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Azushima Kengo  小豆島 健護

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AZUSHIMA Kengo  小豆島 健護

Kengo AZUSHIMA  小豆島 健護

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Researcher Number 00760381
Other IDs
Affiliation (Current) 2025: 横浜市立大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2020 – 2023: 横浜市立大学, 医学部, 助教
2016 – 2017: 横浜市立大学, 医学研究科, 客員研究員
Review Section/Research Field
Principal Investigator
Basic Section 53040:Nephrology-related / 0902:General internal medicine and related fields / Endocrinology
Keywords
Principal Investigator
レニン・アンジオテンシン系 / レニン-アンジオテンシン系 / ATRAP / 皮膚組織 / 高血圧 / アシルカルニチン / エネルギー代謝 / 脂肪酸酸化 / 糖尿病性腎臓病 / 皮膚 … More / ナトリウム / 統合医療 / メタボリック症候群 / 内科 / 肥満 / 脂肪組織 / 受容体 / 肥満症 / インスリン抵抗性 / 骨格筋 / 脂肪細胞 Less
  • Research Projects

    (4 results)
  • Research Products

    (30 results)
  • Co-Researchers

    (7 People)
  •  Skin tissue renin-angiotensin system as a novel mechanism of hypertensionPrincipal Investigator

    • Principal Investigator
      小豆島 健護
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Yokohama City University
  •  Pathophysiological significance of renal energy metabolism in diabetic kidney diseasePrincipal Investigator

    • Principal Investigator
      AZUSHIMA Kengo
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Yokohama City University
  •  Pathophysiological significance of skin renin-angiotensin system in the development of hypertensionPrincipal Investigator

    • Principal Investigator
      AZUSHIMA Kengo
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0902:General internal medicine and related fields
    • Research Institution
      Yokohama City University
  •  Integrative Medicice Focused on the Receptor Biniding Molecule for Obesity and Metabolic SyndromePrincipal Investigator

    • Principal Investigator
      Kengo AZUSHIMA
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Endocrinology
    • Research Institution
      Yokohama City University

All 2024 2023 2022 2021 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Angiotensin II type 1 receptor-associated protein deletion combined with angiotensin II stimulation accelerates the development of diabetic kidney disease in mice on a C57BL/6 strain2023

    • Author(s)
      Taguchi Shinya、Azushima Kengo、Yamaji Takahiro、Suzuki Toru、Abe Eriko、Tanaka Shohei、Hirota Keigo、Tsukamoto Shunichiro、Morita Ryutaro、Kobayashi Ryu、Kinguchi Sho、Yamashita Akio、Wakui Hiromichi、Tamura Kouichi
    • Journal Title

      Hypertension Research

      Volume: 47 Issue: 1 Pages: 55-66

    • DOI

      10.1038/s41440-023-01496-4

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K15252, KAKENHI-PROJECT-23K06871, KAKENHI-PROJECT-23K07678, KAKENHI-PROJECT-22K20890
  • [Journal Article] Enhancement of angiotensin II type 1 receptor-associated protein in the paraventricular nucleus suppresses angiotensin II-dependent hypertension2023

    • Author(s)
      Sotozawa Mari、Kinguchi Sho、Wakui Hiromichi、Azushima Kengo、Funakoshi Kengo、Nakajima Waki、Miyazaki Tomoyuki、Takahashi Takuya、Tamura Kouichi
    • Journal Title

      Hypertension Research

      Volume: 47 Issue: 1 Pages: 67-77

    • DOI

      10.1038/s41440-023-01480-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K06871, KAKENHI-PROJECT-23K07678
  • [Journal Article] Combination of sacubitril/valsartan and blockade of the PI3K pathway enhanced kidney protection in a mouse model of cardiorenal syndrome2023

    • Author(s)
      Tsukamoto Shunichiro、Wakui Hiromichi、Uehara Tatsuki、Shiba Yuka、Azushima Kengo、Abe Eriko、Tanaka Shohei、Taguchi Shinya、Hirota Keigo、Urate Shingo、Suzuki Toru、Yamada Takayuki、Kinguchi Sho、Yamashita Akio、Tamura Kouichi
    • Journal Title

      European Heart Journal Open

      Volume: 3 Issue: 6 Pages: 1-13

    • DOI

      10.1093/ehjopen/oead098

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K14741, KAKENHI-PROJECT-23K15252, KAKENHI-PROJECT-23K06871, KAKENHI-PROJECT-23K07678, KAKENHI-PROJECT-22K20861, KAKENHI-PROJECT-22K20890
  • [Journal Article] Angiotensin II type 1 receptor-associated protein in immune cells: a possible key factor in the pathogenesis of visceral obesity2023

    • Author(s)
      Tsukamoto Shunichiro、Suzuki Toru、Wakui Hiromichi、Uehara Tatsuki、Ichikawa Juri、Okuda Hiroshi、Haruhara Kotaro、Azushima Kengo、Abe Eriko、Tanaka Shohei、Taguchi Shinya、Hirota Keigo、Kinguchi Sho、Yamashita Akio、Tamura Tomohiko、Tamura Kouichi
    • Journal Title

      Metabolism

      Volume: 149 Pages: 155706-155706

    • DOI

      10.1016/j.metabol.2023.155706

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K18129, KAKENHI-PROJECT-23K15252, KAKENHI-PROJECT-23K06871, KAKENHI-PROJECT-23K07678, KAKENHI-PROJECT-22K20890, KAKENHI-PROJECT-21H02954
  • [Journal Article] miR-125a-5p/miR-125b-5p contributes to pathological activation of angiotensin II-AT1R in mouse distal convoluted tubule cells by the suppression of Atrap2023

    • Author(s)
      Hirota Keigo、Yamashita Akio、Abe Eriko、Yamaji Takahiro、Azushima Kengo、Tanaka Shohei、Taguchi Shinya、Tsukamoto Shunichiro、Wakui Hiromichi、Tamura Kouichi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 299 Issue: 12 Pages: 105478-105478

    • DOI

      10.1016/j.jbc.2023.105478

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K06871, KAKENHI-PROJECT-23K07678
  • [Journal Article] Angiotensin II type-1 receptor-associated protein interacts with transferrin receptor-1 and promotes its internalization2022

    • Author(s)
      Abe Eriko、Yamashita Akio、Hirota Keigo、Yamaji Takahiro、Azushima Kengo、Urate Shingo、Suzuki Toru、Tanaka Shohei、Taguchi Shinya、Tsukamoto Shunichiro、Uehara Tatsuki、Wakui Hiromichi、Tamura Kouichi、Takahashi Hidehisa
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 17376-17376

    • DOI

      10.1038/s41598-022-22343-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K20890, KAKENHI-PLANNED-21H05159, KAKENHI-PROJECT-21H02405, KAKENHI-PROJECT-20K07786, KAKENHI-PROJECT-20K09603, KAKENHI-PROJECT-21K19356, KAKENHI-PROJECT-21K16166
  • [Journal Article] Deficiency of the kidney tubular angiotensin II type1 receptor?associated protein ATRAP exacerbates streptozotocin-induced diabetic glomerular injury via reducing protective macrophage polarization2022

    • Author(s)
      Haruhara Kotaro、Suzuki Toru、Wakui Hiromichi、Azushima Kengo、Kurotaki Daisuke、Kawase Wataru、Uneda Kazushi、Kobayashi Ryu、Ohki Kohji、Kinguchi Sho、Yamaji Takahiro、Kato Ikuma、Ohashi Kenichi、Yamashita Akio、Tamura Tomohiko、Tsuboi Nobuo、Yokoo Takashi、Tamura Kouichi
    • Journal Title

      Kidney International

      Volume: 101 Issue: 5 Pages: 912-928

    • DOI

      10.1016/j.kint.2022.01.031

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K22601, KAKENHI-PROJECT-19K17575, KAKENHI-PROJECT-20K22908, KAKENHI-PROJECT-20H03438, KAKENHI-PROJECT-20K07786, KAKENHI-PROJECT-21K19413, KAKENHI-PROJECT-21K16166, KAKENHI-PROJECT-22K20890, KAKENHI-PROJECT-20K21606, KAKENHI-PROJECT-21H02954
  • [Journal Article] Effects of tumor necrosis factor-α inhibition on kidney fibrosis and inflammation in a mouse model of aristolochic acid nephropathy2021

    • Author(s)
      Taguchi Shinya、Azushima Kengo、Yamaji Takahiro、Urate Shingo、Suzuki Toru、Abe Eriko、Tanaka Shohei、Tsukamoto Shunichiro、Kamimura Daisuke、Kinguchi Sho、Yamashita Akio、Wakui Hiromichi、Tamura Kouichi
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 23587-23587

    • DOI

      10.1038/s41598-021-02864-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K22601, KAKENHI-PROJECT-20K22908, KAKENHI-PROJECT-18H02735, KAKENHI-PROJECT-20H03438, KAKENHI-PROJECT-20K07786, KAKENHI-PROJECT-20K21606, KAKENHI-PROJECT-21K19413, KAKENHI-PROJECT-21K16166
  • [Journal Article] Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue2018

    • Author(s)
      Ohki Kohji、Wakui Hiromichi、Kishio Nozomu、Azushima Kengo、Uneda Kazushi、Haku Sona、Kobayashi Ryu、Haruhara Kotaro、Kinguchi Sho、Yamaji Takahiro、Yamada Takayuki、Minegishi Shintaro、Ishigami Tomoaki、Toya Yoshiyuki、Yamashita Akio、Imajo Kento、Nakajima Atsushi、Kato Ikuma、Ohashi Kenichi、Tamura Kouichi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 2846-2846

    • DOI

      10.1038/s41598-018-21270-8

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19665, KAKENHI-PUBLICLY-17H05671, KAKENHI-PROJECT-15H04331, KAKENHI-PROJECT-17H06993, KAKENHI-PROJECT-16K19558, KAKENHI-PROJECT-17K09313, KAKENHI-PROJECT-18H02735, KAKENHI-PROJECT-19K21318
  • [Journal Article] ATRAP Expression in Brown Adipose Tissue Does Not Influence the Development of Diet-Induced Metabolic Disorders in Mice2017

    • Author(s)
      Wakui H, Ohki K, Azushima K, Uneda K, Haku S, Kobayashi R, Haruhara K, Kinguchi S, Matsuda M, Ohsawa M, Maeda A, Minegishi S, Ishigami T, Toya Y, Yamashita A, Umemura S, Tamura K
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 18 Issue: 3 Pages: 676-676

    • DOI

      10.3390/ijms18030676

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19536, KAKENHI-PROJECT-16K09647, KAKENHI-PROJECT-17K09313, KAKENHI-PROJECT-17K19665, KAKENHI-PUBLICLY-17H05671, KAKENHI-PROJECT-15H04331, KAKENHI-PROJECT-15K09293, KAKENHI-PROJECT-16K19558
  • [Journal Article] Adipocyte-Specific Enhancement of Angiotensin II Type 1 Receptor-Associated Protein Ameliorates Diet-Induced Visceral Obesity and Insulin Resistance.2017

    • Author(s)
      Azushima K, Ohki K, Wakui H, Uneda K, Haku S, Kobayashi R, Haruhara K, Kinguchi S, Matsuda M, Maeda A, Toya Y, Yamashita A, Umemura S, Tamura K.
    • Journal Title

      J Am Heart Assoc.

      Volume: 6 Issue: 3

    • DOI

      10.1161/jaha.116.004488

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04331, KAKENHI-PROJECT-15K19536, KAKENHI-PROJECT-16K19558, KAKENHI-PROJECT-17K09313, KAKENHI-PROJECT-17K19665, KAKENHI-PUBLICLY-17H05671, KAKENHI-PROJECT-15K09293
  • [Presentation] Angiotensin II receptor-associated protein in the skin regulates blood pressure via modulating skin renin-angiotensin system activity.2024

    • Author(s)
      Azushima K, Taguchi S, Kitada K, Morisawa N, Wakui H, Nishiyama A, Tamura K.
    • Organizer
      2024 Angiotensin Gordon Research Conference, Lucca (Barga), Italy, February 2024.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K07678
  • [Presentation] Angiotensin II Type 1 Receptor-Associated Protein Deletion Combined with Angiotensin II Stimulation Exacerbates Diabetic Kidney Disease in C57BL/6 Mice.2023

    • Author(s)
      Azushima K, Taguchi S, Wakui H, Tamura K.
    • Organizer
      Hypertension Scientific Sessions 2023, Boston, USA, September 2023.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K07678
  • [Presentation] Beneficial Effects of Tumor Necrosis Factor-α Blockade in a Mouse Model of Diabetic Nephropathy.2022

    • Author(s)
      Yamaji T, Azushima K, Gurley SB, Coffman TM.
    • Organizer
      WCN 2022 - The World Congress of Nephrology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K22908
  • [Presentation] Beneficial Effects of Tumor Necrosis Factor-α Blockade in a Mouse Model of Diabetic Nephropathy.2022

    • Author(s)
      Yamaji T, Azushima K, Gurley SB, Coffman TM.
    • Organizer
      WCN 2022 - The World Congress of Nephrology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K16166
  • [Presentation] Impaired TCA Cycle Metabolism in Diabetic Nephropathy is Linked to Albuminuria and Kidney Injury.2022

    • Author(s)
      Azushima K, Kovalik JP, Yamaji T, Gurley SB, Coffman TM.
    • Organizer
      The 29th Scientific Meeting of the International Society of Hypertension (ISH2022)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K16166
  • [Presentation] Systemic ATRAP deletion exacerbates the development of diabetic nephropathy under angiotensin II stimulation in streptozotocin-diabetic mice.2022

    • Author(s)
      Taguchi S, Azushima K, Wakui H, Suzuki T, Urate S, Abe E, Tanaka S, Tsukamoto S, Tamura K.
    • Organizer
      The 29th Scientific Meeting of the International Society of Hypertension (ISH2022)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K16166
  • [Presentation] Functional Role of Tumor Necrosis Factor-α Pathway in Aristolochic Acid-induced Kidney Injury Model.2021

    • Author(s)
      Taguchi S, Azushima K, Wakui H, Yamaji T, Urate S, Suzuki T, Abe E, Tanaka S, Tsukamoto S, Yamashita A, Tamura K.
    • Organizer
      Kidney Week 2021 (American Society of Nephrology Annual Meeting)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K16166
  • [Presentation] Beneficial Effects of Tumor Necrosis Factor-α Blockade in a Mouse Model of Diabetic Nephropathy.2021

    • Author(s)
      Yamaji T, Azushima K, Gurley SB, Coffman TM.
    • Organizer
      Kidney Week 2021 (American Society of Nephrology Annual Meeting)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K16166
  • [Presentation] Functional Role of Tumor Necrosis Factor-α Pathway in Aristolochic Acid-induced Kidney Injury Model.2021

    • Author(s)
      Taguchi S, Azushima K, Wakui H, Yamaji T, Urate S, Suzuki T, Abe E, Tanaka S, Tsukamoto S, Yamashita A, Tamura K.
    • Organizer
      Kidney Week 2021 (American Society of Nephrology Annual Meeting)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K22908
  • [Presentation] Beneficial Effects of Tumor Necrosis Factor-α Blockade in a Mouse Model of Diabetic Nephropathy.2021

    • Author(s)
      Yamaji T, Azushima K, Gurley SB, Coffman TM.
    • Organizer
      Kidney Week 2021 (American Society of Nephrology Annual Meeting)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K22908
  • [Presentation] The Protective Role of Angiotensin II Type 1 Receptor Associated Protein in Metabolic Disorders2018

    • Author(s)
      Kohji Ohki, Hiromichi Wakui, Kengo Azushima, Kazushi Uneda, Ryu kobayashi, Sona Haku, Kotaro Haruhara, Sho Kinguchi, Takayuki Yamada, Takahiro Yamaji, Nozomu Kishio, Kento Imajo Atsushi Nakajima, Akio Yamashita, Yoshiyuki Toya and Kouichi Tamura
    • Organizer
      ISN Frontiers Meetings 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19558
  • [Presentation] Adipocyte angiotensin II type 1 receptor (AT1R)-associated protein prevents diet-induced visceral obesity and insulin resistance through the suppression of overactivated tissue AT1R signaling2018

    • Author(s)
      Azushima K, Wakui H, Uneda K, Kobayashi R, Haku S, Ohki K, Haruhara K, Kinguchi S, Yamashita A, Umemura S, Tamura K
    • Organizer
      ISN Frontiers Meetings 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19558
  • [Presentation] Adipose tissue angiotensin II type 1 receptor-associated protein prevents diet-induced visceral obesity and insulin resistance2017

    • Author(s)
      Azushima K, Ohki K, Wakui H, Tamura K
    • Organizer
      13th Asian-Pacific Congress of Hypertension
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19558
  • [Presentation] 糖脂質代謝障害における1型アンジオテンシンII受容体結合蛋白ATRAPの機能的意義2017

    • Author(s)
      大城 光二,涌井広道, 大澤正人, 小豆島健護, 畝田一司, 小林竜, 白善雅, 春原浩太郎, 金口翔, 山田貴之, 山地孝拡, 松田美由紀, 岸尾望, 今城健人, 中島淳, 山下暁朗, 戸谷義幸, 田村功一
    • Organizer
      第21回心血管内分泌代謝学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K19558
  • [Presentation] Renin-angiotensin system and metabolic diseases2017

    • Author(s)
      Azushima K
    • Organizer
      Satellite Interstellar Initiative at A*STAR
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19558
  • [Presentation] Mouse models of diabetic nephropathy2017

    • Author(s)
      Azushima K
    • Organizer
      4th Next Generation Kidney Research Meeting
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19558
  • [Presentation] アディポネクチンプロモーター制御下1型アンジオテンシンII受容体結合因子(ATRAP)高発現マウスにおける慢性アンジオテンシンII刺激によるインスリン抵抗性の検討2017

    • Author(s)
      大城 光二,涌井 広道,大澤 正人,小豆島 健護,白 善雅,畝田 一司,小林 竜,春原 浩太郎,金口 翔,山田 貴之,山地 孝拡,岸尾 望,田村 功一
    • Organizer
      第40回日本高血圧学会総会
    • Data Source
      KAKENHI-PROJECT-16K19558
  • [Presentation] Adipose tissue ATRAP (angiotensin II type 1 receptor-associated protein) prevents diet-induced visceral obesity and insulin resistance via the alternation of adipose GLUT4 expression2016

    • Author(s)
      Kengo Azushima
    • Organizer
      The ISH 2016 satellite symposium, Renin-angiotensin-aldosterone system (RAAS)
    • Place of Presentation
      コングレススクエア日本橋(東京都中央区)
    • Year and Date
      2016-09-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19558
  • [Presentation] 脂肪組織におけるアンジオテンシン受容体結合因子(ATRAP/Agtrap)の高発現は食餌性肥満およびインスリン抵抗性の増悪を抑制する2016

    • Author(s)
      小豆島 健護
    • Organizer
      第39回日本高血圧学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-30
    • Data Source
      KAKENHI-PROJECT-16K19558
  • 1.  TAMURA Kouichi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 2.  WAKUI Hiromichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 3.  鈴木 徹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 4.  山下 暁朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 5.  宮崎 智之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  浦手 進吾
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  田村 智彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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