Hitora Yuki 人羅勇気

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HITORA yuki 人羅勇気

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Researcher Number	00755308
Other IDs
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部附属グローバル天然物科学研究センター, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 熊本大学, 大学院生命科学研究部附属グローバル天然物科学研究センター, 准教授 2019 – 2021: 熊本大学, 大学院生命科学研究部附属グローバル天然物科学研究センター, 助教 2018: 熊本大学, 大学院生命科学研究部(薬), 助教 2018: 熊本大学, 大学院生命科学研究部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related / Transformative Research Areas, Section (II) Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Pharmaceutical Sciences and related fields
Keywords	Principal Investigator 天然物 / スクリーニング / タンパク質分解 / 真菌 / 分子ネットワーク解析 / 生物活性物質 / α-synuclein / 活性化 / 活性化物質 / プロテアソーム … More / 培養細胞 / プロテアソーム阻害薬 / ユビキチンープロテアソームシステム / 天然資源 / 表現型解析 / 海洋天然物 / Fucci / 細胞周期 … More Except Principal Investigator 天然資源 / 難病治療薬 / エジプト / がん抑制効果 / Nrf2 / ガン抑制効果 / p53 / 野生型 / がん抑制 / 探索 / 変異型p53 Less

分子ネットワークと生物活性情報の統合解析による微生物由来生物活性物質の探索Principal Investigator
- Principal Investigator
  
  人羅勇気
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Kumamoto University
α-synucleinの分解促進・凝集阻害作用を示す天然物の探索Principal Investigator
- Principal Investigator
  
  人羅勇気
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Kumamoto University
Discovery of the ubiquitin-proteasome inhibitors from natural sources through cell-based assaysPrincipal Investigator
- Principal Investigator
  
  Hitora Yuki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Kumamoto University
Drug development of incurable diseases with versatile Egyptian natural resources
- Principal Investigator
  
  塚本佐知子
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kumamoto University
Search for cell cycle inhibitors from marine natural products by phenotypical screening of HeLa/Fucci2 cellsPrincipal Investigator
- Principal Investigator
  
  Hitora Yuki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Kumamoto University
Search for natural products that modify the p53 functiones
- Principal Investigator
  
  Tsukamoto Sachiko
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pharmaceutical Sciences and related fields
- Research Institution
  Kumamoto University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Arteperoxides A-C, tris-normonoterpene-sesquiterpene conjugates with peroxide-bridges from Artemisia judaica exhibiting antiosteoclastogenic activity2023
- Author(s)
  El-Desoky Ahmed H.、Asano Toshifumi、Maeyama Yuka、Kato Hikaru、Hitora Yuki、Goto Eishu、Kotani Shunsuke、Nakajima Makoto、Tsukamoto Sachiko
- Journal Title
  
  Phytochemistry
  
  Volume: 206 Pages: 113548-113548
- DOI
  10.1016/j.phytochem.2022.113548
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0175, KAKENHI-PROJECT-21K15282, KAKENHI-PROJECT-23K20310
[Journal Article] Syrosingopine Enhances 20S Proteasome Activity and Degradation of α-Synuclein2023
- Author(s)
  Sadahiro Yusaku、Nishimura Soichiro、Hitora Yuki、Tsukamoto Sachiko
- Journal Title
  
  Journal of Natural Products
  
  Volume: 87 Issue: 3 Pages: 554-559
- DOI
  10.1021/acs.jnatprod.3c00661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06679, KAKENHI-PROJECT-21K19341
[Journal Article] Cell-based screening of extracts of natural sources to search for inhibitors of the ubiquitin-proteasome system and identification of proteasome inhibitors from the fungus Remotididymella sp.2022
- Author(s)
  Nishimura Soichiro、Hitora Yuki、Kawahara Teppei、Tanabe Mika、Ogata Eisuke、Kato Hikaru、Srikoon Pattaravadee、Watanabe Takashi、Tsukamoto Sachiko
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 59 Pages: 128566-128566
- DOI
  10.1016/j.bmcl.2022.128566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16026, KAKENHI-PROJECT-19K07135
[Journal Article] Peniphilones A and B: Azaphilone Alkaloids from the Endophytic Fungus Penicillium maximae2021
- Author(s)
  Yuhei Koyanagi , Yuki Hitora , Teppei Kawahara , Sachiko Tsukamoto
- Journal Title
  
  HETEROCYCLES
  
  Volume: 102 Issue: 2 Pages: 325-325
- DOI
  10.3987/com-20-14373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07135, KAKENHI-PROJECT-20K16026
[Journal Article] Melophluosides A and B, new triterpene galactosides from the marine sponge Melophlus sarasinorum2020
- Author(s)
  Sadahiro Yusaku、Hitora Yuki、Fukumoto Arina、Ise Yuji、Angkouw Esther D.、Mangindaan Remy E.P.、Tsukamoto Sachiko
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 61 Issue: 20 Pages: 151852-151852
- DOI
  10.1016/j.tetlet.2020.151852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14933
[Journal Article] Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)2019
- Author(s)
  Kato Hikaru、Sebe Momona、Nagaki Mika、Eguchi Keisuke、Kagiyama Ippei、Hitora Yuki、Frisvad Jens C.、Williams Robert M.、Tsukamoto Sachiko
- Journal Title
  
  Journal of Natural Products
  
  Volume: 82 Issue: 5 Pages: 1377-1381
- DOI
  10.1021/acs.jnatprod.8b01032
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03994, KAKENHI-PROJECT-18K14933
[Journal Article] Halichonic acid, a new rearranged bisabolene-type sesquiterpene from a marine sponge Halichondria sp.2019
- Author(s)
  K. Raiju, Y. Hitora, H. Kato, Y. Ise, E. D. Angkouw, R. E. P. Mangindaan, S. Tsukamoto
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 60 Issue: 15 Pages: 1079-1081
- DOI
  10.1016/j.tetlet.2019.03.030
- NAID
  120007019102
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04646, KAKENHI-PROJECT-17H03994, KAKENHI-PROJECT-18K14933
[Journal Article] Isolation of aaptic acid from the marine sponge Asptos lobata and inhibitory effect of aaptamines on RANKL-induced formation of multinuclear osteoclasts.2018
- Author(s)
  A. Fukumoto, Y. Hitora, A. Kai, H. Kato, E. D. Angkouw, R. E. P. Mangindaan, N. J. de Voogd, S. Tsukamoto
- Journal Title
  
  Heterocycles
  
  Volume: 97 Issue: 2 Pages: 1219-1219
- DOI
  10.3987/com-18-s(t)73
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18898, KAKENHI-PROJECT-18K14933, KAKENHI-PROJECT-17H04646
[Journal Article] Siladenoserinols M?P, sulfonated serinol derivatives from a tunicate2018
- Author(s)
  Torii Masumi、Hitora Yuki、Kato Hikaru、Koyanagi Yuhei、Kawahara Teppei、Losung Fitje、Mangindaan Remy E.P.、Tsukamoto Sachiko
- Journal Title
  
  Tetrahedron
  
  Volume: 74 Issue: 52 Pages: 7516-7521
- DOI
  10.1016/j.tet.2018.11.031
- NAID
  120006949456
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14933, KAKENHI-PROJECT-17H03994, KAKENHI-PROJECT-17H04646
[Journal Article] Lamellodysidines A and B, Sesquiterpenes Isolated from the Marine Sponge Lamellodysidea herbacea2017
- Author(s)
  Torii Masumi、Kato Hikaru、Hitora Yuki、Angkouw Esther D.、Mangindaan Remy E. P.、de Voogd Nicole J.、Tsukamoto Sachiko
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 80 Issue: 9 Pages: 2536-2541
- DOI
  10.1021/acs.jnatprod.7b00610
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19497, KAKENHI-PROJECT-17H03994
[Presentation] Bioactive molecular networkingを利用した真菌由来20Sプロテアソーム活性化物質の探索2024
- Author(s)
  貞廣優作, 人羅勇気, 本田公洋, 手島徳哉, 長野由梨子, 塚本佐知子
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06679
[Presentation] 天然物からの 20S プロテアソーム活性化物質の探索と syrosingopine の作用に関する研究2023
- Author(s)
  貞廣優作, 西村宗一郎, 人羅勇気, 塚本佐知子
- Organizer
  第24回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06679
[Presentation] 細胞試験系を用いたプロテアソーム活性化作用を示す天然物の探索とレセルピン類の活性について2022
- Author(s)
  人羅勇気, 西村宗一郎, 塚本佐知子
- Organizer
  第9回食品薬学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06679
[Presentation] 阿蘇の植物から単離した真菌が産生するユビキチン－プロテアソームシステム阻害物質に関する研究2022
- Author(s)
  田邉美花, 西村宗一郎, 人羅勇気, 塚本佐知子
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K16026
[Presentation] 破骨細胞の分化阻害作用を示す新規Arteperoxides A-Cの構造と類縁体の合成2022
- Author(s)
  Ahmed H. El-Desoky、浅野聡文、前山夕歌、加藤光、人羅勇気、後藤栄舟、小谷俊介、中島誠、塚本佐知子
- Organizer
  第9回食品薬学シンポジウム
- Data Source
  KAKENHI-PROJECT-20KK0175
[Presentation] Bioactive fungal metabolites for drug discovery2021
- Author(s)
  Sachiko Tsukamoto, Soichiro Nishimura, Yuki Hitora
- Organizer
  PACIFICHEM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16026
[Presentation] 天然物由来プロテアソーム活性化物質の探索2021
- Author(s)
  西村宗一郎, 人羅勇気, 塚本佐知子
- Organizer
  第38回日本薬学会九州山口支部大会
- Data Source
  KAKENHI-PROJECT-20K16026
[Presentation] 細胞評価系を用いたユビキチン-プロテアソームシステム阻害物質の探索と Remotididymella 属真菌から単離したプロテアソーム阻害物質に関する研究2021
- Author(s)
  西村宗一郎, 人羅勇気, 田邉美花, 小縣栄佐, 塚本佐知子
- Organizer
  第23回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-20K16026
[Presentation] Artemisia judaicaから得られた新規davanone類縁体の構造と破骨細胞の分化阻害活性について2021
- Author(s)
  Ahmed H. H. El-Desoky、浅野聡文、前山夕歌、加藤光、人羅勇気、後藤栄舟、小谷俊介、中島誠、塚本佐知子
- Organizer
  第23回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-20KK0175
[Presentation] 細胞評価系を用いた真菌由来ユビキチン－プロテアソームシステム阻害物質の探索2021
- Author(s)
  西村宗一郎、人羅勇気、河原哲平、加藤光、Sirkoon Pattaravadee、渡邊高志、塚本佐知子
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K16026
[Presentation] HeLa/Fucci2細胞を用いた天然資源エキススクリーニングと細胞周期阻害物質の探索2020
- Author(s)
  瀬治山藍、人羅勇気、加藤光、河原哲平、Mangindaan Remy E. P. 、塚本佐知子
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K14933
[Presentation] Haliclona属海綿から単離した新規アルキルピリジニウムの構造と細胞周期延長作用2020
- Author(s)
  前田莉花、人羅勇気、Mangindaan Remy E. P.、塚本佐知子
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K14933
[Presentation] インドネシアで採集した海綿から単離した新規 1,3-アルキルピリジニウムの化学構造と生物活性について2019
- Author(s)
  前田莉花、人羅勇気、塚本　佐知子
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K14933
[Presentation] ユビキチン－プロテアソームシステムを阻害する海洋天然物の探索2019
- Author(s)
  小縣栄佐、人羅勇気、Remy E. P. Mangindaan、塚本佐知子
- Organizer
  第36回日本薬学会九州支部大会
- Data Source
  KAKENHI-PROJECT-18K14933
[Presentation] 有明海干潟で採取した真菌から得られた新規ペプタイボールの構造解析2019
- Author(s)
  西銘宜智, 人羅勇気, 塚本佐知子
- Organizer
  日本生薬学会第66回年会
- Data Source
  KAKENHI-PROJECT-18K14933
[Presentation] インドネシアで採取した海綿から得られた新規環状ペプチドの構造決定2019
- Author(s)
  小野寺慶太, 人羅勇気, Remy E, P. Mangindaan, 塚本佐知子
- Organizer
  日本生薬学会第66回年会
- Data Source
  KAKENHI-PROJECT-18K14933
[Presentation] 天然資源由来の細胞内タンパク質蓄積誘導物質の探索2019
- Author(s)
  西村宗一郎, 人羅勇気, 加藤光, Pattaravadee Srikoon, 渡邊高志, 塚本佐知子
- Organizer
  日本生薬学会第66回年会
- Data Source
  KAKENHI-PROJECT-18K14933
[Presentation] Haliclona属海綿から単離した新規1,3-アルキルピリジニウムの化学構造と細胞周期遅延作用2019
- Author(s)
  前田莉花、人羅勇気、Remy E. P. Mangindaan、塚本佐知子
- Organizer
  第36回日本薬学会九州支部大会
- Data Source
  KAKENHI-PROJECT-18K14933
[Presentation] インドネシアで採取した海綿より得られた新規セスキテルペンキノンの構造と生物活性2018
- Author(s)
  瀬治山藍、人羅勇気、塚本　佐知子
- Organizer
  第22回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-18K14933
[Presentation] Fucci2/HeLa細胞を用いた海洋生物由来の細胞周期阻害物質の探索2018
- Author(s)
  小栁侑平、人羅勇気、塚本　佐知子
- Organizer
  日本生薬学会第65回年会
- Data Source
  KAKENHI-PROJECT-18K14933
[Presentation] HeLa/Fucci2 細胞の蛍光イメージングによる細胞周期を阻害する天然物の探索2018
- Author(s)
  人羅勇気、前田莉花、小栁侑平、瀬治山藍、塚本　佐知子
- Organizer
  第22回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-18K14933
[Presentation] ECDスペクトルの加成性を活用した4種のセスキテルペンの構造解析2017
- Author(s)
  塚本佐知子、鳥井万純、人羅勇気、加藤光
- Organizer
  第12回化学生態学研究会
- Data Source
  KAKENHI-PROJECT-17K19497

1. Tsukamoto Sachiko (40192190)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. KATO hikaru (20547129)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 甲斐広文 (30194658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 人羅菜津子 (40762191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Hitora Yuki 人羅 勇気

HITORA yuki 人羅 勇気

Research Projects

Research Products

Co-Researchers

分子ネットワークと生物活性情報の統合解析による微生物由来生物活性物質の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

α-synucleinの分解促進・凝集阻害作用を示す天然物の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Discovery of the ubiquitin-proteasome inhibitors from natural sources through cell-based assaysPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug development of incurable diseases with versatile Egyptian natural resources

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for cell cycle inhibitors from marine natural products by phenotypical screening of HeLa/Fucci2 cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for natural products that modify the p53 functiones

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Arteperoxides A-C, tris-normonoterpene-sesquiterpene conjugates with peroxide-bridges from Artemisia judaica exhibiting antiosteoclastogenic activity2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Syrosingopine Enhances 20S Proteasome Activity and Degradation of α-Synuclein2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell-based screening of extracts of natural sources to search for inhibitors of the ubiquitin-proteasome system and identification of proteasome inhibitors from the fungus Remotididymella sp.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peniphilones A and B: Azaphilone Alkaloids from the Endophytic Fungus Penicillium maximae2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Melophluosides A and B, new triterpene galactosides from the marine sponge Melophlus sarasinorum2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Halichonic acid, a new rearranged bisabolene-type sesquiterpene from a marine sponge Halichondria sp.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Isolation of aaptic acid from the marine sponge Asptos lobata and inhibitory effect of aaptamines on RANKL-induced formation of multinuclear osteoclasts.2018

Author(s)

Journal Title

Hitora Yuki 人羅勇気

HITORA yuki 人羅勇気

[Presentation] 天然物からの 20S プロテアソーム活性化物質の探索と syrosingopine の作用に関する研究2023