Tanaka Yoshinori 田中良法

… Alternative Names

TANAKA Yoshinori 田中良法

Less

Researcher Number	00747933
Other IDs
Affiliation (Current)	2025: 岡山理科大学, 獣医学部, 講師
Affiliation (based on the past Project Information) *help	2019 – 2023: 岡山理科大学, 獣医学部, 助教 2015 – 2016: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / 0704:Neuroscience, brain sciences, and related fields / Nerve anatomy/Neuropathology Except Principal Investigator Medium-sized Section 42:Veterinary medical science, animal science, and related fields
Keywords	Principal Investigator TDP-43 / progranulin / プログラニュリン / リソソーム / オートファジー / ホスホイノシタイド / オートリソソーム / 分泌型オートファジー / vacuolin-1 / abemaciclib … More / PIKfyve / CDK4/6 / マクロオートファジー / 細胞外小胞 / 神経変性 / 乳酸 / 解糖系 / Seeding Activity / aggregation / profilin1 / seeding activity / autolysosome / lysosome / autophagy / プリオン / 筋萎縮性側索硬化症 / アグリソーム / プロフィリン１ / prion / seeding / LC3 / aggresome / mutation / ALS / Profilin1 … More Except Principal Investigator ブタ / CRISPR/Cas9 / ゲノム編集 / アフリカ豚熱 Less

Membrane trafficking for degradation or secretion of TDP-43Principal Investigator
- Principal Investigator
  
  田中良法
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Okayama University of Science
Generation of African Swine Fever virus-resistant pigs by applying the concept of gene editing technology
- Principal Investigator
  
  谷原史倫
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Jichi Medical University
Suppression of neurodegeneration through the interactive action between progranulin and glycolysisPrincipal Investigator
- Principal Investigator
  
  Tanaka Yoshinori
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Okayama University of Science
Screening targets modify the gain of seeding activity of TDP-43Principal Investigator
- Principal Investigator
  
  TANAKA Yoshinori
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0704:Neuroscience, brain sciences, and related fields
- Research Institution
  Okayama University of Science
The mechanism of cytotoxicity from ALS-linked Profilin 1 mutationsPrincipal Investigator
- Principal Investigator
  
  TANAKA Yoshinori
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science

All 2024 2023 2022 2021 2020 2017 2016 2015

All Journal Article Presentation

[Journal Article] Abemaciclib and Vacuolin-1 decrease aggregate-prone TDP-43 accumulation by accelerating autophagic flux2024
- Author(s)
  Tanaka Yoshinori、Kozuma Lina、Hino Hirotsugu、Takeya Kosuke、Eto Masumi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 38 Pages: 101705-101705
- DOI
  10.1016/j.bbrep.2024.101705
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06837
[Journal Article] TDP-43 Secretion via Extracellular Vesicles Is Regulated by Macroautophagy2023
- Author(s)
  Tanaka Yoshinori、Ito Shun-ichi、Suzuki Genjiro
- Journal Title
  
  Autophagy Reports
  
  Volume: 3 Issue: 1 Pages: 3-3
- DOI
  10.1080/27694127.2023.2291250
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07288, KAKENHI-PROJECT-23K06837
[Journal Article] PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis2023
- Author(s)
  Kirkbride Jason A.、Nilsson Garbo Young、Kim Jee In、Takeya Kosuke、Tanaka Yoshinori、Tokumitsu Hiroshi、Suizu Futoshi、Eto Masumi
- Journal Title
  
  Biomolecules
  
  Volume: 13 Issue: 12 Pages: 1741-1741
- DOI
  10.3390/biom13121741
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06339, KAKENHI-PROJECT-23K06837, KAKENHI-PROJECT-21H02429
[Journal Article] Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-432023
- Author(s)
  Tanaka Yoshinori、Ito Shun-ichi、Honma Yuki、Hasegawa Masato、Kametani Fuyuki、Suzuki Genjiro、Kozuma Lina、Takeya Kosuke、Eto Masumi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 11 Pages: 105272-105272
- DOI
  10.1016/j.jbc.2023.105272
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07288, KAKENHI-PROJECT-23K06339, KAKENHI-PROJECT-23K06837
[Journal Article] Abemaciclib and vacuolin-1 induce vacuole-like autolysosome formation - a new tool to study autophagosome-lysosome fusion2022
- Author(s)
  Tanaka Yoshinori、Hino Hirotsugu、Takeya Kosuke、Eto Masumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 614 Pages: 191-197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16508
[Journal Article] Possible roles of N- and C-terminal unstructured tails of CPI-17 in regulating Ca<sup>2+</sup> sensitization force of smooth muscle2022
- Author(s)
  Eto M, Katsuki S, Ohashi M, Miyagawa Y, Tanaka Y, Takeya K, Kitazawa T.
- Journal Title
  
  Journal of Smooth Muscle Research
  
  Volume: 58 Issue: 0 Pages: 22-33
- DOI
  10.1540/jsmr.58.22
- ISSN
  0916-8737, 1884-8796
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06573, KAKENHI-PROJECT-20K16508
[Journal Article] Overexpression of progranulin increases pathological protein accumulation by suppressing autophagic flux2022
- Author(s)
  Tanaka Yoshinori、Kusumoto Shun-ya、Honma Yuki、Takeya Kosuke、Eto Masumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 611 Pages: 78-84
- DOI
  10.1016/j.bbrc.2022.04.064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16508, KAKENHI-PROJECT-19K06573
[Journal Article] Kinase activity-tagged western blotting assay2020
- Author(s)
  Eto Masumi、Katsuki Shuichi、Tanaka Yoshinori、Takeya Kosuke
- Journal Title
  
  BioTechniques
  
  Volume: 68 Issue: 4 Pages: 211-213
- DOI
  10.2144/btn-2019-0136
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06573, KAKENHI-PROJECT-20K16508, KAKENHI-PROJECT-19K23785
[Journal Article] Convulsive responses to seizure-inducible drugs are exacerbated in progranulin-deficient mice2020
- Author(s)
  Kuroda M, Matsuwaki T, Tanaka Y, Yamanouchi K, Nishihara M
- Journal Title
  
  Neuroreport
  
  Volume: 31 Issue: 6 Pages: 478-483
- DOI
  10.1097/wnr.0000000000001425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03930, KAKENHI-PROJECT-17H03931, KAKENHI-PROJECT-20K16508, KAKENHI-PROJECT-19K23785
[Journal Article] Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.2017
- Author(s)
  Tanaka Y, Suzuki G, Matsuwaki T, Hosokawa M, Serrano G, Beach TG, Yamanouchi K, Hasegawa M, Nishihara M.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 26 Pages: 969-988
- DOI
  10.1093/hmg/ddx011
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-15K18370, KAKENHI-PROJECT-16K21650, KAKENHI-PROJECT-15K09850, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.2016
- Author(s)
  Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M.
- Journal Title
  
  The journal of Biological Chemistry
  
  Volume: 291 Issue: 11 Pages: 5473-83
- DOI
  10.1074/jbc.m115.695379
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18370, KAKENHI-PROJECT-221S0003, KAKENHI-ORGANIZER-25115001, KAKENHI-PLANNED-25115006, KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-25250010, KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-25650014, KAKENHI-PROJECT-26251004, KAKENHI-PROJECT-26290016, KAKENHI-PROJECT-16K14569, KAKENHI-PROJECT-16K14675
[Journal Article] Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation.2016
- Author(s)
  Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 25 Issue: 7 Pages: 1420-33
- DOI
  10.1093/hmg/ddw024
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18370, KAKENHI-PROJECT-221S0003, KAKENHI-PUBLICLY-26111730, KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-16K21650
[Journal Article] Profilin 1 mutants form aggregates that induce accumulation of prion-like TDP-43.2016
- Author(s)
  Tanaka Y, Hasegawa M
- Journal Title
  
  Prion
  
  Volume: 10 Issue: 4 Pages: 283-289
- DOI
  10.1080/19336896.2016.1207033
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-15K18370
[Presentation] CDK4/6阻害薬abemaciclibは空胞形成と連動した細胞死を誘導する2024
- Author(s)
  沖本智哉、日野浩嗣、田中良法、池田俊勝、原知世、竹谷浩介、高野直治、平本正樹、相澤信、宮澤啓介、江藤真澄、平井宗一
- Organizer
  第129回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] Comparison of Smooth Muscle Regulatory Factor CPI-17 Expression in Rat Renal Arterioles.2024
- Author(s)
  Kosuke TAKEYA, Hyebeen KIM, Yoshinori TANAKA, Masumi ETO
- Organizer
  第101回日本生理学会
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] TDP-43病理形成をめぐる冒険2024
- Author(s)
  田中良法
- Organizer
  研究打ち合わせ＠つくば産総研
- Invited
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] Abemaciclib rescues suppressed autolysosome formation resulting from progranulin insufficiency in cells and a mouse model2024
- Author(s)
  Yoshinori Tanaka, Misaki Kikuchi, Lina Kozuma, Hirotsugu Hino, Kosuke Takeya, Masumi Eto
- Organizer
  Neuro2024
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] Gastrointestinal implications of high salt diet: insights from a mouse model2024
- Author(s)
  Masumi Eto, Yohei Mochizuki, Toshiyasu Matsui, Minami Ohashi, Yuki Shimojima, Masakatsu Nohara, Kosuke Takeya, Yoshinori Tanaka, Risuke Mizuno
- Organizer
  第101回日本生理学会
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] AbemaciclibとVacuolin-1はオートファジーの促進を介して易凝集型TDP-43の蓄積を抑制する2024
- Author(s)
  田中良法、小妻莉奈、日野浩嗣、竹谷浩介、江藤真澄
- Organizer
  第65回日本生化学会中国四国支部例会
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] Investigation of vacuolar formation mechanism associated with cell death induced by CDK4/6 inhibitor abemaciclib.2024
- Author(s)
  Hirotsugu Hino, Yoshinori Tanaka, Tomoya Okimoto, Toshikatsu Ikeda, Tomoyo Hara, Kosuke Takeya, Naoharu Takano, Masaki Hiramoto, Shin Aizawa, Keisuke Miyazawa, Masumi Eto, Shuichi Hirai
- Organizer
  ホスファターゼ研究会
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] 平滑筋細胞におけるホスファターゼ調節タンパク質PHI-1の構造機能相関の解明2023
- Author(s)
  大橋南海、竹谷浩介、田中良法、江藤真澄
- Organizer
  第65回日本平滑筋学会総会
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] Abemaciclibがプログラニュリンフレームシフト変異マウスの加齢に伴う神経炎症病理に与える影響2023
- Author(s)
  菊池美咲、日野浩嗣、竹谷浩介、江藤真澄、田中良法
- Organizer
  第6回プログラニュリン研究会
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] CDK4/6阻害薬abemaciclibはリソソーム由来の空胞形成を伴った新規細胞死を誘導する2023
- Author(s)
  日野浩嗣、田中良法、池田俊勝、原知世、竹谷浩介、高野直治、平本正樹、相澤信、宮澤啓介、江藤真澄、平井宗一
- Organizer
  第6回プログラニュリン研究会
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] Suppression of progranulin-driven autophagy-lysosome pathway mediates secretion of the nuclear protein TDP-43: a novel protein secretion mechanism2023
- Author(s)
  Yoshinori Tanaka, Shun-ichi Ito, Yuki Honma, Masato Hasegawa, Fuyuki Kametani, Genjiro Suzuki, Lina Kozuma, Kosuke Takeya, Masumi Eto
- Organizer
  JSPS Bilateral Symposium between Taiwan and Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] 抗がん剤アベマシクリブによるFTLD-TDP病態抑制効果の検討2023
- Author(s)
  田中良法, 菊池美咲, 小妻莉奈, 日野浩嗣, 竹谷浩介, 江藤真澄
- Organizer
  第７回先進医薬研究報告会
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] 子宮平滑筋肉腫細胞におけるPP1阻害タンパク質PHI-1の生理的機能2023
- Author(s)
  飯森愛梨、田中良法、竹谷浩介、江藤真澄
- Organizer
  第65回日本平滑筋学会総会
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] CDK4/6阻害薬abemaciclibが誘導する細胞死と連動した空胞形成のメカニズムの検討2023
- Author(s)
  日野浩嗣、田中良法、池田俊勝、原知世、竹谷浩介、高野直治、平本正樹、相澤信、宮澤啓介、江藤真澄、平井宗一
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] 細胞外小胞を介した核タンパク質TDP-43の分泌におけるマクロオートファジーの役割2023
- Author(s)
  田中良法、伊藤俊一、本間優希、長谷川成人、亀谷富由樹、鈴木元治郎、小妻莉奈、竹谷浩介、江藤真澄
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] 細胞外小胞を介したTDP-43の放出におけるオートファジーの役割2023
- Author(s)
  伊藤俊一、竹谷浩介、江藤真澄、田中良法
- Organizer
  第6回プログラニュリン研究会
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] プログラニュリンの過剰発現はオートファゴソーム形成を抑制する2023
- Author(s)
  楠本竣也、竹谷浩介、江藤真澄、田中良法
- Organizer
  第6回プログラニュリン研究会
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] High salt diet induces ROCK signaling augmentation and dysmotility in mouse stomach2023
- Author(s)
  Masumi Eto, Yohei Mochizuki, Toshiyasu Matsui, Minami Ohashi, Yuki Shimojima, Masakatsu Nohara, Kosuke Takeya, Yoshinori Tanaka, Risuke Mizuno
- Organizer
  The 10th Federation of the Asian and Oceanian Physiological Societies Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] PI(3)P産生と関連したabemaciclibとvacuolin-1のオートリソソーム形成促進効果2023
- Author(s)
  田中良法、小妻莉奈、日野浩嗣、竹谷浩介、江藤真澄
- Organizer
  第6回プログラニュリン研究会
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] 細胞外小胞を介したTDP-43分泌におけるオートファジー・リソソーム経路の役割2023
- Author(s)
  田中良法、伊藤俊一、本間優希、2長谷川成人、2亀谷富由樹、2鈴木元治郎、小妻莉奈、竹谷浩介、江藤真澄
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] 腎細動脈平滑筋におけるCPI-17の発現比較2023
- Author(s)
  金慧彬　田中良法　江藤真澄　竹谷浩介
- Organizer
  第65回日本平滑筋学会総会
- Data Source
  KAKENHI-PROJECT-23K06837
[Presentation] CDK4/6阻害薬abemaciclibが誘導する空胞形成の機序及び細胞死との関連の検討2022
- Author(s)
  日野浩嗣、田中良法、竹谷浩介、高野直治、平本正樹、相澤信、宮澤啓介、江藤真澄、平井宗一
- Organizer
  第127回日本解剖学会総会
- Data Source
  KAKENHI-PROJECT-20K16508
[Presentation] リソソーム空胞化を誘導する薬剤によるオートリソソーム形成の促進2021
- Author(s)
  田中良法、松原叶実、日野浩嗣、竹谷浩介、江藤真澄
- Organizer
  第62回日本生化学会中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-20K16508
[Presentation] The role of progranulin in autolysosome formation2021
- Author(s)
  田中良法、松原叶実、日野浩嗣、竹谷浩介、江藤真澄
- Organizer
  第44回日本神経科学大会（CJK第１回国際会議）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16508
[Presentation] プログラニュリンはオートリソソーム形成を制御する2021
- Author(s)
  田中良法、松原叶実、日野浩嗣、竹谷浩介、江藤真澄
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-20K16508
[Presentation] プログラニュリンはオートファゴソームとリソソームの融合を促進する2021
- Author(s)
  田中良法、松原叶実、日野浩嗣、竹谷浩介、江藤真澄
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K16508
[Presentation] CDK4/6阻害薬abemaciclibが誘導する空胞の形成メカニズムの検討2021
- Author(s)
  日野浩嗣、田中良法、竹谷浩介、高野直治、平本正樹、相澤信、宮澤啓介、江藤真澄、平井宗一
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K16508
[Presentation] PGK1によるリソソームを通じたTDP-43凝集抑制作用2020
- Author(s)
  田中良法、亀谷富由樹、竹谷浩介、長谷川成人、江藤真澄
- Organizer
  第３９回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19K23785
[Presentation] CPI-17における機能外領域のリン酸化の影響2020
- Author(s)
  勝木秀一、大橋南海、竹谷浩介、田中良法、北澤俊雄、江藤真澄
- Organizer
  第62回日本平滑筋学会総会
- Data Source
  KAKENHI-PROJECT-20K16508
[Presentation] The role of progranulin in neurite outgrowth involved in acidification of lysosomes2020
- Author(s)
  Yoshinori Tanaka, Kosuke Takeya, Masumi Eto
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K23785
[Presentation] PGK1によるリソソームを通じたTDP-43凝集抑制作用2020
- Author(s)
  田中良法、亀谷富由樹、竹谷浩介、長谷川成人、江藤真澄
- Organizer
  第39回日本認知症学会
- Data Source
  KAKENHI-PROJECT-20K16508
[Presentation] プログラニュリンはリソソーム機能阻害により誘導されるNeuo2a細胞の突起伸長を抑制する2020
- Author(s)
  田中良法、竹谷浩介、江藤真澄
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K23785
[Presentation] プログラニュリンはリソソーム機能阻害により誘導されるNeuo2a細胞の突起伸長を抑制する2020
- Author(s)
  田中良法、竹谷浩介、江藤真澄
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K16508
[Presentation] 平滑筋Ca2+ sensitization forceの調節機構―CPI-17 N・C末端領域の生理的役割2020
- Author(s)
  勝木秀一、大橋南海、竹谷浩介、田中良法、北澤俊雄、江藤真澄
- Organizer
  第62回日本平滑筋学会総会
- Data Source
  KAKENHI-PROJECT-19K23785
[Presentation] The role of progranulin in neurite outgrowth involved in acidification of lysosomes2020
- Author(s)
  Yoshinori Tanaka, Kosuke Takeya, Masumi Eto
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K16508
[Presentation] PGK1によるリソソームを通じたTDP-43凝集抑制作用2020
- Author(s)
  田中良法、亀谷富由樹、竹谷浩介、長谷川成人、江藤真澄
- Organizer
  第39回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19K23785
[Presentation] ALSの原因となるプロフィリン1変異は機能獲得によりTDP-43の蓄積を誘起する2016
- Author(s)
  田中良法、野中隆、鈴木元治郎、亀谷富由樹、長谷川成人
- Organizer
  H27年度　ALS病態解明班　成果報告会
- Place of Presentation
  都市センターホテル(東京都千代田区)
- Year and Date
  2016-01-26
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] プログラニュリンはリソソームの酸性化を促進する2016
- Author(s)
  田中良法
- Organizer
  第1回プログラニュリン研究会
- Place of Presentation
  岐阜スカイウイング37(岐阜県岐阜市)
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] Gain-of-function Profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause intracellular TDP-43 aggregation.2016
- Author(s)
  Tanaka Y, Nonaka T.
- Organizer
  脳内環境平成27年度冬の班会議
- Place of Presentation
  京都大学芝蘭会館(京都府京都市)
- Year and Date
  2016-01-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] Mutations in the PFN1 gene induce degenerative changes through aggregation of both mutant PFN1 and TDP-43.2016
- Author(s)
  Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M.
- Organizer
  第14回医学研国際シンポジウム
- Place of Presentation
  東京都医学総合研究所 (東京都世田谷区)
- Year and Date
  2016-06-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] プログラニュリンはリソソームの酸性化を促進する2016
- Author(s)
  田中良法
- Organizer
  第１回プログラニュリン研究会
- Place of Presentation
  岐阜スカイウイング３７ (岐阜県岐阜市)
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] Progranulin overexpression decrease levels of the matured form of cathepsin D due to enhancement of lysosomal acidificaition.2016
- Author(s)
  Tanaka Y, Suzuki G, Hosokawa M, Kametani F, Hasegawa M, Nishihara M.
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] 原因タンパク質から探るFTLD/ALSの発症機構2016
- Author(s)
  田中良法
- Organizer
  第57回獣医学特論
- Place of Presentation
  東京大学弥生講堂(東京都文京区)
- Year and Date
  2016-01-15
- Invited
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] Gain-of-function Profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause intracellular TDP-43 aggregation.2015
- Author(s)
  Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M.
- Organizer
  Brain Protein Aging and Dementia Control, 1st International Symposium 2015
- Place of Presentation
  野依記念学術交流館(愛知県名古屋市)
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] ALSの原因となるプロフィリン1変異はTDP-43の凝集を誘起する2015
- Author(s)
  田中良法、野中隆、鈴木元治郎、亀谷富由樹、長谷川成人
- Organizer
  第41回日本認知症学会
- Place of Presentation
  リンクステーションホテル青森(青森県青森市)
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] Progranulin mediates neurovascular protection via multiple therapeutic effects in experimental acute ischemic stroke.2015
- Author(s)
  Kanazawa M, Kawamura K, Takahashi T, Miura M, Tanaka Y, Koyama M, Toriyabe M, Igarashi H, Nakada T, Nishihara M, Nishizawa M, Shimohata T.
- Organizer
  Brain and Brain PET 2015
- Place of Presentation
  バンクーバー(カナダ)
- Year and Date
  2015-06-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] ALSの原因となるプロフィリン１変異は機能獲得によりTDP-43の凝集を誘起する2015
- Author(s)
  田中良法、野中隆、鈴木元治郎、亀谷富由樹、長谷川成人
- Organizer
  認知症研究を知る若手研究者の集まり 2015
- Place of Presentation
  ニューサンピア高崎(群馬県高崎市)
- Year and Date
  2015-08-02
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] Mutations in the PFN1 gene induce degenerative changes through aggregation of both mutant PFN1 and TDP-43.2015
- Author(s)
  Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M.
- Organizer
  Neuroscience 2015, SfN's 45th annual meeting
- Place of Presentation
  シカゴ(米国)
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18370

1. HASEGAWA Masato (10251232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. NONAKA Takashi (30356258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
3. KAMETANI Fuyuki (70186013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. SUZUKI Genjiro (60466034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
5. HOSOKAWA Masato (00435116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 谷原史倫 (90754680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 下田宙 (40719887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 音井威重 (30311814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 江藤真澄

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 西原真杉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tanaka Yoshinori 田中 良法

TANAKA Yoshinori 田中 良法

Research Projects

Research Products

Co-Researchers

Membrane trafficking for degradation or secretion of TDP-43Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Generation of African Swine Fever virus-resistant pigs by applying the concept of gene editing technology

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Suppression of neurodegeneration through the interactive action between progranulin and glycolysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Screening targets modify the gain of seeding activity of TDP-43Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanism of cytotoxicity from ALS-linked Profilin 1 mutationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Abemaciclib and Vacuolin-1 decrease aggregate-prone TDP-43 accumulation by accelerating autophagic flux2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TDP-43 Secretion via Extracellular Vesicles Is Regulated by Macroautophagy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-432023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Abemaciclib and vacuolin-1 induce vacuole-like autolysosome formation - a new tool to study autophagosome-lysosome fusion2022

Author(s)

Journal Title

Data Source

[Journal Article] Possible roles of N- and C-terminal unstructured tails of CPI-17 in regulating Ca<sup>2+</sup> sensitization force of smooth muscle2022

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Overexpression of progranulin increases pathological protein accumulation by suppressing autophagic flux2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Kinase activity-tagged western blotting assay2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Convulsive responses to seizure-inducible drugs are exacerbated in progranulin-deficient mice2020

Author(s)

Journal Title

DOI

Tanaka Yoshinori 田中良法

TANAKA Yoshinori 田中良法