Shinkai Yoichi 新海陽一

Researcher Number	00758378
Other IDs
Affiliation (Current)	2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ長
Affiliation (based on the past Project Information) *help	2022 – 2023: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ長 2021: 国立研究開発法人産業技術総合研究所, 生命工学領域, グループ長 2019 – 2020: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 43030:Functional biochemistry-related
Keywords	Principal Investigator 線虫C. elegans / C. elegans / 神経発生 / エピジェネティクス / クロマチン動態 / 神経成熟 / クロマチン / 神経細胞 / 核内凝集タンパク質 / 疎水性相互作用 … More / 凝集体 / 液液相分離 / FGリピートタンパク質 / 液-液相分離 / 神経変性疾患 Less

Removal Mechanism of Nuclear Aggregates - Are nuclear aggregates transported out of the nucleus by the same mechanism as viruses?Principal Investigator
- Principal Investigator
  
  Shinkai Yoichi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
神経個性を決める潜在的クロマチン変化の意義とその制御機構の解明Principal Investigator
- Principal Investigator
  
  新海陽一
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Advanced Industrial Science and Technology

All 2023 2022 2021

All Journal Article Presentation Book Patent

[Book] ゲノム編集の最新技術と医薬品・遺伝子治療・農業・水畜産物・有用物質生産への活用2023
- Author(s)
  宮岡佑一郎、新海陽一、戸井基道、技術情報協会、他57名
- Total Pages
  605
- Publisher
  技術情報協会
- ISBN
  9784861049781
- Data Source
  KAKENHI-PROJECT-20K06569
[Journal Article] A novel NONO variant that causes developmental delay and cardiac phenotypes2023
- Author(s)
  Itai T、Sugie A、Nitta Y、Maki R、Suzuki T、Shinkai Y、Watanabe Y、Nakano Y、Ichikawa K、Okamoto N、Utsuno Y、Koshimizu E、Fujita A、Hamanaka K、Uchiyama Y、Tsuchida N、Miyake N、Misawa K、Mizuguchi T、Miyatake S、Matsumoto N
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 975-975
- DOI
  10.1038/s41598-023-27770-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06569, KAKENHI-PROJECT-21K15619, KAKENHI-PROJECT-20K07907, KAKENHI-PROJECT-20K08164, KAKENHI-PROJECT-20K17936, KAKENHI-PROJECT-21K15907, KAKENHI-PROJECT-23K24308, KAKENHI-PROJECT-21H02837
[Journal Article] Phase-Separation Propensity of Non-ionic Amino Acids in Peptide-Based Complex Coacervation Systems2023
- Author(s)
  Akahoshi Yuto、Sugai Hiroka、Mimura Masahiro、Shinkai Yoichi、Kurita Ryoji、Shiraki Kentaro、Tomita Shunsuke
- Journal Title
  
  Biomacromolecules
  
  Volume: 24 Issue: 2 Pages: 704-713
- DOI
  10.1021/acs.biomac.2c01148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06569
[Journal Article] Time-Resolved X-ray Observation of Intracellular Crystallized Protein in Living Animal2023
- Author(s)
  Kuramochi Masahiro、Sugawara Ibuki、Shinkai Yoichi、Mio Kazuhiro、Sasaki Yuji C.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 23 Pages: 16914-16914
- DOI
  10.3390/ijms242316914
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06569, KAKENHI-PROJECT-23K26511
[Journal Article] A mutation to a fish ice-binding protein synthesized in transgenic Caenorhabditis elegans modulates its cold tolerance2022
- Author(s)
  Kuramochi Masahiro、Zhu Shumiao、Takanashi Chiaki、Yang Yue、Arai Tatsuya、Shinkai Yoichi、Doi Motomichi、Mio Kazuhiro、Tsuda Sakae、Sasaki Yuji C.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 628 Pages: 98-103
- DOI
  10.1016/j.bbrc.2022.08.073
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06569, KAKENHI-PROJECT-21K14466
[Journal Article] Dynamic motions of ice-binding proteins in living Caenorhabditis elegans using diffracted X-ray blinking and tracking2022
- Author(s)
  Kuramochi Masahiro、Dong Yige、Yang Yue、Arai Tatsuya、Okada Rio、Shinkai Yoichi、Doi Motomichi、Aoyama Kouki、Sekiguchi Hiroshi、Mio Kazuhiro、Tsuda Sakae、Sasaki Yuji C.
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 29 Pages: 101224-101224
- DOI
  10.1016/j.bbrep.2022.101224
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22989, KAKENHI-PUBLICLY-20H04660, KAKENHI-PUBLICLY-20H04696, KAKENHI-PROJECT-19H02529, KAKENHI-PROJECT-21K14466, KAKENHI-PROJECT-20K06569
[Journal Article] The molecular and neural regulation of ultraviolet light phototaxis and its food-associated learning behavioral plasticity in C. elegans2022
- Author(s)
  Ozawa Kazuki、Shinkai Yoichi、Kako Koichiro、Fukamizu Akiyoshi、Doi Motomichi
- Journal Title
  
  Neuroscience Letters
  
  Volume: 770 Pages: 136384-136384
- DOI
  10.1016/j.neulet.2021.136384
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06569
[Journal Article] Quadruplex folding promotes the condensation of linker histones and DNAs via liquid-liquid phase separation2021
- Author(s)
  Masahiro Mimura, Shunsuke Tomita, Yoichi Shinkai, Takuya Hosokai, Hiroyuki Kumeta, Tomohide Saio, Kentaro Shiraki, Ryoji Kurita
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 143 Issue: 26 Pages: 9894-9857
- DOI
  10.1021/jacs.1c03447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20J12411, KAKENHI-PROJECT-20K06569
[Journal Article] C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers2021
- Author(s)
  Nanaura Hitoki、Aiba Yuichiro、Nakanishi Mari、Shiota Tomo、Hibino Masaki、Kikuchi Sotaro、Nagata Riko、Morikawa Naritaka、Iguchi Naohiko、Kiriyama Takao、Nagamori Shushi、Sugie Kazuma、Saio Tomohide、Yoshizawa Takuya、Mori Eiichiro et al.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 5301-5301
- DOI
  10.1038/s41467-021-25560-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07978, KAKENHI-PROJECT-19K16060, KAKENHI-PROJECT-20K16583, KAKENHI-PROJECT-18H03984, KAKENHI-PROJECT-18H05229, KAKENHI-PROJECT-20H00327, KAKENHI-PROJECT-20H03199, KAKENHI-PROJECT-20K06493, KAKENHI-PROJECT-20K06527, KAKENHI-PROJECT-20K06569, KAKENHI-PROJECT-20K06579, KAKENHI-PROJECT-21K15032, KAKENHI-PROJECT-19KK0071, KAKENHI-PROJECT-22KJ0024, KAKENHI-PLANNED-20H05925, KAKENHI-PROJECT-19H05648
[Journal Article] New Family Members of FG Repeat Proteins and Their Unexplored Roles During Phase Separation2021
- Author(s)
  Shinkai Yoichi、Kuramochi Masahiro、Miyafusa Takamitsu
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 9
- DOI
  10.3389/fcell.2021.708702
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H04660, KAKENHI-PUBLICLY-20H04696, KAKENHI-PROJECT-20K06569, KAKENHI-PROJECT-21K14466
[Journal Article] Retrogradely transmitted α-synuclein is taken up by the endophilin-independent endocytosis in the C.?elegans neural circuit2021
- Author(s)
  Wang Xuan、Shinkai Yoichi、Doi Motomichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 552 Pages: 176-182
- DOI
  10.1016/j.bbrc.2021.03.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06569
[Journal Article] Uncharged Components of Single-Stranded DNA Modulate Liquid–Liquid Phase Separation With Cationic Linker Histone H12021
- Author(s)
  Masahiro Mimura, Shunsuke Tomita, Hiroka Sugai, Yoichi Shinkai, Sayaka Ishihara, Ryoji Kurita
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 9 Pages: 1-9
- DOI
  10.3389/fcell.2021.710729
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J12411, KAKENHI-PROJECT-20K06569
[Patent] アクチン構造の検出方法2021
- Inventor(s)
  長崎晃、上田太郎、貴嶋紗久、加藤薫、新海陽一、他６名
- Industrial Property Rights Holder
  国立研究開発法人産業技術総合研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K06569
[Presentation] 細胞内液-液相分離の攪乱とその生体応答2023
- Author(s)
  新海陽一
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06569
[Presentation] C9orf72異常反復配列由来ジペプチドリピートによる運動ニューロン障害の分子メカニズム2023
- Author(s)
  新海陽一
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06569
[Presentation] 核膜孔以外に存在するFG repeatタンパク質の知られざる機能2021
- Author(s)
  新海陽一
- Organizer
  第5回LLPS研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06569

1. 戸井基道 (50344213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. 杉江和馬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 七浦仁紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 桐山敬生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 塩田智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 井口直彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 倉持昌弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 津田栄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shinkai Yoichi 新海 陽一

Research Projects

Research Products

Co-Researchers

Removal Mechanism of Nuclear Aggregates - Are nuclear aggregates transported out of the nucleus by the same mechanism as viruses?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経個性を決める潜在的クロマチン変化の意義とその制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] ゲノム編集の最新技術と医薬品・遺伝子治療・農業・水畜産物・有用物質生産への活用2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] A novel NONO variant that causes developmental delay and cardiac phenotypes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phase-Separation Propensity of Non-ionic Amino Acids in Peptide-Based Complex Coacervation Systems2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Time-Resolved X-ray Observation of Intracellular Crystallized Protein in Living Animal2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A mutation to a fish ice-binding protein synthesized in transgenic Caenorhabditis elegans modulates its cold tolerance2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dynamic motions of ice-binding proteins in living Caenorhabditis elegans using diffracted X-ray blinking and tracking2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The molecular and neural regulation of ultraviolet light phototaxis and its food-associated learning behavioral plasticity in C. elegans2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Quadruplex folding promotes the condensation of linker histones and DNAs via liquid-liquid phase separation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New Family Members of FG Repeat Proteins and Their Unexplored Roles During Phase Separation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Retrogradely transmitted α-synuclein is taken up by the endophilin-independent endocytosis in the C.?elegans neural circuit2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Uncharged Components of Single-Stranded DNA Modulate Liquid&#8211;Liquid Phase Separation With Cationic Linker Histone H12021

Author(s)

Journal Title

DOI

Data Source

[Patent] アクチン構造の検出方法2021

Inventor(s)

Industrial Property Rights Holder

Shinkai Yoichi 新海陽一

[Journal Article] Uncharged Components of Single-Stranded DNA Modulate Liquid–Liquid Phase Separation With Cationic Linker Histone H12021