Noguchi Yoshihiko 野口吉彦

Researcher Number	00758170
Other IDs	https://orcid.org/0000-0002-7027-5822
Affiliation (based on the past Project Information) *help	2023: 北里大学, 感染制御科学府, 特任助教 2019 – 2020: 北里大学, 感染制御科学府, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords	Principal Investigator ポリセリン構造 / N末伸長 / 環状デプシペプチド / 抗真菌 / 疎水性タグ / III型分泌装置 / 非抗菌的感染症治療薬 / カスケード反応 / 感染防御薬 / ピリドン … More / cis-テトラヒドロフラン / ポリエン / 収束的全合成 / III型分泌機構 / 非抗菌的坑感染症薬 Less

N-担持型疎水性タグの開発とポリセリン含有抗真菌性環状デプシペプチドの全合成研究Principal Investigator
- Principal Investigator
  
  野口吉彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kitasato University
Synthetic study of naturally occurring type III secretion system inhibitors towards the creation of non-microbial anti-infective agentPrincipal Investigator
- Principal Investigator
  
  Noguchi Yoshihiko
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kitasato University

All 2021 2020 2019

All Journal Article Presentation

[Journal Article] Towards the total synthesis of aurodox: preparation of the key hemiacetal-lactone2021
- Author(s)
  Motoyoshi Ohara, Akari Ikeda, Asuka Nakajuma, Takanori Ono, Yoshihiko Noguchi,Akito Watanabe, Tomoyasu Hirose, Toshiaki Sunazuka
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 66 Pages: 152799-152799
- DOI
  10.1016/j.tetlet.2020.152799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06586, KAKENHI-PROJECT-19K16318, KAKENHI-PROJECT-21K05059
[Journal Article] Unified enantioselective total synthesis of 3,6-dioxygenated diketopiperazine natural products, diatretol and lepistamides A, B and C2021
- Author(s)
  Shu Takahashi, Aoi Kimishima, Tomoyasu Hirose, Takeshi Yamada, Akihiro Sugawara, Tatsuya Shirahata, Yoshihiko Noguchi, Masato Iwatsuki, Rei Hokari, Aki Ishiyama, Yoshinori Kobayashi, Toshiaki Sunazuka
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 67 Pages: 152895-152895
- DOI
  10.1016/j.tetlet.2021.152895
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06586, KAKENHI-PROJECT-19K16318, KAKENHI-PROJECT-20K05502, KAKENHI-PROJECT-21K05059
[Journal Article] Trichothioneic acid, a new antioxidant compound produced by the fungal strain Trichoderma virens FKI-75732020
- Author(s)
  Miyano Rei、Matsuo Hirotaka、Mokudai Takayuki、Noguchi Yoshihiko、Higo Mayuka、Nonaka Kenichi、Niwano Yoshimi、Sunazuka Toshiaki、Shiomi Kazuro、Takahashi Yoko、Omura Satoshi、Nakashima Takuji
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 129 Issue: 4 Pages: 508-513
- DOI
  10.1016/j.jbiosc.2019.11.007
- NAID
  40022216167
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04629, KAKENHI-PROJECT-19K16318
[Journal Article] Efficient synthesis of a ryanodine binding inhibitor verticilide using two practical approache2020
- Author(s)
  Watanabe, A., Noguchi, Y., Hirose, T., Monma, S., Satake T., Arai, M., Masuda, K., Murashima, N., Shiomi, R., Omura, S., and Sunazuka, T.
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 61 Issue: 13 Pages: 151699-151703
- DOI
  10.1016/j.tetlet.2020.151699
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04629, KAKENHI-PROJECT-18K06586, KAKENHI-PROJECT-19K16318
[Journal Article] The Nonantibiotic Macrolide EM900 Attenuates House Dust Mite-Induced Airway Inflammation in a Mouse Model of Obesity-Associated Asthma2020
- Author(s)
  Sadamatsu Hironori、Takahashi Koichiro、Tashiro Hiroki、Kurihara Yuki、Kato Go、Uchida Masaru、Noguchi Yoshihiko、Kurata Keigo、Omura Satoshi、Sunazuka Toshiaki、Kimura Shinya、Sueoka-Aragane Naoko
- Journal Title
  
  International Archives of Allergy and Immunology
  
  Volume: 181 Issue: 9 Pages: 665-674
- DOI
  10.1159/000508709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16318
[Journal Article] Thioporidiols A and B: Two New Sulfur Compounds Discovered by Molybdenum-Catalyzed Oxidation Screening from Trichoderma polypori FKI-73822020
- Author(s)
  Matsuo Hirotaka、Noguchi Yoshihiko、Miyano Rei、Higo Mayuka、Nonaka Kenichi、Sunazuka Toshiaki、Takahashi Yoko、Omura Satoshi、Nakashima Takuji
- Journal Title
  
  Antibiotics
  
  Volume: 9 Issue: 5 Pages: 236-236
- DOI
  10.3390/antibiotics9050236
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16318, KAKENHI-PROJECT-19K15758
[Journal Article] Nanaomycin K, a new epithelial?mesenchymal transition inhibitor produced by the actinomycete “Streptomyces rosa subsp. notoensis” OS-39662020
- Author(s)
  Matsuo Hirotaka、Nakanishi Jun、Noguchi Yoshihiko、Kitagawa Koichi、Shigemura Katsumi、Sunazuka Toshiaki、Takahashi Yoko、Omura Satoshi、Nakashima Takuji
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 129 Issue: 3 Pages: 291-295
- DOI
  10.1016/j.jbiosc.2019.09.007
- NAID
  40022194469
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16318
[Journal Article] Nanaomycin I and J: New nanaomycins generated by mycothiol-mediated compounds from “Streptomyces rosa subsp. notoensis” OS-39662019
- Author(s)
  Matsuo Hirotaka、Noguchi Yoshihiko、Take Akira、Nakanishi Jun、Shigemura Katsumi、Sunazuka Toshiaki、Takahashi Yoko、Omura Satoshi、Nakashima Takuji
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 127 Issue: 5 Pages: 549-553
- DOI
  10.1016/j.jbiosc.2018.10.013
- NAID
  40021891586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16318
[Journal Article] Erythromycin acts through the ghrelin receptor to attenuate inflammatory responses in chondrocytes and maintain joint integrity2019
- Author(s)
  Uchimura Tomoya、Nakamura Daisy S.、Link Eric M.、Noguchi Yoshihiko、Omura Satoshi、Sunazuka Toshiaki、Greenblatt David J.、Zeng Li
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 165 Pages: 79-90
- DOI
  10.1016/j.bcp.2019.03.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16318
[Journal Article] The non-antibiotic macrolide EM900 attenuates HDM and poly(I:C)-induced airway inflammation with inhibition of macrophages in a mouse model2019
- Author(s)
  Sadamatsu Hironori、Takahashi Koichiro、Tashiro Hiroki、Kato Go、Noguchi Yoshihiko、Kurata Keigo、Omura Satoshi、Kimura Shinya、Sunazuka Toshiaki、Sueoka-Aragane Naoko
- Journal Title
  
  Inflammation Research
  
  Volume: 69 Issue: 1 Pages: 139-151
- DOI
  10.1007/s00011-019-01302-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16318
[Journal Article] Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with the virus internalization process2019
- Author(s)
  Tran Huu Dat, Ryuichi Sugamata, Tomoyasu Hirose, Shoichi Suzuki, Yoshihiko Noguchi, Akihiro Sugawara, Fuyu Ito, Tomoko Yamamoto, Shoji Kawachi, Kiyoko S. Akagawa, Satoshi Omura, Toshiaki Sunazuka, Naoki Ito, Masakazu Mimaki, Kazuo Suzuki
- Journal Title
  
  J. Antibiot.
  
  Volume: 72 Issue: 10 Pages: 759-768
- DOI
  10.1038/s41429-019-0204-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06586, KAKENHI-PROJECT-18K07887, KAKENHI-PROJECT-19K16318, KAKENHI-PROJECT-17K18120
[Journal Article] Jietacins, azoxy natural products, as novel NF-kB inhibitors: discovery, synthesis, biological activity, and mode of action2019
- Author(s)
  Mariko Watanabe, Akihiro Sugawara, Yoshihiko Noguchi, Tomoyasu Hirose, Satoshi Omura, Toshiaki Sunazuka, Ryouichi Horie
- Journal Title
  
  Eur. J. Med. Chem.
  
  Volume: 178 Pages: 636-647
- DOI
  10.1016/j.ejmech.2019.05.079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06586, KAKENHI-PROJECT-19K07442, KAKENHI-PROJECT-19K16318, KAKENHI-PROJECT-17K08728
[Presentation] 抗トリパノソーマ活性を有するActinoallolide Aの全合成研究2021
- Author(s)
  大野孝典、野口吉彦、渡邊彰人、岩月正人、稲橋佑起、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-19K16318
[Presentation] 環状デプシペプチド類の効率的合成を志向した疎水性タグのワンポット化2021
- Author(s)
  関川　章悟、野口　吉彦、廣瀬　友靖、砂塚　敏明
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-19K16318
[Presentation] Ⅲ型分泌装置(T3SS)阻害活性を有するAurodoxの全合成研究2021
- Author(s)
  大原基義、池田朱里、中嶋明日香、大野孝典、野口吉彦、渡邊彰人、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-19K16318
[Presentation] 抗マラリア活性を有するDiatretolの不斉全合成と構造活性相関研究2021
- Author(s)
  高橋脩、君嶋葵、山田健、菅原章公、白畑辰弥、野口吉彦、岩月正人、穗苅玲、石山亜紀、小林義典、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-19K16318
[Presentation] 抗嫌気性菌活性を有するエフロトマイシンの全合成研究2020
- Author(s)
  大原基義、池田朱里、中嶋明日香、野口吉彦、渡邊彰人、廣瀬友靖、大村智、砂塚敏明
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-19K16318
[Presentation] 抗嫌気性菌活性を有するエフロトマイシンの全合成研究2019
- Author(s)
  大原基義、池田朱里、中嶋明日香、野口吉彦、渡邊彰人、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第63回日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-19K16318

1. 砂塚敏明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 廣瀬友靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Noguchi Yoshihiko 野口 吉彦

Research Projects

Research Products

Co-Researchers

N-担持型疎水性タグの開発とポリセリン含有抗真菌性環状デプシペプチドの全合成研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Synthetic study of naturally occurring type III secretion system inhibitors towards the creation of non-microbial anti-infective agentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Towards the total synthesis of aurodox: preparation of the key hemiacetal-lactone2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unified enantioselective total synthesis of 3,6-dioxygenated diketopiperazine natural products, diatretol and lepistamides A, B and C2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Trichothioneic acid, a new antioxidant compound produced by the fungal strain Trichoderma virens FKI-75732020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Efficient synthesis of a ryanodine binding inhibitor verticilide using two practical approache2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Nonantibiotic Macrolide EM900 Attenuates House Dust Mite-Induced Airway Inflammation in a Mouse Model of Obesity-Associated Asthma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Thioporidiols A and B: Two New Sulfur Compounds Discovered by Molybdenum-Catalyzed Oxidation Screening from Trichoderma polypori FKI-73822020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nanaomycin K, a new epithelial?mesenchymal transition inhibitor produced by the actinomycete “Streptomyces rosa subsp. notoensis” OS-39662020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Nanaomycin I and J: New nanaomycins generated by mycothiol-mediated compounds from “Streptomyces rosa subsp. notoensis” OS-39662019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Erythromycin acts through the ghrelin receptor to attenuate inflammatory responses in chondrocytes and maintain joint integrity2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The non-antibiotic macrolide EM900 attenuates HDM and poly(I:C)-induced airway inflammation with inhibition of macrophages in a mouse model2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with the virus internalization process2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Jietacins, azoxy natural products, as novel NF-kB inhibitors: discovery, synthesis, biological activity, and mode of action2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] 抗トリパノソーマ活性を有するActinoallolide Aの全合成研究2021

Noguchi Yoshihiko 野口吉彦