IWAI SACHIKO 岩井祥子

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Iwai Sachiko 岩井祥子

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Researcher Number	00768905
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定研究員
Affiliation (based on the past Project Information) *help	2016 – 2024: 京都大学, 医学研究科, 特定研究員
Review Section/Research Field	Principal Investigator Basic Section 56060:Ophthalmology-related / Ophthalmology Except Principal Investigator Basic Section 56060:Ophthalmology-related
Keywords	Principal Investigator 網膜色素変性 / 疾患特異的iPS細胞 / 網膜オルガノイド / CYP4V2 / 遊離コレステロール / cyp4v2 / シクロデキストリン / 疾患特異的iPS-RPE / クリスタリン網膜症 / 遺伝子変異 … More / 網膜色素変性症 / MERTK遺伝子変異 / iPS-RPE / MERTK / 眼細胞生物学 / 加齢黄斑変性 / 網膜保護 / 緑内障 / BCAA / 分岐鎖アミノ酸 … More Except Principal Investigator 自己免疫 / 自己抗体 / 腸内細菌 / 網膜色素変性 / iPS細胞 / 加齢黄斑変性 / 脂質 / 網膜色素上皮 / iPS / ドルーゼン / 黄斑変性 Less

EYS遺伝子異常を有する疾患特異的iPS細胞を用いた網膜色素変性の病態解明Principal Investigator
- Principal Investigator
  
  岩井祥子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Kyoto University
網膜変性疾患における腸内細菌、自己免疫の関与の解明
- Principal Investigator
  
  池田華子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Kyoto University
Drug development for Bietti's crystalline dystrophy using disease-specific iPS cellsPrincipal Investigator
- Principal Investigator
  
  Iwai Sachiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Kyoto University
Lipid profiles of retinal pigment epithelial cells and the mechanism of Drusen formation.
- Principal Investigator
  
  Ikeda Hanako
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Kyoto University
Pathological elucidation in induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelial Cells established from Patient with Retinitis Pigmentosa Carrying novel gene abnormalityPrincipal Investigator
- Principal Investigator
  
  Iwai Sachiko
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Kyoto University
Investigation of the cell protective abilities of branched chain amino acids in mouse models of retinal neurodegenerative diseasesPrincipal Investigator
- Principal Investigator
  
  Iwai Sachiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Kyoto University

All 2022 2021 2020 2018 2017

All Journal Article Presentation Patent

[Journal Article] Involvement of endothelins in neuroprotection of valosin-containing protein modulators against retinal ganglion cell damage2022
- Author(s)
  Kusaka Mami、Hasegawa Tomoko、Ikeda Hanako Ohashi、Inoue Yumi、Iwai Sachiko、Iida Kei、Tsujikawa Akitaka
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 16156-16156
- DOI
  10.1038/s41598-022-20497-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09789, KAKENHI-PROJECT-20K09826
[Journal Article] Branched Chain Amino Acids Promote ATP Production Via Translocation of Glucose Transporters2022
- Author(s)
  Iwai Sachiko、Hasegawa Tomoko、Ikeda Hanako Ohashi、Tsujikawa Akitaka
- Journal Title
  
  Investigative Opthalmology & Visual Science
  
  Volume: 63 Issue: 9 Pages: 7-7
- DOI
  10.1167/iovs.63.9.7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09789, KAKENHI-PROJECT-20J40157, KAKENHI-PROJECT-20K09826
[Journal Article] Author Correction: A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis2021
- Author(s)
  Saito Motoo、Nishitani Kohei、Ikeda Hanako O.、Yoshida Shigeo、Iwai Sachiko、Ji Xiang、Nakahata Akihiro、Ito Akira、Nakamura Shinichiro、Kuriyama Shinichi、Yoshitomi Hiroyuki、Murata Koichi、Aoyama Tomoki、Ito Hiromu、Kuroki Hiroshi、Kakizuka Akira、Matsuda Shuichi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1
- DOI
  10.1038/s41598-021-86883-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09826
[Journal Article] A Protocol for Stepwise Differentiation of Induced Pluripotent Stem Cells into Retinal Pigment Epithelium2021
- Author(s)
  Tagawa Miho、Ikeda Hanako Ohashi、Hata Masayuki、Inoue Yumi、Iwai Sachiko、Tsujikawa Akitaka
- Journal Title
  
  Methods Mol Biol
  
  Volume: - Pages: 307-320
- DOI
  10.1007/7651_2021_418
- ISBN
  9781071625842, 9781071625859
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09991, KAKENHI-PROJECT-20K09826
[Journal Article] Deterioration of phagocytosis in induced pluripotent stem cell-derived retinal pigment epithelial cells established from patients with retinitis pigmentosa carrying Mer tyrosine kinase mutations2021
- Author(s)
  Tagawa Miho、Ikeda Hanako Ohashi、Inoue Yumi、Iwai Sachiko、Iida Yuto、Hata Masayuki、Asaka Isao、Tsujikawa Akitaka
- Journal Title
  
  Experimental Eye Research
  
  Volume: 205 Pages: 108503-108503
- DOI
  10.1016/j.exer.2021.108503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09991, KAKENHI-PROJECT-20K09826
[Journal Article] KUS121 attenuates the progression of monosodium iodoacetate-induced osteoarthritis in rats2021
- Author(s)
  Iwai Sachiko、Ikeda Hanako O.、Mera Hisashi、Nishitani Kohei、Saito Motoo、Tsujikawa Akitaka、Kakizuka Akira
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 15651-15651
- DOI
  10.1038/s41598-021-95173-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09991, KAKENHI-PROJECT-20K09408, KAKENHI-PROJECT-20K09826, KAKENHI-PROJECT-19H03435
[Journal Article] Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model2020
- Author(s)
  Hasegawa Tomoko、Ikeda Hanako O.、Iwai Sachiko、Sasaoka Norio、Kakizuka Akira、Tsujikawa Akitaka
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 21653-21653
- DOI
  10.1038/s41598-020-78731-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09991, KAKENHI-PROJECT-20J40157, KAKENHI-PROJECT-19H03435
[Journal Article] Effect of VCP modulators on gene expression profiles of retinal ganglion cells in an acute injury mouse model2020
- Author(s)
  Hasegawa Tomoko、Ikeda Hanako Ohashi、Gotoh Norimoto、Iida Kei、Iwai Sachiko、Nakano Noriko、Kakizuka Akira、Tsujikawa Akitaka
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 4251-4251
- DOI
  10.1038/s41598-020-61160-6
- NAID
  120006870291
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19610, KAKENHI-PROJECT-18K16923, KAKENHI-PROJECT-19K09991, KAKENHI-PROJECT-19H03435
[Journal Article] Reduction of lipid accumulation rescues Bietti’s crystalline dystrophy phenotypes2018
- Author(s)
  Hata Masayuki、Ikeda Hanako O.、Iwai Sachiko、Iida Yuto、Gotoh Norimoto、Asaka Isao、Ikeda Kazutaka、Isobe Yosuke、Hori Aya、Nakagawa Saori、Yamato Susumu、Arita Makoto、Yoshimura Nagahisa、Tsujikawa Akitaka
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 15 Pages: 3936-3941
- DOI
  10.1073/pnas.1717338115
- NAID
  120006416205
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11285, KAKENHI-PROJECT-17K16967, KAKENHI-PUBLICLY-16H01359, KAKENHI-PROJECT-16K20316, KAKENHI-PROJECT-18K19610, KAKENHI-PROJECT-18K16923, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05898
[Journal Article] Branched chain amino acids attenuate major pathologies in mouse models of retinal degeneration and glaucoma2018
- Author(s)
  Hasegawa Tomoko、Ikeda Hanako Ohashi、Iwai Sachiko、Muraoka Yuki、Tsuruyama Tatsuaki、Okamoto-Furuta Keiko、Kohda Haruyasu、Kakizuka Akira、Yoshimura Nagahisa
- Journal Title
  
  Ｈｅｌｉｙｏｎ
  
  Volume: 4 Issue: 2 Pages: e00544-e00544
- DOI
  10.1016/j.heliyon.2018.e00544
- NAID
  120006425863
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11285, KAKENHI-PROJECT-16K20316, KAKENHI-PROJECT-16H05151
[Journal Article] KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress.2017
- Author(s)
  Hata M, Ikeda HO, Kikkawa C, Iwai S, Muraoka Y, Hasegawa T, Kakizuka A, Yoshimura N
- Journal Title
  
  Sci Rep
  
  Volume: - Issue: 1 Pages: 44873-44873
- DOI
  10.1038/srep44873
- NAID
  120006222005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K20255, KAKENHI-PROJECT-16K11285, KAKENHI-PROJECT-16H05151, KAKENHI-PROJECT-16K20316, KAKENHI-PROJECT-24249082, KAKENHI-PUBLICLY-16H01359
[Patent] 軟骨保護用の医薬組成物2020
- Inventor(s)
  西谷江平、垣塚彰、池田華子ほか一、岩井祥子、斉藤元央、武蔵国弘
- Industrial Property Rights Holder
  西谷江平、垣塚彰、池田華子ほか一、岩井祥子、斉藤元央、武蔵国弘
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-19K09991
[Presentation] PS細胞を用いたMERTKの新規遺伝子異常を有する網膜色素変性の病態解明2021
- Author(s)
  田川美穂, 池田華子, 井上由美, 岩井祥子,　飯田悠人, 畑匡侑, 浅香勲, 辻川明孝
- Organizer
  第125回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-19K09991

1. IKEDA hanako (20372162)

# of Collaborated Projects: 5 results

# of Collaborated Products: 12 results
2. HASEGAWA tomoko (90802760)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 大石明生 (50572955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 井上由美 (70867481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YOSHIMURA nagahisa

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. IIDA yuto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KAWAGUCHI eri

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SUETHUGU masami

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MURAOKA Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. KAKIZUKA Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. TSUJIKAWA Akitaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 畑匡侑

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

IWAI SACHIKO 岩井 祥子

Iwai Sachiko 岩井 祥子

Research Projects

Research Products

Co-Researchers

EYS遺伝子異常を有する疾患特異的iPS細胞を用いた網膜色素変性の病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

網膜変性疾患における腸内細菌、自己免疫の関与の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug development for Bietti's crystalline dystrophy using disease-specific iPS cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Lipid profiles of retinal pigment epithelial cells and the mechanism of Drusen formation.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathological elucidation in induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelial Cells established from Patient with Retinitis Pigmentosa Carrying novel gene abnormalityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the cell protective abilities of branched chain amino acids in mouse models of retinal neurodegenerative diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Involvement of endothelins in neuroprotection of valosin-containing protein modulators against retinal ganglion cell damage2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Branched Chain Amino Acids Promote ATP Production Via Translocation of Glucose Transporters2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Author Correction: A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Protocol for Stepwise Differentiation of Induced Pluripotent Stem Cells into Retinal Pigment Epithelium2021

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Deterioration of phagocytosis in induced pluripotent stem cell-derived retinal pigment epithelial cells established from patients with retinitis pigmentosa carrying Mer tyrosine kinase mutations2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] KUS121 attenuates the progression of monosodium iodoacetate-induced osteoarthritis in rats2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of VCP modulators on gene expression profiles of retinal ganglion cells in an acute injury mouse model2020

Author(s)

Journal Title

IWAI SACHIKO 岩井祥子

Iwai Sachiko 岩井祥子