MATSUMOTO SHIGEYUKI 松本篤幸

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Matsumoto Shigeyuki 松本篤幸

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Researcher Number	00753906
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 京都大学, 医学研究科, 特定准教授 2018 – 2020: 国立研究開発法人理化学研究所, 科技ハブ産連本部, 研究員 2017: 神戸大学, 医学研究科, 特命助教 2016: 神戸大学, 大学院医学研究科, 助教 2015 – 2016: 神戸大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Biophysics Except Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / General medical chemistry / Drug development chemistry
Keywords	Principal Investigator 分子動力学計算 / 低分子化合物 / 結合親和性予測 / 深層学習 / 親和性予測 / NMR / ダイナミクス / State遷移 / 立体構造 / 分子動力学シミュレーション … More / state transition / 動的平衡 / X線結晶構造解析 / がん変異体 / Ras … More Except Principal Investigator 癌 / シグナル伝達 / 抗ウイルス薬 / ヌクレオカプシド / エボラウイルス / 電子顕微鏡 / 融合構造解析 / ハイブリッド構造解析 / NMR / 単粒子解析 / クライオ電子顕微鏡 / 高分子構造・物性 / 脂質 / 蛋白質 / がん遺伝子 / がん / 分子標的薬 / 医薬分子設計 Less

フィロウイルスの増殖機構の分子構造基盤の解明と制御法の開発
- Principal Investigator
  
  野田岳志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Kyoto University
深層学習技術を用いた動的情報からの化合物ータンパク質結合親和性の抽出Principal Investigator
- Principal Investigator
  
  松本篤幸
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Kyoto University
cryoEM-NMR融合構造解析の確立
- Principal Investigator
  
  加藤貴之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Osaka University
Elucidation of functional mechanism based on the dynamic properties for the ongene products RasPrincipal Investigator
- Principal Investigator
  
  Matsumoto Shigeyuki
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  Kyoto University
  Institute of Physical and Chemical Research
  Kobe University
Research on the molecular basis of conformational dynamics of oncogene product Ras for application to the development of its specific inhibitors
- Principal Investigator
  
  shima fumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kobe University
Structural study on the role of post-translational lipid modifications of the small G protein Ras
- Principal Investigator
  
  KATAOKA TOHRU
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University

All 2022 2021 2020 2017 2016 2015

All Journal Article Presentation Book

[Book] がん分子標的治療2015
- Author(s)
  Fumi Shima, Yoko Yoshikawa, Higeyuki Matsumoto, Tohru Kataoka
- Total Pages
  166
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-26293026
[Journal Article] Oncogenic mutations Q61L and Q61H confer active form-like structural features to the inactive state (state 1) conformation of H-Ras protein2021
- Author(s)
  Matsumoto Shigeyuki、Taniguchi-Tamura Haruka、Araki Mitsugu、Kawamura Takashi、Miyamoto Ryo、Tsuda Chiemi、Shima Fumi、Kumasaka Takashi、Okuno Yasushi、Kataoka Tohru
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 565 Pages: 85-90
- DOI
  10.1016/j.bbrc.2021.05.084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15106
[Journal Article] Extraction of protein dynamics information from cryo-EM maps using deep learning2021
- Author(s)
  Matsumoto Shigeyuki、Ishida Shoichi、Araki Mitsugu、Kato Takayuki、Terayama Kei、Okuno Yasushi
- Journal Title
  
  Nature Machine Intelligence
  
  Volume: 3 Issue: 2 Pages: 153-160
- DOI
  10.1038/s42256-020-00290-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15106
[Journal Article] E487K-induced disorder in functionally relevant dynamics of mitochondrial aldehyde dehydrogenase 22020
- Author(s)
  Matsumoto S, Araki M, Isaka Y, Ono F, Hirohashi K, Ohashi S, Muto M, Okuno Y
- Journal Title
  
  Biophysical Journal
  
  Volume: 119 Issue: 3 Pages: 628-637
- DOI
  10.1016/j.bpj.2020.07.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08369, KAKENHI-PROJECT-17K15106, KAKENHI-PROJECT-18H02692
[Journal Article] Structural basis for intramolecular interaction of post-translationally modified H-Ras?GTP prepared by protein ligation2017
- Author(s)
  Ke Haoliang、Matsumoto Shigeyuki、Murashima Yosuke、Taniguchi-Tamura Haruka、Miyamoto Ryo、Yoshikawa Yoko、Tsuda Chiemi、Kumasaka Takashi、Mizohata Eiichi、Edamatsu Hironori、Kataoka Tohru
- Journal Title
  
  FEBS Letters
  
  Volume: 591 Issue: 16 Pages: 2470-2481
- DOI
  10.1002/1873-3468.12759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15106
[Journal Article] Structural transition of solvated H-Ras/GTP revealed by molecular dynamics simulation and local network entropy2017
- Author(s)
  Matsunaga Shota、Hano Yuta、Saito Yuta、Fujimoto Kazuhiro J.、Kumasaka Takashi、Matsumoto Shigeyuki、Kataoka Tohru、Shima Fumi、Tanaka Shigenori
- Journal Title
  
  Journal of Molecular Graphics and Modelling
  
  Volume: 77 Pages: 51-63
- DOI
  10.1016/j.jmgm.2017.07.028
- NAID
  120006406708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15106, KAKENHI-PLANNED-17H06353
[Journal Article] Molecular Mechanism for Conformational Dynamics of Ras·GTP Elucidated from In-Situ Structural Transition in Crystal.2016
- Author(s)
  Matsumoto S, Miyano N, Baba S, Liao J, Kawamura T, Tsuda C, Takeda A, Yamamoto M, Kumasaka T, Kataoka T, Shima F.
- Journal Title
  
  Sci Rep.
  
  Volume: - Issue: 1
- DOI
  10.1038/srep25931
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293026, KAKENHI-PROJECT-26293065
[Journal Article] rasがん遺伝子産物Rasを分子標的としたがん治療薬開発の現状2015
- Author(s)
  島扶美、吉川陽子、松本篤幸、片岡徹
- Journal Title
  
  がん分子標的治療
  
  Volume: 13巻 Pages: 92-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293065
[Journal Article] Current status of the development of Ras inhibitors.2015
- Author(s)
  Fumi Shima, Shigeyuki Matsumoto, Yoko Yoshikawa, Takashi Kawamura, Masayuki Isa, Tohru Kataoka
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 158 Issue: 2 Pages: 91-99
- DOI
  10.1093/jb/mvv060
- NAID
  40020554051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293065
[Journal Article] Current statue of the development of Ras inhibitors2015
- Author(s)
  Shima F, Matsumoto S, Yoshikawa Y, Kawamura T, Isa M, Kataoka T
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 158 Pages: 91-99
- NAID
  40020554051
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293026
[Presentation] Extracting protein dynamics from experimental cryo-EM maps using a machine learning technique combining with MdD simulations2022
- Author(s)
  Shigeyuki Matsumoto
- Organizer
  第60回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06112
[Presentation] Novel insights into the structural perturbation induced by the oncogenic mutations, Q61L and Q61H, in Ras state 12020
- Author(s)
  Shigeyuki Matsumoto
- Organizer
  64th Annual Meeting of the Biophysical Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15106
[Presentation] 深層学習技術による cryo-EM密度マップデータに隠された動的情報の抽出2020
- Author(s)
  松本篤幸
- Organizer
  第一回クライオ電子顕微鏡画像からの高度情報処理研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K15106
[Presentation] がん遺伝子産物H-RasQ61L 変異体の構造解析2017
- Author(s)
  谷口-田村はるか　松本篤幸　宮本涼生　河村高志　熊坂崇　片岡徹
- Organizer
  平成29年度日本結晶学会年会
- Data Source
  KAKENHI-PROJECT-17K15106
[Presentation] 翻訳後修飾型H-Ras・GTPにおける分子内相互作用によるc-Raf-1認識のための立体構造の形成2017
- Author(s)
  松本篤幸　柯浩亮　村嶋陽亮　谷口-田村はるか　宮本涼生、吉川陽子　津田智恵美　熊坂崇　溝端栄一　枝松裕紀　片岡徹
- Organizer
  consortium of biological sciences 2017
- Data Source
  KAKENHI-PROJECT-17K15106
[Presentation] Sortase Aを利用した翻訳後脂質修飾型Rasの産生と構造物学研究2016
- Author(s)
  村嶋　陽亮、柯　浩亮、松本　篤幸、枝松　裕紀、片岡　徹
- Organizer
  第14回次世代を担う若手のためのフィジカル・ファーマフォーラム（日本薬学会物理系薬学部会）
- Place of Presentation
  ロッジ舞洲（大阪府・大阪市）
- Year and Date
  2016-08-27
- Data Source
  KAKENHI-PROJECT-26293065

1. shima fumi (60335445)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. KATAOKA TOHRU (40144472)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. KITAHARA Ryou (70512284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 田中成典 (10379480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 熊坂崇 (30291066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 枝松裕紀 (70335438)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 加藤貴之 (20423155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 宮ノ入洋平 (80547521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 野田岳志 (00422410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 大野浩章 (30322192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 大橋真也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MATSUMOTO SHIGEYUKI 松本 篤幸

Matsumoto Shigeyuki 松本 篤幸

Research Projects

Research Products

Co-Researchers

フィロウイルスの増殖機構の分子構造基盤の解明と制御法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

深層学習技術を用いた動的情報からの化合物ータンパク質結合親和性の抽出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

cryoEM-NMR融合構造解析の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of functional mechanism based on the dynamic properties for the ongene products RasPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on the molecular basis of conformational dynamics of oncogene product Ras for application to the development of its specific inhibitors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural study on the role of post-translational lipid modifications of the small G protein Ras

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] がん分子標的治療2015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Oncogenic mutations Q61L and Q61H confer active form-like structural features to the inactive state (state 1) conformation of H-Ras protein2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extraction of protein dynamics information from cryo-EM maps using deep learning2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] E487K-induced disorder in functionally relevant dynamics of mitochondrial aldehyde dehydrogenase 22020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis for intramolecular interaction of post-translationally modified H-Ras?GTP prepared by protein ligation2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural transition of solvated H-Ras/GTP revealed by molecular dynamics simulation and local network entropy2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Molecular Mechanism for Conformational Dynamics of Ras&middot;GTP Elucidated from In-Situ Structural Transition in Crystal.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] rasがん遺伝子産物Rasを分子標的としたがん治療薬開発の現状2015

Author(s)

Journal Title

MATSUMOTO SHIGEYUKI 松本篤幸

Matsumoto Shigeyuki 松本篤幸

[Journal Article] Molecular Mechanism for Conformational Dynamics of Ras·GTP Elucidated from In-Situ Structural Transition in Crystal.2016