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Kurita Hisaka  栗田 尚佳

Researcher Number 00746315
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-6582-3129
Affiliation (Current) 2025: 岐阜薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help 2025: 岐阜薬科大学, 薬学部, 准教授
2017 – 2021: 岐阜薬科大学, 薬学部, 講師
2015 – 2017: 岐阜薬科大学, 薬学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 63030:Chemical substance influence on environment-related / Biological pharmacy / Environmental and hygienic pharmacy
Except Principal Investigator
Neurology / General internal medicine and related fields
Keywords
Principal Investigator
エピジェネティクス / 神経分化 / DOHaD / 神経突起 / メチル水銀 / 金属代謝 / 脳神経疾患 / シグナル伝達 / 発生・分化 / MTF1 / メタロチオネイン / 亜鉛 / 筋萎縮性側索硬化症 … More
Except Principal Investigator
… More PFBC / IBGC / ファール病 / 血管平滑筋細胞 / 周皮細胞 / リン / 血管石灰化 / リン酸 (Pi) / 無機リン酸 (Pi) / 特発性基底核石灰化症 / 原発性家族性脳石灰化症(PFBC) / 特発性基底核石灰化症(IBGC) / 抗酸化剤 / リン酸トランスポーター / 無機リン酸(Pi) / 脳内石灰化 / 脳・神経疾患 / 脳・神経 / 内科 / ヒト乳歯歯髄幹細胞培養上清 / 筋萎縮性側索硬化症 / 筋萎縮性側索硬化症(ALS) / iPS細胞 / 凝集体 / Cu/Zn SOD (SOD1) / ヒト乳歯歯髄幹細胞培養上清 (SHED-CM) / 筋萎縮性側索硬化症 (ALS) Less
  • Research Projects

    (6 results)
  • Research Products

    (45 results)
  • Co-Researchers

    (9 People)
  •  発達期メチル水銀による神経機能攪乱のエピゲノム解析と多世代影響評価Principal Investigator

    • Principal Investigator
      栗田 尚佳
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 63030:Chemical substance influence on environment-related
    • Research Institution
      Gifu Pharmaceutical University
  •  Study for target epigenome molecules exposed to low-concentration methylmercury that cause neuronal differentiation effectsPrincipal Investigator

    • Principal Investigator
      Kurita Hisaka
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 63030:Chemical substance influence on environment-related
    • Research Institution
      Gifu Pharmaceutical University
  •  Novel therapeutic strategies for amyotrophic lateral sclerosis using human deciduous dental pulp stem cells and their active ingredients

    • Principal Investigator
      Hozimi Isao
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      General internal medicine and related fields
    • Research Institution
      Gifu Pharmaceutical University
  •  Study of epigenetic roles of MTF1 on neurodevelopment and neurodegenerative diseasePrincipal Investigator

    • Principal Investigator
      Kurita Hisaka
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Gifu Pharmaceutical University
  •  Research on the molecular mechanism of intracranial calcification and novel therapies

    • Principal Investigator
      Hozumi Isao
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Gifu Pharmaceutical University
  •  Analysis of epigenetics mechanism of metallothionein-3 decrease in amyotrophic lateral sclerosis patientsPrincipal Investigator

    • Principal Investigator
      Kurita Hisaka
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Environmental and hygienic pharmacy
    • Research Institution
      Gifu Pharmaceutical University

All 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

  • [Book] 生命金属ダイナミクス: 生体内における金属の挙動と制御2021

    • Author(s)
      保住 功, 位田雅俊, 栗田尚佳
    • Total Pages
      511
    • Publisher
      エヌ・ティー・エス出版
    • Data Source
      KAKENHI-PROJECT-17H04198
  • [Journal Article] DNA methyltransferase- and histone deacetylase-mediated epigenetic alterations induced by low-level methylmercury exposure disrupt neuronal development2021

    • Author(s)
      Go Suzuna、Kurita Hisaka、Hatano Manami、Matsumoto Kana、Nogawa Hina、Fujimura Masatake、Inden Masatoshi、Hozumi Isao
    • Journal Title

      Archives of Toxicology

      Volume: 95 Issue: 4 Pages: 1227-1239

    • DOI

      10.1007/s00204-021-02984-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K12341, KAKENHI-PROJECT-19J15480, KAKENHI-PLANNED-19H05767
  • [Journal Article] Characteristics and Therapeutic Potential of Dental Pulp Stem Cells on Neurodegenerative Diseases2020

    • Author(s)
      Ueda Tomoyuki、Inden Masatoshi、Ito Taisei、Kurita Hisaka、Hozumi Isao
    • Journal Title

      Frontiers in Neuroscience

      Volume: 14 Pages: 407-407

    • DOI

      10.3389/fnins.2020.00407

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19666, KAKENHI-PLANNED-19H05767
  • [Journal Article] The Novel gem-Dihydroperoxide 12AC3O Suppresses High Phosphate-Induced Calcification via Antioxidant Effects in p53LMAco1 Smooth Muscle Cells2020

    • Author(s)
      Takase Naoko、Inden Masatoshi、Hirai Shunsuke、Yamada Yumeka、Kurita Hisaka、Takeda Mitsumi、Yamaguchi Eiji、Itoh Akichika、Hozumi Isao
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 13 Pages: 4628-4628

    • DOI

      10.3390/ijms21134628

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-19H05767, KAKENHI-PROJECT-17H04198, KAKENHI-PROJECT-19J15479
  • [Journal Article] 特発性基底核石灰化症の病態解明と治療薬の開発.2020

    • Author(s)
      保住 功, 栗田尚佳, 位田雅俊, 山田 恵, 林 祐一, 下畑享良, 犬塚 貴
    • Journal Title

      神経治療学

      Volume: 37(3) Pages: 393-397

    • NAID

      130007981254

    • Open Access
    • Data Source
      KAKENHI-PROJECT-17H04198
  • [Journal Article] Partial reduced Pi transport function of PiT-2 might not be sufficient to induce brain calcification of idiopathic basal ganglia calcification2019

    • Author(s)
      Nishii Kazuya、Shimogawa Ritsuko、Kurita Hisaka、Inden Masatoshi、Kobayashi Michio、Toyoshima Itaru、Taguchi Yoshiharu、Ueda Akihiro、Tamune Hidetaka、Hozumi Isao
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 17288-17288

    • DOI

      10.1038/s41598-019-53401-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07513, KAKENHI-PLANNED-19H05767, KAKENHI-PROJECT-17H04198
  • [Journal Article] SLC20A2 variants cause dysfunctional phosphate transport activity in endothelial cells induced from Idiopathic Basal Ganglia Calcification patients-derived iPSCs2019

    • Author(s)
      Sekine Shin-ichiro、Nishii Kazuya、Masaka Tomohiko、Kurita Hisaka、Inden Masatoshi、Hozumi Isao
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 510 Issue: 2 Pages: 303-308

    • DOI

      10.1016/j.bbrc.2019.01.096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04198
  • [Journal Article] p-Coumaric Acid Has Protective Effects against Mutant Copper?Zinc Superoxide Dismutase 1 via the Activation of Autophagy in N2a Cells2019

    • Author(s)
      Ueda Tomoyuki、Ito Taisei、Kurita Hisaka、Inden Masatoshi、Hozumi Isao
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 12 Pages: 2942-2942

    • DOI

      10.3390/ijms20122942

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-19H05767, KAKENHI-PROJECT-17K19666
  • [Journal Article] Inorganic phosphorus (Pi) in CSF is a biomarker for SLC20A2 -associated idiopathic basal ganglia calcification (IBGC1)2018

    • Author(s)
      Hozumi Isao、Kurita Hisaka、Ozawa Kazuhiro、Furuta Nobuyuki、Inden Masatoshi、Sekine Shin-ichiro、Yamada Megumi、Hayashi Yuichi、Kimura Akio、Inuzuka Takashi、Seishima Mitsuru
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 388 Pages: 150-154

    • DOI

      10.1016/j.jns.2018.03.014

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19666, KAKENHI-PROJECT-17H04198
  • [Journal Article] Protective function of SLC30A10 induced via PERK-ATF4 pathway against 1-methyl-4-phenylpyridinium2017

    • Author(s)
      Go Suzuna、Kurita Hisaka、Yokoo Kazuki、Inden Masatoshi、Kambe Taiho、Hozumi Isao
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 490 Issue: 4 Pages: 1307-1313

    • DOI

      10.1016/j.bbrc.2017.07.018

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K18001, KAKENHI-PROJECT-15H04501, KAKENHI-PROJECT-17H04198
  • [Journal Article] Neuroprotective effect of 5-aminolevulinic acid against low inorganic phosphate in neuroblastoma SH-SY5Y cells2017

    • Author(s)
      Takase Naoko、Inden Masatoshi、Sekine Shin-ichiro、Ishii Yumi、Yonemitsu Hiroko、Iwashita Wakana、Kurita Hisaka、Taketani Yutaka、Hozumi Isao
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 5768-5768

    • DOI

      10.1038/s41598-017-06406-6

    • NAID

      120006535051

    • Data Source
      KAKENHI-PROJECT-17H04198
  • [Journal Article] Protective roles of SLC30A3 against endoplasmic reticulum stress via ERK1/2 activation.2016

    • Author(s)
      Hisaka Kurita, Rika Okuda, Kazuki Yokoo, Masatoshi Inden, Isao Hozumi.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 459 Issue: 4 Pages: 853-859

    • DOI

      10.1016/j.bbrc.2016.09.119

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K21278
  • [Presentation] メチル水銀曝露の神経分化に及ぼす影響と関連遺伝子のエピゲノム解析2021

    • Author(s)
      栗田尚佳、郷 すずな、増田 遥、保住 功、位田雅俊
    • Organizer
      メタルバイオサイエンス研究会2021
    • Data Source
      KAKENHI-PROJECT-19K12341
  • [Presentation] メチル水銀が神経分化・発達に及ぼす影響とエピジェネティクスメカニズムの解析2021

    • Author(s)
      栗田尚佳
    • Organizer
      メタルバイオサイエンス研究会2021 研究奨励賞受賞講演
    • Data Source
      KAKENHI-PROJECT-19K12341
  • [Presentation] メチル水銀曝露の神経分化に及ぼす影響とDNAメチル化の関与2021

    • Author(s)
      栗田尚佳、郷すずな, 藤村成剛, 位田雅俊, 保住 功
    • Organizer
      フォーラム2021衛生薬学・環境トキシコロジー
    • Data Source
      KAKENHI-PROJECT-19K12341
  • [Presentation] オプトジェネティクスを用いたPDGFRβ活性化システムの構築2021

    • Author(s)
      木村優那,位田雅俊,栗田尚佳,保住 功
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-17H04198
  • [Presentation] 神経発達期におけるメチル水銀によるエピジェネティクス変化の解析2020

    • Author(s)
      栗田尚佳
    • Organizer
      平成31年度重金属等による健康影響に関する総合的研究 メチル水銀研究ミーティング
    • Data Source
      KAKENHI-PROJECT-19K12341
  • [Presentation] 胎生期化学物質曝露による次世代の毒性発現メカニズムの研究2020

    • Author(s)
      栗田尚佳
    • Organizer
      第47回日本毒性学会学術年会 日本毒性学会 奨励賞
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K12341
  • [Presentation] 血管平滑筋細胞における高リン酸誘導性石灰化に対する低分子化合物12AC3Oの影響2020

    • Author(s)
      山田夢華,高瀬奈央子,平井俊輔,武田充未,栗田尚佳,位田雅俊,山口英士,伊藤彰近,保住 功
    • Organizer
      メタルバイオサイエンス研究会2020
    • Data Source
      KAKENHI-PROJECT-17H04198
  • [Presentation] Functional studies and therapeutic strategies for SLC20A2-associated primary brain calcification2020

    • Author(s)
      Hozumi I, Kurita H, Inden M, Yamada M, Hayashi Y, Shimohata T, Inuzuka T
    • Organizer
      2020 American Academy of Neurology Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04198
  • [Presentation] 神経難病と微量元素2020

    • Author(s)
      保住 功,栗田尚佳,位田雅俊
    • Organizer
      第61回日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04198
  • [Presentation] 環境化学物質暴露の神経分化に及ぼす影響とDNAメチル化の関与2020

    • Author(s)
      野川 斐奈、郷 すずな、畑野 愛、松本 夏南、栗田 尚佳、位田 雅俊、保住 功
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-19K12341
  • [Presentation] 孤発性筋萎縮症側索硬化症患者における新規microRNAの探索と機能解析2019

    • Author(s)
      栗田尚佳、位田雅俊、保住 功他
    • Organizer
      メタルバイオサイエンス研究会2019
    • Data Source
      KAKENHI-PROJECT-17K19666
  • [Presentation] p-coumaric acidのオートファジーを介した変異SOD1毒性に対する神経保護効果2019

    • Author(s)
      上田智之、位田雅俊、栗田尚佳、保住 功他
    • Organizer
      第135回日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-17K19666
  • [Presentation] 胎生期における低濃度環境化学物質曝露が神経分化に及ぼす影響およびエピゲノム解析2019

    • Author(s)
      郷すずな、畑野 愛、松本夏南、栗田尚佳、位田雅俊、保住 功
    • Organizer
      第46日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-19K12341
  • [Presentation] Determination of epigenetic modifications in fetal brain exposed to methylmercury during development.2019

    • Author(s)
      Kurita H., Hatano M., Go S., Matsumoto K., Inden M., Hozumi I.
    • Organizer
      Hawaii 15th International Congress of Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K12341
  • [Presentation] 脳ホメオスタシスとプロテオパチーに関与する神経毒に対する機能性食品成分の効果2019

    • Author(s)
      位田雅俊、栗田尚佳、保住 功他
    • Organizer
      第10回岐阜薬科大学機能性健康食品研究講演会
    • Data Source
      KAKENHI-PROJECT-17K19666
  • [Presentation] タミバロテンはPiT2発現を増加し、細胞内無機リン酸の恒常性を維持する可能性がある2019

    • Author(s)
      仁澤 卓也、位田雅俊、栗田尚佳、保住 功他
    • Organizer
      第92回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-17H04198
  • [Presentation] SH-SY5Y細胞における細胞内リン酸異常に起因した細胞障害に対するPDGF-BBの神経保護効果2019

    • Author(s)
      高瀬奈央子、位田雅俊、栗田尚佳、保住 功他
    • Organizer
      第135回日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-17H04198
  • [Presentation] Analysis of epigenetic effect of low-level methylmercury on neuronal differentiation by using an in vitro model.2019

    • Author(s)
      Go S., Matsumoto K., Hatano M., Kurita H., Inden M., Hozumi I.
    • Organizer
      Hawaii 15th International Congress of Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K12341
  • [Presentation] 本邦における特発性基底核石灰化症(IBGC)患者の遺伝子解析と機能解析の現状2019

    • Author(s)
      保住 功、栗田尚佳、位田雅俊、林 祐一、田中真生他
    • Organizer
      第60回神経学会総会
    • Data Source
      KAKENHI-PROJECT-17H04198
  • [Presentation] 変異Cu/Zn superoxide dismutase1毒性に対するプロポリス含有成分の神経保護効果2019

    • Author(s)
      伊藤泰生、位田雅俊、栗田尚佳、保住 功他
    • Organizer
      第1回日本脳サプリメント学会
    • Data Source
      KAKENHI-PROJECT-17K19666
  • [Presentation] 特発性基底核石灰化症 (IBGC) における血管内皮細胞に対するラロキシフェンの保護効果2019

    • Author(s)
      金子由希、位田雅俊、栗田尚佳、保住 功他
    • Organizer
      第135回日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-17H04198
  • [Presentation] p-coumaric acidのオートファジーを介した変異SOD1毒性に対する神経保護効果2019

    • Author(s)
      上田 智之、伊藤 泰生、栗田 尚佳、位田 雅俊、保住 功
    • Organizer
      第135回日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-17K19666
  • [Presentation] Evaluation and functional study of idiopathic basal ganglia calcification in Japan2018

    • Author(s)
      保住 功、栗田尚佳、位田雅俊、林 祐一他
    • Organizer
      16TH ASIAN OCEANIAN CONGRESS OF NEUROLOGY
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04198
  • [Presentation] The effects of kaempferol against mutant copper-zinc superoxide dismutase-mediated toxicity via autophagy2018

    • Author(s)
      Ueda T, Inden M, Kurita H, Hozumi I et al.
    • Organizer
      第18回国際薬理学・臨床薬理学会(WCP2018)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19666
  • [Presentation] 変異Cu/Zn superoxide dismutase1の毒性に対する桂皮酸誘導体の神経保護効2018

    • Author(s)
      伊藤泰生、栗田尚佳、位田雅俊、保住 功他
    • Organizer
      第9回岐阜薬科大学機能性健康食品研究講演会
    • Data Source
      KAKENHI-PROJECT-17K19666
  • [Presentation] 特発性基底核石灰化症(IBGC)の病態解明に基づいた治療薬開発の試み2018

    • Author(s)
      保住 功、栗田尚佳、位田雅俊、林 祐一他
    • Organizer
      第36回日本神経治療学会学術集会(優秀口演発表)
    • Data Source
      KAKENHI-PROJECT-17H04198
  • [Presentation] SLC20A2に変異を認める特発性基底核石灰化症(IBGC1)患者の病態解析2018

    • Author(s)
      保住 功、栗田尚佳、位田雅俊、林 祐一他
    • Organizer
      第59回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-17H04198
  • [Presentation] 特発性基底核石灰化症(IBGC)の病態解明に基づいた治療薬開発の試み2018

    • Author(s)
      西飯和哉、栗田尚佳、位田雅俊、保住 功他
    • Organizer
      日本毒性学会分化会 メタルバイオ研究会2018
    • Data Source
      KAKENHI-PROJECT-17H04198
  • [Presentation] The effects of the ethanol extract of Brazilian green propolis that contains flavonols against mutant copper-zinc superoxide dismutase-mediated toxicity2018

    • Author(s)
      Inden M, Kurita H, Hozumi I et al.
    • Organizer
      Neuroscience 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19666
  • [Presentation] Effect of 5-aminolevulinic acid against low inorganic phosphate in neuroblastoma SH-SY5Y cells2018

    • Author(s)
      高瀬奈央子、位田雅俊、栗田尚佳、保住 功他
    • Organizer
      第18回国際薬理学・臨床薬理学会(WCP2018)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04198
  • [Presentation] SLC30A3の小胞体ストレス応答に対する防御的役割の検討2016

    • Author(s)
      横尾一樹、奥田莉加、栗田尚佳、位田雅俊、保住 功
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
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    • Data Source
      KAKENHI-PROJECT-15K21278
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      栗田尚佳、奥田莉加、横尾一樹、位田雅俊、保住 功
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    • Place of Presentation
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    • Data Source
      KAKENHI-PROJECT-15K21278
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    • Organizer
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    • Place of Presentation
      名古屋
    • Year and Date
      2015-08-27
    • Data Source
      KAKENHI-PROJECT-15K21278
  • 1.  Hozimi Isao (20242430)
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  • 2.  位田 雅俊 (70512424)
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