Akamatsu Megumi 赤松恵

Researcher Number	00753675
Affiliation (based on the past Project Information) *help	2018 – 2022: 東京大学, 医学部附属病院, 特任研究員 2017: 東京大学, 大学院医学系研究科(医学部), 特任研究員
Review Section/Research Field	Principal Investigator Neurology
Keywords	Principal Investigator AMPA受容体 / 運動ニューロン死 / アプタマー / 分子標的治療薬 / 孤発性筋萎縮性側索硬化症 / ALSモデルマウス / ADAR2 / 運動ニューロン / カルシウム透過性 / ALSモデル / RNAアプタマー / ALS治療薬

The study of molecularly targeted drug RNA aptamer for treatments for sporadic Amyotrophic Lateral Sclerosis (ALS)Principal Investigator
- Principal Investigator
  
  Akamatsu Megumi
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokyo

All 2022 2019 2018 2017

All Journal Article Presentation

[Journal Article] Testing of the therapeutic efficacy and safety of AMPA receptor RNA aptamers in an ALS mouse model2022
- Author(s)
  Akamatsu Megumi、Yamashita Takenari、Teramoto Sayaka、Huang Zhen、Lynch Janet、Toda Tatsushi、Niu Li、Kwak Shin
- Journal Title
  
  Life Science Alliance
  
  Volume: 5 Issue: 4 Pages: e202101193-e202101193
- DOI
  10.26508/lsa.202101193
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09747, KAKENHI-PROJECT-22H04923
[Journal Article] 孤発性ALSの病態と治療ーAMPA受容体阻害薬による筋萎縮性側索硬化症治療の可能性2017
- Author(s)
  赤松　恵、山下　雄也、郭　伸
- Journal Title
  
  神経治療学
  
  Volume: 34-2 Pages: 86-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09747
[Journal Article] Calpain-dependent disruption of nucleo-cytoplasmic transport in ALS motor neurons.2017
- Author(s)
  Yamashita T, Aizawa H, Teramoto S, Akamatsu M, Kwak S
- Journal Title
  
  Sci Reports
  
  Volume: 7-39994 Issue: 1
- DOI
  10.1038/srep39994
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25253063, KAKENHI-PROJECT-16K09666, KAKENHI-PROJECT-17K09747
[Journal Article] Altered intracellular milieu of ADAR2-deficient motor neurons in amyotrophic lateral sclerosis2017
- Author(s)
  Yamashita T, Akamatsu M, Kwak S
- Journal Title
  
  Genes
  
  Volume: 8(2)-60 Issue: 2 Pages: 60-60
- DOI
  10.3390/genes8020060
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25253063, KAKENHI-PROJECT-16K09666, KAKENHI-PROJECT-17K09747
[Presentation] An AMPA receptor subunit-specific RNA aptamer rescued ALS phenotype in AR2 mice2019
- Author(s)
  Megumi Akamatsu, Takenari Yamashita, Sayaka Teramoto, Zhen Huang, Tatsushi Toda, Li Niu, Shin Kwak
- Organizer
  The 42th Annual Meeting of the Japan Neuroscience Society
- Data Source
  KAKENHI-PROJECT-17K09747
[Presentation] Target therapy for ALS with RNA aptamers - rescue of ALS phenotype resulting from loss of motor neurons with TDP-43 pathology in ALS model mice2018
- Author(s)
  Megumi Akamatsu, Takenari Yamashita, Sayaka Teramoto, Zhen Huang, Li Niu, Shin Kwak
- Organizer
  Society for Neuroscience, Neuroscience 2018, annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09747
[Presentation] AMPA receptor-specific RNA aptamers rescued ALS phenotype in conditional ADAR2 knockout mice2018
- Author(s)
  Megumi Akamatsu, Takenari Yamashita, Sayaka Teramoto, Zhen Huang, Li Niu, Shin Kwak
- Organizer
  29th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09747
[Presentation] RNA aptamer as a potential drug candidate for ALS - rescue of clinicopathologic ALS phenotype in model mice2018
- Author(s)
  Megumi Akamatsu, Takenari Yamashita, Sayaka Teramoto, Zhen Huang, Li Niu, Shin Kwak
- Organizer
  5th RNA Metabolism in Neurological Disease Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09747

1. 郭伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Akamatsu Megumi 赤松 恵

Research Projects

Research Products

Co-Researchers

The study of molecularly targeted drug RNA aptamer for treatments for sporadic Amyotrophic Lateral Sclerosis (ALS)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Testing of the therapeutic efficacy and safety of AMPA receptor RNA aptamers in an ALS mouse model2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 孤発性ALSの病態と治療ーAMPA受容体阻害薬による筋萎縮性側索硬化症治療の可能性2017

Author(s)

Journal Title

Data Source

[Journal Article] Calpain-dependent disruption of nucleo-cytoplasmic transport in ALS motor neurons.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Altered intracellular milieu of ADAR2-deficient motor neurons in amyotrophic lateral sclerosis2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] An AMPA receptor subunit-specific RNA aptamer rescued ALS phenotype in AR2 mice2019

Author(s)

Organizer

Data Source

[Presentation] Target therapy for ALS with RNA aptamers - rescue of ALS phenotype resulting from loss of motor neurons with TDP-43 pathology in ALS model mice2018

Author(s)

Organizer

Data Source

[Presentation] AMPA receptor-specific RNA aptamers rescued ALS phenotype in conditional ADAR2 knockout mice2018

Author(s)

Organizer

Data Source

[Presentation] RNA aptamer as a potential drug candidate for ALS - rescue of clinicopathologic ALS phenotype in model mice2018

Author(s)

Organizer

Data Source

Akamatsu Megumi 赤松恵