive Sulfur Species as their Regulator Molecules2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] 1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts2017

Author(s)

Journal Title

DOI

Unoki Takamitsu 鵜木隆光

UNOKI TAKAMITSU 鵜木隆光